Motif ID: HAND1,2.p2

Z-value: 1.989


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_1746869180.175.2e-01Click!
HAND1chr5_-_153838013,
chr5_-_153837975
0.146.1e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_10074332 6.469 NM_031917
ANGPTL6
angiopoietin-like 6
chr6_+_6533932 4.251 NM_004271
LY86
lymphocyte antigen 86
chr11_+_66927976 4.242 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_+_55614006 4.043 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr5_-_149772563 3.587 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr7_+_99654806 3.468 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr22_+_23333610 3.081 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr4_-_40326603 2.964 NM_001098634
RBM47
RNA binding motif protein 47
chr5_-_149772528 2.844


chr16_+_28413421 2.804 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_158948176 2.660 NM_001778
CD48
CD48 molecule
chr15_+_42815851 2.574 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr12_+_111900650 2.522 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr19_+_44886785 2.512 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr6_+_167445284 2.509 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr6_-_133161318 2.497 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr3_+_99733432 2.456 NM_005290
GPR15
G protein-coupled receptor 15
chr1_-_158815895 2.332 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr11_-_63087430 2.170 NM_017878
HRASLS2
HRAS-like suppressor 2
chr1_+_159943385 2.161 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chrX_+_128741578 2.159 SASH3
SAM and SH3 domain containing 3
chr17_-_8711701 2.152 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr1_+_159899528 2.097 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr5_-_149772469 2.085 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_-_158815850 2.039 CD84
CD84 molecule
chr1_-_92724181 2.014 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr22_-_34886727 2.003 NM_145640
APOL3
apolipoprotein L, 3
chrX_+_128741562 1.955 NM_018990
SASH3
SAM and SH3 domain containing 3
chr14_+_75058518 1.869 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr12_-_7153068 1.862 NM_016546
C1RL
complement component 1, r subcomponent-like
chr19_-_56564068 1.842 NM_152353
CLDND2
claudin domain containing 2
chr22_+_43451600 1.803 PRR5
proline rich 5 (renal)
chr11_+_118463906 1.802 NM_001024382
HMBS
hydroxymethylbilane synthase
chr1_+_159817752 1.791 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_-_31293882 1.789 NM_001145122
CAPN14
calpain 14
chr16_-_45339605 1.782 NM_182493
MYLK3
myosin light chain kinase 3
chr14_+_75058591 1.780 BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_33151703 1.771 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr10_-_104201234 1.747 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr19_+_60850765 1.692 NM_013301
CCDC106
coiled-coil domain containing 106
chr19_+_41085221 1.687 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr16_+_29582065 1.671 SPN
sialophorin
chr6_+_37081387 1.655 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr9_-_99740243 1.650 NM_197978
HEMGN
hemogen
chr11_+_22646229 1.644 NM_177553
GAS2
growth arrest-specific 2
chr19_+_10404110 1.630 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr22_+_21393107 1.629 IGLJ3
immunoglobulin lambda joining 3
chr22_+_23329113 1.516 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr1_-_26517342 1.505 NM_145345
UBXN11
UBX domain protein 11
chrX_-_48213508 1.479 SLC38A5
solute carrier family 38, member 5
chr8_+_11388918 1.455 NM_001715
BLK
B lymphoid tyrosine kinase
chr4_-_40327396 1.445 RBM47
RNA binding motif protein 47
chr17_+_16259812 1.436 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr22_+_43451351 1.402 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr14_-_64479198 1.365 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr19_-_10311262 1.359 NM_002162
ICAM3
intercellular adhesion molecule 3
chr6_+_70633168 1.335 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr14_-_106241445 1.291 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr12_-_51887318 1.288 ITGB7
integrin, beta 7
chr12_+_117067214 1.279 PEBP1
phosphatidylethanolamine binding protein 1
chr2_-_25328452 1.270 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_154389945 1.270 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chrX_-_48213545 1.267 NM_033518
SLC38A5
solute carrier family 38, member 5
chr19_-_17819773 1.249 JAK3
Janus kinase 3
chr9_-_129707392 1.247 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr19_-_56585603 1.237 NM_001193623
LOC147646
hypothetical protein LOC147646
chr11_-_60880799 1.228 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr1_+_26517045 1.225 CD52
CD52 molecule
chr13_-_40491405 1.220 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_+_60851207 1.203 CCDC106
coiled-coil domain containing 106
chrX_+_55951280 1.195


chr9_-_70780574 1.175


chr12_+_48003237 1.160 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr13_-_40491491 1.159 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_22608252 1.149


chr6_-_41781655 1.147 TFEB
transcription factor EB
chr14_-_106240998 1.143 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_26516967 1.118 NM_001803
CD52
CD52 molecule
chrX_+_1415508 1.109 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr18_+_19826734 1.098 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr16_+_56286212 1.091 NM_032269
CCDC135
coiled-coil domain containing 135
chr3_-_143230124 1.054 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr22_+_37823174 1.042 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr1_+_205328834 1.041 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr16_+_29581783 1.039 NM_001030288
SPN
sialophorin
chr10_-_75080784 1.036 NM_024875
SYNPO2L
synaptopodin 2-like
chr14_-_23846993 1.034 CIDEB
cell death-inducing DFFA-like effector b
chr17_-_39630951 1.030 NM_001098833
NM_020218
ATXN7L3

ataxin 7-like 3

chr5_-_176763789 1.023 F12
coagulation factor XII (Hageman factor)
chr10_+_82287637 1.023 NM_207372
SH2D4B
SH2 domain containing 4B
chr12_-_51887266 1.023 NM_000889
ITGB7
integrin, beta 7
chr13_+_23742846 1.022 SPATA13
spermatogenesis associated 13
chr1_-_146543102 1.009


chr1_-_146543016 1.005


chr1_-_114215768 1.004 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr19_+_40511909 0.996 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr14_-_93512818 0.985 ASB2
ankyrin repeat and SOCS box containing 2
chr13_-_45640679 0.980 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_16259636 0.974 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr3_+_52325374 0.942 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr1_+_45251007 0.931 UROD
uroporphyrinogen decarboxylase
chr3_-_20202622 0.915 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
SGOL1





shugoshin-like 1 (S. pombe)





chr1_+_36121403 0.913 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr8_-_42742729 0.896 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr5_-_138753443 0.879 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr17_+_16259573 0.878 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr6_-_30760413 0.875 KIAA1949
KIAA1949
chr22_+_21053972 0.861


chr14_-_23846904 0.859 CIDEB
cell death-inducing DFFA-like effector b
chr22_-_49317408 0.858 ODF3B
outer dense fiber of sperm tails 3B
chr1_+_179269761 0.850 MR1
major histocompatibility complex, class I-related
chr12_+_53177806 0.845 NCKAP1L
NCK-associated protein 1-like
chr1_+_111215343 0.836 NM_001040033
CD53
CD53 molecule
chr14_+_23527866 0.833 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr12_-_120725210 0.829 LOC338799
hypothetical LOC338799
chr3_-_13032130 0.818


chr2_+_68815416 0.818 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr12_-_9804682 0.777 NM_001781
CD69
CD69 molecule
chr12_+_53177789 0.776 NCKAP1L
NCK-associated protein 1-like
chr6_+_64289585 0.773 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr22_+_35586950 0.770 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chrX_+_48978923 0.766 CCDC22
coiled-coil domain containing 22
chr11_+_66927955 0.758 TBC1D10C
TBC1 domain family, member 10C
chr6_+_88026338 0.751 ZNF292
zinc finger protein 292
chr1_+_179269766 0.743 MR1
major histocompatibility complex, class I-related
chr17_+_44643067 0.738 ABI3
ABI family, member 3
chrX_-_47374187 0.727 NM_001145252
CFP
complement factor properdin
chr22_-_35875890 0.712 NM_000878
IL2RB
interleukin 2 receptor, beta
chr7_+_63411813 0.710 ZNF736
zinc finger protein 736
chr1_+_179269689 0.704 MR1
major histocompatibility complex, class I-related
chr9_+_107464558 0.700 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr1_-_154988647 0.698 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr17_+_72958330 0.691 SEPT9
septin 9
chr3_+_49032911 0.688 NM_199074
NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr12_+_14429499 0.688 ATF7IP
activating transcription factor 7 interacting protein
chr19_-_56567602 0.684 NM_005601
NKG7
natural killer cell group 7 sequence
chr20_+_34937928 0.683 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr19_+_52113772 0.683 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr1_-_31003181 0.683 LAPTM5
lysosomal protein transmembrane 5
chr17_-_9863929 0.680 GAS7
growth arrest-specific 7
chr17_-_36346240 0.667 KRT23
keratin 23 (histone deacetylase inducible)
chr3_+_113534710 0.659 CD200
CD200 molecule
chr5_-_121842680 0.653


chr18_+_70317548 0.650 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_+_69974361 0.648 CD300A
CD300a molecule
chr3_+_113534604 0.644 NM_001004196
NM_005944
CD200

CD200 molecule

chr2_-_85490997 0.641 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chrX_+_65299157 0.638 NM_138737
HEPH
hephaestin
chr6_-_11490487 0.637 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_26744929 0.635 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_85490984 0.634 CAPG
capping protein (actin filament), gelsolin-like
chr6_-_76259976 0.629 NM_015687
FILIP1
filamin A interacting protein 1
chr19_+_3713650 0.625 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr19_+_3713671 0.622 MRPL54
mitochondrial ribosomal protein L54
chr20_+_43764068 0.613 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr16_+_10878539 0.600 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_+_69974116 0.599 NM_007261
CD300A
CD300a molecule
chr20_-_1113116 0.598 NM_018354
C20orf46
chromosome 20 open reading frame 46
chrX_+_49718954 0.594 NM_000084
CLCN5
chloride channel 5
chr1_-_180824967 0.593 RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr2_-_42441798 0.593 NM_004718
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr17_-_44642934 0.583 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chrX_+_69314060 0.576 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr12_-_100979869 0.567 CCDC53
coiled-coil domain containing 53
chr16_-_28515868 0.565 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr10_-_121286034 0.562 NM_002925
RGS10
regulator of G-protein signaling 10
chr14_-_23847000 0.548 CIDEB
cell death-inducing DFFA-like effector b
chr7_+_102078007 0.545 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr3_-_120761092 0.545 NM_005191
CD80
CD80 molecule
chr12_+_1596482 0.541 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr1_+_26744893 0.541 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_+_169367345 0.538 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr1_+_28134090 0.537 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr5_-_142795269 0.537 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr11_-_5227611 0.536 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr19_+_60879802 0.535 NM_001130071
EPN1
epsin 1
chr16_-_88669833 0.533 NM_001098173
PRDM7
PR domain containing 7
chr6_+_31651319 0.529 NM_000594
TNF
tumor necrosis factor
chr17_+_65582981 0.528 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_+_154573728 0.525 NM_144627
C1orf182
chromosome 1 open reading frame 182
chr1_-_31003260 0.525 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr1_-_232681471 0.523 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr1_+_556968 0.522


chr8_-_103206310 0.520 NM_001040630
NCALD
neurocalcin delta
chr13_+_30207690 0.519 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_+_52121699 0.513 NM_001005354
NM_018457
PRR13

proline rich 13

chr11_-_5130174 0.512 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr8_-_18585721 0.511 PSD3
pleckstrin and Sec7 domain containing 3
chr2_+_218978375 0.511 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr11_+_22652957 0.510 GAS2
growth arrest-specific 2
chr12_+_27511009 0.509 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr15_-_32662352 0.509 GOLGA8B
golgin A8 family, member B
chr2_+_134728299 0.508 NM_002410
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr2_-_138762909 0.504


chr17_-_9864048 0.504 GAS7
growth arrest-specific 7
chr12_+_56114724 0.501 NM_005538
INHBC
inhibin, beta C
chr11_+_22652894 0.500 NM_005256
GAS2
growth arrest-specific 2
chr8_-_82769761 0.498 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr8_-_38127489 0.496 NM_000349
STAR
steroidogenic acute regulatory protein
chr12_+_119617060 0.494



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.71 4.95e-03 GO:0006959 humoral immune response
1.99 1.24e-02 GO:0050776 regulation of immune response
1.72 1.77e-02 GO:0006955 immune response
3.44 4.95e-02 GO:0007015 actin filament organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 1.09e-06 GO:0005886 plasma membrane
1.34 1.39e-06 GO:0071944 cell periphery
1.41 7.38e-04 GO:0044459 plasma membrane part
1.16 4.76e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.01 3.64e-04 GO:0004252 serine-type endopeptidase activity
1.46 2.02e-03 GO:0004872 receptor activity
4.80 5.29e-03 GO:0003823 antigen binding
2.60 5.60e-03 GO:0008236 serine-type peptidase activity
3.17 6.00e-03 GO:0005179 hormone activity
2.55 7.66e-03 GO:0017171 serine hydrolase activity
1.37 1.54e-02 GO:0004871 signal transducer activity
1.37 1.54e-02 GO:0060089 molecular transducer activity