Motif ID: EVI1.p2

Z-value: 0.996


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_1703467600.504.7e-02Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_38127489 1.620 NM_000349
STAR
steroidogenic acute regulatory protein
chrX_-_119095544 1.455 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr6_-_50025115 1.342 NM_001166478
DEFB133
defensin, beta 133
chr2_+_157822355 1.242 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr12_-_8110268 1.240 C3AR1
complement component 3a receptor 1
chr12_-_8110196 1.128 NM_004054
C3AR1
complement component 3a receptor 1
chr14_+_54291255 1.032 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr17_-_39822366 0.888 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr8_+_110443881 0.850 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr15_+_41672543 0.833 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_152560179 0.820 NM_080429
AQP10
aquaporin 10
chr11_+_93940121 0.812 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr6_-_30760413 0.805 KIAA1949
KIAA1949
chr11_-_33848061 0.797 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_41276901 0.786 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr15_+_64661560 0.782


chr6_+_105511615 0.779 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr15_-_100280784 0.771 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr11_-_33848013 0.769 LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_-_138842526 0.759 NM_198282
TMEM173
transmembrane protein 173
chr12_+_112344529 0.758 NM_138432
SDSL
serine dehydratase-like
chr1_+_202033273 0.740 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr11_-_33847937 0.738 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr20_+_19863716 0.726 RIN2
Ras and Rab interactor 2
chr15_-_91078307 0.722 FAM174B
family with sequence similarity 174, member B
chr1_+_58899 0.711 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr7_+_106292975 0.705 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_9804682 0.691 NM_001781
CD69
CD69 molecule
chr9_-_99746923 0.683 NM_018437
HEMGN
hemogen
chrX_-_11194015 0.673 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr17_-_64462976 0.666 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_-_110724594 0.659 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr17_-_59437782 0.648 NM_000873
ICAM2
intercellular adhesion molecule 2
chr4_-_90197140 0.643 NM_014883
FAM13A
family with sequence similarity 13, member A
chr6_-_11887265 0.636 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr7_+_106292932 0.635 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_106293112 0.633 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_27126721 0.628 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr19_+_61624 0.627 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_100302885 0.620 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr1_+_207668787 0.604 NM_001104548
LOC642587
NPC-A-5
chr6_-_29081015 0.595 NM_001010877
ZNF311
zinc finger protein 311
chr1_-_32054164 0.588 NM_144569
SPOCD1
SPOC domain containing 1
chr4_-_40212670 0.586 NM_019027
RBM47
RNA binding motif protein 47
chr1_-_47468029 0.583 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chrX_-_23955223 0.574 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr2_+_169637255 0.566 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_5247948 0.560 NM_005330
HBE1
hemoglobin, epsilon 1
chr1_-_148854503 0.553


chr11_+_123625632 0.543 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr17_-_35911340 0.508 NM_032865
TNS4
tensin 4
chr22_+_43451351 0.504 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr6_-_49712483 0.501 NM_000324
RHAG
Rh-associated glycoprotein
chr1_+_181028016 0.488 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr1_+_208067986 0.476 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr6_-_6632197 0.474


chr2_+_108604111 0.474 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_143230124 0.468 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_+_208067890 0.468 NM_014388
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr7_+_129634935 0.466 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr1_+_203503214 0.461 TMCC2
transmembrane and coiled-coil domain family 2
chr4_+_111053488 0.457 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr5_+_71438796 0.454 NM_005909
MAP1B
microtubule-associated protein 1B
chr7_-_16471817 0.453 NM_015464
SOSTDC1
sclerostin domain containing 1
chr6_+_135558744 0.445 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_179269183 0.441 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr17_+_53769562 0.434 LOC100506779
hypothetical LOC100506779
chr1_+_179269766 0.434 MR1
major histocompatibility complex, class I-related
chrX_-_78509662 0.427 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr7_-_112545840 0.427 LOC401397
hypothetical LOC401397
chr3_-_180467483 0.421 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr21_-_31012965 0.415 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr10_-_88707299 0.409 NM_024756
MMRN2
multimerin 2
chr1_+_208068022 0.408 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr15_-_35178888 0.407 NM_172316
MEIS2
Meis homeobox 2
chr1_+_179269761 0.403 MR1
major histocompatibility complex, class I-related
chr21_+_42583259 0.402 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr22_-_25343959 0.401 NM_001887
CRYBB1
crystallin, beta B1
chr2_-_144994349 0.397 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr9_+_74956601 0.393 ANXA1
annexin A1
chr16_+_33168191 0.383 NM_001099687
TP53TG3B
TP53 target 3B
chr11_+_64694200 0.380 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr11_+_59580630 0.379 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr11_+_59580705 0.378 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr12_+_55018925 0.370 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr7_+_90731614 0.369 FZD1
frizzled homolog 1 (Drosophila)
chr12_-_48902692 0.367 NM_001113547
LIMA1
LIM domain and actin binding 1
chr2_+_102401580 0.366 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr15_+_39839866 0.364 MGA
MAX gene associated
chr21_+_29322100 0.364 USP16
ubiquitin specific peptidase 16
chr6_-_32892705 0.362 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr1_+_179269689 0.359 MR1
major histocompatibility complex, class I-related
chr10_+_49279647 0.359 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr1_-_180822686 0.355 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr11_-_10487212 0.355 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr7_+_123036312 0.355 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr12_-_48017223 0.346 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr6_+_38798529 0.344 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr14_-_62638336 0.343 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr19_-_60241424 0.341 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr4_-_89963177 0.340 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr14_-_22722658 0.340 SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chrX_+_101388810 0.340 NM_022053
NXF2
nuclear RNA export factor 2
chr19_-_45022993 0.340 FBL
fibrillarin
chr1_-_154964256 0.338 NM_030980
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr7_-_13992351 0.337 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_178100204 0.335


chr5_-_158567411 0.334 NM_144726
RNF145
ring finger protein 145
chr16_-_4795160 0.333 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr18_+_3437607 0.332 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_-_118405288 0.331 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_+_205105776 0.331 NM_018724
IL20
interleukin 20
chr11_-_64520964 0.329 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr11_+_64950074 0.328 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr16_-_4794749 0.328 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr2_-_1905508 0.326 MYT1L
myelin transcription factor 1-like
chr11_-_119499188 0.325 TRIM29
tripartite motif containing 29
chr6_+_34314545 0.324 NM_145905
HMGA1
high mobility group AT-hook 1
chr4_+_130236731 0.324 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr11_+_113671744 0.319 NM_006169
NNMT
nicotinamide N-methyltransferase
chr7_+_139750311 0.318 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr1_-_171838802 0.316 NM_178527
SLC9A11
solute carrier family 9, member 11
chr6_-_26343139 0.315 NM_005320
HIST1H1D
histone cluster 1, H1d
chr15_-_62460622 0.314 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr1_+_153222393 0.313 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr7_-_112545847 0.313 LOC401397
hypothetical LOC401397
chr12_-_84754112 0.313 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr5_+_121493113 0.312 NM_207317
ZNF474
zinc finger protein 474
chr1_+_169171235 0.307 NM_001163629
NM_025063
C1orf129

chromosome 1 open reading frame 129

chr2_+_183651756 0.307 DUSP19
dual specificity phosphatase 19
chr15_-_35179185 0.307 MEIS2
Meis homeobox 2
chr5_-_79982584 0.306 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr1_-_68735267 0.306 DEPDC1
DEP domain containing 1
chrX_+_154880439 0.305 NM_002186
IL9R
interleukin 9 receptor
chr12_-_47031287 0.305 NM_001172682
ZNF641
zinc finger protein 641
chr16_+_31446703 0.305 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr4_-_15549047 0.304 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr1_+_153222464 0.303 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr4_-_68678181 0.302 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr9_+_74956614 0.302 ANXA1
annexin A1
chr1_+_50342168 0.301 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_90731671 0.299 NM_003505
FZD1
frizzled homolog 1 (Drosophila)
chr3_+_161877640 0.297 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr2_+_17861266 0.297 NM_001105569
MSGN1
mesogenin 1
chr12_+_56802 0.297 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr2_-_144991386 0.295 ZEB2
zinc finger E-box binding homeobox 2
chr22_-_25344037 0.294 CRYBB1
crystallin, beta B1
chr1_+_15675182 0.293 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chrX_-_153716130 0.293 NM_001162936
LOC100132963
hypothetical protein LOC100132963
chr5_+_64956586 0.288 C5orf44
chromosome 5 open reading frame 44
chr17_+_59244363 0.287 DDX42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr17_+_53769659 0.287 LOC100506779
hypothetical LOC100506779
chr1_-_151352587 0.286 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr19_+_45973139 0.280 NM_006533
MIA
melanoma inhibitory activity
chr6_+_135558572 0.280


chr17_-_74244539 0.278


chr18_+_59705918 0.277 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr18_+_59405513 0.274 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr14_-_49932366 0.271 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr20_+_35445350 0.270 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr6_+_31623370 0.270 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_+_86662356 0.268 NM_006536
CLCA2
chloride channel accessory 2
chr2_+_108571177 0.268 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_25096755 0.261 LRMP
lymphoid-restricted membrane protein
chr3_-_15515382 0.260 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr9_+_33230165 0.257 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr22_+_21340757 0.254


chr12_+_94200306 0.253 VEZT
vezatin, adherens junctions transmembrane protein
chr11_+_10433241 0.252 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr3_+_137224266 0.251 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chrX_+_86659370 0.250 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr5_-_39400319 0.250 NM_001737
C9
complement component 9
chr1_-_153537810 0.250 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr9_+_124355211 0.249 NM_001004457
OR1N2
olfactory receptor, family 1, subfamily N, member 2
chr7_-_122627235 0.246 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr1_+_233597385 0.243 TBCE
tubulin folding cofactor E
chr1_-_68735314 0.242 NM_001114120
NM_017779
DEPDC1

DEP domain containing 1

chr1_+_108904493 0.240 NM_001010883
FAM102B
family with sequence similarity 102, member B
chrX_+_15435351 0.239 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr12_-_10983072 0.239 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr14_+_20580224 0.239 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr12_-_69434650 0.239 PTPRR
protein tyrosine phosphatase, receptor type, R
chr18_-_12646730 0.238 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr12_-_69434598 0.237 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr9_+_134843918 0.236 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr2_-_144991556 0.235 ZEB2
zinc finger E-box binding homeobox 2
chr19_-_58016696 0.235 NM_006969
ZNF28
zinc finger protein 28
chr22_+_21543671 0.232 IGLV4-3
immunoglobulin lambda variable 4-3
chrX_+_30169977 0.232 NM_002367
MAGEB4
melanoma antigen family B, 4
chr3_-_112796855 0.232 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr11_+_30209138 0.232 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr16_+_2807228 0.230 PRSS21
protease, serine, 21 (testisin)
chr15_-_56093477 0.229 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr9_+_95886558 0.228 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr2_+_172252473 0.228 DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr1_-_31251315 0.227 PUM1
pumilio homolog 1 (Drosophila)
chr10_-_18980512 0.226 NM_182543
NSUN6
NOP2/Sun domain family, member 6
chr12_-_84754289 0.226 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chrX_-_63532057 0.226 NM_017677
MTMR8
myotubularin related protein 8
chr9_+_95886625 0.225 PTPDC1
protein tyrosine phosphatase domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.40 3.02e-08 GO:0007608 sensory perception of smell
2.21 6.44e-07 GO:0007606 sensory perception of chemical stimulus
1.72 3.51e-04 GO:0007600 sensory perception
1.42 5.53e-03 GO:0003008 system process
1.20 1.37e-02 GO:0032501 multicellular organismal process
2.75 2.59e-02 GO:0051606 detection of stimulus
3.22 2.99e-02 GO:0009913 epidermal cell differentiation
1.43 3.53e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 3.06e-08 GO:0005886 plasma membrane
1.33 3.65e-08 GO:0071944 cell periphery
1.18 2.66e-04 GO:0044425 membrane part
1.14 1.41e-03 GO:0016020 membrane
1.18 3.49e-03 GO:0031224 intrinsic to membrane
1.34 3.99e-03 GO:0005576 extracellular region
1.17 9.75e-03 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.44 7.36e-09 GO:0004984 olfactory receptor activity
1.85 2.59e-07 GO:0004930 G-protein coupled receptor activity
1.52 4.61e-04 GO:0004888 transmembrane receptor activity
1.43 6.20e-04 GO:0004872 receptor activity
1.36 2.45e-03 GO:0004871 signal transducer activity
1.36 2.45e-03 GO:0060089 molecular transducer activity