Motif ID: HSF1,2.p2

Z-value: 1.287


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF1chr8_+_1454862450.562.3e-02Click!
HSF2chr6_+_1227623840.312.5e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_152366970 2.224 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr13_+_48582389 2.122 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr14_+_62740878 1.895 NM_020663
RHOJ
ras homolog gene family, member J
chr9_+_130485926 1.827 SET
SET nuclear oncogene
chr20_+_19818209 1.816 NM_018993
RIN2
Ras and Rab interactor 2
chr9_+_130485754 1.790 NM_001122821
SET
SET nuclear oncogene
chr12_-_119172339 1.788 NM_025157
PXN
paxillin
chr17_+_7199178 1.780 NM_198154
TMEM95
transmembrane protein 95
chr6_+_151688327 1.717 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr4_-_153820535 1.682 NM_152680
TMEM154
transmembrane protein 154
chr20_-_17487480 1.663 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr5_-_148422799 1.617 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr7_+_134114957 1.585 CALD1
caldesmon 1
chr3_+_191588354 1.484 NM_006580
CLDN16
claudin 16
chr18_-_44723116 1.480 NM_001190823
SMAD7
SMAD family member 7
chr19_-_54258935 1.457 NM_006179
NTF4
neurotrophin 4
chr16_+_54158084 1.416 NM_032330
CAPNS2
calpain, small subunit 2
chr7_+_134114701 1.339 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr3_+_195336625 1.325 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr11_+_12265022 1.316 NM_032867
MICALCL
MICAL C-terminal like
chr11_-_104411065 1.263 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr8_-_110689396 1.240 SYBU
syntabulin (syntaxin-interacting)
chr6_+_134800533 1.218 LOC154092
hypothetical LOC154092
chr2_+_159533329 1.198 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr18_+_54013575 1.187 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_83662152 1.165 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_1812115 1.143 NM_138567
SYT8
synaptotagmin VIII
chr7_+_134114912 1.134 CALD1
caldesmon 1
chr1_+_157246305 1.130 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_-_80386258 1.110 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_-_116434102 1.092 ABLIM1
actin binding LIM protein 1
chr19_+_40298571 1.059 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr14_-_69953433 1.036 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr2_+_17861266 1.029 NM_001105569
MSGN1
mesogenin 1
chr6_+_31190505 0.972 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr13_+_96672541 0.965 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr12_-_14887648 0.965 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr7_-_80386602 0.961 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr2_-_162808123 0.956 NM_004460
FAP
fibroblast activation protein, alpha
chr3_+_195336631 0.943 HES1
hairy and enhancer of split 1, (Drosophila)
chr12_+_74160779 0.931 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr6_-_56615544 0.930 NM_001723
NM_015548
DST

dystonin

chr6_+_106640903 0.920 PRDM1
PR domain containing 1, with ZNF domain
chr2_+_66516196 0.915 MEIS1
Meis homeobox 1
chr13_+_75232797 0.914 NM_015842
LMO7
LIM domain 7
chr10_-_116434364 0.909 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_-_113259441 0.907 NM_000575
IL1A
interleukin 1, alpha
chr1_+_20788027 0.900 NM_001785
CDA
cytidine deaminase
chr11_-_104344473 0.874 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_-_111995213 0.871 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr13_+_96672705 0.863 MBNL2
muscleblind-like 2 (Drosophila)
chr3_-_115585178 0.857 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_50663089 0.857 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr11_+_65027721 0.850


chr18_-_45630154 0.844 MYO5B
myosin VB
chr3_-_9265592 0.832 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr14_+_104218487 0.814


chr15_+_94670160 0.813 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr12_-_68369322 0.811 NM_152439
BEST3
bestrophin 3
chr4_+_108965167 0.794 NM_001136258
SGMS2
sphingomyelin synthase 2
chr9_-_32516164 0.790 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr8_+_40130143 0.783 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr4_-_22126437 0.776 NM_145290
GPR125
G protein-coupled receptor 125
chr3_-_113842350 0.769 CCDC80
coiled-coil domain containing 80
chr3_-_64648703 0.767 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr2_+_108604111 0.764 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_+_122206455 0.759 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr10_+_94584449 0.750 NM_001013848
EXOC6
exocyst complex component 6
chr14_-_22610572 0.746 ACIN1
apoptotic chromatin condensation inducer 1
chr15_+_47249700 0.740 NM_002044
GALK2
galactokinase 2
chr1_-_148174722 0.727 NM_181873
MTMR11
myotubularin related protein 11
chr16_+_68516401 0.726 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr11_+_27019084 0.725 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr21_-_34820916 0.709 NM_203418
RCAN1
regulator of calcineurin 1
chr3_-_113842553 0.709 CCDC80
coiled-coil domain containing 80
chrX_-_15593074 0.705 NM_020665
TMEM27
transmembrane protein 27
chr4_+_128773529 0.705 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr13_-_32658215 0.702 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_153060722 0.702 NM_025107
MYCT1
myc target 1
chr8_+_22900863 0.698 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr3_-_48607596 0.696 NM_000094
COL7A1
collagen, type VII, alpha 1
chrX_-_33139349 0.685 NM_004006
DMD
dystrophin
chrX_+_135058402 0.676 NM_001159700
FHL1
four and a half LIM domains 1
chr17_+_71174993 0.673 NM_013260
SAP30BP
SAP30 binding protein
chr5_+_149960820 0.671 NM_001166208
SYNPO
synaptopodin
chr1_-_148175345 0.669 MTMR11
myotubularin related protein 11
chr3_+_30623376 0.667 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_-_161614962 0.666 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr3_-_124893875 0.664 MYLK
myosin light chain kinase
chr15_+_60838053 0.658 TLN2
talin 2
chr22_+_39583001 0.657 NM_022098
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr1_+_176577228 0.655 NM_004841
RASAL2
RAS protein activator like 2
chr1_+_143807876 0.653 SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr16_+_4842077 0.651 NM_016936
UBN1
ubinuclein 1
chr3_-_15814678 0.650 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_+_118100977 0.649 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_-_78217278 0.648 FUBP1
far upstream element (FUSE) binding protein 1
chr12_-_27126721 0.645 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr14_-_22610610 0.636 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr6_+_106640881 0.635 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr1_-_148175383 0.635 NM_001145862
MTMR11
myotubularin related protein 11
chrX_-_102828238 0.635 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr12_-_55316350 0.632 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr16_-_73292188 0.628 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr15_-_72981595 0.616 C15orf17
chromosome 15 open reading frame 17
chr12_+_13240868 0.614 NM_001423
EMP1
epithelial membrane protein 1
chr18_+_3441589 0.610 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr4_-_74307637 0.607 ANKRD17
ankyrin repeat domain 17
chr19_+_15079141 0.603 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_+_28088406 0.600 METTL15
methyltransferase like 15
chr8_-_38505331 0.592 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr11_-_6298284 0.591 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chrX_-_31436335 0.585 NM_004014
DMD
dystrophin
chr5_-_94443300 0.577 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr6_-_134540666 0.575 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_75641587 0.559 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr2_-_189752575 0.557 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_188127294 0.556 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr18_+_18003401 0.552 NM_005257
GATA6
GATA binding protein 6
chr7_+_28692122 0.547 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr7_-_27125738 0.543 NM_030661
HOXA3
homeobox A3
chr3_-_113842652 0.536 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr7_-_158304062 0.534 ESYT2
extended synaptotagmin-like protein 2
chr2_-_188127430 0.534 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_-_75641535 0.532 FAM176A
family with sequence similarity 176, member A
chr15_-_79403494 0.532 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr12_-_51200347 0.531 NM_000424
KRT5
keratin 5
chr6_+_10803141 0.531 NM_017906
PAK1IP1
PAK1 interacting protein 1
chr10_+_104525877 0.531 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_-_205272619 0.530 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr10_-_53129315 0.528 NM_015235
CSTF2T
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
chr1_+_144188375 0.526 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr14_-_64479198 0.525 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_151848039 0.523 S100A16
S100 calcium binding protein A16
chr21_+_29439768 0.522 C21orf7
chromosome 21 open reading frame 7
chr15_+_45263517 0.522 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_+_45042754 0.522 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr1_+_149437602 0.519 NM_001135636
NM_001135637
NM_001135638
NM_003557
PIP5K1A



phosphatidylinositol-4-phosphate 5-kinase, type I, alpha



chr6_+_126143971 0.519 NCOA7
nuclear receptor coactivator 7
chr7_+_18515488 0.516 HDAC9
histone deacetylase 9
chr3_+_161877640 0.515 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr3_-_110155237 0.514 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr7_-_104696678 0.510 NM_182691
SRPK2
SRSF protein kinase 2
chr12_-_83830700 0.508 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr17_+_72065440 0.508 LOC100507246
hypothetical LOC100507246
chr17_-_71174816 0.496 NM_004259
NM_001003715
NM_001003716
RECQL5


RecQ protein-like 5


chr2_+_74502364 0.494 NM_032118
WDR54
WD repeat domain 54
chr3_+_113061218 0.494 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr4_-_159863889 0.492 NM_005038
PPID
peptidylprolyl isomerase D
chr7_+_18515440 0.490 HDAC9
histone deacetylase 9
chr14_-_51605695 0.487 NM_007361
NID2
nidogen 2 (osteonidogen)
chr18_-_26996742 0.484 NM_004948
NM_024421
DSC1

desmocollin 1

chr7_+_105304445 0.482 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr3_+_113061330 0.478 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr12_-_83830670 0.475 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr10_+_53744043 0.475 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr11_+_101488380 0.475 NM_001195045
YAP1
Yes-associated protein 1
chr6_+_116939500 0.471 NM_153711
FAM26E
family with sequence similarity 26, member E
chr3_+_102926126 0.470 NM_024548
CEP97
centrosomal protein 97kDa
chr5_-_94442941 0.468 MCTP1
multiple C2 domains, transmembrane 1
chr19_-_54252813 0.465 CGB7
chorionic gonadotropin, beta polypeptide 7
chr19_+_40299058 0.463 FXYD3
FXYD domain containing ion transport regulator 3
chr7_-_33047042 0.462 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr9_-_129381086 0.460 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr6_+_10663934 0.458 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr7_+_27102508 0.453


chr3_+_113061296 0.452 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr7_-_6441109 0.445 DAGLB
diacylglycerol lipase, beta
chr10_+_75343352 0.442 PLAU
plasminogen activator, urokinase
chr18_+_59295123 0.442 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chrX_+_80344253 0.441 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr6_+_47774247 0.436 NM_153838
GPR115
G protein-coupled receptor 115
chr6_+_28342766 0.433 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr9_+_130719034 0.432 LRRC8A
leucine rich repeat containing 8 family, member A
chr2_+_26478280 0.431 NM_145038
CCDC164
coiled-coil domain containing 164
chr11_+_66764064 0.429 KDM2A
lysine (K)-specific demethylase 2A
chr5_+_36644187 0.425 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_40735619 0.424 NM_004294
MTRF1
mitochondrial translational release factor 1
chr17_-_36996611 0.424 NM_000526
KRT14
keratin 14
chr2_-_192419896 0.423 SDPR
serum deprivation response
chr12_+_120055013 0.422 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr2_+_28469864 0.420 FOSL2
FOS-like antigen 2
chr22_-_34564611 0.417 RPL41P5
ribosomal protein L41 pseudogene 5
chr9_-_15240113 0.416 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr20_+_4614796 0.416 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr14_-_22458199 0.416 RBM23
RNA binding motif protein 23
chr19_-_14121728 0.413 LPHN1
latrophilin 1
chr8_-_81246215 0.406 NM_001025253
NM_005079
TPD52

tumor protein D52

chr17_-_15495534 0.405 TRIM16
tripartite motif containing 16
chr2_-_113310796 0.405 NM_000576
IL1B
interleukin 1, beta
chr14_-_51605487 0.403 NID2
nidogen 2 (osteonidogen)
chr14_-_22458134 0.401 RBM23
RNA binding motif protein 23
chr3_+_191714533 0.399 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr19_-_14490160 0.399 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr12_-_84754289 0.398 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr1_-_108032645 0.397 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr8_+_70541412 0.397 NM_001128204
NM_015170
SULF1

sulfatase 1

chr13_-_30634031 0.396 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chr4_-_75123193 0.396 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr8_-_102029997 0.396 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.89 4.11e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.45 1.28e-04 GO:0009653 anatomical structure morphogenesis
1.25 1.42e-04 GO:0032502 developmental process
1.28 1.91e-04 GO:0048856 anatomical structure development
1.59 2.50e-04 GO:0040011 locomotion
1.26 3.75e-04 GO:0007275 multicellular organismal development
1.09 8.78e-04 GO:0009987 cellular process
1.70 1.89e-03 GO:0006928 cellular component movement
1.98 2.24e-03 GO:0001944 vasculature development
1.25 2.53e-03 GO:0016043 cellular component organization
2.02 2.70e-03 GO:0001568 blood vessel development
1.27 4.34e-03 GO:0048731 system development
1.46 5.89e-03 GO:0022607 cellular component assembly
1.23 6.47e-03 GO:0071840 cellular component organization or biogenesis
1.39 9.78e-03 GO:0009966 regulation of signal transduction
1.31 1.11e-02 GO:0048869 cellular developmental process
1.42 1.43e-02 GO:0044085 cellular component biogenesis
2.20 1.96e-02 GO:0001525 angiogenesis
2.03 2.11e-02 GO:0048514 blood vessel morphogenesis
1.26 2.34e-02 GO:0071842 cellular component organization at cellular level
1.67 2.77e-02 GO:0072358 cardiovascular system development
1.67 2.77e-02 GO:0072359 circulatory system development
1.62 4.62e-02 GO:0006935 chemotaxis
1.62 4.62e-02 GO:0042330 taxis
1.56 4.83e-02 GO:0032989 cellular component morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.21 1.42e-03 GO:0070161 anchoring junction
1.43 2.93e-03 GO:0044421 extracellular region part
2.18 6.25e-03 GO:0005912 adherens junction
2.37 1.09e-02 GO:0030055 cell-substrate junction
1.32 1.41e-02 GO:0005856 cytoskeleton
2.37 1.60e-02 GO:0005924 cell-substrate adherens junction
2.39 1.97e-02 GO:0005925 focal adhesion

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 5.62e-09 GO:0005515 protein binding