Motif ID: IRF1,2,7.p3

Z-value: 6.758


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_6056490.793.0e-04Click!
IRF2chr4_-_1856326100.759.2e-04Click!
IRF1chr5_-_1318543250.711.9e-03Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_111900650 48.299 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_78858675 42.800 NM_006820
 IFI44L
interferon-induced protein 44-like
chr10_+_91082218 23.107 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_37518213 21.831 NM_024119
 DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr21_+_41655786 20.367 NM_002463
 LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_157246305 20.343 NM_005531
 IFI16
interferon, gamma-inducible protein 16
chr1_+_938709 17.053 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr7_+_150013716 16.372 NM_015660
 GIMAP2
GTPase, IMAP family member 2
chr3_+_188568861 15.789 NM_022147
 RTP4
receptor (chemosensory) transporter protein 4
chr13_-_42464301 15.294 NM_001002264
NM_033255
 EPSTI1

epithelial stromal interaction 1 (breast)

chr7_+_128367961 14.581 NM_001098627
 IRF5
interferon regulatory factor 5
chr16_-_88358946 13.636 FANCA
Fanconi anemia, complementation group A
chr1_-_25164061 13.611 NM_001031680
 RUNX3
runt-related transcription factor 3
chr6_-_27948065 13.337 NM_003533
 HIST1H3I
histone cluster 1, H3i
chr11_-_605920 12.569 IRF7
interferon regulatory factor 7
chr4_+_142777172 12.528 NM_000585
NM_172174
 IL15

interleukin 15

chr9_+_5500544 12.221 NM_025239
 PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_605998 11.945 NM_001572
NM_004029
 IRF7

interferon regulatory factor 7

chr11_+_5602782 11.855 NM_021616
 TRIM34
tripartite motif containing 34
chr7_+_134483305 11.837 NM_018295
 TMEM140
transmembrane protein 140

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
14.17 1.30e-02 GO:0019883 antigen processing and presentation of endogenous antigen
12.21 8.65e-05 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
10.71 1.49e-24 GO:0034340 response to type I interferon
10.56 1.66e-23 GO:0060337 type I interferon-mediated signaling pathway
10.56 1.66e-23 GO:0071357 cellular response to type I interferon
8.93 4.26e-04 GO:0048002 antigen processing and presentation of peptide antigen
8.60 1.38e-06 GO:0060338 regulation of type I interferon-mediated signaling pathway
8.17 2.11e-02 GO:0050691 regulation of defense response to virus by host
5.95 2.30e-02 GO:0032480 negative regulation of type I interferon production
5.55 1.20e-06 GO:0071346 cellular response to interferon-gamma
5.50 4.94e-21 GO:0019221 cytokine-mediated signaling pathway
5.44 1.33e-05 GO:0060333 interferon-gamma-mediated signaling pathway
5.28 8.69e-16 GO:0009615 response to virus
5.21 5.38e-07 GO:0034341 response to interferon-gamma
5.16 1.76e-20 GO:0071345 cellular response to cytokine stimulus
5.12 9.56e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
5.04 1.22e-04 GO:0060759 regulation of response to cytokine stimulus
4.55 4.23e-02 GO:0032479 regulation of type I interferon production
4.33 3.05e-02 GO:0019882 antigen processing and presentation
4.18 4.48e-02 GO:0002819 regulation of adaptive immune response

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
6.95 1.08e-02 GO:0005839 proteasome core complex

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
6.62 2.31e-02 GO:0004298 threonine-type endopeptidase activity
6.62 2.31e-02 GO:0070003 threonine-type peptidase activity
5.76 6.80e-03 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
2.68 2.96e-03 GO:0005126 cytokine receptor binding