Motif ID: EGR1..3.p2

Z-value: 2.033


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642489320.514.2e-02Click!
EGR1chr5_+_1378290770.467.3e-02Click!
EGR3chr8_-_22606401-0.068.3e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_127549437 2.262 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr17_-_44010543 1.719 NM_024015
HOXB4
homeobox B4
chr19_+_1226510 1.592 NM_017914
C19orf24
chromosome 19 open reading frame 24
chr7_+_128257698 1.533 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr10_+_11099860 1.452 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr2_+_109112428 1.447 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr21_+_45318861 1.413 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr19_-_1518875 1.323 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr17_-_8006979 1.321 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr10_+_11100075 1.271 CELF2
CUGBP, Elav-like family member 2
chr5_+_60663842 1.252 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr7_-_150576660 1.251 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_-_1034453 1.211 C7orf50
chromosome 7 open reading frame 50
chr19_+_16296734 1.204 KLF2
Kruppel-like factor 2 (lung)
chr16_-_19803606 1.178 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr2_-_236740710 1.167


chr2_-_144991386 1.160 ZEB2
zinc finger E-box binding homeobox 2
chr19_+_1200882 1.138 MIDN
midnolin
chr9_-_129701644 1.100 NM_013443
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_-_95317928 1.088 CDK17
cyclin-dependent kinase 17
chr8_-_72919161 1.066 MSC
musculin
chr17_-_60345364 1.061 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr5_-_81082699 1.044 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr1_-_1812353 1.044 NM_002074
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr2_-_96899396 1.031 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr9_-_129701695 1.021 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_-_39877883 1.010 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr1_-_33420213 1.008 NM_018207
TRIM62
tripartite motif containing 62
chr14_-_68515742 1.002 ACTN1
actinin, alpha 1
chr4_-_105631915 0.988 NM_025212
CXXC4
CXXC finger protein 4
chr7_-_27180398 0.982 NM_018951
HOXA10
homeobox A10
chr1_-_39877928 0.979 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr4_+_151218862 0.978 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chrX_+_9392980 0.974 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr5_-_88215034 0.970 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr9_-_129701602 0.961 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_-_236741352 0.960 NM_001485
GBX2
gastrulation brain homeobox 2
chr1_-_32574185 0.959 NM_023009
MARCKSL1
MARCKS-like 1
chr9_+_35819208 0.956 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr22_+_22881944 0.944 CABIN1
calcineurin binding protein 1
chr19_-_15304307 0.943 BRD4
bromodomain containing 4
chr19_-_61680510 0.940 NM_022103
ZNF667
zinc finger protein 667
chr5_-_176857207 0.938 NM_005451
NM_203352
NM_213636
PDLIM7


PDZ and LIM domain 7 (enigma)


chr7_-_525556 0.934 PDGFA
platelet-derived growth factor alpha polypeptide
chr9_+_89302239 0.934 DAPK1
death-associated protein kinase 1
chr7_+_151792052 0.933 LOC100128822
hypothetical LOC100128822
chr17_-_39652391 0.932 UBTF
upstream binding transcription factor, RNA polymerase I
chr8_+_72918889 0.925


chr8_-_72919241 0.920 NM_005098
MSC
musculin
chr3_+_171558143 0.918 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr10_-_128884411 0.911 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr14_-_68515791 0.896 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr4_+_129951877 0.895 PHF17
PHD finger protein 17
chr1_-_11663762 0.892 NM_006341
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr13_+_19430881 0.891 ZMYM2
zinc finger, MYM-type 2
chr16_+_84204424 0.889 NM_014615
KIAA0182
KIAA0182
chr17_-_39652449 0.884 NM_001076684
UBTF
upstream binding transcription factor, RNA polymerase I
chr21_+_36993302 0.883


chr12_+_50271283 0.878 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr9_-_129701707 0.877 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr15_-_80125403 0.870 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr6_-_109883778 0.869 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr6_-_109883635 0.868 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr5_-_176857158 0.865 PDLIM7
PDZ and LIM domain 7 (enigma)
chr6_-_151754337 0.861 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr4_-_111763655 0.860 NM_000325
PITX2
paired-like homeodomain 2
chr6_-_165996031 0.848 LOC100132188
LP7097
chr14_-_68515761 0.845 ACTN1
actinin, alpha 1
chr13_+_75108450 0.841 LMO7
LIM domain 7
chr8_+_72918772 0.839 LOC100132891
hypothetical LOC100132891
chr13_+_19430788 0.835 NM_003453
NM_197968
NM_001190964
ZMYM2


zinc finger, MYM-type 2


chr8_-_72918938 0.833 MSC
musculin
chr18_+_12397894 0.832 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr19_+_16296632 0.832 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr12_+_52653176 0.819 NM_014212
HOXC11
homeobox C11
chr6_-_85530617 0.818 NM_001080508
TBX18
T-box 18
chr19_-_44032388 0.806 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr19_-_15304304 0.806 BRD4
bromodomain containing 4
chr16_-_3870714 0.804 CREBBP
CREB binding protein
chr16_-_71650034 0.803 NM_001164766
ZFHX3
zinc finger homeobox 3
chr14_-_68515727 0.802 ACTN1
actinin, alpha 1
chr5_-_81082614 0.801 SSBP2
single-stranded DNA binding protein 2
chr2_+_200031333 0.799


chr10_+_11100111 0.797 CELF2
CUGBP, Elav-like family member 2
chr15_+_38520594 0.796 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr17_+_7728819 0.795 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr21_-_45532176 0.791 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr3_+_148610516 0.789 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr9_+_138341752 0.786 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr3_-_39170105 0.784 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr17_+_44927591 0.779 NM_002507
NGFR
nerve growth factor receptor
chr10_+_133850325 0.778 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr20_-_3944035 0.777 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr4_+_38341982 0.766 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr7_+_150414704 0.761 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr6_-_46566969 0.758 RCAN2
regulator of calcineurin 2
chr6_-_109883639 0.758 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_+_177261627 0.757 FAM20B
family with sequence similarity 20, member B
chr14_-_68515701 0.754 ACTN1
actinin, alpha 1
chr17_-_63798851 0.754 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr16_+_65620536 0.746 NM_001755
NM_022845
CBFB

core-binding factor, beta subunit

chr1_+_35507145 0.746 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr17_+_78630793 0.739 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr9_-_16860719 0.739 NM_017637
BNC2
basonuclin 2
chr1_-_1812389 0.736 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chrX_+_153339814 0.735 NM_017514
PLXNA3
plexin A3
chr9_+_35819375 0.733 NM_001042590
TMEM8B
transmembrane protein 8B
chr19_-_18253436 0.731 JUND
jun D proto-oncogene
chr19_-_44032415 0.731 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr10_-_131652007 0.729 NM_001005463
EBF3
early B-cell factor 3
chr7_-_526005 0.726 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr6_-_109883864 0.719 NM_001159291
NM_022765
MICAL1

microtubule associated monoxygenase, calponin and LIM domain containing 1

chr4_-_2233504 0.716 NM_006454
MXD4
MAX dimerization protein 4
chr7_-_81910740 0.712 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr9_-_13269562 0.712 MPDZ
multiple PDZ domain protein
chr7_-_81910956 0.709 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr19_-_15172773 0.708 NM_000435
NOTCH3
notch 3
chr22_+_42751487 0.704 NM_013327
PARVB
parvin, beta
chr16_+_2503676 0.703 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr12_+_50586958 0.702 ACVRL1
activin A receptor type II-like 1
chr17_+_58058774 0.693 MRC2
mannose receptor, C type 2
chr22_+_18081968 0.691 NM_002688
SEPT5
septin 5
chr16_-_3870686 0.686 CREBBP
CREB binding protein
chr7_+_39956480 0.685 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr1_+_78126787 0.685 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr7_-_150576634 0.685 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr10_+_49184658 0.683 MAPK8
mitogen-activated protein kinase 8
chr12_+_19483578 0.677 NM_001114176
NM_153207
AEBP2

AE binding protein 2

chr3_-_39170038 0.671 CSRNP1
cysteine-serine-rich nuclear protein 1
chr9_-_15500209 0.670 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr14_+_51850754 0.669 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr1_+_148388870 0.666 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr7_-_75206152 0.664 HIP1
huntingtin interacting protein 1
chr17_+_63799228 0.664 ARSG
arylsulfatase G
chr14_-_68515525 0.661 ACTN1
actinin, alpha 1
chr21_-_38210531 0.660 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr6_+_157141565 0.657 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr7_-_150576957 0.657 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr2_+_170392146 0.652 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr14_+_99220349 0.648 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr9_-_138958893 0.646 FBXW5
F-box and WD repeat domain containing 5
chr13_-_109236897 0.646 NM_003749
IRS2
insulin receptor substrate 2
chr19_+_39611053 0.645 NM_005499
UBA2
ubiquitin-like modifier activating enzyme 2
chr13_-_113916115 0.642 RASA3
RAS p21 protein activator 3
chr13_-_113916159 0.641 RASA3
RAS p21 protein activator 3
chr1_+_6767968 0.640 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr13_-_113916066 0.639 RASA3
RAS p21 protein activator 3
chr8_-_102032852 0.639 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr16_+_4683710 0.634 NUDT16L1
nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
chr2_-_96899326 0.633 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr1_+_35507197 0.632 ZMYM4
zinc finger, MYM-type 4
chr15_+_29406335 0.631 NM_015995
KLF13
Kruppel-like factor 13
chr13_+_19430906 0.631 NM_001190965
ZMYM2
zinc finger, MYM-type 2
chr2_-_238813284 0.630 HES6
hairy and enhancer of split 6 (Drosophila)
chr10_-_128067062 0.625 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr10_+_129595349 0.624 PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_-_15723279 0.623 CASP9
caspase 9, apoptosis-related cysteine peptidase
chr16_-_960982 0.623 NM_022773
LMF1
lipase maturation factor 1
chr16_+_4683694 0.621 NM_001193452
NM_032349
NUDT16L1

nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1

chr7_-_19123787 0.621 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr13_-_113916186 0.621 NM_007368
RASA3
RAS p21 protein activator 3
chr15_+_88874098 0.619 NM_001042574
NM_022769
CRTC3

CREB regulated transcription coactivator 3

chr12_-_105056577 0.619 NUAK1
NUAK family, SNF1-like kinase, 1
chr17_+_14145051 0.615 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr15_-_23659329 0.614 NM_024490
ATP10A
ATPase, class V, type 10A
chr19_-_54314090 0.613 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr10_+_129595289 0.610 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr17_-_3546047 0.607 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr8_-_72918697 0.605 MSC
musculin
chr19_+_2220529 0.604 OAZ1
ornithine decarboxylase antizyme 1
chr7_-_19123765 0.601 TWIST1
twist homolog 1 (Drosophila)
chr7_+_149696901 0.598 REPIN1
replication initiator 1
chr17_-_1335763 0.597 NM_001080950
MYO1C
myosin IC
chr10_-_128067052 0.597 ADAM12
ADAM metallopeptidase domain 12
chr3_-_38666122 0.593 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr7_-_2320576 0.590 NM_013321
SNX8
sorting nexin 8
chr6_+_3697328 0.589


chr16_+_12902955 0.584 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr16_-_2258067 0.579 RNPS1
RNA binding protein S1, serine-rich domain
chr11_-_61415429 0.578 NM_021727
FADS3
fatty acid desaturase 3
chr19_-_1603325 0.576 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr8_-_80842452 0.574 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr1_-_1812361 0.568 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr5_-_142763393 0.567 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr14_-_68515731 0.567 ACTN1
actinin, alpha 1
chr19_+_10574055 0.566 NM_001145056
SLC44A2
solute carrier family 44, member 2
chr13_-_49597776 0.564 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_26895108 0.563 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr5_-_142764168 0.562 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_142764295 0.561 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_137396674 0.561 FAM13B
family with sequence similarity 13, member B
chr8_+_144789339 0.559 NM_001082480
ZNF623
zinc finger protein 623
chr20_+_56701224 0.558 NM_024663
NPEPL1
aminopeptidase-like 1
chr5_-_137396669 0.557 FAM13B
family with sequence similarity 13, member B
chr8_-_101803466 0.556 PABPC1
poly(A) binding protein, cytoplasmic 1
chr21_+_45532377 0.555 LOC642852
hypothetical LOC642852
chr4_-_10068055 0.554 NM_053042
ZNF518B
zinc finger protein 518B
chr16_-_4604895 0.553 NM_145253
FAM100A
family with sequence similarity 100, member A
chr1_-_1812342 0.550 CDK11A
cyclin-dependent kinase 11A
chr14_-_101623139 0.549 NM_005348
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 1.36e-20 GO:0050794 regulation of cellular process
1.39 1.27e-19 GO:0010468 regulation of gene expression
1.67 2.36e-19 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.18 6.41e-19 GO:0050789 regulation of biological process
1.32 8.86e-19 GO:0060255 regulation of macromolecule metabolic process
1.41 3.01e-18 GO:0051252 regulation of RNA metabolic process
1.30 8.01e-18 GO:0031323 regulation of cellular metabolic process
1.17 8.37e-18 GO:0065007 biological regulation
1.38 7.63e-17 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.30 1.53e-16 GO:0080090 regulation of primary metabolic process
1.27 1.15e-15 GO:0019222 regulation of metabolic process
1.36 1.32e-15 GO:0010556 regulation of macromolecule biosynthetic process
1.38 3.01e-15 GO:0006355 regulation of transcription, DNA-dependent
1.33 8.85e-15 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.10 1.74e-14 GO:0009987 cellular process
1.35 7.19e-14 GO:0048519 negative regulation of biological process
1.24 1.06e-13 GO:0044260 cellular macromolecule metabolic process
1.36 2.95e-13 GO:0048523 negative regulation of cellular process
1.31 3.17e-13 GO:0051171 regulation of nitrogen compound metabolic process
1.32 4.60e-13 GO:0031326 regulation of cellular biosynthetic process
1.31 8.12e-13 GO:0009889 regulation of biosynthetic process
1.72 1.01e-12 GO:0010629 negative regulation of gene expression
1.33 1.51e-12 GO:0048522 positive regulation of cellular process
1.55 9.32e-12 GO:0022008 neurogenesis
1.89 1.38e-11 GO:0016568 chromatin modification
1.64 4.19e-11 GO:0010628 positive regulation of gene expression
1.29 4.79e-11 GO:0048518 positive regulation of biological process
1.56 5.38e-11 GO:0048699 generation of neurons
1.70 1.01e-10 GO:0051253 negative regulation of RNA metabolic process
1.41 1.08e-10 GO:0007399 nervous system development
1.29 3.06e-10 GO:0071842 cellular component organization at cellular level
1.16 5.34e-10 GO:0044237 cellular metabolic process
1.69 5.63e-10 GO:0045892 negative regulation of transcription, DNA-dependent
1.52 7.10e-10 GO:0006351 transcription, DNA-dependent
1.35 8.04e-10 GO:0006464 protein modification process
1.60 8.86e-10 GO:0051254 positive regulation of RNA metabolic process
1.33 1.39e-09 GO:0043412 macromolecule modification
1.62 1.84e-09 GO:0045893 positive regulation of transcription, DNA-dependent
1.18 2.43e-09 GO:0043170 macromolecule metabolic process
1.61 3.06e-09 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.27 4.62e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.59 5.65e-09 GO:0010558 negative regulation of macromolecule biosynthetic process
1.26 5.79e-09 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 6.88e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
1.54 7.41e-09 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 8.34e-09 GO:0031327 negative regulation of cellular biosynthetic process
1.49 1.11e-08 GO:0010605 negative regulation of macromolecule metabolic process
1.35 1.24e-08 GO:0023051 regulation of signaling
1.60 1.25e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 1.42e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.48 1.48e-08 GO:0050793 regulation of developmental process
1.41 2.00e-08 GO:0031325 positive regulation of cellular metabolic process
1.56 2.05e-08 GO:0009890 negative regulation of biosynthetic process
1.52 3.24e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.58 4.29e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
1.48 1.06e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.39 1.09e-07 GO:0009893 positive regulation of metabolic process
1.71 1.41e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.44 1.59e-07 GO:0009892 negative regulation of metabolic process
1.47 2.18e-07 GO:0009891 positive regulation of biosynthetic process
1.22 2.24e-07 GO:0016043 cellular component organization
1.14 3.66e-07 GO:0044238 primary metabolic process
1.22 3.76e-07 GO:0034641 cellular nitrogen compound metabolic process
1.63 5.30e-07 GO:0006325 chromatin organization
1.31 6.04e-07 GO:0016070 RNA metabolic process
1.19 8.20e-07 GO:0032502 developmental process
1.21 8.74e-07 GO:0007275 multicellular organismal development
1.62 8.81e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.28 9.82e-07 GO:0030154 cell differentiation
1.27 1.39e-06 GO:0090304 nucleic acid metabolic process
1.21 1.46e-06 GO:0006807 nitrogen compound metabolic process
1.20 1.63e-06 GO:0071840 cellular component organization or biogenesis
1.34 1.72e-06 GO:0009966 regulation of signal transduction
1.45 1.84e-06 GO:0051128 regulation of cellular component organization
1.50 1.92e-06 GO:0030182 neuron differentiation
1.43 3.13e-06 GO:0031324 negative regulation of cellular metabolic process
1.27 4.31e-06 GO:0048869 cellular developmental process
1.40 6.12e-06 GO:0032774 RNA biosynthetic process
1.48 7.60e-06 GO:0045595 regulation of cell differentiation
1.46 8.58e-06 GO:2000026 regulation of multicellular organismal development
1.30 1.01e-05 GO:0006996 organelle organization
1.56 1.47e-05 GO:0031175 neuron projection development
1.11 1.86e-05 GO:0008152 metabolic process
1.48 2.49e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.92 2.59e-05 GO:0016569 covalent chromatin modification
1.23 3.53e-05 GO:0044267 cellular protein metabolic process
1.60 3.54e-05 GO:0007409 axonogenesis
1.58 5.63e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.54 6.15e-05 GO:0000904 cell morphogenesis involved in differentiation
1.50 6.28e-05 GO:0048666 neuron development
1.30 7.39e-05 GO:0009653 anatomical structure morphogenesis
1.90 7.41e-05 GO:0016570 histone modification
1.38 9.01e-05 GO:0048468 cell development
1.56 9.64e-05 GO:0048812 neuron projection morphogenesis
1.47 1.23e-04 GO:0051276 chromosome organization
1.19 1.97e-04 GO:0048856 anatomical structure development
1.50 2.89e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.63 3.01e-04 GO:0007411 axon guidance
2.15 3.31e-04 GO:0040029 regulation of gene expression, epigenetic
3.66 3.68e-04 GO:0043489 RNA stabilization
3.66 3.68e-04 GO:0048255 mRNA stabilization
2.25 4.01e-04 GO:0018205 peptidyl-lysine modification
1.19 5.13e-04 GO:0048731 system development
1.30 5.98e-04 GO:0051239 regulation of multicellular organismal process
1.65 9.13e-04 GO:0032446 protein modification by small protein conjugation
1.60 9.35e-04 GO:0033043 regulation of organelle organization
2.40 9.38e-04 GO:0018394 peptidyl-lysine acetylation
2.40 1.45e-03 GO:0016573 histone acetylation
1.42 1.46e-03 GO:0030030 cell projection organization
1.82 2.28e-03 GO:0051493 regulation of cytoskeleton organization
2.36 2.28e-03 GO:0018393 internal peptidyl-lysine acetylation
3.04 2.37e-03 GO:0043487 regulation of RNA stability
1.71 2.40e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.56 2.66e-03 GO:0018193 peptidyl-amino acid modification
1.24 3.75e-03 GO:0034645 cellular macromolecule biosynthetic process
1.49 3.90e-03 GO:0032583 regulation of gene-specific transcription
1.24 3.93e-03 GO:0009059 macromolecule biosynthetic process
1.64 4.14e-03 GO:0016567 protein ubiquitination
1.56 4.41e-03 GO:0070647 protein modification by small protein conjugation or removal
1.31 4.94e-03 GO:0032268 regulation of cellular protein metabolic process
1.30 5.00e-03 GO:0010646 regulation of cell communication
1.41 5.12e-03 GO:0000902 cell morphogenesis
2.29 5.41e-03 GO:0006475 internal protein amino acid acetylation
1.45 5.79e-03 GO:0048858 cell projection morphogenesis
1.45 5.81e-03 GO:0032990 cell part morphogenesis
1.40 6.28e-03 GO:0032989 cellular component morphogenesis
1.58 6.33e-03 GO:0051130 positive regulation of cellular component organization
2.98 7.27e-03 GO:0043488 regulation of mRNA stability
1.22 7.50e-03 GO:0010467 gene expression
1.51 1.28e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.00 1.32e-02 GO:0043414 macromolecule methylation
2.08 1.33e-02 GO:0043543 protein acylation
2.14 1.62e-02 GO:0000209 protein polyubiquitination
1.16 2.21e-02 GO:0019538 protein metabolic process
2.13 2.46e-02 GO:0006473 protein acetylation
1.21 2.57e-02 GO:0048583 regulation of response to stimulus
1.44 2.65e-02 GO:0051094 positive regulation of developmental process
1.66 3.30e-02 GO:0044087 regulation of cellular component biogenesis
1.52 3.90e-02 GO:0060284 regulation of cell development
1.40 4.87e-02 GO:0007417 central nervous system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 8.36e-39 GO:0044424 intracellular part
1.14 1.59e-38 GO:0005622 intracellular
1.27 1.38e-28 GO:0005634 nucleus
1.16 2.76e-28 GO:0043226 organelle
1.16 3.83e-28 GO:0043229 intracellular organelle
1.18 5.41e-27 GO:0043227 membrane-bounded organelle
1.17 8.78e-27 GO:0043231 intracellular membrane-bounded organelle
1.41 6.72e-16 GO:0031981 nuclear lumen
1.37 1.09e-15 GO:0044428 nuclear part
1.14 5.68e-15 GO:0005737 cytoplasm
1.43 5.92e-12 GO:0005654 nucleoplasm
1.32 1.45e-11 GO:0070013 intracellular organelle lumen
1.30 3.45e-11 GO:0031974 membrane-enclosed lumen
1.30 7.12e-11 GO:0043233 organelle lumen
1.57 1.20e-10 GO:0044451 nucleoplasm part
1.17 4.59e-10 GO:0044446 intracellular organelle part
1.16 2.10e-09 GO:0044422 organelle part
1.23 1.10e-08 GO:0043234 protein complex
1.29 1.83e-08 GO:0005829 cytosol
1.14 3.37e-08 GO:0044444 cytoplasmic part
1.04 1.03e-07 GO:0005623 cell
1.04 1.39e-07 GO:0044464 cell part
2.29 7.20e-06 GO:0016585 chromatin remodeling complex
1.17 1.52e-05 GO:0032991 macromolecular complex
2.63 4.05e-05 GO:0035770 RNA granule
1.71 5.60e-05 GO:0005667 transcription factor complex
2.71 7.84e-04 GO:0000118 histone deacetylase complex
2.25 1.88e-03 GO:0000123 histone acetyltransferase complex
1.33 2.76e-03 GO:0031982 vesicle
1.33 3.04e-03 GO:0031410 cytoplasmic vesicle
4.00 4.24e-03 GO:0010494 stress granule
1.34 4.60e-03 GO:0015630 microtubule cytoskeleton
1.66 8.43e-03 GO:0031252 cell leading edge
3.69 1.49e-02 GO:0016581 NuRD complex
2.63 2.11e-02 GO:0000932 cytoplasmic mRNA processing body
1.54 2.14e-02 GO:0000785 chromatin
1.30 2.83e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.90 3.84e-02 GO:0008021 synaptic vesicle
2.29 4.03e-02 GO:0000792 heterochromatin
1.29 4.22e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 3.69e-29 GO:0005515 protein binding
1.11 2.64e-24 GO:0005488 binding
1.70 9.08e-24 GO:0030528 transcription regulator activity
1.35 1.66e-15 GO:0003677 DNA binding
1.29 1.88e-15 GO:0003676 nucleic acid binding
1.53 5.27e-13 GO:0001071 nucleic acid binding transcription factor activity
1.53 5.27e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.86 4.48e-10 GO:0016563 transcription activator activity
1.79 3.92e-08 GO:0016564 transcription repressor activity
1.50 3.06e-07 GO:0043565 sequence-specific DNA binding
1.26 9.08e-07 GO:0008270 zinc ion binding
1.85 6.36e-06 GO:0000975 regulatory region DNA binding
1.85 6.36e-06 GO:0001067 regulatory region nucleic acid binding
1.85 6.36e-06 GO:0044212 transcription regulatory region DNA binding
1.69 9.86e-06 GO:0008134 transcription factor binding
1.22 2.68e-05 GO:0046914 transition metal ion binding
1.83 2.83e-05 GO:0010843 promoter binding
1.56 1.46e-04 GO:0000988 protein binding transcription factor activity
1.56 1.46e-04 GO:0000989 transcription factor binding transcription factor activity
1.55 2.31e-04 GO:0003712 transcription cofactor activity
1.15 4.89e-04 GO:0046872 metal ion binding
1.14 7.63e-04 GO:0043167 ion binding
1.14 7.68e-04 GO:0043169 cation binding
1.65 1.55e-03 GO:0019787 small conjugating protein ligase activity
1.72 1.81e-03 GO:0003682 chromatin binding
1.62 1.93e-03 GO:0003702 RNA polymerase II transcription factor activity
1.59 2.32e-03 GO:0016881 acid-amino acid ligase activity
1.19 2.42e-03 GO:0000166 nucleotide binding
1.45 3.26e-03 GO:0019904 protein domain specific binding
1.55 3.51e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.34 3.86e-03 GO:0019899 enzyme binding
1.61 1.06e-02 GO:0003713 transcription coactivator activity
1.49 1.52e-02 GO:0003779 actin binding
3.69 2.64e-02 GO:0070412 R-SMAD binding
2.35 3.00e-02 GO:0046332 SMAD binding
1.88 3.29e-02 GO:0016566 specific transcriptional repressor activity
1.57 3.34e-02 GO:0004842 ubiquitin-protein ligase activity
2.21 4.37e-02 GO:0035258 steroid hormone receptor binding
1.28 4.52e-02 GO:0003723 RNA binding