Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 2.329


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L2chr10_+_1146999530.784.1e-04Click!
LEF1chr4_-_109307325-0.543.1e-02Click!
TCF7chr5_+_133478252-0.476.3e-02Click!
TCF7L1chr2_+_852138840.185.0e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_11597530 8.747 NM_148903
 GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_76985538 6.997


chr6_-_128883125 6.708 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_120781002 6.613 NM_002150
 HPD
4-hydroxyphenylpyruvate dioxygenase
chr17_-_60986905 6.036 AXIN2
axin 2
chr3_+_152970904 4.570 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr3_-_150422474 4.388 NM_000096
 CP
ceruloplasmin (ferroxidase)
chr14_-_22521544 4.330 NM_032876
 JUB
jub, ajuba homolog (Xenopus laevis)
chr6_+_167624792 4.308 NM_001143947
NM_018974
 UNC93A

unc-93 homolog A (C. elegans)

chr2_+_228386800 4.269 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr5_-_16791346 4.190 MYO10
myosin X
chr10_+_7785347 3.905 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785360 3.661 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_101488380 3.633 NM_001195045
 YAP1
Yes-associated protein 1
chr2_+_171280046 3.630 NM_001003845
 SP5
Sp5 transcription factor
chr8_+_121892719 3.583


chr10_+_53744043 3.550 NM_012242
 DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_75641587 3.515 NM_001135032
 FAM176A
family with sequence similarity 176, member A
chr10_+_7785331 3.509 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_75641535 3.470 FAM176A
family with sequence similarity 176, member A

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.14 1.40e-02 GO:0005515 protein binding