Motif ID: EN1,2.p2

Z-value: 2.515


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN1chr2_-_119322228-0.126.6e-01Click!
EN2chr7_+_1549434660.077.9e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_50318801 5.959 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr3_+_188197029 4.606


chr10_-_98021144 4.355 NM_001114094
NM_013314
 BLNK

B-cell linker

chr2_+_102401580 3.937 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr12_-_7172641 3.412 NM_031491
 RBP5
retinol binding protein 5, cellular
chr2_-_158008763 3.353 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr1_+_173111306 3.313 NM_001035230
 RABGAP1L
RAB GTPase activating protein 1-like
chr4_-_40211324 3.099 RBM47
RNA binding motif protein 47
chr20_-_57015698 3.017 NM_001336
 CTSZ
cathepsin Z
chr4_+_39874921 2.924 NM_004310
 RHOH
ras homolog gene family, member H
chr15_-_32416336 2.886 NM_001042497
NM_133647
 SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr11_+_59979857 2.840 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr22_+_38627031 2.762 NM_004810
 GRAP2
GRB2-related adaptor protein 2
chr11_+_123600553 2.724 NM_001007249
 OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr2_+_96355661 2.713 NM_178495
NM_001163524
 ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr17_-_31441390 2.632 NM_002983
 CCL3
chemokine (C-C motif) ligand 3
chrX_+_65152004 2.520


chr20_-_45410033 2.459 ZMYND8
zinc finger, MYND-type containing 8
chr20_-_57015547 2.446 CTSZ
cathepsin Z
chr12_+_6424293 2.425 NM_001242
 CD27
CD27 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
3.73 9.82e-32 GO:0007608 sensory perception of smell
3.58 2.01e-32 GO:0007606 sensory perception of chemical stimulus
3.25 2.60e-02 GO:0002449 lymphocyte mediated immunity
3.18 1.14e-02 GO:0006959 humoral immune response
2.61 4.37e-25 GO:0007600 sensory perception
2.53 1.49e-02 GO:0002252 immune effector process
1.99 3.45e-17 GO:0050877 neurological system process
1.97 5.05e-03 GO:0045087 innate immune response
1.86 3.40e-06 GO:0006955 immune response
1.85 1.01e-16 GO:0003008 system process
1.71 3.02e-04 GO:0006952 defense response
1.51 2.89e-03 GO:0002376 immune system process
1.32 5.52e-13 GO:0050896 response to stimulus
1.29 6.13e-08 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.16 4.00e-02 GO:0005882 intermediate filament
1.42 9.04e-14 GO:0005886 plasma membrane
1.41 7.72e-14 GO:0071944 cell periphery
1.33 4.51e-03 GO:0005576 extracellular region
1.26 1.18e-07 GO:0031224 intrinsic to membrane
1.25 5.97e-07 GO:0016021 integral to membrane
1.20 1.18e-05 GO:0044425 membrane part
1.14 1.15e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.87 1.10e-33 GO:0004984 olfactory receptor activity
2.62 4.79e-27 GO:0004930 G-protein coupled receptor activity
2.11 2.20e-21 GO:0004888 transmembrane receptor activity
1.85 9.02e-18 GO:0004872 receptor activity
1.77 6.07e-19 GO:0004871 signal transducer activity
1.77 6.07e-19 GO:0060089 molecular transducer activity