Motif ID: HNF4A_NR2F1,2.p2

Z-value: 6.783


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424175020.919.6e-07Click!
NR2F2chr15_+_94670160-0.224.2e-01Click!
NR2F1chr5_+_929446800.165.5e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_131190237 14.465 NM_001195597
LOC285733
hypothetical LOC285733
chr17_+_69950782 14.077 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_+_51783540 13.576 NM_003578
SOAT2
sterol O-acyltransferase 2
chr17_+_24394281 13.487 PIPOX
pipecolic acid oxidase
chr9_-_14858974 13.432 FREM1
FRAS1 related extracellular matrix 1
chr12_+_51783554 13.012 SOAT2
sterol O-acyltransferase 2
chr14_-_23847000 12.591 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846993 12.276 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23847024 12.213 CIDEB
cell death-inducing DFFA-like effector b
chr5_-_42847716 11.870 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr14_-_23846904 11.709 CIDEB
cell death-inducing DFFA-like effector b
chr10_+_102722275 11.676 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_-_167822248 11.283 F5
coagulation factor V (proaccelerin, labile factor)
chr9_-_129752687 11.139 NM_203305
FAM102A
family with sequence similarity 102, member A
chr2_+_241193492 11.114 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr17_-_31353196 11.043 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr9_-_126309510 10.532 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr14_-_93924873 10.424 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31731647 10.113 NM_019101
APOM
apolipoprotein M
chr12_-_7935010 10.067 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr16_-_86527608 10.019 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr6_+_31731667 9.995 APOM
apolipoprotein M
chr1_-_153537810 9.313 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr2_+_219354692 9.204 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_-_167822334 8.796 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr6_+_32090516 8.729 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr13_+_112825113 7.868 NM_000504
F10
coagulation factor X
chr17_-_31352720 7.858 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr6_+_32021793 7.821 CFB
complement factor B
chr17_-_31352643 7.786 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr16_+_21152516 7.717 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr2_-_238164042 7.670 RAB17
RAB17, member RAS oncogene family
chr17_-_7023378 7.654 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr10_-_101831579 7.614 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr19_-_63715135 7.567 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr1_-_159459814 7.435 APOA2
apolipoprotein A-II
chr17_+_24394043 7.255 NM_016518
PIPOX
pipecolic acid oxidase
chr12_+_119900931 7.141 NM_000545
HNF1A
HNF1 homeobox A
chr2_-_74606819 7.050 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr2_+_11597530 6.835 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr8_+_21972631 6.811 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr22_+_43451600 6.734 PRR5
proline rich 5 (renal)
chr17_-_68769613 6.712 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr12_+_119900677 6.671 HNF1A
HNF1 homeobox A
chr1_-_176205672 6.565 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_+_32021742 6.560 CFB
complement factor B
chr16_-_16224791 6.540 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr16_-_51138306 6.407 NM_001080430
TOX3
TOX high mobility group box family member 3
chr4_-_9632192 6.404 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr20_+_55569542 6.398 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_27573206 6.358 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr8_+_21972804 6.325 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr20_+_35406497 6.301 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr11_-_116213511 6.299 NM_000039
APOA1
apolipoprotein A-I
chr16_+_464844 6.260 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr16_+_29597965 6.223 QPRT
quinolinate phosphoribosyltransferase
chr3_-_42892195 6.116 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_32057779 6.077 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr11_+_74548472 6.076 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_-_159459999 6.050 NM_001643
APOA2
apolipoprotein A-II
chr17_+_4638966 6.037 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr3_-_58497913 6.016 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr1_-_176205970 6.006 SEC16B
SEC16 homolog B (S. cerevisiae)
chr2_-_238164452 5.958 NM_022449
RAB17
RAB17, member RAS oncogene family
chr1_-_149611768 5.936 NM_003944
SELENBP1
selenium binding protein 1
chr5_+_133870175 5.785


chr11_+_60858611 5.782 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr20_+_32762976 5.752 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr20_+_31059038 5.730 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr3_-_121883647 5.725 HGD
homogentisate 1,2-dioxygenase
chr1_-_172153087 5.686 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_55963883 5.679 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_-_228916559 5.632 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_218992053 5.592 NM_007127
VIL1
villin 1
chr6_+_32021831 5.588 CFB
complement factor B
chr2_+_242398954 5.544 NEU4
sialidase 4
chr13_+_49658016 5.479


chr13_+_112808102 5.464 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr17_+_4621924 5.437 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_-_172153024 5.415 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_153537362 5.392 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr6_+_32003380 5.360 C2
complement component 2
chr11_-_116168316 5.186 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr13_-_112392051 5.120 LOC440149
hypothetical LOC440149
chr11_+_46697335 5.118 F2
coagulation factor II (thrombin)
chr11_+_110675175 5.111 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr14_-_38642029 5.062 SEC23A
Sec23 homolog A (S. cerevisiae)
chr15_+_38082041 5.057 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr11_+_46697312 5.034 NM_000506
F2
coagulation factor II (thrombin)
chr11_+_46697345 5.020 F2
coagulation factor II (thrombin)
chr11_-_16992524 4.987 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr13_+_112392355 4.970 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr1_-_228916958 4.964 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_219026661 4.954 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr14_-_93924663 4.950 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_-_56561391 4.928 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_219780192 4.883 ZFAND2B
zinc finger, AN1-type domain 2B
chr10_+_101532544 4.877 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr17_+_35147697 4.872 NM_005310
GRB7
growth factor receptor-bound protein 7
chr3_-_198784590 4.823 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr8_-_82769761 4.782 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr17_-_33178987 4.775 HNF1B
HNF1 homeobox B
chr2_-_88208650 4.761 NM_001443
FABP1
fatty acid binding protein 1, liver
chr17_+_72958207 4.750 NM_001113496
SEPT9
septin 9
chr19_-_56561444 4.748 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr20_-_3097070 4.732 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr11_+_696607 4.693 EPS8L2
EPS8-like 2
chr2_-_233586145 4.677 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_110108048 4.677 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr3_-_195553297 4.633 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr7_-_100630912 4.628 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr21_+_41616590 4.618 FAM3B
family with sequence similarity 3, member B
chr10_+_114123828 4.612 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_-_50600536 4.573 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr17_-_33179118 4.530 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr10_+_101532450 4.473 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_233586164 4.472 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr6_+_30238961 4.470 NM_033229
TRIM15
tripartite motif containing 15
chr10_+_60607232 4.448 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr6_+_32003180 4.439 NM_000063
NM_001145903
C2

complement component 2

chr17_-_6958773 4.388 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr1_+_28435167 4.370 NM_016311
NM_178190
NM_178191
ATPIF1


ATPase inhibitory factor 1


chr8_-_71478560 4.368 NM_006540
NCOA2
nuclear receptor coactivator 2
chr17_+_72958330 4.351 SEPT9
septin 9
chr7_+_101704145 4.332 CUX1
cut-like homeobox 1
chrX_+_152565849 4.257 DUSP9
dual specificity phosphatase 9
chr9_-_35804982 4.232


chr17_-_23721351 4.178 VTN
vitronectin
chr11_-_60819110 4.174 VWCE
von Willebrand factor C and EGF domains
chr22_+_43451351 4.167 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr22_-_29231597 4.140 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr6_+_32021687 4.135 NM_001710
CFB
complement factor B
chr12_+_56114724 4.123 NM_005538
INHBC
inhibin, beta C
chr10_+_114123765 4.103 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_-_11277806 4.063 NM_002762
PRM2
protamine 2
chr17_-_6958695 4.019 ASGR2
asialoglycoprotein receptor 2
chr4_+_100714995 4.015 MTTP
microsomal triglyceride transfer protein
chr17_+_38259620 4.014 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr6_-_31812266 4.011 CLIC1
chloride intracellular channel 1
chr9_-_35804997 3.976 HINT2
histidine triad nucleotide binding protein 2
chr19_+_4104593 3.939 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr9_-_35805040 3.915 NM_032593
HINT2
histidine triad nucleotide binding protein 2
chr1_+_153366928 3.889 NM_004428
NM_182685
EFNA1

ephrin-A1

chr6_-_31812260 3.886 CLIC1
chloride intracellular channel 1
chr19_-_50912429 3.876


chr2_+_10009242 3.871 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr6_-_31812251 3.871 CLIC1
chloride intracellular channel 1
chr17_+_38306339 3.831 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr6_-_31812283 3.825 CLIC1
chloride intracellular channel 1
chr12_-_52975823 3.818 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr5_+_132237253 3.804 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr11_-_60819273 3.789 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr6_-_31812214 3.777 CLIC1
chloride intracellular channel 1
chr12_-_120781002 3.756 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_1346465 3.733 NM_001145210
LOC441869
hypothetical protein LOC441869
chr19_+_18357966 3.695 NM_004864
GDF15
growth differentiation factor 15
chr6_-_31812072 3.674 CLIC1
chloride intracellular channel 1
chr6_-_31812297 3.651 NM_001288
CLIC1
chloride intracellular channel 1
chr6_-_31812049 3.617 CLIC1
chloride intracellular channel 1
chr19_+_876984 3.612 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr3_-_42892636 3.597 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr19_-_15906669 3.592 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr1_+_20751518 3.543 NM_207334
FAM43B
family with sequence similarity 43, member B
chr15_+_63124760 3.529 NM_178859
OSTBETA
organic solute transporter beta
chr17_+_35147738 3.528 GRB7
growth factor receptor-bound protein 7
chr14_+_20226762 3.524 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr6_+_43565192 3.517 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr16_+_29597829 3.492 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr5_-_16791346 3.489 MYO10
myosin X
chr2_+_119841611 3.487 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr1_-_15784048 3.470 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr14_+_22860547 3.446 PABPN1
poly(A) binding protein, nuclear 1
chr17_+_69939130 3.444 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr3_+_187813405 3.439 AHSG
alpha-2-HS-glycoprotein
chr7_-_75461814 3.389 TMEM120A
transmembrane protein 120A
chr2_+_242398832 3.364 NM_001167600
NM_001167601
NEU4

sialidase 4

chr17_-_35331435 3.358 ORMDL3
ORM1-like 3 (S. cerevisiae)
chr19_+_18312365 3.355 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr11_+_22644732 3.354 NM_001143830
GAS2
growth arrest-specific 2
chr12_-_1791146 3.342 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr16_+_31619427 3.335 KIAA0664L3
KIAA0664-like 3
chr11_+_73036241 3.335 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_+_32021899 3.335 CFB
complement factor B
chr20_-_32363268 3.320 NM_001161766
AHCY
adenosylhomocysteinase
chr14_+_22860511 3.319 PABPN1
poly(A) binding protein, nuclear 1
chr4_+_140806536 3.314 MGST2
microsomal glutathione S-transferase 2
chr4_-_1156959 3.302 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr22_+_23333610 3.291 NM_001032365
GGT1
gamma-glutamyltransferase 1
chrX_-_105169370 3.254 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_-_11029882 3.240 MASP2
mannan-binding lectin serine peptidase 2
chr2_+_26422404 3.219 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr17_-_71352090 3.203 UNC13D
unc-13 homolog D (C. elegans)
chr2_-_70329067 3.200 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr16_+_631902 3.190 FAM195A
family with sequence similarity 195, member A
chr3_-_52454082 3.170 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr8_+_144706699 3.159 NM_001166237
GSDMD
gasdermin D
chr17_+_73638430 3.144 NM_152468
TMC8
transmembrane channel-like 8
chr12_-_52975777 3.127 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_+_37972590 3.125 NM_170607
NM_198204
NM_198205
MLX


MAX-like protein X


chr17_+_1593040 3.123 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 2.16e-05 GO:0044281 small molecule metabolic process
1.13 5.41e-05 GO:0008152 metabolic process
1.46 2.01e-04 GO:0055114 oxidation-reduction process
1.28 2.02e-04 GO:0042221 response to chemical stimulus
1.14 2.25e-04 GO:0044237 cellular metabolic process
1.08 2.86e-04 GO:0009987 cellular process
1.50 8.50e-04 GO:0042180 cellular ketone metabolic process
1.49 1.58e-03 GO:0006082 organic acid metabolic process
1.49 1.88e-03 GO:0019752 carboxylic acid metabolic process
1.49 1.88e-03 GO:0043436 oxoacid metabolic process
1.84 5.55e-03 GO:0008202 steroid metabolic process
1.36 2.63e-02 GO:0006629 lipid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 3.10e-10 GO:0044444 cytoplasmic part
1.13 1.20e-08 GO:0005737 cytoplasm
1.44 5.51e-08 GO:0005739 mitochondrion
1.63 8.39e-08 GO:0044429 mitochondrial part
1.66 1.71e-05 GO:0005740 mitochondrial envelope
1.52 1.81e-05 GO:0031967 organelle envelope
1.51 3.39e-05 GO:0031975 envelope
1.15 3.94e-05 GO:0044446 intracellular organelle part
1.15 4.32e-05 GO:0044422 organelle part
1.27 9.80e-05 GO:0031090 organelle membrane
1.38 2.21e-04 GO:0000267 cell fraction
1.61 2.93e-04 GO:0031966 mitochondrial membrane
1.44 3.43e-04 GO:0005624 membrane fraction
1.43 4.06e-04 GO:0005626 insoluble fraction
1.07 4.41e-04 GO:0044424 intracellular part
1.66 2.50e-03 GO:0005743 mitochondrial inner membrane
1.34 2.55e-03 GO:0005783 endoplasmic reticulum
1.24 2.93e-03 GO:0005829 cytosol
1.40 3.81e-03 GO:0044432 endoplasmic reticulum part
1.08 4.76e-03 GO:0043227 membrane-bounded organelle
1.61 5.00e-03 GO:0019866 organelle inner membrane
1.06 5.78e-03 GO:0005622 intracellular
1.71 6.23e-03 GO:0042598 vesicular fraction
1.08 6.61e-03 GO:0043231 intracellular membrane-bounded organelle
1.69 7.93e-03 GO:0005759 mitochondrial matrix
1.68 1.72e-02 GO:0005792 microsome
1.24 3.47e-02 GO:0012505 endomembrane system

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.50 1.33e-04 GO:0016491 oxidoreductase activity
1.73 6.42e-03 GO:0048037 cofactor binding
1.12 3.36e-02 GO:0003824 catalytic activity