Motif ID: HIF1A.p2

Z-value: 1.867


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.391.4e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_97016027 3.713 NM_001122646
 FAM178B
family with sequence similarity 178, member B
chr1_-_26105954 1.508 NM_203399
 STMN1
stathmin 1
chr1_-_26105477 1.412 NM_001145454
NM_005563
 STMN1

stathmin 1

chr21_+_25856311 1.357 MIR155HG
MIR155 host gene (non-protein coding)
chr10_-_88720908 1.307 LOC100133190
hypothetical LOC100133190
chr10_+_112247614 1.303 NM_004419
 DUSP5
dual specificity phosphatase 5
chr8_-_101804114 1.300 PABPC1
poly(A) binding protein, cytoplasmic 1
chr15_-_90999606 1.288 NM_207446
 FAM174B
family with sequence similarity 174, member B
chr19_-_53516962 1.286 CCDC114
coiled-coil domain containing 114
chr3_-_180652024 1.242 NM_021629
 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr7_-_72609957 1.221 NM_001197244
NM_001707
 BCL7B

B-cell CLL/lymphoma 7B

chr19_+_1358664 1.212 DAZAP1
DAZ associated protein 1
chr3_-_16530132 1.175 NM_015150
 RFTN1
raftlin, lipid raft linker 1
chr20_+_18516541 1.164 NM_080820
 DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr4_-_10068055 1.154 NM_053042
 ZNF518B
zinc finger protein 518B
chr3_-_180651874 1.127 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr7_+_148590152 1.107 NM_001195220
 ZNF783
zinc finger family member 783
chr6_+_33697023 1.092 NM_002224
 ITPR3
inositol 1,4,5-triphosphate receptor, type 3
chr3_-_16529996 1.052 RFTN1
raftlin, lipid raft linker 1
chr1_+_13899272 1.051 NM_001135610
 PRDM2
PR domain containing 2, with ZNF domain

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.56 3.98e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.49 5.11e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.35 1.35e-03 GO:0043412 macromolecule modification
1.35 4.11e-03 GO:0006464 protein modification process
1.30 1.52e-02 GO:0065008 regulation of biological quality
1.24 2.66e-05 GO:0044260 cellular macromolecule metabolic process
1.23 5.68e-03 GO:0031323 regulation of cellular metabolic process
1.23 1.11e-02 GO:0080090 regulation of primary metabolic process
1.22 3.09e-02 GO:0060255 regulation of macromolecule metabolic process
1.20 2.03e-02 GO:0019222 regulation of metabolic process
1.19 5.27e-05 GO:0044237 cellular metabolic process
1.19 4.67e-03 GO:0043170 macromolecule metabolic process
1.15 6.59e-03 GO:0044238 primary metabolic process
1.14 4.86e-03 GO:0008152 metabolic process
1.13 2.85e-02 GO:0050794 regulation of cellular process
1.12 4.38e-02 GO:0065007 biological regulation
1.08 4.98e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.96 2.41e-03 GO:0005635 nuclear envelope
1.29 5.61e-03 GO:0005829 cytosol
1.24 4.23e-09 GO:0005634 nucleus
1.17 4.71e-10 GO:0043231 intracellular membrane-bounded organelle
1.17 6.55e-10 GO:0043227 membrane-bounded organelle
1.16 1.28e-17 GO:0044424 intracellular part
1.16 4.08e-08 GO:0005737 cytoplasm
1.16 2.90e-04 GO:0044444 cytoplasmic part
1.15 1.08e-17 GO:0005622 intracellular
1.15 2.15e-09 GO:0043226 organelle
1.14 3.62e-09 GO:0043229 intracellular organelle
1.05 2.22e-04 GO:0044464 cell part
1.05 2.30e-04 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
6.69 4.59e-02 GO:0070742 C2H2 zinc finger domain binding
4.25 1.29e-02 GO:0003887 DNA-directed DNA polymerase activity
4.15 7.05e-03 GO:0034061 DNA polymerase activity
1.74 4.00e-02 GO:0016564 transcription repressor activity
1.48 1.09e-03 GO:0030528 transcription regulator activity
1.29 4.20e-02 GO:0016740 transferase activity
1.28 2.85e-03 GO:0003677 DNA binding
1.27 8.57e-03 GO:0000166 nucleotide binding
1.24 1.15e-03 GO:0003676 nucleic acid binding
1.15 7.42e-05 GO:0005515 protein binding
1.08 2.00e-04 GO:0005488 binding