Motif ID: HIC1.p2

Z-value: 6.021


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19051040.665.6e-03Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101485946 8.940 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr14_+_105012106 8.757 NM_001312
 CRIP2
cysteine-rich protein 2
chr21_-_43671355 7.680 NM_173354
 SIK1
salt-inducible kinase 1
chr6_+_147871477 6.955 NM_001030060
 SAMD5
sterile alpha motif domain containing 5
chr6_-_112301123 6.725 NM_002037
 FYN
FYN oncogene related to SRC, FGR, YES
chr5_+_14196287 6.700 NM_007118
 TRIO
triple functional domain (PTPRF interacting)
chr13_-_109757442 6.519 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr13_+_109757593 6.451 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr2_-_112907577 6.385 NM_001164463
 RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr17_+_52026058 6.244 NM_005450
 NOG
noggin
chr20_+_8997660 6.208 NM_001172646
 PLCB4
phospholipase C, beta 4
chr2_-_160972606 6.018 RBMS1
RNA binding motif, single stranded interacting protein 1
chr18_+_7557313 5.760 NM_001105244
NM_002845
 PTPRM

protein tyrosine phosphatase, receptor type, M

chr2_+_9532087 5.713 NM_001039613
 IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr2_+_241586927 5.471 NM_001080437
 SNED1
sushi, nidogen and EGF-like domains 1
chr2_+_238200922 5.434 NM_001137550
 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr12_+_26003218 5.399 NM_001164748
NM_007211
 RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr9_-_135847106 5.386 NM_001134398
NM_003371
 VAV2

vav 2 guanine nucleotide exchange factor

chr1_-_8008934 5.309 ERRFI1
ERBB receptor feedback inhibitor 1
chrX_+_9943793 5.290 NM_015691
 WWC3
WWC family member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 142 entries
enrichment   p-value GO term description
2.24 3.48e-02 GO:0030509 BMP signaling pathway
1.91 4.83e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.90 1.28e-03 GO:0010720 positive regulation of cell development
1.88 1.96e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.83 5.88e-03 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.74 2.70e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.71 1.25e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.70 2.49e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.63 2.99e-09 GO:0007409 axonogenesis
1.63 7.42e-07 GO:0007411 axon guidance
1.61 3.49e-09 GO:0048812 neuron projection morphogenesis
1.61 1.17e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.60 1.61e-04 GO:0001568 blood vessel development
1.59 1.09e-04 GO:0001944 vasculature development
1.58 3.40e-09 GO:0000904 cell morphogenesis involved in differentiation
1.58 6.73e-04 GO:0016567 protein ubiquitination
1.57 8.68e-09 GO:0031175 neuron projection development
1.55 3.54e-08 GO:0048858 cell projection morphogenesis
1.55 1.64e-02 GO:0045786 negative regulation of cell cycle
1.55 2.05e-02 GO:0048514 blood vessel morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
1.92 1.31e-07 GO:0005912 adherens junction
1.86 6.72e-04 GO:0005925 focal adhesion
1.85 3.48e-04 GO:0030055 cell-substrate junction
1.81 1.56e-03 GO:0005924 cell-substrate adherens junction
1.79 2.05e-02 GO:0030027 lamellipodium
1.78 6.80e-06 GO:0070161 anchoring junction
1.70 4.08e-05 GO:0031252 cell leading edge
1.30 8.52e-03 GO:0030054 cell junction
1.28 9.48e-03 GO:0015630 microtubule cytoskeleton
1.26 1.18e-03 GO:0005794 Golgi apparatus
1.26 1.85e-02 GO:0031410 cytoplasmic vesicle
1.26 2.69e-02 GO:0031988 membrane-bounded vesicle
1.25 1.31e-08 GO:0005829 cytosol
1.25 1.93e-02 GO:0031982 vesicle
1.25 3.99e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.21 3.86e-03 GO:0005654 nucleoplasm
1.20 2.75e-04 GO:0031981 nuclear lumen
1.20 1.30e-03 GO:0012505 endomembrane system
1.20 1.60e-03 GO:0005856 cytoskeleton
1.17 7.47e-04 GO:0044428 nuclear part

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
3.77 6.24e-04 GO:0070411 I-SMAD binding
2.43 1.56e-04 GO:0046332 SMAD binding
1.82 9.86e-03 GO:0017016 Ras GTPase binding
1.77 3.00e-03 GO:0051020 GTPase binding
1.75 1.79e-02 GO:0031267 small GTPase binding
1.73 3.18e-02 GO:0005057 receptor signaling protein activity
1.68 8.79e-06 GO:0004842 ubiquitin-protein ligase activity
1.61 1.36e-04 GO:0019787 small conjugating protein ligase activity
1.56 4.72e-04 GO:0016791 phosphatase activity
1.56 4.24e-02 GO:0004721 phosphoprotein phosphatase activity
1.56 4.24e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.55 2.44e-04 GO:0016881 acid-amino acid ligase activity
1.53 1.94e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.53 1.39e-02 GO:0000975 regulatory region DNA binding
1.53 1.39e-02 GO:0001067 regulatory region nucleic acid binding
1.53 1.39e-02 GO:0044212 transcription regulatory region DNA binding
1.51 7.16e-04 GO:0005083 small GTPase regulator activity
1.51 3.36e-02 GO:0010843 promoter binding
1.49 2.16e-04 GO:0042578 phosphoric ester hydrolase activity
1.49 4.25e-04 GO:0003779 actin binding