Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 3.131


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
UBTFchr17_-_39651189-0.656.4e-03Click!
HBP1chr7_+_1065966410.639.0e-03Click!
SSRP1chr11_-_568599000.381.5e-01Click!
HMGB3chrX_+_1499024150.263.3e-01Click!
HMGB2chr4_-_174492029-0.194.9e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_12398514 11.563 NM_001168319
NM_001955
 EDN1

endothelin 1

chr16_+_85169615 11.367 NM_005250
 FOXL1
forkhead box L1
chr7_-_27186400 9.592 NM_153715
 HOXA10
homeobox A10
chr7_+_134114957 9.479 CALD1
caldesmon 1
chr13_-_73605914 9.319 NM_007249
 KLF12
Kruppel-like factor 12
chr7_+_134114912 9.206 CALD1
caldesmon 1
chr11_-_85107569 8.467 NM_206929
 SYTL2
synaptotagmin-like 2
chr13_-_98428244 8.155 NM_001130048
NM_001130050
 DOCK9

dedicator of cytokinesis 9

chr13_-_73606362 8.149 KLF12
Kruppel-like factor 12
chr6_-_111995213 8.102 NM_001164283
 TRAF3IP2
TRAF3 interacting protein 2
chr11_-_85108030 7.792 NM_001162952
NM_206930
 SYTL2

synaptotagmin-like 2

chr2_-_207738858 7.358 NM_003709
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr8_-_108579270 7.135 NM_001146
 ANGPT1
angiopoietin 1
chr5_+_98132898 6.913 NM_001012761
 RGMB
RGM domain family, member B
chr5_-_111119846 6.848 NM_001142483
 C5orf13
chromosome 5 open reading frame 13
chr10_+_104525877 6.810 NM_017787
 C10orf26
chromosome 10 open reading frame 26
chr2_-_162808123 6.702 NM_004460
 FAP
fibroblast activation protein, alpha
chr7_-_27171673 6.615 NM_152739
 HOXA9
homeobox A9
chr8_-_72436519 6.392 EYA1
eyes absent homolog 1 (Drosophila)
chr2_+_69093641 6.365 NM_018153
NM_032208
NM_053034
 ANTXR1


anthrax toxin receptor 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 108 entries
enrichment   p-value GO term description
3.47 3.29e-08 GO:0030336 negative regulation of cell migration
3.47 3.29e-08 GO:2000146 negative regulation of cell motility
3.31 8.14e-08 GO:0051271 negative regulation of cellular component movement
3.05 1.21e-06 GO:0040013 negative regulation of locomotion
3.01 2.91e-02 GO:0010594 regulation of endothelial cell migration
2.80 3.24e-02 GO:0016202 regulation of striated muscle tissue development
2.75 4.39e-02 GO:0010810 regulation of cell-substrate adhesion
2.58 9.36e-03 GO:0048706 embryonic skeletal system development
2.29 9.51e-03 GO:0006469 negative regulation of protein kinase activity
2.26 4.94e-03 GO:0048705 skeletal system morphogenesis
2.24 4.26e-02 GO:0048736 appendage development
2.24 4.26e-02 GO:0060173 limb development
2.22 5.95e-03 GO:0007156 homophilic cell adhesion
2.18 3.23e-02 GO:0033673 negative regulation of kinase activity
2.11 4.43e-06 GO:0001568 blood vessel development
2.09 8.97e-03 GO:0009952 anterior/posterior pattern formation
2.08 3.01e-06 GO:0001944 vasculature development
2.04 5.45e-05 GO:0030334 regulation of cell migration
2.02 9.01e-05 GO:2000145 regulation of cell motility
1.97 2.46e-03 GO:0048011 nerve growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
7.85 1.59e-02 GO:0071437 invadopodium
3.33 1.06e-02 GO:0042641 actomyosin
2.80 3.01e-05 GO:0030027 lamellipodium
2.54 1.58e-04 GO:0005925 focal adhesion
2.47 1.39e-04 GO:0030055 cell-substrate junction
2.42 5.42e-04 GO:0005924 cell-substrate adherens junction
2.32 2.25e-05 GO:0005912 adherens junction
2.29 1.35e-03 GO:0044420 extracellular matrix part
2.17 7.01e-03 GO:0030016 myofibril
2.15 1.07e-02 GO:0044449 contractile fiber part
2.14 2.04e-04 GO:0070161 anchoring junction
2.11 9.75e-03 GO:0043292 contractile fiber
1.98 9.30e-07 GO:0005578 proteinaceous extracellular matrix
1.97 2.28e-03 GO:0031252 cell leading edge
1.85 4.94e-06 GO:0031012 extracellular matrix
1.64 1.11e-05 GO:0030054 cell junction
1.34 1.66e-02 GO:0044421 extracellular region part
1.28 1.04e-02 GO:0005856 cytoskeleton
1.23 4.97e-07 GO:0071944 cell periphery
1.23 7.60e-07 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.58 5.49e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.24 3.79e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.21 1.01e-02 GO:0017124 SH3 domain binding
2.18 3.59e-02 GO:0004222 metalloendopeptidase activity
1.94 3.70e-06 GO:0003779 actin binding
1.67 2.49e-05 GO:0008092 cytoskeletal protein binding
1.66 2.59e-03 GO:0004984 olfactory receptor activity
1.62 4.82e-02 GO:0016563 transcription activator activity
1.54 4.40e-04 GO:0005509 calcium ion binding
1.49 2.01e-05 GO:0001071 nucleic acid binding transcription factor activity
1.49 2.01e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.48 1.80e-05 GO:0030528 transcription regulator activity
1.48 4.17e-03 GO:0043565 sequence-specific DNA binding