Motif ID: E2F1..5.p2

Z-value: 3.694


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F2chr1_-_237298710.837.8e-05Click!
E2F1chr20_-_317378150.621.0e-02Click!
E2F4chr16_+_657835990.591.7e-02Click!
E2F3chr6_+_205100190.562.4e-02Click!
E2F5chr8_+_862768700.449.1e-02Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_23729871 7.727 E2F2
E2F transcription factor 2
chr1_-_23730298 7.495 NM_004091
 E2F2
E2F transcription factor 2
chr6_+_135544138 6.043 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135544214 5.663 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544170 5.469 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr20_-_35157744 5.057 RBL1
retinoblastoma-like 1 (p107)
chr20_-_35157815 4.783 NM_002895
NM_183404
 RBL1

retinoblastoma-like 1 (p107)

chr22_+_34126104 4.493 NM_006739
 MCM5
minichromosome maintenance complex component 5
chr22_+_34126154 4.285 MCM5
minichromosome maintenance complex component 5
chr10_+_124885556 4.141 NM_001105574
 HMX3
H6 family homeobox 3
chr9_-_122679387 4.122 NM_001009936
NM_015651
 PHF19

PHD finger protein 19

chr22_-_18484695 4.044 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr22_+_18485145 4.040 RANBP1
RAN binding protein 1
chr22_+_18485057 3.891 RANBP1
RAN binding protein 1
chr22_+_18485076 3.884 RANBP1
RAN binding protein 1
chr11_-_19219000 3.839 NM_024680
 E2F8
E2F transcription factor 8
chr9_-_122679283 3.715 PHF19
PHD finger protein 19
chr22_+_18485095 3.605 RANBP1
RAN binding protein 1
chr1_+_3558958 3.584 NM_005427
 TP73
tumor protein p73
chr22_-_18484744 3.567 NM_022727
NM_182984
 TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 149 entries
enrichment   p-value GO term description
9.49 4.96e-05 GO:0071897 DNA biosynthetic process
8.44 4.02e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
8.44 4.02e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
8.23 4.73e-07 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
7.48 2.61e-06 GO:0006270 DNA-dependent DNA replication initiation
7.23 5.92e-08 GO:0006271 DNA strand elongation involved in DNA replication
6.75 2.43e-07 GO:0022616 DNA strand elongation
6.33 1.94e-03 GO:2000104 negative regulation of DNA-dependent DNA replication
6.33 7.09e-03 GO:0007062 sister chromatid cohesion
6.05 9.49e-04 GO:0090329 regulation of DNA-dependent DNA replication
6.00 1.25e-02 GO:0032201 telomere maintenance via semi-conservative replication
6.00 1.25e-02 GO:0051225 spindle assembly
5.70 2.12e-02 GO:0000722 telomere maintenance via recombination
5.70 2.12e-02 GO:0006298 mismatch repair
4.88 1.88e-09 GO:0006261 DNA-dependent DNA replication
4.87 3.60e-02 GO:0006312 mitotic recombination
4.52 1.21e-11 GO:0031497 chromatin assembly
4.36 5.92e-10 GO:0006334 nucleosome assembly
4.35 4.68e-02 GO:0000724 double-strand break repair via homologous recombination
4.35 4.68e-02 GO:0000725 recombinational repair

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
9.49 2.42e-03 GO:0042555 MCM complex
8.44 6.78e-03 GO:0035098 ESC/E(Z) complex
5.96 7.72e-03 GO:0030894 replisome
5.96 7.72e-03 GO:0043601 nuclear replisome
5.75 9.88e-04 GO:0043596 nuclear replication fork
5.63 1.29e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
5.47 2.14e-06 GO:0005657 replication fork
5.33 2.08e-02 GO:0031519 PcG protein complex
4.60 4.08e-05 GO:0000792 heterochromatin
4.37 1.84e-02 GO:0005720 nuclear heterochromatin
4.29 1.81e-06 GO:0000786 nucleosome
4.05 2.20e-09 GO:0032993 protein-DNA complex
3.52 4.84e-03 GO:0034708 methyltransferase complex
3.52 4.84e-03 GO:0035097 histone methyltransferase complex
3.48 7.44e-17 GO:0000785 chromatin
3.24 3.95e-04 GO:0000790 nuclear chromatin
3.20 1.44e-09 GO:0044454 nuclear chromosome part
3.14 1.97e-11 GO:0000228 nuclear chromosome
3.06 4.03e-24 GO:0044427 chromosomal part
3.05 7.87e-29 GO:0005694 chromosome

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
6.33 2.47e-02 GO:0030983 mismatched DNA binding
5.84 1.16e-04 GO:0003887 DNA-directed DNA polymerase activity
5.68 5.42e-05 GO:0034061 DNA polymerase activity
3.78 6.49e-04 GO:0003697 single-stranded DNA binding
3.69 7.77e-03 GO:0003684 damaged DNA binding
3.56 8.17e-04 GO:0008094 DNA-dependent ATPase activity
2.67 6.47e-06 GO:0043566 structure-specific DNA binding
2.63 1.07e-03 GO:0003690 double-stranded DNA binding
2.57 2.82e-05 GO:0003682 chromatin binding
1.90 1.24e-02 GO:0016564 transcription repressor activity
1.70 1.15e-19 GO:0003677 DNA binding
1.63 3.59e-25 GO:0003676 nucleic acid binding
1.61 3.99e-05 GO:0030528 transcription regulator activity
1.59 1.37e-03 GO:0003723 RNA binding
1.56 4.50e-04 GO:0001071 nucleic acid binding transcription factor activity
1.56 4.50e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.34 5.57e-04 GO:0000166 nucleotide binding
1.24 4.83e-12 GO:0005515 protein binding
1.13 1.36e-12 GO:0005488 binding