Motif ID: CDX1,2,4.p2

Z-value: 0.831


Transcription factors associated with CDX1,2,4.p2:

Gene SymbolEntrez IDGene Name
CDX1 1044 caudal type homeobox 1
CDX2 1045 caudal type homeobox 2
CDX4 1046 caudal type homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CDX2chr13_-_274414230.371.5e-01Click!
CDX1chr5_+_149526533-0.292.7e-01Click!
CDX4chrX_+_725838140.068.4e-01Click!


Activity profile for motif CDX1,2,4.p2.

activity profile for motif CDX1,2,4.p2


Sorted Z-values histogram for motif CDX1,2,4.p2

Sorted Z-values for motif CDX1,2,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDX1,2,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_98757634 1.626 NM_004951
GPR183
G protein-coupled receptor 183
chr2_+_161701711 1.480 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr1_+_158975662 1.391 NM_021181
SLAMF7
SLAM family member 7
chr10_-_98021144 1.369 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_-_5078773 1.350 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr11_-_104411065 1.059 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr4_-_38460983 1.052 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr2_-_45648608 0.941 SRBD1
S1 RNA binding domain 1
chr21_+_41719847 0.923 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr12_-_12740387 0.906 NM_006143
GPR19
G protein-coupled receptor 19
chr6_-_137536412 0.871 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr5_+_96237923 0.739 ERAP2
endoplasmic reticulum aminopeptidase 2
chr11_-_104421240 0.731 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr6_+_29963328 0.722 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr5_+_40877053 0.716 NM_032587
CARD6
caspase recruitment domain family, member 6
chr19_-_4782711 0.693 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr1_+_239762179 0.680 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr5_+_159368690 0.665 TTC1
tetratricopeptide repeat domain 1
chr12_+_9713472 0.661 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr16_+_27346079 0.656 NM_021798
IL21R
interleukin 21 receptor
chr1_-_197173159 0.633 LOC100131234
familial acute myelogenous leukemia related factor
chr5_-_98290117 0.632 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr19_+_40895669 0.619 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr5_+_159368733 0.602 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr19_-_44518516 0.596 NM_004877
GMFG
glia maturation factor, gamma
chr5_+_159368721 0.584 TTC1
tetratricopeptide repeat domain 1
chr1_-_168310232 0.558 NM_014970
KIFAP3
kinesin-associated protein 3
chr19_+_14554895 0.546 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr10_-_85921703 0.542 LOC642934
hypothetical LOC642934
chr12_-_10983072 0.541 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr8_+_107807415 0.539 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr12_+_74160779 0.532 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr5_-_94442941 0.525 MCTP1
multiple C2 domains, transmembrane 1
chr19_+_3087026 0.525 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr6_+_126143971 0.524 NCOA7
nuclear receptor coactivator 7
chr4_+_47181987 0.521 NM_020453
ATP10D
ATPase, class V, type 10D
chr4_-_38710376 0.517 NM_024943
TMEM156
transmembrane protein 156
chr1_-_27825178 0.512 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr8_-_42742729 0.512 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr5_-_64813459 0.511 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr19_+_14352920 0.508 CD97
CD97 molecule
chr3_-_184756101 0.507 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr5_-_88155360 0.494 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_-_134042500 0.490 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr1_+_181421796 0.486 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr3_-_191321367 0.477 LEPREL1
leprecan-like 1
chr12_+_53178834 0.470 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr22_+_36008511 0.468 CYTH4
cytohesin 4
chr5_+_35892747 0.466 NM_002185
IL7R
interleukin 7 receptor
chr7_+_73826244 0.459 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr1_-_100003936 0.450 NM_001013660
FRRS1
ferric-chelate reductase 1
chr1_+_190811479 0.443 NM_002922
RGS1
regulator of G-protein signaling 1
chr9_+_126094067 0.441 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr6_+_153060722 0.439 NM_025107
MYCT1
myc target 1
chr21_-_42219849 0.438 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr19_-_4289750 0.437 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_-_24112345 0.433 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr13_-_40491405 0.432 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_91620749 0.429 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr17_-_31441390 0.429 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr19_-_6621078 0.422 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr19_-_55539769 0.421 NAPSB
napsin B aspartic peptidase pseudogene
chr1_-_77457664 0.420 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr11_+_63060848 0.418 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr15_-_78050515 0.418 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr14_+_87541220 0.417 NM_003608
GPR65
G protein-coupled receptor 65
chrX_+_69314060 0.413 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr13_+_45174446 0.411 NM_152719
SPERT
spermatid associated
chr19_-_19793512 0.410 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr5_+_162862808 0.409 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr16_+_79829794 0.408 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr11_+_57285809 0.406 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr10_+_70517823 0.406 NM_002727
SRGN
serglycin
chr22_-_16080265 0.402 CECR1
cat eye syndrome chromosome region, candidate 1
chr5_+_49997489 0.395 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr13_-_40491491 0.393 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_53444733 0.392 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr19_+_17253453 0.390 NM_152363
ANKLE1
ankyrin repeat and LEM domain containing 1
chr19_+_53450743 0.386


chr10_+_70517863 0.385 SRGN
serglycin
chr1_-_143232526 0.381 FAM91A2
family with sequence similarity 91, member A2
chr1_+_169549996 0.378 NM_002022
FMO4
flavin containing monooxygenase 4
chr4_-_77176163 0.375 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr21_-_14840506 0.369 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_91488704 0.368 KIF20B
kinesin family member 20B
chr12_-_51887318 0.368 ITGB7
integrin, beta 7
chr12_+_111829191 0.366 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_84536636 0.363 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr7_-_104696678 0.363 NM_182691
SRPK2
SRSF protein kinase 2
chr4_-_153523113 0.363 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr12_-_51887266 0.360 NM_000889
ITGB7
integrin, beta 7
chr1_-_1701313 0.359 NM_001198994
NADK
NAD kinase
chr5_-_149772563 0.357 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr16_+_80370400 0.353 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr13_-_40454360 0.352 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_188021117 0.352 NM_005795
CALCRL
calcitonin receptor-like
chr3_-_122862391 0.350 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_-_23733411 0.349 NM_138286
ZNF681
zinc finger protein 681
chr12_-_101115677 0.349 NM_002674
PMCH
pro-melanin-concentrating hormone
chr17_-_35975227 0.348 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr22_-_40666168 0.348 NM_001110215
CENPM
centromere protein M
chr17_-_25112393 0.347 SSH2
slingshot homolog 2 (Drosophila)
chr3_-_143230124 0.341 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr2_+_61225710 0.340 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr4_-_153493133 0.340 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr10_+_97505398 0.340 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr14_+_75058591 0.339 BATF
basic leucine zipper transcription factor, ATF-like
chr11_-_104274606 0.338 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr3_-_122862447 0.338 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr15_+_99276982 0.337 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr6_-_27943287 0.336 NM_005322
HIST1H1B
histone cluster 1, H1b
chr7_-_13992351 0.336 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr3_-_113701073 0.335 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr7_-_112545840 0.332 LOC401397
hypothetical LOC401397
chr11_-_104477367 0.331 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr8_-_110411283 0.330 NM_001128211
NUDCD1
NudC domain containing 1
chr15_+_46957556 0.327 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chrX_+_100241453 0.327 NM_006733
CENPI
centromere protein I
chr6_+_158990982 0.327 NM_001009991
SYTL3
synaptotagmin-like 3
chr1_+_148511806 0.326 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr22_+_36008465 0.324 CYTH4
cytohesin 4
chr6_-_79732391 0.322 PHIP
pleckstrin homology domain interacting protein
chr1_-_142536082 0.320


chr1_-_181826633 0.318 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr17_+_7180571 0.317 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr12_-_25692754 0.316 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr19_-_56612653 0.316 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr17_+_55098280 0.314 CLTC
clathrin, heavy chain (Hc)
chr7_-_112545847 0.312 LOC401397
hypothetical LOC401397
chr11_+_64949365 0.311 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr6_-_33085329 0.310 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr7_-_107930170 0.309 PNPLA8
patatin-like phospholipase domain containing 8
chr19_-_58016696 0.308 NM_006969
ZNF28
zinc finger protein 28
chr7_-_92615593 0.307 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr12_+_111829121 0.306 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr1_-_195382189 0.306 NM_018136
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr18_+_59705918 0.306 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr18_+_54013575 0.305 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_165565006 0.304 POU2F1
POU class 2 homeobox 1
chr9_+_5500544 0.302 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr1_+_160868822 0.302 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr14_+_57964462 0.301 NM_014749
KIAA0586
KIAA0586
chr4_-_130233855 0.301 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr3_-_170970296 0.299 NM_032487
ARPM1
actin related protein M1
chr2_-_242205556 0.299 NM_001164356
THAP4
THAP domain containing 4
chr18_+_59726183 0.298 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr2_+_201691513 0.294 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_-_58815415 0.293 TACSTD2
tumor-associated calcium signal transducer 2
chr6_+_26070957 0.293 NM_006355
TRIM38
tripartite motif containing 38
chr3_+_123779122 0.292 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr8_+_11388918 0.291 NM_001715
BLK
B lymphoid tyrosine kinase
chr2_-_162808123 0.289 NM_004460
FAP
fibroblast activation protein, alpha
chr20_+_42644633 0.287 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr1_-_165326148 0.286 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr19_-_55091942 0.285 NM_152899
IL4I1
interleukin 4 induced 1
chr1_+_218768170 0.283 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr5_-_149772528 0.279


chr13_+_77007809 0.278 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr9_+_5440455 0.276 NM_014143
CD274
CD274 molecule
chr6_+_134800533 0.274 LOC154092
hypothetical LOC154092
chr6_+_31651319 0.274 NM_000594
TNF
tumor necrosis factor
chr5_-_149772469 0.273 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr14_-_80475636 0.273 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr2_-_175170674 0.272 WIPF1
WAS/WASL interacting protein family, member 1
chr15_-_97607108 0.269 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr1_-_149004852 0.268 CTSS
cathepsin S
chr10_+_35504526 0.266 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr12_-_9777126 0.266 NM_172004
CLECL1
C-type lectin-like 1
chr12_+_27066749 0.264 NM_004264
MED21
mediator complex subunit 21
chr1_+_84539876 0.263 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr1_+_28637247 0.261 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr14_+_57964148 0.261


chr6_-_32268267 0.260 GPSM3
G-protein signaling modulator 3
chr12_-_93921586 0.260 NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr10_+_118177371 0.259 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_-_148936123 0.258 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr20_-_33658823 0.258 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr22_+_36008369 0.257 NM_013385
CYTH4
cytohesin 4
chr3_-_17757402 0.256 NM_014744
TBC1D5
TBC1 domain family, member 5
chr1_-_149004879 0.253 CTSS
cathepsin S
chr1_+_78888064 0.252 NM_006417
IFI44
interferon-induced protein 44
chr8_-_38324809 0.250 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr12_+_49155798 0.249 LARP4
La ribonucleoprotein domain family, member 4
chr12_-_93921618 0.248 NM_018838
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chrX_+_114734074 0.247 NM_001136025
NM_001172335
PLS3

plastin 3

chr1_-_181889070 0.247 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr2_+_108604111 0.246 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_171286634 0.244 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr1_-_178100204 0.243


chr7_-_149960218 0.243 GIMAP6
GTPase, IMAP family member 6
chr12_+_21481804 0.242 NM_024854
PYROXD1
pyridine nucleotide-disulphide oxidoreductase domain 1
chr6_+_26473376 0.241 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr1_+_40508336 0.241 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr6_-_32268615 0.239 GPSM3
G-protein signaling modulator 3
chr1_+_35623688 0.238 ZMYM4
zinc finger, MYM-type 4
chr18_+_37789187 0.235 NM_002647
PIK3C3
phosphoinositide-3-kinase, class 3
chr14_-_22354851 0.235 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr14_-_30927931 0.235 NM_015473
HEATR5A
HEAT repeat containing 5A
chr5_+_56507029 0.234 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr8_+_75066117 0.233 NM_001195797
NM_015364
LY96

lymphocyte antigen 96


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.56 6.33e-06 GO:0002376 immune system process
1.68 1.16e-04 GO:0006955 immune response
2.00 2.27e-02 GO:0002694 regulation of leukocyte activation
2.05 2.55e-02 GO:0051249 regulation of lymphocyte activation
1.97 2.71e-02 GO:0050865 regulation of cell activation

Nothing significant found in compartment category.

Nothing significant found in function category.