Motif ID: IKZF1.p2

Z-value: 1.512


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_50314801-0.411.2e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_95720870 1.978 LOC100288748
hypothetical LOC100288748
chr2_-_113310796 1.629 NM_000576
IL1B
interleukin 1, beta
chr5_+_66160359 1.498 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_151855413 1.434 NM_020672
S100A14
S100 calcium binding protein A14
chr1_-_23393808 1.416 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_+_31814709 1.371 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_31814672 1.370 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_117253882 1.344 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr15_+_38923470 1.308 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_26728846 1.267 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_+_20001130 1.256 NM_001111019
NAV2
neuron navigator 2
chr3_+_42176662 1.253 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr4_+_128773529 1.228 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr3_-_139315011 1.188 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr1_+_26728827 1.164 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26728839 1.137 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_+_20000938 1.132 NAV2
neuron navigator 2
chr1_-_207892420 1.130 NM_000228
LAMB3
laminin, beta 3
chr12_+_50913274 1.119 KRT7
keratin 7
chr12_-_56447090 1.116 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_31814712 1.089 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_57599571 1.064 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_208046011 1.047 NM_006147
IRF6
interferon regulatory factor 6
chr1_-_207892296 1.030 NM_001127641
LAMB3
laminin, beta 3
chr2_+_17585287 1.014 NM_003385
VSNL1
visinin-like 1
chr4_+_108965167 1.008 NM_001136258
SGMS2
sphingomyelin synthase 2
chr14_+_64240902 0.975 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_+_50913220 0.954 NM_005556
KRT7
keratin 7
chr6_+_31190505 0.947 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr18_-_26935883 0.930 NM_004949
NM_024422
DSC2

desmocollin 2

chr2_+_17585462 0.925 VSNL1
visinin-like 1
chr15_+_65205107 0.895 NM_001145102
SMAD3
SMAD family member 3
chr14_+_22845851 0.894 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr18_+_3441589 0.892 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr2_+_27705018 0.886 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chr4_+_124537334 0.886 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_-_6473216 0.853 NM_001042664
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr14_+_64240996 0.843 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr22_+_38720881 0.812 NM_138435
FAM83F
family with sequence similarity 83, member F
chr5_+_76150588 0.809 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr8_-_81246215 0.797 NM_001025253
NM_005079
TPD52

tumor protein D52

chr2_-_27705248 0.790 NM_001142683
NM_024584
CCDC121

coiled-coil domain containing 121

chrX_+_117745551 0.762 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr12_+_64504408 0.760 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr19_+_43447262 0.756 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_+_27705366 0.753 NM_007266
GPN1
GPN-loop GTPase 1
chr9_-_15297148 0.745 TTC39B
tetratricopeptide repeat domain 39B
chr18_+_3443771 0.743 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr19_-_56147971 0.743 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr1_+_153366559 0.731 EFNA1
ephrin-A1
chr6_+_150505849 0.730 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr12_-_32940931 0.719 NM_001005242
NM_004572
PKP2

plakophilin 2

chr10_+_96295511 0.716 NM_018063
HELLS
helicase, lymphoid-specific
chr2_+_27705404 0.714 GPN1
GPN-loop GTPase 1
chr12_+_94391952 0.710 NM_006838
METAP2
methionyl aminopeptidase 2
chr3_-_189354510 0.710 LOC339929
hypothetical LOC339929
chr1_+_35020425 0.699 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr17_+_63144500 0.696 NM_015462
NOL11
nucleolar protein 11
chr5_-_125958503 0.696 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr17_+_50333021 0.688 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr2_-_189752575 0.686 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_27062215 0.683 NM_006142
SFN
stratifin
chr17_-_37181636 0.679 JUP
junction plakoglobin
chr22_+_27609889 0.677 NM_032173
ZNRF3
zinc and ring finger 3
chr17_-_57295451 0.668 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr11_+_85017269 0.661 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr2_+_203587807 0.651 NM_001114132
NBEAL1
neurobeachin-like 1
chr18_+_44319365 0.646 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr19_+_43447078 0.644 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_+_76150637 0.640 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr3_+_191714533 0.624 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr3_+_195336631 0.623 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_-_69518119 0.623 NM_015123
FRMD4B
FERM domain containing 4B
chr17_-_7434113 0.623 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_+_181421796 0.622 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_-_120413542 0.609 NOTCH2
notch 2
chr1_+_52380633 0.603 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr15_+_39907447 0.597 NM_001114632
NM_001198588
NM_005090
JMJD7
JMJD7-PLA2G4B

jumonji domain containing 7
JMJD7-PLA2G4B readthrough

chr3_-_69517913 0.591 FRMD4B
FERM domain containing 4B
chr19_-_40693176 0.590 NM_001126059
DMKN
dermokine
chr1_+_202033273 0.589 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr15_+_61123327 0.588 TPM1
tropomyosin 1 (alpha)
chr2_-_238164042 0.587 RAB17
RAB17, member RAS oncogene family
chr5_-_150441150 0.585 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr1_-_94779727 0.584 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_+_125532223 0.579 NM_017956
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr1_-_159257486 0.573 F11R
F11 receptor
chr19_-_50779924 0.569 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr19_-_50779914 0.568 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr19_-_10558906 0.568 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_43446937 0.564 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr1_-_28392966 0.563 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr1_+_143920424 0.562 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr4_+_109033868 0.556 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_-_12561962 0.556 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr6_-_47117951 0.555 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr3_+_143925904 0.549 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr1_+_92268072 0.547 NM_173567
EPHX4
epoxide hydrolase 4
chr10_+_124124196 0.546 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr17_+_35727998 0.542 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr17_+_71154240 0.540 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr1_-_26553168 0.539 NM_001039775
AIM1L
absent in melanoma 1-like
chr1_-_120413698 0.538 NOTCH2
notch 2
chr5_-_16989371 0.533 NM_012334
MYO10
myosin X
chr19_-_10375242 0.525 NM_007065
CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr1_+_32992131 0.524


chr3_-_139317140 0.521 NM_173543
DZIP1L
DAZ interacting protein 1-like
chr21_-_29286982 0.521 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr9_-_40782062 0.519 NM_033160
ZNF658
zinc finger protein 658
chr18_+_59295123 0.510 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_-_38575737 0.509 BRCA1
breast cancer 1, early onset
chr3_+_103029523 0.509 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr19_+_50004134 0.509 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr5_-_16989290 0.509 MYO10
myosin X
chr10_-_62163083 0.508 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr22_-_30388165 0.508 PISD
phosphatidylserine decarboxylase
chr11_+_66580861 0.507 NM_014578
RHOD
ras homolog gene family, member D
chr9_+_115367122 0.507 NM_134427
RGS3
regulator of G-protein signaling 3
chr3_+_11153778 0.507 NM_001098213
HRH1
histamine receptor H1
chr2_-_238164452 0.506 NM_022449
RAB17
RAB17, member RAS oncogene family
chr14_+_73388259 0.505 NM_001146154
NM_001146155
NM_152444
PTGR2


prostaglandin reductase 2


chr12_-_51153788 0.505 NM_173086
KRT6C
keratin 6C
chrX_-_102828238 0.501 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr1_-_120413783 0.500 NOTCH2
notch 2
chr14_-_68514723 0.499 ACTN1
actinin, alpha 1
chr1_-_7998265 0.498 ERRFI1
ERBB receptor feedback inhibitor 1
chr2_-_98646367 0.497 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr9_+_129951552 0.496 NM_005564
LCN2
lipocalin 2
chr19_-_10375185 0.495 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr20_-_1257782 0.493 SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_49552638 0.491 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr17_+_38575939 0.490 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr17_+_35728070 0.488 RARA
retinoic acid receptor, alpha
chr12_+_94135645 0.483 NM_017599
VEZT
vezatin, adherens junctions transmembrane protein
chr14_+_20580224 0.482 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr20_-_1257809 0.480 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr1_+_40769819 0.479 NM_152373
ZNF684
zinc finger protein 684
chr17_+_35728039 0.476 RARA
retinoic acid receptor, alpha
chr19_+_59062982 0.472 MYADM
myeloid-associated differentiation marker
chr3_-_69183926 0.471 NM_007114
TMF1
TATA element modulatory factor 1
chr17_-_58877276 0.469 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr1_-_120413798 0.467 NM_024408
NOTCH2
notch 2
chr7_+_89621624 0.467 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr4_+_169789327 0.465 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr1_+_1971762 0.462 NM_002744
PRKCZ
protein kinase C, zeta
chr22_+_28493351 0.459 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr14_-_69953433 0.458 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr5_+_121325554 0.458 NM_152546
SRFBP1
serum response factor binding protein 1
chr19_+_59062937 0.458 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr1_+_40769877 0.457 ZNF684
zinc finger protein 684
chr12_+_39372456 0.457 NM_001843
NM_175038
CNTN1

contactin 1

chr19_-_50779861 0.455 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr10_+_53744043 0.454 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr19_+_59062962 0.454 MYADM
myeloid-associated differentiation marker
chr15_-_38417564 0.452 C15orf52
chromosome 15 open reading frame 52
chr2_+_95303947 0.452 PROM2
prominin 2
chr1_+_26478799 0.452 NM_031286
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr8_+_95722516 0.450 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr19_-_52427698 0.449 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr22_-_28492990 0.449


chr14_+_38772870 0.446 NM_054024
MIA2
melanoma inhibitory activity 2
chr5_+_79819555 0.444 NM_205548
FAM151B
family with sequence similarity 151, member B
chr11_+_111294868 0.435 C11orf52
chromosome 11 open reading frame 52
chr20_+_43896178 0.429 SNX21
sorting nexin family member 21
chr2_-_165406173 0.429 NM_014900
COBLL1
COBL-like 1
chr17_-_30414789 0.427 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_+_19842309 0.425 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr1_+_203740391 0.424 CDK18
cyclin-dependent kinase 18
chr19_-_10375150 0.423 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr13_-_110011866 0.423 NM_017817
RAB20
RAB20, member RAS oncogene family
chr3_-_12775718 0.420 NM_018306
TMEM40
transmembrane protein 40
chr7_-_22363036 0.420 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_153366928 0.417 NM_004428
NM_182685
EFNA1

ephrin-A1

chr2_-_39201066 0.415 NM_005633
SOS1
son of sevenless homolog 1 (Drosophila)
chr17_+_46067114 0.414 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr12_-_56445653 0.414 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr3_+_173240983 0.413 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr22_+_36531246 0.412 H1F0
H1 histone family, member 0
chr9_+_102231616 0.412 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr18_+_53865455 0.411 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_63609317 0.411 LOC100499466
hypothetical LOC100499466
chr22_-_28492933 0.411 NM_001003692
NM_019103
ZMAT5

zinc finger, matrin-type 5

chr13_-_51878235 0.410 THSD1
thrombospondin, type I, domain containing 1
chr2_-_165406098 0.409 COBLL1
COBL-like 1
chr1_-_199635057 0.404 LAD1
ladinin 1
chr5_-_137695337 0.404 NM_001790
NM_022809
CDC25C

cell division cycle 25 homolog C (S. pombe)

chr19_-_53814173 0.400 NM_000979
RPL18
ribosomal protein L18
chr10_-_46593923 0.399 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr17_-_63965156 0.398 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr17_+_54652609 0.398 NM_001165993
NM_001165994
NM_182569
GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr3_+_195336625 0.397 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr17_-_37181626 0.396


chr9_+_111927601 0.393 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr16_+_15644624 0.392 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr1_+_15123165 0.392 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr8_+_95722575 0.390 ESRP1
epithelial splicing regulatory protein 1
chr17_-_60088773 0.389 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr1_-_70443748 0.388 LRRC40
leucine rich repeat containing 40
chr12_-_51585004 0.386 NM_002273
KRT8
keratin 8
chr10_-_61335967 0.384



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.43e-06 GO:0009987 cellular process
1.45 2.88e-03 GO:0008104 protein localization
1.79 3.84e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.39 4.89e-03 GO:0033036 macromolecule localization
1.63 1.05e-02 GO:0070727 cellular macromolecule localization
1.48 1.49e-02 GO:0033554 cellular response to stress
1.71 1.71e-02 GO:0006886 intracellular protein transport
1.24 1.88e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 2.45e-02 GO:0045184 establishment of protein localization
1.60 2.67e-02 GO:0034613 cellular protein localization
1.21 3.44e-02 GO:0016043 cellular component organization
1.13 3.54e-02 GO:0044237 cellular metabolic process
1.45 4.12e-02 GO:0015031 protein transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 6.45e-09 GO:0005737 cytoplasm
1.20 8.84e-08 GO:0044444 cytoplasmic part
1.39 3.40e-07 GO:0005829 cytosol
1.08 3.37e-05 GO:0005622 intracellular
1.08 1.22e-04 GO:0044424 intracellular part
1.14 5.88e-03 GO:0044446 intracellular organelle part
1.14 7.02e-03 GO:0044422 organelle part
1.09 3.18e-02 GO:0043231 intracellular membrane-bounded organelle
1.09 3.19e-02 GO:0043227 membrane-bounded organelle
1.78 3.48e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 5.11e-04 GO:0005515 protein binding