Motif ID: ESR1.p2

Z-value: 2.321


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152053323-0.572.2e-02Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_184257337 2.796 NM_024949
WWC2
WW and C2 domain containing 2
chr10_+_115428924 2.468 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr7_+_1543644 2.409 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr13_+_75108450 2.225 LMO7
LIM domain 7
chr4_+_151218862 2.153 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr8_+_16929116 2.085 NM_181723
EFHA2
EF-hand domain family, member A2
chr13_-_32822759 2.074 STARD13
StAR-related lipid transfer (START) domain containing 13
chrX_+_117745551 2.067 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr3_-_129690056 1.980 NM_001145661
GATA2
GATA binding protein 2
chr9_+_89302574 1.873 NM_004938
DAPK1
death-associated protein kinase 1
chr7_+_45894480 1.746 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr16_-_73842884 1.688 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr2_+_238200922 1.674 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr9_+_89302239 1.618 DAPK1
death-associated protein kinase 1
chr1_-_29322993 1.548 NM_001003682
TMEM200B
transmembrane protein 200B
chr12_-_123568781 1.528


chr19_+_15079141 1.478 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr17_-_30724732 1.464 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr3_+_52504391 1.457 NM_015136
STAB1
stabilin 1
chr1_+_179148935 1.449 NM_020950
KIAA1614
KIAA1614
chr5_+_178219519 1.442 NM_058230
ZNF354B
zinc finger protein 354B
chr10_+_129595289 1.392 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_+_36436316 1.359 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr12_-_69317441 1.354 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_-_145090892 1.354 NM_201381
PLEC
plectin
chr1_+_15955719 1.346 FBLIM1
filamin binding LIM protein 1
chr14_+_99273751 1.322 EML1
echinoderm microtubule associated protein like 1
chr5_-_178090203 1.269 NM_005649
ZNF354A
zinc finger protein 354A
chr19_-_40939756 1.260 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr14_+_105012106 1.257 NM_001312
CRIP2
cysteine-rich protein 2
chr19_-_10475083 1.242 KEAP1
kelch-like ECH-associated protein 1
chr11_-_118716244 1.241 MFRP
membrane frizzled-related protein
chr6_+_107917965 1.227 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr7_+_1536847 1.227 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr9_+_136673464 1.212 NM_000093
COL5A1
collagen, type V, alpha 1
chr19_-_10474767 1.212 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr6_-_154873396 1.196 NM_173515
CNKSR3
CNKSR family member 3
chr9_-_85342868 1.192 NM_174938
FRMD3
FERM domain containing 3
chr9_-_13269562 1.178 MPDZ
multiple PDZ domain protein
chr6_-_154873480 1.167 CNKSR3
CNKSR family member 3
chr3_+_171558215 1.152 SKIL
SKI-like oncogene
chr9_-_83493415 1.151 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr16_+_88512769 1.140 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr17_+_71892271 1.139 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr4_-_122837590 1.122 NM_001154
ANXA5
annexin A5
chr13_+_109757593 1.117 NM_001846
COL4A2
collagen, type IV, alpha 2
chr17_+_71893014 1.114 SPHK1
sphingosine kinase 1
chr4_-_57671307 1.102 IGFBP7
insulin-like growth factor binding protein 7
chr7_-_47588160 1.085 TNS3
tensin 3
chr9_-_16860719 1.084 NM_017637
BNC2
basonuclin 2
chr6_+_3696224 1.078


chr17_+_71892538 1.078 SPHK1
sphingosine kinase 1
chr4_-_122837579 1.071 ANXA5
annexin A5
chr18_+_18003401 1.065 NM_005257
GATA6
GATA binding protein 6
chr1_+_158017380 1.065 NM_017823
DUSP23
dual specificity phosphatase 23
chr1_-_181188625 1.059 SHCBP1L
SHC SH2-domain binding protein 1-like
chr10_+_11099860 1.056 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr16_-_65984836 1.055 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr3_+_171558143 1.049 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr11_-_72530605 1.047 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr5_-_156935317 1.037 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr3_+_171558188 1.037 SKIL
SKI-like oncogene
chr9_+_132579088 1.037 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_-_172594691 1.030 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr8_+_21980315 1.025 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr16_+_1974017 1.022 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr7_-_47588266 1.017 TNS3
tensin 3
chr11_+_128067598 1.016 NM_001167681
FLI1
Friend leukemia virus integration 1
chr20_-_39199936 1.007


chr11_-_63138516 1.003 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr4_-_122837501 1.000 ANXA5
annexin A5
chr5_-_37285160 0.999 NM_023073
C5orf42
chromosome 5 open reading frame 42
chr6_-_154873344 0.996 CNKSR3
CNKSR family member 3
chr9_-_16860664 0.993 BNC2
basonuclin 2
chr12_-_51759434 0.983 SPRYD3
SPRY domain containing 3
chr11_-_63138483 0.974 NM_007069
PLA2G16
phospholipase A2, group XVI
chr12_-_51759438 0.965 NM_032840
SPRYD3
SPRY domain containing 3
chr5_-_156935283 0.961


chr13_-_27967215 0.955 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr2_+_119697859 0.953 STEAP3
STEAP family member 3
chr11_-_63138416 0.949 PLA2G16
phospholipase A2, group XVI
chr11_-_70641267 0.947 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr2_+_205118710 0.937 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr11_-_63138061 0.936 PLA2G16
phospholipase A2, group XVI
chr10_-_49483002 0.934 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr5_-_92982927 0.934


chr20_+_23279372 0.932 NM_013248
NXT1
NTF2-like export factor 1
chr19_-_11234117 0.929 NM_020812
DOCK6
dedicator of cytokinesis 6
chr17_+_71892781 0.924 NM_001142602
SPHK1
sphingosine kinase 1
chr19_-_13074973 0.922 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr17_-_7238546 0.915 NM_020360
PLSCR3
phospholipid scramblase 3
chr21_+_45649719 0.913


chr10_-_30388439 0.909 NM_020848
KIAA1462
KIAA1462
chr15_-_93671314 0.902 LOC400456
hypothetical LOC400456
chr7_-_27190882 0.898 HOXA11
homeobox A11
chr16_+_67017 0.898 NM_001015054
MPG
N-methylpurine-DNA glycosylase
chr16_+_64958060 0.896 CDH5
cadherin 5, type 2 (vascular endothelium)
chr20_-_61039672 0.895 DIDO1
death inducer-obliterator 1
chr5_-_1165106 0.894 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr3_+_52504410 0.889 STAB1
stabilin 1
chrX_-_2857351 0.885 NM_001669
NM_009589
ARSD

arylsulfatase D

chrX_-_2857315 0.882 ARSD
arylsulfatase D
chr6_-_90119068 0.878 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr10_+_122206455 0.867 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr5_-_178983281 0.861 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr17_-_37794102 0.860 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr16_+_81218074 0.854 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr5_-_178983241 0.854 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr3_+_156280129 0.853 NM_000902
MME
membrane metallo-endopeptidase
chr17_-_24068759 0.843 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr5_-_176857158 0.842 PDLIM7
PDZ and LIM domain 7 (enigma)
chr12_+_50592379 0.840 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr10_-_99042381 0.840 NM_032900
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 read-through transcript
Rho GTPase activating protein 19
chr17_-_37793885 0.836 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr6_-_90119158 0.834 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr14_+_73073570 0.834 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr1_+_167342149 0.830 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr10_+_11100075 0.827 CELF2
CUGBP, Elav-like family member 2
chr15_-_50375143 0.825 NM_018728
MYO5C
myosin VC
chr6_-_90119169 0.816 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr15_-_49174107 0.816 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr10_+_123862430 0.815 TACC2
transforming, acidic coiled-coil containing protein 2
chr16_+_81218142 0.809 CDH13
cadherin 13, H-cadherin (heart)
chr17_-_8006979 0.801 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr6_-_90119329 0.800 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr17_-_37794017 0.796 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr10_-_99042419 0.796 ARHGAP19
Rho GTPase activating protein 19
chr15_-_61913134 0.795 HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr19_-_48815853 0.794 NM_182498
ZNF428
zinc finger protein 428
chr16_+_64958025 0.789 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr1_-_229070796 0.785 NM_032800
C1orf198
chromosome 1 open reading frame 198
chr19_-_13074669 0.783 LYL1
lymphoblastic leukemia derived sequence 1
chr6_+_45498354 0.783 RUNX2
runt-related transcription factor 2
chr6_-_90119008 0.782 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr2_-_144991386 0.781 ZEB2
zinc finger E-box binding homeobox 2
chr4_-_118226119 0.779 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr16_+_54072969 0.775 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_1727220 0.770 PXDN
peroxidasin homolog (Drosophila)
chr2_-_101134146 0.768 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr7_+_2638156 0.768 TTYH3
tweety homolog 3 (Drosophila)
chr19_+_40224457 0.767 HPN
hepsin
chr7_+_149696263 0.764 REPIN1
replication initiator 1
chr10_-_99042348 0.755 ARHGAP19
Rho GTPase activating protein 19
chr2_+_205118801 0.753 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_-_1727247 0.751 PXDN
peroxidasin homolog (Drosophila)
chr10_+_129595349 0.746 PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_+_77520874 0.744 NM_012093
AK5
adenylate kinase 5
chr15_+_30797466 0.742 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr9_-_130980302 0.738 IER5L
immediate early response 5-like
chr17_-_39211706 0.737 NM_004090
DUSP3
dual specificity phosphatase 3
chr1_-_23730298 0.737 NM_004091
E2F2
E2F transcription factor 2
chr6_+_17501589 0.735 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr11_-_61341011 0.734 NM_013402
FADS1
fatty acid desaturase 1
chr17_-_3518654 0.731 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr19_-_48815572 0.729 ZNF428
zinc finger protein 428
chr1_-_224441023 0.725 ACBD3
acyl-CoA binding domain containing 3
chr13_-_25523164 0.724 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr15_-_61913165 0.724 HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr2_-_1727324 0.723 PXDN
peroxidasin homolog (Drosophila)
chr4_+_4912272 0.723 NM_002448
MSX1
msh homeobox 1
chr2_+_233123544 0.723 NM_004846
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr13_-_109757442 0.722 NM_001845
COL4A1
collagen, type IV, alpha 1
chr15_+_83324651 0.714 PDE8A
phosphodiesterase 8A
chr1_+_6537924 0.709 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr14_+_95575319 0.709 C14orf132
chromosome 14 open reading frame 132
chr10_-_105411339 0.703 SH3PXD2A
SH3 and PX domains 2A
chr2_+_201384505 0.701 BZW1
basic leucine zipper and W2 domains 1
chr16_-_1600654 0.700 IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr2_-_204108151 0.700 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr4_-_141293572 0.699 MAML3
mastermind-like 3 (Drosophila)
chr9_-_35738875 0.699 GBA2
glucosidase, beta (bile acid) 2
chr6_+_117910472 0.698 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr3_+_195889845 0.696 FAM43A
family with sequence similarity 43, member A
chr6_+_17389752 0.696 NM_001143942
RBM24
RNA binding motif protein 24
chr22_+_42651018 0.696 PNPLA3
patatin-like phospholipase domain containing 3
chr15_-_76890626 0.696 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr14_+_101500650 0.694 DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr13_-_36531568 0.692 NM_001014286
NM_017569
FAM48A

family with sequence similarity 48, member A

chr17_-_3518568 0.689 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr5_-_43593277 0.688 NM_183323
PAIP1
poly(A) binding protein interacting protein 1
chr13_-_22847620 0.685 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr4_-_8481085 0.685 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr21_-_26867138 0.682 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr2_+_119697853 0.680 NM_001008410
NM_018234
NM_182915
STEAP3


STEAP family member 3


chr1_-_92124201 0.677 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr2_+_190916440 0.672 NM_001128928
NM_002194
INPP1

inositol polyphosphate-1-phosphatase

chr7_-_75206212 0.669 NM_005338
HIP1
huntingtin interacting protein 1
chr9_+_91115924 0.667 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr16_+_65196153 0.666 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr17_+_3518834 0.665 NM_001014764
NM_031298
TMEM93

transmembrane protein 93

chr17_-_3518628 0.665 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr2_+_190916571 0.663 INPP1
inositol polyphosphate-1-phosphatase
chr22_+_36927884 0.661 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr12_-_24947233 0.660 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_59429442 0.655 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chrX_-_2428963 0.654 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr16_+_57106883 0.652 NM_001160305
NM_024860
SETD6

SET domain containing 6

chr16_+_1974182 0.650 GFER
growth factor, augmenter of liver regeneration
chr2_+_85213884 0.650 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr10_-_105410840 0.649



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 3.49e-02 GO:0032879 regulation of localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 9.92e-05 GO:0005737 cytoplasm
1.07 8.03e-03 GO:0044424 intracellular part
1.07 9.21e-03 GO:0005622 intracellular
1.73 2.87e-02 GO:0015629 actin cytoskeleton
3.46 3.55e-02 GO:0042641 actomyosin

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 1.43e-05 GO:0005515 protein binding
1.08 2.62e-04 GO:0005488 binding
1.45 3.87e-02 GO:0019899 enzyme binding