Motif ID: ATF4.p2

Z-value: 1.857


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.165.5e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_32610161 5.407 NM_032514
 MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr6_+_139497933 4.939 NM_016217
 HECA
headcase homolog (Drosophila)
chr7_-_44992729 4.935 C7orf40
chromosome 7 open reading frame 40
chr7_-_129379947 3.016 NM_003344
NM_182697
 UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr20_+_19863716 2.811 RIN2
Ras and Rab interactor 2
chr18_+_55718171 2.755 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr9_-_109291575 2.412 KLF4
Kruppel-like factor 4 (gut)
chr3_-_109423858 2.361 NM_018010
 IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr8_+_128875902 2.337 PVT1
Pvt1 oncogene (non-protein coding)
chr14_+_75521806 2.234 NM_001102564
NM_052873
 C14orf179

chromosome 14 open reading frame 179

chr7_+_20336849 2.224 ITGB8
integrin, beta 8
chrX_-_83644054 2.221 NM_001177478
NM_001177479
NM_144657
 HDX


highly divergent homeobox


chr9_-_109291866 2.132 NM_004235
 KLF4
Kruppel-like factor 4 (gut)
chr5_+_60663842 2.081 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr19_-_7459867 1.978 NM_080662
 PEX11G
peroxisomal biogenesis factor 11 gamma
chr7_+_39739690 1.934 NCRNA00265
non-protein coding RNA 265
chr15_-_27349300 1.902 NM_138704
 NDNL2
necdin-like 2
chr2_-_156897286 1.872 NM_006186
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr8_+_42248008 1.860 NM_001190721
 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr11_-_76862197 1.841 NM_001128620
NM_002576
 PAK1

p21 protein (Cdc42/Rac)-activated kinase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
5.62 3.49e-02 GO:0010332 response to gamma radiation
2.32 3.38e-02 GO:0009154 purine ribonucleotide catabolic process
2.30 4.07e-02 GO:0009261 ribonucleotide catabolic process
2.10 1.28e-02 GO:0006281 DNA repair
1.90 3.93e-02 GO:0000279 M phase
1.84 9.49e-04 GO:0022403 cell cycle phase
1.78 3.44e-02 GO:0000278 mitotic cell cycle
1.77 1.02e-03 GO:0022402 cell cycle process
1.71 4.61e-03 GO:0033554 cellular response to stress
1.63 4.62e-03 GO:0007049 cell cycle
1.55 4.53e-02 GO:0043067 regulation of programmed cell death
1.54 4.89e-02 GO:0010941 regulation of cell death
1.50 2.21e-03 GO:0006996 organelle organization
1.48 8.35e-04 GO:0006464 protein modification process
1.45 2.81e-03 GO:0043412 macromolecule modification
1.44 9.75e-05 GO:0044267 cellular protein metabolic process
1.44 7.49e-04 GO:0090304 nucleic acid metabolic process
1.43 3.06e-02 GO:0034645 cellular macromolecule biosynthetic process
1.43 3.51e-02 GO:0009059 macromolecule biosynthetic process
1.41 2.48e-04 GO:0071842 cellular component organization at cellular level

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.83 9.29e-03 GO:0044427 chromosomal part
1.75 9.48e-03 GO:0005694 chromosome
1.32 1.13e-09 GO:0005634 nucleus
1.21 9.03e-10 GO:0043231 intracellular membrane-bounded organelle
1.21 1.16e-09 GO:0043227 membrane-bounded organelle
1.21 8.17e-04 GO:0044422 organelle part
1.21 8.55e-04 GO:0044446 intracellular organelle part
1.19 3.02e-10 GO:0043229 intracellular organelle
1.19 4.74e-10 GO:0043226 organelle
1.17 3.47e-12 GO:0044424 intracellular part
1.17 2.18e-05 GO:0005737 cytoplasm
1.16 9.29e-13 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.40 3.67e-04 GO:0003677 DNA binding
1.32 2.88e-04 GO:0003676 nucleic acid binding
1.21 4.47e-06 GO:0005515 protein binding
1.11 2.24e-05 GO:0005488 binding