Motif ID: EGR1..3.p2

Z-value: 2.033


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642489320.514.2e-02Click!
EGR1chr5_+_1378290770.467.3e-02Click!
EGR3chr8_-_22606401-0.068.3e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_127549437 2.262 NM_006195
 PBX3
pre-B-cell leukemia homeobox 3
chr17_-_44010543 1.719 NM_024015
 HOXB4
homeobox B4
chr19_+_1226510 1.592 NM_017914
 C19orf24
chromosome 19 open reading frame 24
chr7_+_128257698 1.533 NM_001127487
NM_001458
 FLNC

filamin C, gamma

chr10_+_11099860 1.452 NM_006561
 CELF2
CUGBP, Elav-like family member 2
chr2_+_109112428 1.447 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr21_+_45318861 1.413 NM_001112
NM_001160230
NM_015833
NM_015834
 ADARB1



adenosine deaminase, RNA-specific, B1



chr19_-_1518875 1.323 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)

chr17_-_8006979 1.321 NM_014232
 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr10_+_11100075 1.271 CELF2
CUGBP, Elav-like family member 2
chr5_+_60663842 1.252 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr7_-_150576660 1.251 NM_001003801
 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_-_1034453 1.211 C7orf50
chromosome 7 open reading frame 50
chr19_+_16296734 1.204 KLF2
Kruppel-like factor 2 (lung)
chr16_-_19803606 1.178 NM_016235
 GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr2_-_236740710 1.167


chr2_-_144991386 1.160 ZEB2
zinc finger E-box binding homeobox 2
chr19_+_1200882 1.138 MIDN
midnolin
chr9_-_129701644 1.100 NM_013443
 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_-_95317928 1.088 CDK17
cyclin-dependent kinase 17

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 140 entries
enrichment   p-value GO term description
3.66 3.68e-04 GO:0043489 RNA stabilization
3.66 3.68e-04 GO:0048255 mRNA stabilization
3.04 2.37e-03 GO:0043487 regulation of RNA stability
2.98 7.27e-03 GO:0043488 regulation of mRNA stability
2.40 9.38e-04 GO:0018394 peptidyl-lysine acetylation
2.40 1.45e-03 GO:0016573 histone acetylation
2.36 2.28e-03 GO:0018393 internal peptidyl-lysine acetylation
2.29 5.41e-03 GO:0006475 internal protein amino acid acetylation
2.25 4.01e-04 GO:0018205 peptidyl-lysine modification
2.15 3.31e-04 GO:0040029 regulation of gene expression, epigenetic
2.14 1.62e-02 GO:0000209 protein polyubiquitination
2.13 2.46e-02 GO:0006473 protein acetylation
2.08 1.33e-02 GO:0043543 protein acylation
2.00 1.32e-02 GO:0043414 macromolecule methylation
1.92 2.59e-05 GO:0016569 covalent chromatin modification
1.90 7.41e-05 GO:0016570 histone modification
1.89 1.38e-11 GO:0016568 chromatin modification
1.82 2.28e-03 GO:0051493 regulation of cytoskeleton organization
1.72 1.01e-12 GO:0010629 negative regulation of gene expression
1.71 1.41e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
4.00 4.24e-03 GO:0010494 stress granule
3.69 1.49e-02 GO:0016581 NuRD complex
2.71 7.84e-04 GO:0000118 histone deacetylase complex
2.63 4.05e-05 GO:0035770 RNA granule
2.63 2.11e-02 GO:0000932 cytoplasmic mRNA processing body
2.29 7.20e-06 GO:0016585 chromatin remodeling complex
2.29 4.03e-02 GO:0000792 heterochromatin
2.25 1.88e-03 GO:0000123 histone acetyltransferase complex
1.90 3.84e-02 GO:0008021 synaptic vesicle
1.71 5.60e-05 GO:0005667 transcription factor complex
1.66 8.43e-03 GO:0031252 cell leading edge
1.57 1.20e-10 GO:0044451 nucleoplasm part
1.54 2.14e-02 GO:0000785 chromatin
1.43 5.92e-12 GO:0005654 nucleoplasm
1.41 6.72e-16 GO:0031981 nuclear lumen
1.37 1.09e-15 GO:0044428 nuclear part
1.34 4.60e-03 GO:0015630 microtubule cytoskeleton
1.33 2.76e-03 GO:0031982 vesicle
1.33 3.04e-03 GO:0031410 cytoplasmic vesicle
1.32 1.45e-11 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
3.69 2.64e-02 GO:0070412 R-SMAD binding
2.35 3.00e-02 GO:0046332 SMAD binding
2.21 4.37e-02 GO:0035258 steroid hormone receptor binding
1.88 3.29e-02 GO:0016566 specific transcriptional repressor activity
1.86 4.48e-10 GO:0016563 transcription activator activity
1.85 6.36e-06 GO:0000975 regulatory region DNA binding
1.85 6.36e-06 GO:0001067 regulatory region nucleic acid binding
1.85 6.36e-06 GO:0044212 transcription regulatory region DNA binding
1.83 2.83e-05 GO:0010843 promoter binding
1.79 3.92e-08 GO:0016564 transcription repressor activity
1.72 1.81e-03 GO:0003682 chromatin binding
1.70 9.08e-24 GO:0030528 transcription regulator activity
1.69 9.86e-06 GO:0008134 transcription factor binding
1.65 1.55e-03 GO:0019787 small conjugating protein ligase activity
1.62 1.93e-03 GO:0003702 RNA polymerase II transcription factor activity
1.61 1.06e-02 GO:0003713 transcription coactivator activity
1.59 2.32e-03 GO:0016881 acid-amino acid ligase activity
1.57 3.34e-02 GO:0004842 ubiquitin-protein ligase activity
1.56 1.46e-04 GO:0000988 protein binding transcription factor activity
1.56 1.46e-04 GO:0000989 transcription factor binding transcription factor activity