Motif ID: EP300.p2

Z-value: 3.190


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398177330.421.0e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_160964574 5.417 SCHIP1
schwannomin interacting protein 1
chr10_-_126839546 4.258 NM_001083914
CTBP2
C-terminal binding protein 2
chr5_+_96024434 4.050 CAST
calpastatin
chr15_-_80125403 3.602 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr15_-_80125514 3.457 MEX3B
mex-3 homolog B (C. elegans)
chr13_+_113546841 3.388 NM_000820
GAS6
growth arrest-specific 6
chr3_+_156280539 3.141 MME
membrane metallo-endopeptidase
chr8_-_145085616 3.023 NM_201384
PLEC
plectin
chr13_+_113546897 2.941 GAS6
growth arrest-specific 6
chr8_+_106400322 2.918 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr1_+_179148935 2.882 NM_020950
KIAA1614
KIAA1614
chr3_+_156280497 2.847 MME
membrane metallo-endopeptidase
chr13_-_43259032 2.780 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr9_-_33437527 2.706 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr8_+_22513043 2.678 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr4_+_183302105 2.565 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr13_+_113546912 2.519 GAS6
growth arrest-specific 6
chr8_-_122722674 2.499 NM_005328
HAS2
hyaluronan synthase 2
chr12_-_104153920 2.449 NM_018171
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr10_+_102782156 2.360 SFXN3
sideroflexin 3
chr3_+_113061296 2.342 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_113061330 2.334 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_113061218 2.315 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr13_+_113546943 2.306 GAS6
growth arrest-specific 6
chr4_-_177950658 2.244 NM_005429
VEGFC
vascular endothelial growth factor C
chr11_+_35641234 2.222 TRIM44
tripartite motif containing 44
chr3_-_38046034 2.191 NM_006225
PLCD1
phospholipase C, delta 1
chr12_+_51727076 2.183 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_154351200 2.141 LMNA
lamin A/C
chr17_+_76988134 2.132 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr12_-_26169074 2.107 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr17_+_52026058 2.081 NM_005450
NOG
noggin
chr17_-_76985538 2.037


chr4_-_5761194 2.007 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr3_-_180652024 1.994 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr3_+_156280129 1.953 NM_000902
MME
membrane metallo-endopeptidase
chr9_-_116920232 1.948 NM_002160
TNC
tenascin C
chr15_-_81743198 1.922 BNC1
basonuclin 1
chr1_-_154913712 1.909 NM_006617
NES
nestin
chr14_+_92049396 1.908 NM_024832
RIN3
Ras and Rab interactor 3
chr3_+_156280604 1.904 NM_007288
MME
membrane metallo-endopeptidase
chr5_+_174084137 1.859 NM_002449
MSX2
msh homeobox 2
chr4_-_187884721 1.855


chr7_+_128257698 1.849 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr1_-_94779727 1.835 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr11_+_35640994 1.835 TRIM44
tripartite motif containing 44
chr3_+_157875408 1.829 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr17_+_58058783 1.803 MRC2
mannose receptor, C type 2
chr16_-_30993004 1.803 NM_024706
ZNF668
zinc finger protein 668
chr8_-_23077392 1.784 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr11_+_35116961 1.771 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
CD44




CD44 molecule (Indian blood group)




chr6_-_33822659 1.754 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr1_-_32940943 1.730 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr11_+_35640918 1.721 NM_017583
TRIM44
tripartite motif containing 44
chr1_+_143920424 1.717 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr11_+_35117226 1.704 CD44
CD44 molecule (Indian blood group)
chr3_+_156280338 1.680 NM_007287
MME
membrane metallo-endopeptidase
chr11_+_12355600 1.672 NM_018222
PARVA
parvin, alpha
chr11_+_131286513 1.669 NTM
neurotrimin
chr5_+_158622843 1.665 UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr5_-_33927724 1.644 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr16_-_30992574 1.644 ZNF668
zinc finger protein 668
chr1_-_93919789 1.638 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr3_+_180348818 1.623 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr2_-_40532651 1.600 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr14_+_105028614 1.597 NM_001134875
NM_001134876
C14orf80

chromosome 14 open reading frame 80

chr4_+_86615275 1.592 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr10_-_99151003 1.592 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr3_-_180651874 1.590 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr6_-_72187168 1.570 C6orf155
chromosome 6 open reading frame 155
chr19_+_4229597 1.544 NM_020209
SHD
Src homology 2 domain containing transforming protein D
chr10_-_99150977 1.533 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr2_-_97016027 1.527 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr1_-_32940850 1.525 SYNC
syncoilin, intermediate filament protein
chr7_+_37926687 1.525 NM_017549
EPDR1
ependymin related protein 1 (zebrafish)
chr11_+_124539814 1.505 PKNOX2
PBX/knotted 1 homeobox 2
chr11_+_1925075 1.476 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr19_-_60573552 1.464 NM_000641
IL11
interleukin 11
chr1_-_108544486 1.462 NM_013386
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr2_+_191818124 1.457 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr11_+_1925162 1.454 MRPL23
mitochondrial ribosomal protein L23
chr4_-_169638146 1.452 DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr10_+_88720477 1.450 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr1_+_221955876 1.447 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_156229934 1.438 KIRREL
kin of IRRE like (Drosophila)
chr2_-_200030944 1.432 NM_001172509
SATB2
SATB homeobox 2
chr10_-_49483002 1.430 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr19_-_51608665 1.418 NM_032040
CCDC8
coiled-coil domain containing 8
chr13_+_110604039 1.403 NM_003899
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr7_-_45927263 1.397 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr4_-_157094443 1.397 NM_001334
CTSO
cathepsin O
chr19_-_40938046 1.396 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr9_+_35782405 1.392 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr10_-_80875097 1.390 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr9_+_108665168 1.390 NM_021224
ZNF462
zinc finger protein 462
chrX_+_37093448 1.382 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr15_-_80123935 1.379 MEX3B
mex-3 homolog B (C. elegans)
chr6_-_86409701 1.376 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr17_-_24068759 1.369 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr10_-_17283623 1.361 TRDMT1
tRNA aspartic acid methyltransferase 1
chr14_+_104523660 1.342 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr1_-_108544416 1.341 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr11_+_124539768 1.330 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr3_+_113060716 1.328 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr8_-_145090045 1.327 NM_201382
PLEC
plectin
chr15_+_21361901 1.326 MKRN3
makorin ring finger protein 3
chr2_-_204108151 1.325 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr11_-_122571198 1.324 NM_024769
CLMP
CXADR-like membrane protein
chr16_+_30993223 1.324 NM_014699
ZNF646
zinc finger protein 646
chr12_+_52653176 1.321 NM_014212
HOXC11
homeobox C11
chrX_-_133984157 1.318 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr11_-_56951167 1.316 NM_199329
SLC43A3
solute carrier family 43, member 3
chr2_+_109112428 1.312 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr5_+_82803248 1.311 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr1_+_31659246 1.307 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr2_+_109729176 1.306 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_+_1580504 1.291 WDR81
WD repeat domain 81
chr3_+_113060826 1.282 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr16_+_30993252 1.276 ZNF646
zinc finger protein 646
chr21_-_37561463 1.270 DSCR3
Down syndrome critical region gene 3
chr18_-_20231783 1.270 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr5_+_109053507 1.267 MAN2A1
mannosidase, alpha, class 2A, member 1
chr13_-_39075304 1.263 LHFP
lipoma HMGIC fusion partner
chr3_+_157875063 1.258 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_182622850 1.239 C1orf21
chromosome 1 open reading frame 21
chr5_+_109053628 1.225 MAN2A1
mannosidase, alpha, class 2A, member 1
chr1_+_116320698 1.225 SLC22A15
solute carrier family 22, member 15
chr11_+_101485946 1.224 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr13_-_32822759 1.211 STARD13
StAR-related lipid transfer (START) domain containing 13
chr16_+_85158357 1.211 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr16_+_87765661 1.204 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr7_+_1576263 1.202 KIAA1908
hypothetical LOC114796
chr17_+_73886290 1.195 NM_024419
PGS1
phosphatidylglycerophosphate synthase 1
chr11_-_56951161 1.193 SLC43A3
solute carrier family 43, member 3
chr7_-_35700997 1.192 HERPUD2
HERPUD family member 2
chr9_-_25668230 1.189 TUSC1
tumor suppressor candidate 1
chr6_-_86409415 1.186 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr16_-_85099941 1.184 LOC400550
hypothetical LOC400550
chr9_+_88953378 1.181 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr6_-_31805547 1.180 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr1_+_182622751 1.177 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr1_-_151852128 1.172 NM_080388
S100A16
S100 calcium binding protein A16
chr5_-_92982927 1.171


chr15_+_90738108 1.168 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr7_+_65784500 1.164 RABGEF1
RAB guanine nucleotide exchange factor (GEF) 1
chr10_+_80569464 1.164 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_+_154351082 1.163 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr11_-_56951088 1.162 NM_014096
SLC43A3
solute carrier family 43, member 3
chr10_+_20145350 1.160 NM_032812
PLXDC2
plexin domain containing 2
chr5_+_119827797 1.160 PRR16
proline rich 16
chr14_-_68515791 1.158 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr9_+_71848555 1.158 MAMDC2
MAM domain containing 2
chr21_-_37561495 1.156 NM_006052
DSCR3
Down syndrome critical region gene 3
chr1_+_219119358 1.155 NM_021958
HLX
H2.0-like homeobox
chr4_-_186693574 1.154 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr10_-_42953787 1.154


chr5_+_158622666 1.153 NM_145049
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr1_-_120413783 1.146 NOTCH2
notch 2
chr8_-_134378630 1.143 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr18_-_20231709 1.140 OSBPL1A
oxysterol binding protein-like 1A
chr2_-_175337386 1.137 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr15_-_32875040 1.137 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr1_-_225572419 1.134 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr1_-_120413798 1.129 NM_024408
NOTCH2
notch 2
chr5_+_119827903 1.125 NM_016644
PRR16
proline rich 16
chr11_-_56951132 1.121 SLC43A3
solute carrier family 43, member 3
chr22_-_37425937 1.116 NM_014876
JOSD1
Josephin domain containing 1
chr10_-_49534304 1.111 ARHGAP22
Rho GTPase activating protein 22
chr12_+_26003218 1.106 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr2_-_229844198 1.098 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr10_+_42953886 1.098 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr1_-_108544261 1.094 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr11_-_64641700 1.093 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr1_+_199519202 1.092 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr10_-_103991219 1.091 NM_005029
PITX3
paired-like homeodomain 3
chr18_-_55515623 1.090 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr21_+_44256601 1.089 TRAPPC10
trafficking protein particle complex 10
chr7_-_35701287 1.084 NM_022373
HERPUD2
HERPUD family member 2
chr1_+_182622809 1.083 C1orf21
chromosome 1 open reading frame 21
chr1_+_219119430 1.081 HLX
H2.0-like homeobox
chr21_+_46226072 1.079 NM_001848
COL6A1
collagen, type VI, alpha 1
chr9_-_4290028 1.076 NM_001042413
GLIS3
GLIS family zinc finger 3
chr1_-_120413698 1.073 NOTCH2
notch 2
chr7_+_107997527 1.071 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr12_+_32151351 1.070 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chr12_+_52696908 1.067 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr8_+_144420939 1.067 NM_138465
GLI4
GLI family zinc finger 4
chr17_+_58058774 1.067 MRC2
mannose receptor, C type 2
chr15_+_97010219 1.066 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr10_-_125843092 1.063 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr12_+_52697160 1.058 HOXC5
HOXC6
homeobox C5
homeobox C6
chr19_-_40938251 1.058 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr7_-_525336 1.056 PDGFA
platelet-derived growth factor alpha polypeptide
chr18_-_63334902 1.056 NM_032160
DSEL
dermatan sulfate epimerase-like
chr16_+_84204424 1.055 NM_014615
KIAA0182
KIAA0182
chr11_-_128279670 1.052 C11orf45
chromosome 11 open reading frame 45
chr5_-_142763418 1.051 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_-_76003407 1.050 LOC100294362
hypothetical LOC100294362
chr20_-_39379533 1.050 ZHX3
zinc fingers and homeoboxes 3
chr3_+_157874898 1.044 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 2.43e-04 GO:0065007 biological regulation
1.12 3.76e-04 GO:0050794 regulation of cellular process
1.23 6.74e-04 GO:0048522 positive regulation of cellular process
1.21 7.69e-04 GO:0048518 positive regulation of biological process
1.11 9.05e-04 GO:0050789 regulation of biological process
1.23 9.28e-03 GO:0030154 cell differentiation
1.22 1.28e-02 GO:0048869 cellular developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 5.31e-06 GO:0030054 cell junction
1.92 6.46e-05 GO:0031252 cell leading edge
1.27 7.08e-04 GO:0005856 cytoskeleton
2.09 8.94e-04 GO:0030055 cell-substrate junction
1.12 2.90e-03 GO:0005634 nucleus
1.81 3.20e-03 GO:0070161 anchoring junction
1.85 3.44e-03 GO:0005912 adherens junction
1.67 3.67e-03 GO:0016323 basolateral plasma membrane
2.01 6.36e-03 GO:0005924 cell-substrate adherens junction
2.09 6.92e-03 GO:0001726 ruffle
1.99 1.27e-02 GO:0005925 focal adhesion
1.54 2.37e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 3.97e-05 GO:0005515 protein binding
1.51 2.25e-04 GO:0008092 cytoskeletal protein binding
1.06 8.44e-04 GO:0005488 binding
1.59 3.10e-03 GO:0003779 actin binding