Motif ID: HNF4A_NR2F1,2.p2

Z-value: 6.783


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424175020.919.6e-07Click!
NR2F2chr15_+_94670160-0.224.2e-01Click!
NR2F1chr5_+_929446800.165.5e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_131190237 14.465 NM_001195597
 LOC285733
hypothetical LOC285733
chr17_+_69950782 14.077 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_+_51783540 13.576 NM_003578
 SOAT2
sterol O-acyltransferase 2
chr17_+_24394281 13.487 PIPOX
pipecolic acid oxidase
chr9_-_14858974 13.432 FREM1
FRAS1 related extracellular matrix 1
chr12_+_51783554 13.012 SOAT2
sterol O-acyltransferase 2
chr14_-_23847000 12.591 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846993 12.276 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23847024 12.213 CIDEB
cell death-inducing DFFA-like effector b
chr5_-_42847716 11.870 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr14_-_23846904 11.709 CIDEB
cell death-inducing DFFA-like effector b
chr10_+_102722275 11.676 NM_017893
 SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_-_167822248 11.283 F5
coagulation factor V (proaccelerin, labile factor)
chr9_-_129752687 11.139 NM_203305
 FAM102A
family with sequence similarity 102, member A
chr2_+_241193492 11.114 NM_001195381
NM_001195382
 GPR35

G protein-coupled receptor 35

chr17_-_31353196 11.043 NM_032965
 CCL15
chemokine (C-C motif) ligand 15
chr9_-_126309510 10.532 NM_004959
 NR5A1
nuclear receptor subfamily 5, group A, member 1
chr14_-_93924873 10.424 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31731647 10.113 NM_019101
 APOM
apolipoprotein M
chr12_-_7935010 10.067 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.84 5.55e-03 GO:0008202 steroid metabolic process
1.50 8.50e-04 GO:0042180 cellular ketone metabolic process
1.49 1.58e-03 GO:0006082 organic acid metabolic process
1.49 1.88e-03 GO:0019752 carboxylic acid metabolic process
1.49 1.88e-03 GO:0043436 oxoacid metabolic process
1.46 2.01e-04 GO:0055114 oxidation-reduction process
1.36 2.63e-02 GO:0006629 lipid metabolic process
1.34 2.16e-05 GO:0044281 small molecule metabolic process
1.28 2.02e-04 GO:0042221 response to chemical stimulus
1.14 2.25e-04 GO:0044237 cellular metabolic process
1.13 5.41e-05 GO:0008152 metabolic process
1.08 2.86e-04 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.71 6.23e-03 GO:0042598 vesicular fraction
1.69 7.93e-03 GO:0005759 mitochondrial matrix
1.68 1.72e-02 GO:0005792 microsome
1.66 1.71e-05 GO:0005740 mitochondrial envelope
1.66 2.50e-03 GO:0005743 mitochondrial inner membrane
1.63 8.39e-08 GO:0044429 mitochondrial part
1.61 2.93e-04 GO:0031966 mitochondrial membrane
1.61 5.00e-03 GO:0019866 organelle inner membrane
1.52 1.81e-05 GO:0031967 organelle envelope
1.51 3.39e-05 GO:0031975 envelope
1.44 5.51e-08 GO:0005739 mitochondrion
1.44 3.43e-04 GO:0005624 membrane fraction
1.43 4.06e-04 GO:0005626 insoluble fraction
1.40 3.81e-03 GO:0044432 endoplasmic reticulum part
1.38 2.21e-04 GO:0000267 cell fraction
1.34 2.55e-03 GO:0005783 endoplasmic reticulum
1.27 9.80e-05 GO:0031090 organelle membrane
1.24 2.93e-03 GO:0005829 cytosol
1.24 3.47e-02 GO:0012505 endomembrane system
1.19 3.10e-10 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.73 6.42e-03 GO:0048037 cofactor binding
1.50 1.33e-04 GO:0016491 oxidoreductase activity
1.12 3.36e-02 GO:0003824 catalytic activity