Motif ID: HNF1A.p2

Z-value: 7.107


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199006770.992.6e-14Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_24491498 44.987 NM_001195610
 DCDC2
doublecortin domain containing 2
chr12_-_15757114 33.578 EPS8
epidermal growth factor receptor pathway substrate 8
chr8_-_17797127 28.663 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chrX_-_105169370 27.741 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_61655915 27.259 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_44547382 26.244 NM_001101648
NM_013389
 NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr7_+_45894480 25.804 NM_000596
 IGFBP1
insulin-like growth factor binding protein 1
chr4_-_977163 25.623 NM_022042
NM_134425
NM_213613
 SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr20_+_41621119 25.289 SGK2
serum/glucocorticoid regulated kinase 2
chr4_-_69852090 24.840 NM_024743
 UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr20_+_41621079 24.721 NM_170693
 SGK2
serum/glucocorticoid regulated kinase 2
chr14_-_93829309 24.111 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr7_-_47545717 23.970 NM_022748
 TNS3
tensin 3
chr10_+_114144512 23.968 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_-_86527608 23.781 NM_001739
 CA5A
carbonic anhydrase VA, mitochondrial
chr14_-_93829113 23.645 NM_016186
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_+_11211282 23.478 NM_018687
 LOC55908
hepatocellular carcinoma-associated gene TD26
chr14_+_20226762 23.361 NM_001097577
NM_194431
 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr14_-_93829347 23.331 NM_001100607
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_+_74520796 22.753 NM_001134
 AFP
alpha-fetoprotein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
46.95 1.94e-02 GO:0015712 hexose phosphate transport
46.95 1.94e-02 GO:0015760 glucose-6-phosphate transport
27.82 9.14e-03 GO:0051918 negative regulation of fibrinolysis
26.08 8.76e-04 GO:0051917 regulation of fibrinolysis
22.76 2.34e-02 GO:0046415 urate metabolic process
19.26 4.93e-02 GO:0030194 positive regulation of blood coagulation
16.48 1.17e-02 GO:0034381 plasma lipoprotein particle clearance
13.42 5.31e-03 GO:0030195 negative regulation of blood coagulation
12.95 6.61e-03 GO:0050819 negative regulation of coagulation
10.96 3.50e-03 GO:0030301 cholesterol transport
10.73 2.08e-02 GO:0097006 regulation of plasma lipoprotein particle levels
10.69 4.17e-03 GO:0015918 sterol transport
10.15 2.91e-02 GO:0008206 bile acid metabolic process
9.63 3.97e-02 GO:0030193 regulation of blood coagulation
9.13 1.24e-02 GO:0033993 response to lipid
8.35 5.71e-03 GO:0033500 carbohydrate homeostasis
8.35 5.71e-03 GO:0042593 glucose homeostasis
7.59 1.18e-02 GO:0055088 lipid homeostasis
5.56 5.75e-03 GO:0030162 regulation of proteolysis
4.72 2.73e-02 GO:0006869 lipid transport

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
26.83 2.37e-02 GO:0005577 fibrinogen complex
8.43 3.08e-03 GO:0031983 vesicle lumen
7.99 1.70e-02 GO:0031093 platelet alpha granule lumen
7.83 1.91e-02 GO:0034774 secretory granule lumen
7.56 6.39e-03 GO:0031091 platelet alpha granule
7.51 2.41e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.56 2.63e-02 GO:0045177 apical part of cell
2.75 2.38e-05 GO:0005615 extracellular space
2.38 1.43e-04 GO:0044421 extracellular region part
1.93 4.72e-02 GO:0000267 cell fraction
1.66 3.23e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
20.87 7.04e-04 GO:0008514 organic anion transmembrane transporter activity
8.54 1.77e-02 GO:0043498 cell surface binding
3.20 3.58e-02 GO:0004857 enzyme inhibitor activity