Motif ID: ATF5_CREB3.p2

Z-value: 4.250


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF5chr19_+_55124211-0.862.2e-05Click!
CREB3chr9_+_357224900.263.2e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_50663089 10.941 NM_001114171
NM_006732
 FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr4_-_187884721 9.467


chr2_-_156897286 8.660 NM_006186
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr3_+_189354167 7.772 NM_001167672
 LPP
LIM domain containing preferred translocation partner in lipoma
chr20_+_19863716 7.535 RIN2
Ras and Rab interactor 2
chr14_+_74815233 7.036 NM_005252
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_101623957 6.775 NM_006981
NM_173199
 NR4A3

nuclear receptor subfamily 4, group A, member 3

chr2_-_216009015 6.399 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr11_+_12652427 6.260 NM_021961
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_-_16355013 6.102 NM_004431
 EPHA2
EPH receptor A2
chr10_+_102782151 5.936 SFXN3
sideroflexin 3
chr16_-_78192111 5.745 NM_001031804
NM_005360
 MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr18_+_44319365 5.722 NM_001142397
NM_014772
 CTIF

CBP80/20-dependent translation initiation factor

chr8_+_94998258 5.588 NM_018444
NM_001161780
NM_001161779
NM_001161781
 PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr4_+_85723080 5.123 NM_001263
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr4_+_75699652 4.887 NM_001657
 AREG
amphiregulin
chr4_+_75529716 4.734 NM_001657
 AREG
amphiregulin
chr5_-_57791544 4.589 NM_006622
 PLK2
polo-like kinase 2
chr5_-_1935764 4.534 NM_016358
 IRX4
iroquois homeobox 4
chr6_-_128883125 4.527 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 72 entries
enrichment   p-value GO term description
4.34 1.50e-02 GO:0000188 inactivation of MAPK activity
2.86 1.87e-02 GO:0034130 toll-like receptor 1 signaling pathway
2.86 1.87e-02 GO:0034134 toll-like receptor 2 signaling pathway
2.83 1.36e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.84 3.98e-02 GO:0010608 posttranscriptional regulation of gene expression
1.78 4.68e-03 GO:0006886 intracellular protein transport
1.71 1.47e-03 GO:0034613 cellular protein localization
1.71 1.65e-02 GO:0007243 intracellular protein kinase cascade
1.71 1.65e-02 GO:0023014 signal transduction via phosphorylation event
1.70 1.94e-03 GO:0070727 cellular macromolecule localization
1.68 6.54e-06 GO:0046907 intracellular transport
1.66 3.91e-06 GO:0045184 establishment of protein localization
1.65 7.71e-06 GO:0015031 protein transport
1.62 2.13e-02 GO:0044265 cellular macromolecule catabolic process
1.60 1.73e-02 GO:0000278 mitotic cell cycle
1.57 4.26e-06 GO:0051649 establishment of localization in cell
1.56 1.61e-05 GO:0008104 protein localization
1.55 1.23e-06 GO:0051641 cellular localization
1.52 2.61e-03 GO:0006351 transcription, DNA-dependent
1.52 1.92e-02 GO:0016192 vesicle-mediated transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.16 3.41e-02 GO:0016607 nuclear speck
1.72 1.08e-02 GO:0005815 microtubule organizing center
1.67 1.04e-05 GO:0015630 microtubule cytoskeleton
1.63 2.87e-03 GO:0005730 nucleolus
1.49 8.93e-03 GO:0044451 nucleoplasm part
1.46 3.49e-08 GO:0031981 nuclear lumen
1.45 6.63e-10 GO:0044428 nuclear part
1.45 3.74e-05 GO:0005654 nucleoplasm
1.37 5.83e-07 GO:0043233 organelle lumen
1.37 8.38e-07 GO:0070013 intracellular organelle lumen
1.36 1.00e-06 GO:0031974 membrane-enclosed lumen
1.34 4.43e-05 GO:0005829 cytosol
1.27 5.25e-04 GO:0043228 non-membrane-bounded organelle
1.27 5.25e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.26 6.97e-12 GO:0044422 organelle part
1.26 1.88e-11 GO:0044446 intracellular organelle part
1.24 1.32e-09 GO:0005634 nucleus
1.23 2.78e-03 GO:0043234 protein complex
1.20 6.58e-15 GO:0043227 membrane-bounded organelle
1.20 6.70e-15 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.58 4.80e-03 GO:0017016 Ras GTPase binding
2.33 3.36e-02 GO:0031267 small GTPase binding
2.07 1.80e-02 GO:0004721 phosphoprotein phosphatase activity
1.87 9.21e-03 GO:0003702 RNA polymerase II transcription factor activity
1.83 2.41e-02 GO:0016791 phosphatase activity
1.55 2.11e-04 GO:0003723 RNA binding
1.49 3.58e-04 GO:0001071 nucleic acid binding transcription factor activity
1.49 3.58e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 1.71e-02 GO:0043565 sequence-specific DNA binding
1.44 3.47e-02 GO:0016462 pyrophosphatase activity
1.43 4.12e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.43 4.89e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.41 1.32e-06 GO:0017076 purine nucleotide binding
1.41 1.40e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.41 1.85e-06 GO:0032553 ribonucleotide binding
1.41 1.85e-06 GO:0032555 purine ribonucleotide binding
1.38 3.16e-04 GO:0030554 adenyl nucleotide binding
1.38 4.80e-04 GO:0032559 adenyl ribonucleotide binding
1.38 5.38e-04 GO:0005524 ATP binding
1.38 3.77e-02 GO:0030528 transcription regulator activity