Motif ID: CRX.p2

Z-value: 1.682


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_530169100.068.2e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_56567839 3.255 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr20_-_48165886 2.237 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr1_+_61319976 2.052 NM_001145512
NFIA
nuclear factor I/A
chr9_-_99740243 2.047 NM_197978
HEMGN
hemogen
chr14_+_57964462 1.983 NM_014749
KIAA0586
KIAA0586
chr7_+_111850367 1.966 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr11_+_43622348 1.875


chr8_+_26206648 1.790 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_-_118405288 1.741 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_-_100003936 1.726 NM_001013660
FRRS1
ferric-chelate reductase 1
chr1_+_559129 1.710


chr1_+_559618 1.710


chr5_-_74568458 1.537 NM_001164443
ANKRD31
ankyrin repeat domain 31
chr9_+_132990760 1.501 NM_005085
NUP214
nucleoporin 214kDa
chr6_+_28425666 1.438 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr1_+_144149794 1.418 NM_006472
TXNIP
thioredoxin interacting protein
chr14_+_57964148 1.406


chr11_+_61473931 1.330 NM_001139443
NM_004183
BEST1

bestrophin 1

chr12_+_56114724 1.285 NM_005538
INHBC
inhibin, beta C
chr19_-_12858956 1.279 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr6_-_31812251 1.239 CLIC1
chloride intracellular channel 1
chr10_-_76538859 1.214 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chrX_-_24600661 1.205 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr15_+_40353657 1.188 NM_198141
GANC
glucosidase, alpha; neutral C
chr11_+_61279436 1.166 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr6_-_31812260 1.163 CLIC1
chloride intracellular channel 1
chr6_-_31812214 1.147 CLIC1
chloride intracellular channel 1
chr3_+_50281582 1.127 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_156923111 1.116 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr14_-_22516271 1.096 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr6_-_74284522 1.072 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr6_-_31812283 1.068 CLIC1
chloride intracellular channel 1
chr6_-_31812266 1.057 CLIC1
chloride intracellular channel 1
chr4_-_74307637 1.051 ANKRD17
ankyrin repeat domain 17
chr6_+_20642665 1.035 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr7_-_99115454 1.025 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr14_-_22610572 1.020 ACIN1
apoptotic chromatin condensation inducer 1
chr14_-_22610610 1.014 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr4_-_186969041 1.013 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr10_-_62431203 1.010 RHOBTB1
Rho-related BTB domain containing 1
chr17_-_34262862 1.003 RPL23
ribosomal protein L23
chr17_-_44847214 1.000 PHB
prohibitin
chr16_+_56286212 1.000 NM_032269
CCDC135
coiled-coil domain containing 135
chr10_+_70745615 0.995 NM_033496
HK1
hexokinase 1
chr1_+_202033273 0.991 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr8_-_38324809 0.987 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr6_-_31812297 0.979 NM_001288
CLIC1
chloride intracellular channel 1
chr5_-_134290789 0.978


chr1_+_159462456 0.977 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr17_-_44847215 0.966 NM_002634
PHB
prohibitin
chr6_-_49712483 0.961 NM_000324
RHAG
Rh-associated glycoprotein
chr3_+_63928459 0.952 NM_001128149
ATXN7
ataxin 7
chr20_-_16501911 0.948 NM_024704
KIF16B
kinesin family member 16B
chr2_-_180580024 0.933 NM_020943
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr1_+_45250503 0.931 UROD
uroporphyrinogen decarboxylase
chr9_+_4829763 0.923 RCL1
RNA terminal phosphate cyclase-like 1
chr19_-_56585603 0.904 NM_001193623
LOC147646
hypothetical protein LOC147646
chr3_+_161877640 0.904 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr17_+_35718948 0.904 NM_000964
RARA
retinoic acid receptor, alpha
chr7_+_142692165 0.897 NM_153345
TMEM139
transmembrane protein 139
chr6_+_105511615 0.894 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr19_+_60283571 0.889 NM_017729
EPS8L1
EPS8-like 1
chr3_+_186529376 0.889 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr7_+_116447499 0.886 ST7
suppression of tumorigenicity 7
chr6_+_147568795 0.884 STXBP5
syntaxin binding protein 5 (tomosyn)
chr17_+_1586034 0.875 WDR81
WD repeat domain 81
chr18_+_53865455 0.872 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_82039158 0.868 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr4_-_88531245 0.867 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr11_-_117628211 0.846 NM_198275
MPZL3
myelin protein zero-like 3
chr11_-_5110383 0.835 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr20_+_42417752 0.835 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr13_+_96726197 0.833 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_182287388 0.822 NM_001127394
NM_052965
TSEN15

tRNA splicing endonuclease 15 homolog (S. cerevisiae)

chr4_+_95595419 0.806 PDLIM5
PDZ and LIM domain 5
chr2_-_75650355 0.798 NM_032181
FAM176A
family with sequence similarity 176, member A
chr15_-_32398220 0.797 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr3_+_50281309 0.783 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr3_-_19950675 0.782 NM_144715
EFHB
EF-hand domain family, member B
chr3_+_138159396 0.778 NM_144717
IL20RB
interleukin 20 receptor beta
chr6_-_149847809 0.774 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr7_+_116447527 0.771 ST7
suppression of tumorigenicity 7
chr1_+_45250475 0.764 UROD
uroporphyrinogen decarboxylase
chr17_+_50333021 0.764 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr7_+_29486010 0.750 NM_001039936
CHN2
chimerin (chimaerin) 2
chr3_+_47004457 0.743 NBEAL2
neurobeachin-like 2
chr4_-_186969202 0.739 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_+_45250388 0.733 NM_000374
UROD
uroporphyrinogen decarboxylase
chr18_+_27281729 0.730 NM_001944
DSG3
desmoglein 3
chr10_+_74540215 0.728 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr6_+_43651855 0.725 NM_006502
POLH
polymerase (DNA directed), eta
chr2_+_201806410 0.721 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr1_+_148726497 0.721 TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr6_-_32265489 0.720 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr21_-_38415273 0.706 NM_005867
DSCR4
Down syndrome critical region gene 4
chr9_+_80101810 0.705 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr11_+_93394025 0.702 NM_001098672
HEPHL1
hephaestin-like 1
chr6_+_132000134 0.701 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr11_-_46569489 0.701 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr17_-_36346240 0.693 KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_226399026 0.693 NM_001159391
GUK1
guanylate kinase 1
chr11_-_117589283 0.691 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr4_+_170817787 0.688 CLCN3
chloride channel 3
chr1_+_148726537 0.687 NM_025150
TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr12_+_108038774 0.684 ACACB
acetyl-CoA carboxylase beta
chr2_+_228386800 0.681 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chrX_+_69426603 0.679 NM_012310
KIF4A
kinesin family member 4A
chr1_-_148854503 0.677


chr1_+_65492679 0.674 LOC645195
DNAJC6
hypothetical LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_-_33463194 0.674 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr2_+_157822355 0.673 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_-_47428310 0.664 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_153537362 0.656 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr16_+_29597965 0.655 QPRT
quinolinate phosphoribosyltransferase
chr1_-_26266571 0.650 NM_032588
TRIM63
tripartite motif containing 63
chr1_+_76024466 0.649 NM_004582
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr14_-_23847000 0.645 CIDEB
cell death-inducing DFFA-like effector b
chr16_+_22432344 0.642 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr20_+_41621079 0.642 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr16_+_29597829 0.641 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr12_-_52975823 0.640 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr20_+_41621119 0.640 SGK2
serum/glucocorticoid regulated kinase 2
chr10_-_5035967 0.640 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_-_159604287 0.639 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr1_-_47428190 0.636 PDZK1IP1
PDZK1 interacting protein 1
chr21_-_42060334 0.635 RIPK4
receptor-interacting serine-threonine kinase 4
chr14_-_23846993 0.633 CIDEB
cell death-inducing DFFA-like effector b
chr15_+_47249700 0.631 NM_002044
GALK2
galactokinase 2
chr10_+_4995685 0.627 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_+_123526700 0.627 NM_005213
CSTA
cystatin A (stefin A)
chr17_-_39500512 0.625 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_152560179 0.624 NM_080429
AQP10
aquaporin 10
chr1_+_45251007 0.615 UROD
uroporphyrinogen decarboxylase
chrX_-_107569256 0.610 NM_001847
COL4A6
collagen, type IV, alpha 6
chr13_+_96726415 0.608 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_130004404 0.606 NM_198827
GPR133
G protein-coupled receptor 133
chr5_-_150264696 0.603 NM_001172831
NM_001172832
NM_052860
ZNF300


zinc finger protein 300


chr4_+_107456215 0.601 NM_001142415
NM_004757
AIMP1

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

chr20_-_43972061 0.599 PLTP
phospholipid transfer protein
chr3_-_52712639 0.595 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr8_-_17797127 0.594 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr3_+_82117978 0.592


chr15_+_32304477 0.584 NM_016454
TMEM85
transmembrane protein 85
chr15_+_57691272 0.580 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr7_-_33047042 0.580 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chrX_-_70248022 0.580 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr3_-_17757402 0.577 NM_014744
TBC1D5
TBC1 domain family, member 5
chr10_-_64698831 0.571 NM_004241
JMJD1C
jumonji domain containing 1C
chr14_+_87560646 0.570 LOC283587
hypothetical protein LOC283587
chr2_+_201755865 0.561 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr11_+_118483379 0.557 C2CD2L
C2CD2-like
chr6_-_25940247 0.555 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr1_+_172395277 0.552 RABGAP1L
RAB GTPase activating protein 1-like
chr6_-_31779099 0.549 NM_021160
ABHD16A
abhydrolase domain containing 16A
chr14_-_23847024 0.539 CIDEB
cell death-inducing DFFA-like effector b
chr14_+_20580224 0.536 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr19_-_17377383 0.534 NM_004335
BST2
bone marrow stromal cell antigen 2
chr6_-_31779082 0.532 ABHD16A
abhydrolase domain containing 16A
chr2_-_55090759 0.530 NM_007008
RTN4
reticulon 4
chr22_-_41685827 0.528 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr4_-_184480572 0.527 NM_001185149
CLDN24
claudin 24
chr2_-_200033445 0.526 SATB2
SATB homeobox 2
chr20_-_33793593 0.525 NM_004902
NM_184234
RBM39

RNA binding motif protein 39

chr1_-_167822248 0.525 F5
coagulation factor V (proaccelerin, labile factor)
chr13_-_33148899 0.522 STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_+_205329206 0.521 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr11_+_118483297 0.520 NM_014807
C2CD2L
C2CD2-like
chr2_+_160180049 0.519 LOC643072
hypothetical LOC643072
chr12_-_52305900 0.518 ATF7
activating transcription factor 7
chr19_+_47272173 0.518 ZNF574
zinc finger protein 574
chr12_-_31370351 0.515 FAM60A
family with sequence similarity 60, member A
chr19_+_17377502 0.510 LOC100507535
hypothetical LOC100507535
chr19_+_47272138 0.508 ZNF574
zinc finger protein 574
chr2_-_88208650 0.504 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_167822334 0.504 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr2_+_113601608 0.502 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr19_-_60360768 0.499 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr14_-_23846904 0.499 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_87152905 0.492 NM_001134492
NM_012262
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chr1_-_108032645 0.491 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr9_+_134884627 0.490 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr20_-_33793591 0.486 RBM39
RNA binding motif protein 39
chr1_-_152225312 0.486 NM_002870
RAB13
RAB13, member RAS oncogene family
chr12_+_16391795 0.485 NM_020300
NM_145791
MGST1

microsomal glutathione S-transferase 1

chr1_-_93030538 0.485 NM_005665
EVI5
ecotropic viral integration site 5
chr18_+_19947314 0.485 TTC39C
tetratricopeptide repeat domain 39C
chr9_+_122923864 0.483 CEP110
centrosomal protein 110kDa
chr15_+_89248423 0.482 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr2_-_111152075 0.479 NM_004336
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast)
chr16_-_65108605 0.479 TK2
thymidine kinase 2, mitochondrial
chr9_-_34652629 0.478 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr6_+_126143971 0.476 NCOA7
nuclear receptor coactivator 7
chr5_+_76181581 0.474 NM_130772
S100Z
S100 calcium binding protein Z
chr19_-_5789740 0.474 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr16_-_70685715 0.474 NM_001142318
TXNL4B
thioredoxin-like 4B
chr19_-_47498768 0.471 NM_001145939
NM_001145940
PAFAH1B3

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)

chr1_-_28392966 0.470 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr22_+_23329113 0.470 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr2_+_108604111 0.468 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_+_77928372 0.466 ZFHX4
zinc finger homeobox 4

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 3.05e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
13.01 2.22e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity