Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.907


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA6chr7_-_271538920.601.5e-02Click!
HOXA7chr7_-_271626880.467.0e-02Click!
HOXB7chr17_-_44042924-0.146.1e-01Click!
HOXB6chr17_-_44037332-0.126.5e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_122722674 8.781 NM_005328
 HAS2
hyaluronan synthase 2
chr11_+_101488380 8.105 NM_001195045
 YAP1
Yes-associated protein 1
chr3_-_55489973 6.243 WNT5A
wingless-type MMTV integration site family, member 5A
chr10_-_21847126 6.242


chr1_+_168898898 5.950 PRRX1
paired related homeobox 1
chr7_-_27149750 5.371 NM_019102
 HOXA5
homeobox A5
chr7_-_41709191 5.320 NM_002192
 INHBA
inhibin, beta A
chr10_+_24795446 5.198 KIAA1217
KIAA1217
chr7_-_83662152 5.124 NM_006080
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr10_+_24795465 5.043 KIAA1217
KIAA1217
chr21_-_34820916 4.746 NM_203418
 RCAN1
regulator of calcineurin 1
chr14_+_51025604 4.746 NM_001042481
 FRMD6
FERM domain containing 6
chr9_-_116920232 4.461 NM_002160
 TNC
tenascin C
chr7_+_134226727 4.399 CALD1
caldesmon 1
chr10_+_69539255 4.267 NM_032578
 MYPN
myopalladin
chr7_-_27108826 4.262 NM_006735
 HOXA2
homeobox A2
chr2_-_164300758 4.260 NM_018086
 FIGN
fidgetin
chr18_-_44723116 4.175 NM_001190823
 SMAD7
SMAD family member 7
chr2_+_66516196 4.014 MEIS1
Meis homeobox 1
chr18_+_30544193 3.950 NM_001198941
NM_032978
 DTNA

dystrobrevin, alpha


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 104 entries
enrichment   p-value GO term description
3.22 3.76e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
2.74 2.67e-02 GO:0071363 cellular response to growth factor stimulus
2.62 8.51e-07 GO:0048706 embryonic skeletal system development
2.55 1.86e-11 GO:0007156 homophilic cell adhesion
2.44 4.31e-03 GO:0048634 regulation of muscle organ development
2.44 4.31e-03 GO:0048704 embryonic skeletal system morphogenesis
2.44 6.92e-03 GO:0016202 regulation of striated muscle tissue development
2.38 4.40e-02 GO:0070848 response to growth factor stimulus
2.18 2.46e-02 GO:0022612 gland morphogenesis
1.87 7.58e-08 GO:0016337 cell-cell adhesion
1.86 3.08e-02 GO:0048705 skeletal system morphogenesis
1.82 2.52e-07 GO:0001501 skeletal system development
1.81 1.21e-02 GO:0009952 anterior/posterior pattern formation
1.81 1.94e-02 GO:0043062 extracellular structure organization
1.80 1.03e-02 GO:0001525 angiogenesis
1.77 5.99e-05 GO:0001568 blood vessel development
1.76 1.47e-03 GO:0048514 blood vessel morphogenesis
1.76 6.55e-03 GO:0048732 gland development
1.76 4.74e-02 GO:0048562 embryonic organ morphogenesis
1.75 6.90e-03 GO:0007584 response to nutrient

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.53 2.77e-02 GO:0005581 collagen
2.24 3.13e-02 GO:0031983 vesicle lumen
2.06 1.54e-04 GO:0044420 extracellular matrix part
1.92 2.65e-03 GO:0030016 myofibril
1.88 7.76e-03 GO:0044449 contractile fiber part
1.85 6.25e-03 GO:0043292 contractile fiber
1.74 6.94e-07 GO:0005578 proteinaceous extracellular matrix
1.63 4.91e-02 GO:0005882 intermediate filament
1.62 9.17e-06 GO:0031012 extracellular matrix
1.42 6.02e-08 GO:0044421 extracellular region part
1.40 1.23e-03 GO:0030054 cell junction
1.39 7.47e-05 GO:0005615 extracellular space
1.31 2.66e-09 GO:0005576 extracellular region
1.26 1.98e-16 GO:0005886 plasma membrane
1.26 2.98e-16 GO:0071944 cell periphery
1.22 8.41e-05 GO:0044459 plasma membrane part
1.08 1.01e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.62 1.60e-04 GO:0042562 hormone binding
2.38 1.10e-02 GO:0003707 steroid hormone receptor activity
2.34 1.04e-02 GO:0004879 ligand-dependent nuclear receptor activity
1.88 3.04e-04 GO:0008083 growth factor activity
1.85 2.72e-02 GO:0008201 heparin binding
1.79 1.01e-09 GO:0004984 olfactory receptor activity
1.73 1.17e-03 GO:0000975 regulatory region DNA binding
1.73 1.17e-03 GO:0001067 regulatory region nucleic acid binding
1.73 1.17e-03 GO:0044212 transcription regulatory region DNA binding
1.72 2.32e-03 GO:0010843 promoter binding
1.54 2.02e-10 GO:0004930 G-protein coupled receptor activity
1.53 1.33e-07 GO:0005509 calcium ion binding
1.51 4.65e-07 GO:0043565 sequence-specific DNA binding
1.37 1.95e-07 GO:0004888 transmembrane receptor activity
1.35 8.95e-05 GO:0001071 nucleic acid binding transcription factor activity
1.35 8.95e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.32 6.17e-04 GO:0005102 receptor binding
1.32 7.27e-04 GO:0030528 transcription regulator activity
1.30 7.84e-07 GO:0004872 receptor activity
1.26 5.07e-06 GO:0004871 signal transducer activity