Motif ID: HES1.p2

Z-value: 2.254


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336631-0.312.5e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_18969724 3.279 NM_001100619
 CABLES1
Cdk5 and Abl enzyme substrate 1
chr16_+_66153810 1.836 NM_001191022
NM_006565
 CTCF

CCCTC-binding factor (zinc finger protein)

chr21_-_45786709 1.636 NM_194255
 SLC19A1
solute carrier family 19 (folate transporter), member 1
chr3_+_129690735 1.605


chr22_-_27405708 1.535 NM_001145418
 TTC28
tetratricopeptide repeat domain 28
chr17_+_37941715 1.501 NAGLU
N-acetylglucosaminidase, alpha
chr10_+_92912676 1.409 PCGF5
polycomb group ring finger 5
chr19_-_10474767 1.399 NM_203500
 KEAP1
kelch-like ECH-associated protein 1
chr17_+_37941790 1.340 NAGLU
N-acetylglucosaminidase, alpha
chr19_-_10475083 1.329 KEAP1
kelch-like ECH-associated protein 1
chr7_+_98084531 1.323 NM_002523
 NPTX2
neuronal pentraxin II
chr17_+_37941476 1.279 NM_000263
 NAGLU
N-acetylglucosaminidase, alpha
chr3_+_51403760 1.264 NM_013286
 RBM15B
RNA binding motif protein 15B
chr7_+_149696263 1.262 REPIN1
replication initiator 1
chr2_-_10506033 1.262 ODC1
ornithine decarboxylase 1
chr5_+_75734759 1.256 NM_006633
 IQGAP2
IQ motif containing GTPase activating protein 2
chr2_+_10101822 1.238 NM_001177718
 KLF11
Kruppel-like factor 11
chr2_-_10505902 1.168 NM_002539
 ODC1
ornithine decarboxylase 1
chr11_-_67645246 1.166 CHKA
choline kinase alpha
chr12_+_6893751 1.160 NM_001975
 ENO2
enolase 2 (gamma, neuronal)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 101 entries
enrichment   p-value GO term description
2.16 2.94e-02 GO:0040029 regulation of gene expression, epigenetic
2.13 1.46e-12 GO:0016568 chromatin modification
2.12 2.49e-05 GO:0016569 covalent chromatin modification
2.12 3.37e-05 GO:0016570 histone modification
2.10 1.79e-02 GO:0051188 cofactor biosynthetic process
1.92 6.99e-11 GO:0006325 chromatin organization
1.80 7.87e-04 GO:0010608 posttranscriptional regulation of gene expression
1.78 3.34e-10 GO:0051276 chromosome organization
1.70 6.15e-04 GO:0044419 interspecies interaction between organisms
1.67 5.88e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.65 6.10e-03 GO:0018193 peptidyl-amino acid modification
1.64 3.71e-06 GO:0010629 negative regulation of gene expression
1.64 2.24e-05 GO:0051253 negative regulation of RNA metabolic process
1.63 4.28e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.62 5.48e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.62 2.24e-03 GO:0040008 regulation of growth
1.61 1.72e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 1.32e-02 GO:0090066 regulation of anatomical structure size
1.61 4.16e-02 GO:0032535 regulation of cellular component size
1.60 1.14e-08 GO:0006351 transcription, DNA-dependent

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
4.44 1.24e-02 GO:0016581 NuRD complex
3.71 1.71e-02 GO:0031519 PcG protein complex
2.49 4.46e-05 GO:0016585 chromatin remodeling complex
1.68 1.26e-02 GO:0000785 chromatin
1.50 4.01e-11 GO:0005654 nucleoplasm
1.49 3.77e-05 GO:0044451 nucleoplasm part
1.46 1.80e-13 GO:0031981 nuclear lumen
1.45 9.74e-16 GO:0044428 nuclear part
1.43 1.40e-02 GO:0005694 chromosome
1.42 7.71e-15 GO:0031974 membrane-enclosed lumen
1.42 1.26e-14 GO:0070013 intracellular organelle lumen
1.41 4.74e-14 GO:0043233 organelle lumen
1.33 5.83e-08 GO:0005829 cytosol
1.32 3.55e-04 GO:0005739 mitochondrion
1.30 1.91e-25 GO:0005634 nucleus
1.23 5.93e-35 GO:0043227 membrane-bounded organelle
1.23 8.28e-35 GO:0043231 intracellular membrane-bounded organelle
1.23 3.99e-14 GO:0044446 intracellular organelle part
1.22 2.90e-13 GO:0044422 organelle part
1.20 2.00e-32 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
5.13 1.20e-02 GO:0046965 retinoid X receptor binding
4.81 7.82e-03 GO:0042974 retinoic acid receptor binding
2.55 5.94e-04 GO:0042393 histone binding
1.99 9.42e-05 GO:0003682 chromatin binding
1.86 2.68e-06 GO:0016564 transcription repressor activity
1.84 3.05e-06 GO:0016563 transcription activator activity
1.71 2.65e-03 GO:0016881 acid-amino acid ligase activity
1.67 2.90e-02 GO:0019787 small conjugating protein ligase activity
1.65 5.01e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.64 7.42e-03 GO:0008134 transcription factor binding
1.63 5.95e-05 GO:0016874 ligase activity
1.58 1.27e-07 GO:0019899 enzyme binding
1.55 3.01e-03 GO:0019904 protein domain specific binding
1.51 4.55e-08 GO:0030528 transcription regulator activity
1.41 7.52e-05 GO:0001071 nucleic acid binding transcription factor activity
1.41 7.52e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 1.43e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.38 2.04e-08 GO:0016740 transferase activity
1.38 1.74e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.38 7.58e-03 GO:0016301 kinase activity