Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.764


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CEBPAchr19_-_384852810.862.4e-05Click!
CEBPBchr20_+_482407050.533.4e-02Click!
DDIT3chr12_-_562005470.302.5e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_116125123 7.605 NM_000607
ORM1
orosomucoid 1
chr1_+_149221122 7.259 NM_003568
ANXA9
annexin A9
chr17_-_36346240 6.380 KRT23
keratin 23 (histone deacetylase inducible)
chr3_+_187813553 5.129 AHSG
alpha-2-HS-glycoprotein
chr3_+_187813538 5.025 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr6_+_167624792 4.660 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr3_+_187813405 4.551 AHSG
alpha-2-HS-glycoprotein
chr6_+_32003380 4.222 C2
complement component 2
chr6_+_32003180 3.720 NM_000063
NM_001145903
C2

complement component 2

chr12_-_120781002 3.604 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr14_-_22515725 3.602 JUB
jub, ajuba homolog (Xenopus laevis)
chr4_-_9632192 3.482 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr9_+_80101810 3.467 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr17_-_61655915 3.245 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_-_20122638 3.240 NM_014589
PLA2G2E
phospholipase A2, group IIE
chrX_+_9391314 3.191 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr1_+_111571803 2.804 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr9_-_129752687 2.711 NM_203305
FAM102A
family with sequence similarity 102, member A
chr14_-_22516271 2.393 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr3_-_150422474 2.247 NM_000096
CP
ceruloplasmin (ferroxidase)
chr9_+_674193 1.970


chr1_-_55103938 1.961 DHCR24
24-dehydrocholesterol reductase
chr10_-_92670764 1.853 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr13_+_51496679 1.847 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr20_+_309272 1.843 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr20_+_309938 1.815 TRIB3
tribbles homolog 3 (Drosophila)
chr5_-_16791346 1.811 MYO10
myosin X
chr12_-_61615124 1.796 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_+_80397690 1.701 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr11_+_47236072 1.680 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr9_-_122852356 1.631 NM_001735
C5
complement component 5
chr19_+_11211282 1.623 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr17_+_71508581 1.568 NM_001258
CDK3
cyclin-dependent kinase 3
chr12_+_99391870 1.565 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr11_+_62893836 1.412 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr9_-_94095807 1.394 IARS
isoleucyl-tRNA synthetase
chr4_+_187424336 1.388 F11
coagulation factor XI
chr3_-_49701085 1.369 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr10_-_92671005 1.334 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_159543847 1.320 MPZ
myelin protein zero
chr1_+_99884018 1.317 NM_017734
PALMD
palmdelphin
chr9_-_94095787 1.294 NM_013417
IARS
isoleucyl-tRNA synthetase
chr5_-_139993469 1.287 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr1_+_17779528 1.256 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_+_233961538 1.248 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr7_-_36991189 1.231 NM_001039459
ELMO1
engulfment and cell motility 1
chr17_+_1612056 1.194 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr20_+_309675 1.166 TRIB3
tribbles homolog 3 (Drosophila)
chr11_-_116168316 1.163 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr12_+_54910086 1.158 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr1_-_149611768 1.156 NM_003944
SELENBP1
selenium binding protein 1
chr20_+_5935897 1.152 NM_001127458
CRLS1
cardiolipin synthase 1
chr8_+_82807218 1.129 NM_152284
CHMP4C
chromatin modifying protein 4C
chr17_-_53847937 1.091 RNF43
ring finger protein 43
chr11_-_8695974 1.066 ST5
suppression of tumorigenicity 5
chr9_-_94095810 1.037 NM_002161
IARS
isoleucyl-tRNA synthetase
chr11_+_20000938 1.008 NAV2
neuron navigator 2
chrX_-_15198509 1.006 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr17_+_1612092 0.993 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_+_52121699 0.987 NM_001005354
NM_018457
PRR13

proline rich 13

chr10_-_116434364 0.974 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr17_-_75427644 0.969 NM_003655
CBX4
chromobox homolog 4
chr16_-_28457728 0.968 NUPR1
nuclear protein, transcriptional regulator, 1
chr6_+_132000134 0.968 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr14_+_31868229 0.946 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr1_-_176205672 0.927 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_+_1612031 0.922 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_77488258 0.918 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr22_+_43451351 0.910 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr16_-_28457825 0.910 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr19_-_53950458 0.908 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr22_+_24174039 0.899 CRYBB2P1
crystallin, beta B2 pseudogene 1
chr6_+_32021899 0.884 CFB
complement factor B
chr3_-_42818221 0.880


chr11_+_67534364 0.878 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr1_-_228916486 0.874 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_+_32926452 0.871 ACSS2
acyl-CoA synthetase short-chain family member 2
chr6_+_32021831 0.869 CFB
complement factor B
chr17_+_4621924 0.851 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr19_+_50144267 0.834 APOC2
apolipoprotein C-II
chr10_+_85994788 0.833 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr11_+_67534371 0.817 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr20_+_31613800 0.799 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_-_53335748 0.792 NM_017949
CUEDC1
CUE domain containing 1
chr20_+_61842880 0.772 SLC2A4RG
SLC2A4 regulator
chr12_+_27740694 0.768 NM_001029874
REP15
RAB15 effector protein
chr2_+_32244406 0.749 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr15_+_80434362 0.733 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr1_+_45738442 0.710 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr10_-_79459296 0.703 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr16_-_30694799 0.689


chr1_-_228916470 0.686 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_108360798 0.679 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr17_+_18588050 0.670 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr7_+_99263571 0.667 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr10_+_135010833 0.667 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr19_+_11837843 0.648 NM_152262
ZNF439
zinc finger protein 439
chr2_-_216009015 0.644 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr10_-_116434102 0.638 ABLIM1
actin binding LIM protein 1
chr1_-_67292286 0.638 SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr8_-_13018123 0.634 NM_001164271
DLC1
deleted in liver cancer 1
chr4_+_184257337 0.624 NM_024949
WWC2
WW and C2 domain containing 2
chr9_-_94095734 0.600 IARS
isoleucyl-tRNA synthetase
chr16_-_68880908 0.599 NM_001605
AARS
alanyl-tRNA synthetase
chr17_+_1611983 0.583 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_-_143708467 0.575 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_74499651 0.572 ALB
albumin
chr1_-_57057956 0.565 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr17_+_3324096 0.557 NM_001128085
ASPA
aspartoacylase
chr17_-_17426416 0.553 PEMT
phosphatidylethanolamine N-methyltransferase
chr16_-_66827449 0.544 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr1_+_173111306 0.530 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chrX_-_102828238 0.527 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr8_+_26569709 0.527 DPYSL2
dihydropyrimidinase-like 2
chr6_-_11219932 0.519 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr14_-_67232172 0.517 NM_016026
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr1_+_234748187 0.513 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr11_+_62252518 0.507 NM_173810
TTC9C
tetratricopeptide repeat domain 9C
chr11_-_8636958 0.505 NM_014818
TRIM66
tripartite motif containing 66
chr16_-_68880844 0.500 AARS
alanyl-tRNA synthetase
chr2_-_21084911 0.499 APOB
apolipoprotein B (including Ag(x) antigen)
chr20_+_54420574 0.495 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr7_-_56069324 0.493 PSPH
phosphoserine phosphatase
chr19_-_40684638 0.488 NM_001035516
DMKN
dermokine
chr11_+_22646229 0.487 NM_177553
GAS2
growth arrest-specific 2
chr3_-_9570412 0.486 NM_198560
LHFPL4
lipoma HMGIC fusion partner-like 4
chr8_-_17787342 0.484 FGL1
fibrinogen-like 1
chr6_+_131936057 0.477 NM_000045
ARG1
arginase, liver
chr1_-_172153024 0.471 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_-_15198093 0.470 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr6_+_7524691 0.451 DSP
desmoplakin
chr8_-_38127489 0.451 NM_000349
STAR
steroidogenic acute regulatory protein
chr5_+_75734759 0.442 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chrX_-_13745108 0.441 GPM6B
glycoprotein M6B
chr12_-_55404530 0.438 NACA
nascent polypeptide-associated complex alpha subunit
chr4_+_187424111 0.436 NM_000128
F11
coagulation factor XI
chr6_-_52217185 0.431 NM_052872
IL17F
interleukin 17F
chr12_+_52105131 0.430 AMHR2
anti-Mullerian hormone receptor, type II
chr6_-_157664464 0.428 C6orf35
chromosome 6 open reading frame 35
chr15_-_70385709 0.428 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr2_+_65517316 0.412 FLJ16124
FLJ16124 protein
chr6_+_126282078 0.409 NCOA7
nuclear receptor coactivator 7
chr15_+_78520634 0.409 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr11_+_59580630 0.408 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr17_-_15463742 0.392 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr1_-_16006779 0.391 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr6_+_158654464 0.386 TULP4
tubby like protein 4
chrX_-_13745134 0.385 GPM6B
glycoprotein M6B
chr19_+_54707347 0.377 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_150264622 0.366 ZNF300
zinc finger protein 300
chr2_-_21081694 0.360 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_+_3345889 0.359 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr7_+_29569913 0.351 NM_175887
PRR15
proline rich 15
chr17_-_17426469 0.351 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr2_+_169465995 0.350 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr5_-_139992621 0.349 NM_000591
CD14
CD14 molecule
chr1_-_31117948 0.345 SDC3
syndecan 3
chr7_-_1562272 0.345 NM_001097620
TMEM184A
transmembrane protein 184A
chr10_+_70650064 0.341 NM_025130
HKDC1
hexokinase domain containing 1
chr17_-_37599953 0.341 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr21_-_10120690 0.341 NM_001187
NM_182484
NM_181704
NM_182481
NM_182482
BAGE
BAGE5
BAGE4
BAGE3
BAGE2
B melanoma antigen
B melanoma antigen family, member 5
B melanoma antigen family, member 4
B melanoma antigen family, member 3
B melanoma antigen family, member 2
chr11_-_69228286 0.341 NM_005117
FGF19
fibroblast growth factor 19
chr9_+_95886625 0.338 PTPDC1
protein tyrosine phosphatase domain containing 1
chr20_+_16312 0.336 NM_153325
DEFB125
defensin, beta 125
chr5_-_150264583 0.334 ZNF300
zinc finger protein 300
chr7_-_91601972 0.329 NM_001146152
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr6_+_158654890 0.323


chr11_+_62813947 0.323 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr7_-_156494741 0.323 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr1_+_116744992 0.321 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr2_+_233605625 0.320 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr4_+_159350850 0.320 NM_018342
TMEM144
transmembrane protein 144
chr9_-_113286845 0.318 NM_001080398
KIAA0368
KIAA0368
chr3_-_48634192 0.316 NM_001008269
TMEM89
transmembrane protein 89
chr3_+_9451506 0.316


chr2_-_39310176 0.314 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr2_+_61225710 0.312 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr8_-_110726921 0.312 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr5_-_150264486 0.312 ZNF300
zinc finger protein 300
chr8_-_27997306 0.310 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr20_+_30501108 0.310


chr14_+_34583863 0.309 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr4_-_184478920 0.308 NM_001111319
CLDN22
claudin 22
chr12_-_47545816 0.307 NM_014470
RND1
Rho family GTPase 1
chr12_-_56200547 0.306 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr5_+_64956586 0.306 C5orf44
chromosome 5 open reading frame 44
chrX_+_7147471 0.294 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr10_-_104201234 0.293 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr16_+_46835678 0.293 NM_031490
LONP2
lon peptidase 2, peroxisomal
chr9_+_109085386 0.291 RAD23B
RAD23 homolog B (S. cerevisiae)
chrX_-_105169370 0.287 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_+_559129 0.283


chr17_-_27252863 0.282 UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr1_+_26220895 0.277 EXTL1
exostoses (multiple)-like 1
chr2_+_168383427 0.274 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr7_-_91601613 0.272 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr1_-_159474503 0.271 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr11_-_95715976 0.270 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr22_-_41685827 0.267 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_121964373 0.265 CLASP1
cytoplasmic linker associated protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
16.46 9.33e-03 GO:0010885 regulation of cholesterol storage
8.13 2.54e-02 GO:0016525 negative regulation of angiogenesis
7.90 3.10e-02 GO:0097006 regulation of plasma lipoprotein particle levels
19.75 3.51e-02 GO:0051006 positive regulation of lipoprotein lipase activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
13.17 4.32e-02 GO:0042627 chylomicron

Gene overrepresentation in function category:

enrichment   p-value GO term description
39.50 5.24e-03 GO:0060230 lipoprotein lipase activator activity