Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 6.825


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.702.5e-03Click!
FOSBchr19_+_506630890.702.8e-03Click!
JUNDchr19_-_18253436-0.514.2e-02Click!
FOSL1chr11_-_654244360.467.1e-02Click!
JUNBchr19_+_127632850.371.6e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_177378801 47.097 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr18_+_19706979 44.490 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_221955876 39.742 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr6_+_47774247 35.485 NM_153838
GPR115
G protein-coupled receptor 115
chr1_+_181421984 34.959 LAMC2
laminin, gamma 2
chr20_-_17487480 31.517 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr3_+_11153778 31.187 NM_001098213
HRH1
histamine receptor H1
chr21_+_29439768 31.162 C21orf7
chromosome 21 open reading frame 7
chr10_-_88720908 28.655 LOC100133190
hypothetical LOC100133190
chr12_+_13240868 28.345 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 28.010 EMP1
epithelial membrane protein 1
chr12_+_13240983 27.312 EMP1
epithelial membrane protein 1
chr3_-_152517204 26.833 NM_023915
GPR87
G protein-coupled receptor 87
chr7_+_116099648 26.442 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_+_181421796 25.377 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr5_+_150000394 24.869 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_181422016 23.444 LAMC2
laminin, gamma 2
chr9_+_102231616 23.337 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr8_+_22900863 22.706 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr10_+_24795465 21.753 KIAA1217
KIAA1217

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
9.82 3.10e-03 GO:0031581 hemidesmosome assembly
7.72 2.71e-02 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
2.36 3.67e-02 GO:0008544 epidermis development
2.00 6.21e-03 GO:0043086 negative regulation of catalytic activity
1.76 3.29e-02 GO:0042060 wound healing
1.73 3.48e-02 GO:0001932 regulation of protein phosphorylation
1.70 4.02e-02 GO:0042325 regulation of phosphorylation
1.69 3.43e-03 GO:0009888 tissue development
1.68 2.41e-04 GO:0051246 regulation of protein metabolic process
1.68 2.18e-03 GO:0009611 response to wounding
1.68 1.29e-02 GO:0031399 regulation of protein modification process
1.60 9.61e-03 GO:0032268 regulation of cellular protein metabolic process
1.57 4.47e-02 GO:0042127 regulation of cell proliferation
1.28 4.66e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.68 3.38e-03 GO:0000502 proteasome complex
1.56 1.94e-02 GO:0005626 insoluble fraction
1.13 1.50e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.63 5.00e-03 GO:0004866 endopeptidase inhibitor activity
2.62 3.37e-03 GO:0061135 endopeptidase regulator activity
2.59 4.30e-03 GO:0030414 peptidase inhibitor activity
2.34 1.42e-02 GO:0061134 peptidase regulator activity
2.03 2.56e-02 GO:0004857 enzyme inhibitor activity
1.14 4.24e-02 GO:0005515 protein binding