Motif ID: FEV.p2

Z-value: 2.954


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
FEV 54738 FEV (ETS oncogene family)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FEVchr2_-_2195585170.029.3e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_25398690 6.601 LOC388889
hypothetical LOC388889
chr5_+_61910318 4.787 NM_181506
 LRRC70
leucine rich repeat containing 70
chr11_-_72111027 3.601 NM_001135190
NM_015242
 ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr21_-_38792173 3.530 NM_001136155
NM_182918
 ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr3_-_184756101 3.500 NM_130446
 KLHL6
kelch-like 6 (Drosophila)
chr13_+_110653407 3.420 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_-_122862447 3.349 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_+_40877053 3.245 NM_032587
 CARD6
caspase recruitment domain family, member 6
chr3_+_120495906 3.217 NM_020754
 ARHGAP31
Rho GTPase activating protein 31
chr3_-_122862391 3.199 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr20_+_19818209 3.061 NM_018993
 RIN2
Ras and Rab interactor 2
chr2_+_161701711 3.005 NM_004180
NM_133484
 TANK

TRAF family member-associated NFKB activator

chr9_-_116190038 2.976 AKNA
AT-hook transcription factor
chr6_+_153060722 2.937 NM_025107
 MYCT1
myc target 1
chr2_-_225519974 2.815 DOCK10
dedicator of cytokinesis 10
chr5_-_88214720 2.791 MEF2C
myocyte enhancer factor 2C
chr11_+_65164167 2.764 NM_153253
 SIPA1
signal-induced proliferation-associated 1
chr4_-_153820535 2.669 NM_152680
 TMEM154
transmembrane protein 154
chr6_-_32268267 2.631 GPSM3
G-protein signaling modulator 3
chr6_-_32268615 2.587 GPSM3
G-protein signaling modulator 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 95 entries
enrichment   p-value GO term description
2.33 2.10e-06 GO:0050851 antigen receptor-mediated signaling pathway
2.26 8.60e-04 GO:0042113 B cell activation
2.23 9.07e-04 GO:0050852 T cell receptor signaling pathway
2.18 2.09e-02 GO:0030217 T cell differentiation
2.15 3.23e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.14 6.94e-05 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.14 2.19e-04 GO:0030098 lymphocyte differentiation
2.00 1.36e-04 GO:0002521 leukocyte differentiation
1.96 1.68e-09 GO:0045321 leukocyte activation
1.94 2.40e-03 GO:0042110 T cell activation
1.93 1.39e-06 GO:0046649 lymphocyte activation
1.90 3.06e-02 GO:0050670 regulation of lymphocyte proliferation
1.88 4.13e-02 GO:0032944 regulation of mononuclear cell proliferation
1.87 3.87e-02 GO:0070663 regulation of leukocyte proliferation
1.86 5.63e-05 GO:0002764 immune response-regulating signaling pathway
1.85 1.14e-04 GO:0002757 immune response-activating signal transduction
1.85 3.08e-03 GO:0050870 positive regulation of T cell activation
1.84 3.95e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.82 6.06e-04 GO:0051251 positive regulation of lymphocyte activation
1.78 1.24e-13 GO:0001775 cell activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.82 2.23e-02 GO:0005925 focal adhesion
1.80 1.77e-02 GO:0030055 cell-substrate junction
1.78 3.51e-02 GO:0005924 cell-substrate adherens junction
1.61 1.48e-02 GO:0031252 cell leading edge
1.39 5.01e-03 GO:0005730 nucleolus
1.35 1.37e-08 GO:0005654 nucleoplasm
1.34 2.84e-02 GO:0030529 ribonucleoprotein complex
1.33 1.81e-03 GO:0044451 nucleoplasm part
1.33 2.55e-02 GO:0005694 chromosome
1.32 1.87e-10 GO:0031981 nuclear lumen
1.30 9.70e-11 GO:0044428 nuclear part
1.28 1.33e-08 GO:0005829 cytosol
1.24 2.38e-07 GO:0043233 organelle lumen
1.24 3.97e-07 GO:0031974 membrane-enclosed lumen
1.24 4.30e-07 GO:0070013 intracellular organelle lumen
1.22 1.47e-07 GO:0043228 non-membrane-bounded organelle
1.22 1.47e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.22 2.90e-03 GO:0005856 cytoskeleton
1.17 8.76e-06 GO:0032991 macromolecular complex
1.15 1.39e-08 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
2.04 1.15e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.88 2.45e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.82 2.35e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.50 9.76e-03 GO:0005083 small GTPase regulator activity
1.49 4.09e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.49 6.27e-05 GO:0030695 GTPase regulator activity
1.40 4.86e-02 GO:0000988 protein binding transcription factor activity
1.40 4.86e-02 GO:0000989 transcription factor binding transcription factor activity
1.16 2.29e-16 GO:0005515 protein binding
1.06 9.14e-07 GO:0005488 binding