Motif ID: EWSR1-FLI1.p2

Z-value: 1.107


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EWSR1chr22_+_27998367-0.351.9e-01Click!
FLI1chr11_+_1280675980.155.8e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_10520264 4.478 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520592 4.071 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr5_-_148422799 2.472 NM_024577
 SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr4_+_183302105 2.065 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_68071635 1.956 NM_018841
 GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr11_-_117628211 1.941 NM_198275
 MPZL3
myelin protein zero-like 3
chrX_+_107569671 1.900 NM_000495
NM_033380
 COL4A5

collagen, type IV, alpha 5

chrX_-_148394570 1.526 NM_000202
NM_001166550
NM_006123
 IDS


iduronate 2-sulfatase


chr11_+_101485946 1.515 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr7_+_16759845 1.487 NM_014399
 TSPAN13
tetraspanin 13
chr1_-_6468600 1.295 NM_001042665
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr16_+_67697622 1.290 NM_138612
 HAS3
hyaluronan synthase 3
chr17_-_31146660 1.276 NM_001032278
NM_024302
 MMP28

matrix metallopeptidase 28

chr1_-_150276064 1.273 S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.186 S100A11
S100 calcium binding protein A11
chr1_-_150276114 1.184 NM_005620
 S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.169 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr7_-_106991941 1.145 NM_001161520
NM_006348
NM_181733
 COG5


component of oligomeric golgi complex 5


chrX_-_107569256 1.141 NM_001847
 COL4A6
collagen, type IV, alpha 6
chr3_-_65999548 1.120 NM_001033057
NM_004742
NM_015520
 MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
40.38 3.45e-02 GO:0061036 positive regulation of cartilage development
4.02 1.75e-05 GO:0007409 axonogenesis
3.98 1.03e-05 GO:0048812 neuron projection morphogenesis
3.88 3.39e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
3.73 3.90e-03 GO:0007411 axon guidance
3.72 1.96e-05 GO:0000904 cell morphogenesis involved in differentiation
3.69 2.33e-05 GO:0048858 cell projection morphogenesis
3.65 2.76e-05 GO:0032990 cell part morphogenesis
3.61 6.72e-05 GO:0031175 neuron projection development
3.49 1.01e-05 GO:0000902 cell morphogenesis
3.31 3.21e-05 GO:0032989 cellular component morphogenesis
3.25 2.69e-04 GO:0048666 neuron development
3.13 1.32e-02 GO:0051094 positive regulation of developmental process
3.03 5.69e-04 GO:0030030 cell projection organization
3.00 2.41e-04 GO:0030182 neuron differentiation
2.70 5.44e-04 GO:0048699 generation of neurons
2.63 6.37e-04 GO:0022008 neurogenesis
2.52 2.38e-03 GO:0048468 cell development
2.40 3.74e-02 GO:0048584 positive regulation of response to stimulus
2.31 7.34e-05 GO:0009653 anatomical structure morphogenesis

Nothing significant found in compartment category.

Nothing significant found in function category.