Motif ID: KLF4.p3

Z-value: 3.719


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1092905280.692.8e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_32992131 8.076


chr19_-_6718417 7.906 NM_005490
 SH2D3A
SH2 domain containing 3A
chr19_-_45888259 5.194 NM_004756
 NUMBL
numb homolog (Drosophila)-like
chr5_-_16989371 5.008 NM_012334
 MYO10
myosin X
chr8_-_99906944 4.516 NM_006281
 STK3
serine/threonine kinase 3
chr8_+_1699276 4.421 NM_018941
 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr17_-_37196463 4.413 NM_002230
NM_021991
 JUP

junction plakoglobin

chr11_-_94603857 3.618 NM_144665
 SESN3
sestrin 3
chr1_-_208046011 3.500 NM_006147
 IRF6
interferon regulatory factor 6
chr8_-_127639647 3.433 FAM84B
family with sequence similarity 84, member B
chr5_-_9599157 3.430 NM_003966
 SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_129371171 3.409 NM_022833
 FAM129B
family with sequence similarity 129, member B
chr2_+_24153255 3.371 LOC375190
hypothetical protein LOC375190
chr9_-_129370954 3.314 FAM129B
family with sequence similarity 129, member B
chr18_-_50004458 3.230 MBD2
methyl-CpG binding domain protein 2
chr3_-_46710137 3.162 NM_001190707
NM_147129
 ALS2CL

ALS2 C-terminal like

chr8_-_144887876 3.144 NM_198488
 FAM83H
family with sequence similarity 83, member H
chr22_-_37062114 3.117 CSNK1E
casein kinase 1, epsilon
chr10_-_80875097 3.110 NM_153367
 ZCCHC24
zinc finger, CCHC domain containing 24
chr19_+_54558798 3.054 NM_001197302
NM_001197301
NM_014419
 DKKL1


dickkopf-like 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 73 entries
enrichment   p-value GO term description
1.78 1.58e-02 GO:0051403 stress-activated MAPK cascade
1.45 9.53e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.37 5.94e-03 GO:0000165 MAPKKK cascade
1.33 4.32e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.33 5.63e-05 GO:0048812 neuron projection morphogenesis
1.33 1.48e-04 GO:0007409 axonogenesis
1.31 7.89e-05 GO:0031175 neuron projection development
1.30 2.03e-02 GO:0007411 axon guidance
1.30 3.61e-02 GO:0051347 positive regulation of transferase activity
1.29 4.90e-04 GO:0000904 cell morphogenesis involved in differentiation
1.27 2.05e-03 GO:0032990 cell part morphogenesis
1.27 2.13e-03 GO:0048858 cell projection morphogenesis
1.26 1.18e-04 GO:0030182 neuron differentiation
1.26 1.85e-03 GO:0048666 neuron development
1.25 7.89e-04 GO:0030030 cell projection organization
1.24 3.98e-02 GO:0051338 regulation of transferase activity
1.24 4.66e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.23 8.43e-05 GO:0048699 generation of neurons
1.23 5.03e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.23 2.45e-02 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.31 4.38e-03 GO:0015629 actin cytoskeleton
1.27 4.49e-02 GO:0044456 synapse part
1.26 6.55e-03 GO:0045202 synapse
1.23 2.04e-03 GO:0030054 cell junction
1.20 4.18e-05 GO:0005794 Golgi apparatus
1.20 9.38e-03 GO:0015630 microtubule cytoskeleton
1.18 9.18e-07 GO:0012505 endomembrane system
1.17 3.70e-08 GO:0005829 cytosol
1.17 2.08e-02 GO:0005626 insoluble fraction
1.17 3.35e-02 GO:0005624 membrane fraction
1.15 3.49e-06 GO:0031090 organelle membrane
1.14 1.02e-03 GO:0005856 cytoskeleton
1.13 1.54e-03 GO:0031981 nuclear lumen
1.13 2.35e-02 GO:0005654 nucleoplasm
1.12 6.99e-18 GO:0044444 cytoplasmic part
1.12 1.05e-03 GO:0044428 nuclear part
1.11 1.62e-24 GO:0005737 cytoplasm
1.10 3.52e-10 GO:0044446 intracellular organelle part
1.10 3.85e-10 GO:0005634 nucleus
1.10 8.76e-10 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.21 1.46e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.20 1.63e-03 GO:0016301 kinase activity
1.18 3.04e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.16 1.80e-04 GO:0030554 adenyl nucleotide binding
1.16 2.70e-02 GO:0001071 nucleic acid binding transcription factor activity
1.16 2.70e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.15 2.45e-05 GO:0017076 purine nucleotide binding
1.15 2.80e-05 GO:0032553 ribonucleotide binding
1.15 2.80e-05 GO:0032555 purine ribonucleotide binding
1.15 2.68e-04 GO:0032559 adenyl ribonucleotide binding
1.15 8.48e-04 GO:0005524 ATP binding
1.14 5.14e-06 GO:0000166 nucleotide binding
1.14 1.46e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.13 5.23e-29 GO:0005515 protein binding
1.12 1.14e-02 GO:0016740 transferase activity
1.07 2.35e-24 GO:0005488 binding
1.06 2.16e-02 GO:0003824 catalytic activity