Motif ID: AIRE.p2

Z-value: 1.066


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_445345750.273.1e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 1.920 ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_+_75734759 1.830 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr22_-_34886727 1.555 NM_145640
APOL3
apolipoprotein L, 3
chr13_-_40454360 1.543 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_53444733 1.434 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr16_+_20328355 1.300 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr4_+_69716298 1.235 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr19_+_55627971 1.169 NM_004533
MYBPC2
myosin binding protein C, fast type
chr11_-_73371531 1.128 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr13_-_40491491 1.118 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_+_18069596 1.104 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr4_-_139382672 1.016 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr16_-_3567354 1.008 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr7_-_149960612 0.863 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr19_-_6621078 0.858 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr2_-_190336168 0.852 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr6_+_10629550 0.848 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr13_-_40491405 0.846 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_153222464 0.824 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr19_-_44518516 0.817 NM_004877
GMFG
glia maturation factor, gamma
chr6_+_6533932 0.815 NM_004271
LY86
lymphocyte antigen 86
chr7_+_116238309 0.812 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr3_-_17757402 0.811 NM_014744
TBC1D5
TBC1 domain family, member 5
chr1_-_89437098 0.780 NM_052941
GBP4
guanylate binding protein 4
chr17_-_59437782 0.764 NM_000873
ICAM2
intercellular adhesion molecule 2
chr9_+_116413443 0.754 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr4_+_88187215 0.738 AFF1
AF4/FMR2 family, member 1
chr17_-_31231421 0.730 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr19_-_53450953 0.718 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr11_-_62195587 0.696 C11orf48
chromosome 11 open reading frame 48
chr1_+_158975662 0.695 NM_021181
SLAMF7
SLAM family member 7
chr5_-_149772563 0.681 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr7_-_64104441 0.668 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr11_+_64694200 0.653 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr2_-_231498184 0.649 NM_005683
GPR55
G protein-coupled receptor 55
chr11_-_104274606 0.648 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr8_-_42742729 0.640 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr15_-_97607108 0.640 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr10_-_32707549 0.629 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr19_-_6542012 0.618 CD70
CD70 molecule
chr1_+_157067729 0.618 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chrX_-_100193747 0.608 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chrX_-_100193698 0.602 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr15_+_39363442 0.602 LOC729082
hypothetical LOC729082
chr2_-_188021117 0.599 NM_005795
CALCRL
calcitonin receptor-like
chr18_+_27425727 0.585 NM_000371
TTR
transthyretin
chr22_+_34979118 0.576 APOL1
apolipoprotein L, 1
chr2_+_215885053 0.561 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_-_30704984 0.553 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr19_-_12695628 0.551 NM_001136195
TNPO2
transportin 2
chr1_+_153222393 0.549 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr22_+_34979062 0.533 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_33085329 0.521 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr14_+_101345878 0.514 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr19_-_10474767 0.513 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr19_-_44618375 0.512 NM_001020
RPS16
ribosomal protein S16
chr1_-_167947301 0.509 NM_000655
SELL
selectin L
chr2_+_215884923 0.504 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr16_-_11282595 0.493 NM_002761
PRM1
protamine 1
chr4_+_17187936 0.476 NM_015907
LAP3
leucine aminopeptidase 3
chr1_-_32157845 0.466 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr15_+_53398697 0.465 PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr2_-_170138558 0.461 NM_024622
FASTKD1
FAST kinase domains 1
chr1_-_9052207 0.458 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr4_-_123761615 0.457 NM_021803
IL21
interleukin 21
chr12_+_49605010 0.456 METTL7A
methyltransferase like 7A
chr12_+_45896318 0.453 NM_138371
FAM113B
family with sequence similarity 113, member B
chr6_-_37575599 0.449 C6orf129
chromosome 6 open reading frame 129
chr4_-_38710376 0.439 NM_024943
TMEM156
transmembrane protein 156
chr1_-_114855281 0.438 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr6_+_43005214 0.431 CNPY3
canopy 3 homolog (zebrafish)
chr2_+_215885063 0.431 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr16_+_80370400 0.430 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr6_+_53043729 0.425 NM_012347
FBXO9
F-box protein 9
chr2_-_176656935 0.417 NM_001080458
EVX2
even-skipped homeobox 2
chr12_-_30740072 0.409 NM_006390
IPO8
importin 8
chr1_-_143708467 0.402 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr6_-_99957253 0.400 SFRS18
splicing factor, arginine/serine-rich 18
chr4_+_53986759 0.394 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr3_+_173954940 0.392 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr21_-_42219849 0.392 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_7785360 0.387 ITIH2
inter-alpha (globulin) inhibitor H2
chr13_-_98708549 0.387 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_-_55405209 0.382 NM_001113201
NM_005594
NACA

nascent polypeptide-associated complex alpha subunit

chr16_+_28993770 0.374 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr16_-_727889 0.371 NARFL
nuclear prelamin A recognition factor-like
chr2_+_113911737 0.358 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr17_+_39778191 0.357 GRN
granulin
chr8_+_7340777 0.357 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr9_-_85761353 0.350 C9orf64
chromosome 9 open reading frame 64
chr6_+_31910623 0.350 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr10_+_7785347 0.349 ITIH2
inter-alpha (globulin) inhibitor H2
chr21_-_18697829 0.347 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr6_-_32892705 0.345 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_+_39874921 0.337 NM_004310
RHOH
ras homolog gene family, member H
chr15_+_64372876 0.335 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr10_+_7785331 0.334 ITIH2
inter-alpha (globulin) inhibitor H2
chr22_+_24174039 0.333 CRYBB2P1
crystallin, beta B2 pseudogene 1
chr6_-_149847809 0.330 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr12_+_70119785 0.329 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr22_-_16080265 0.324 CECR1
cat eye syndrome chromosome region, candidate 1
chr9_-_124329392 0.322 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr19_+_17499064 0.316 FAM129C
family with sequence similarity 129, member C
chr6_-_31668476 0.316 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr10_+_7785290 0.313 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_+_32240357 0.309 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr6_-_11490487 0.297 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chrX_-_2892288 0.294 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr22_+_34126294 0.292 MCM5
minichromosome maintenance complex component 5
chr13_+_48968097 0.292 PHF11
PHD finger protein 11
chr11_-_73371452 0.289 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr6_+_43005126 0.286 CNPY3
canopy 3 homolog (zebrafish)
chr17_-_18207416 0.283 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr19_-_16111594 0.280


chrX_+_153310313 0.279 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr2_+_201806410 0.277 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr6_+_26473376 0.276 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr8_-_102034777 0.274 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_-_85490997 0.270 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr19_-_14646626 0.269 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr13_-_45640679 0.266 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_68445821 0.266 NM_002664
PLEK
pleckstrin
chr1_+_239762179 0.265 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_-_9052253 0.263 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr19_-_8314120 0.261 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chr7_-_149960218 0.261 GIMAP6
GTPase, IMAP family member 6
chr16_-_73258218 0.260 RFWD3
ring finger and WD repeat domain 3
chr2_-_61098867 0.256 NM_144709
PUS10
pseudouridylate synthase 10
chr6_-_159386007 0.255 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr7_+_2565238 0.253 IQCE
IQ motif containing E
chr19_-_16111695 0.253


chr9_-_98580148 0.251 NM_014930
ZNF510
zinc finger protein 510
chr17_+_38259620 0.246 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr15_-_43458247 0.246 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_-_28528780 0.244 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr17_-_30414789 0.244 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr19_+_59866237 0.242 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr19_-_42355407 0.241 NM_152655
ZNF585A
zinc finger protein 585A
chr2_+_232354675 0.240 COPS7B
COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
chr15_+_20287609 0.238 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr1_+_84382562 0.238 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_-_84254912 0.237 PLAC8
placenta-specific 8
chr5_-_156502363 0.237 NM_001100816
NM_004270
MED7

mediator complex subunit 7

chr9_+_70840298 0.236 NM_000144
NM_001161706
NM_181425
FXN


frataxin


chr12_+_49604782 0.234 NM_014033
METTL7A
methyltransferase like 7A
chr19_+_21056792 0.233 NM_182515
ZNF714
zinc finger protein 714
chr8_+_30072463 0.233 NM_001128208
NM_015344
LEPROTL1

leptin receptor overlapping transcript-like 1

chr1_+_51208499 0.233 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_-_90119169 0.232 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr6_-_37575666 0.231 NM_138493
C6orf129
chromosome 6 open reading frame 129
chr6_+_4835224 0.231 NM_001143971
CDYL
chromodomain protein, Y-like
chr1_-_21249974 0.230 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr20_-_18425811 0.226 NM_006606
RBBP9
retinoblastoma binding protein 9
chr12_-_7979896 0.226 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr11_+_129484540 0.222 APLP2
amyloid beta (A4) precursor-like protein 2
chr22_+_21359175 0.219 IGLV3-25
immunoglobulin lambda variable 3-25
chr19_-_10475083 0.216 KEAP1
kelch-like ECH-associated protein 1
chr19_+_10223598 0.215 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr13_-_35327798 0.215 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr11_-_75057299 0.214 MAP6
microtubule-associated protein 6
chr16_+_20682812 0.212 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr2_+_68445936 0.212 PLEK
pleckstrin
chr4_+_39084867 0.211 NM_175737
KLB
klotho beta
chr16_-_56886380 0.210 NM_001080492
PRSS54
protease, serine, 54
chr2_+_231829021 0.209


chr19_-_6542136 0.208 NM_001252
CD70
CD70 molecule
chr13_+_49100435 0.207 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr14_+_57964462 0.206 NM_014749
KIAA0586
KIAA0586
chr6_-_90119329 0.206 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr20_-_33658823 0.205 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr22_-_23281842 0.203 C22orf13
chromosome 22 open reading frame 13
chr17_+_39778153 0.203 GRN
granulin
chr10_-_101831579 0.202 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr20_-_31452964 0.201 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr20_-_10360569 0.200 NM_018848
MKKS
McKusick-Kaufman syndrome
chr4_+_170817787 0.197 CLCN3
chloride channel 3
chr10_+_135057597 0.194 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr9_-_129740583 0.194 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr3_-_152403636 0.193 NM_013308
GPR171
G protein-coupled receptor 171
chr17_+_64922420 0.192 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr4_-_84254873 0.192 PLAC8
placenta-specific 8
chr15_+_57067442 0.192 RNF111
ring finger protein 111
chr18_+_2896178 0.191 EMILIN2
elastin microfibril interfacer 2
chr13_+_96726197 0.191 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_246635918 0.190 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_159543847 0.190 MPZ
myelin protein zero
chr16_+_65144019 0.190 CKLF
chemokine-like factor
chr12_+_108035424 0.190


chr4_-_84254932 0.188 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr6_+_33352886 0.188 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr1_-_89364273 0.186 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr10_+_22645304 0.185 NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 read-through transcript
COMM domain containing 3
chr17_+_39778180 0.184 GRN
granulin
chr13_-_36471474 0.183 NM_001142364
NM_013338
ALG5

asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)

chr17_+_63766874 0.181 NM_014960
ARSG
arylsulfatase G
chr19_+_46489987 0.178 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr9_-_85761451 0.178 C9orf64
chromosome 9 open reading frame 64
chr6_+_74228331 0.177 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chrX_-_47815426 0.177 NM_001037735
ZNF630
zinc finger protein 630
chr17_+_63367052 0.177 BPTF
bromodomain PHD finger transcription factor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.04 7.24e-03 GO:0006952 defense response
2.03 4.93e-02 GO:0002682 regulation of immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.