Motif ID: MSX1,2.p2

Z-value: 1.753


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX1chr4_+_49122720.656.2e-03Click!
MSX2chr5_+_174084137-0.243.8e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_150422474 5.095 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_7785360 5.049 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_115880372 4.793 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7785331 4.574 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_180135559 4.106 NM_001113398
ZNF385B
zinc finger protein 385B
chr21_-_36774257 4.046 NM_001146079
NM_144492
CLDN14

claudin 14

chrX_+_115481774 3.618 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_+_70119785 3.549 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr9_-_115880425 3.375 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_115880281 3.308 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_149245503 3.227 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr9_-_126309510 3.114 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr6_-_48186868 2.908 C6orf138
chromosome 6 open reading frame 138
chr14_-_64479198 2.641 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_-_90645974 2.606 LOC100505994
hypothetical LOC100505994
chr2_-_192420168 2.515 NM_004657
SDPR
serum deprivation response
chr10_+_7785347 2.429 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_52803823 2.317 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chrX_+_115481848 2.272 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_-_74384569 2.117 PLA2G12B
phospholipase A2, group XIIB
chr5_+_59819761 2.105 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr10_+_7785290 2.096 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_-_150578148 2.070 TM4SF1
transmembrane 4 L six family member 1
chr16_-_11918019 2.041 NM_001130007
GSPT1
G1 to S phase transition 1
chrX_-_15530112 2.009 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr10_-_74384485 1.995 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr12_+_108038774 1.992 ACACB
acetyl-CoA carboxylase beta
chr4_+_71096830 1.980 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr4_+_90252990 1.945 NM_145715
TIGD2
tigger transposable element derived 2
chr4_-_159311959 1.943 FAM198B
family with sequence similarity 198, member B
chr1_-_145163520 1.940 FMO5
flavin containing monooxygenase 5
chr7_-_96471544 1.918 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr3_-_150578207 1.871 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr4_-_186970366 1.797 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr17_-_61655915 1.752 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_-_44794146 1.702 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_-_115880366 1.678 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_192419896 1.618 SDPR
serum deprivation response
chr3_+_129690735 1.602


chr1_+_200246370 1.594 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr7_+_116238309 1.566 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_-_108032645 1.476 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_165133239 1.448 GRB14
growth factor receptor-bound protein 14
chr2_+_138438277 1.355 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr6_+_64289585 1.271 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_-_29817841 1.231 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr3_-_121884091 1.228 NM_000187
HGD
homogentisate 1,2-dioxygenase
chrX_+_128966844 1.208 NM_021946
BCORL1
BCL6 corepressor-like 1
chr12_-_69837831 1.160 TSPAN8
tetraspanin 8
chr3_+_9919295 1.149 NM_153483
IL17RE
interleukin 17 receptor E
chr16_+_55042924 1.123 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr12_+_56114724 1.079 NM_005538
INHBC
inhibin, beta C
chr8_-_145613058 1.074 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr12_-_15757114 1.073 EPS8
epidermal growth factor receptor pathway substrate 8
chr13_-_45577144 1.062 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_-_121883647 1.055 HGD
homogentisate 1,2-dioxygenase
chr12_+_49605010 1.050 METTL7A
methyltransferase like 7A
chr13_+_51496679 1.042 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr3_-_150578023 1.021 TM4SF1
transmembrane 4 L six family member 1
chr16_+_55042936 1.013 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr8_-_145613034 1.010 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr10_+_7785235 0.998 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr19_-_14030970 0.969 NM_001145028
PALM3
paralemmin 3
chr5_-_148738980 0.958 NM_014443
IL17B
interleukin 17B
chr4_+_89115862 0.951 SPP1
secreted phosphoprotein 1
chr7_+_111850367 0.950 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr4_+_89115825 0.919 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr2_+_216695062 0.916 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr2_-_237987554 0.895 COL6A3
collagen, type VI, alpha 3
chr3_-_150578103 0.888 TM4SF1
transmembrane 4 L six family member 1
chr2_-_237987579 0.877 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr3_+_9919511 0.874 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr14_-_93324518 0.871 NM_178013
PRIMA1
proline rich membrane anchor 1
chr2_-_237987545 0.850 COL6A3
collagen, type VI, alpha 3
chr2_-_237987553 0.840 COL6A3
collagen, type VI, alpha 3
chr16_-_55042614 0.839 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr22_+_33792125 0.838 NM_001008494
ISX
intestine-specific homeobox
chr12_+_32546243 0.838 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_-_26038817 0.831 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr4_+_89115892 0.815 SPP1
secreted phosphoprotein 1
chr4_-_39199527 0.795 UGDH
UDP-glucose 6-dehydrogenase
chr6_-_24491498 0.792 NM_001195610
DCDC2
doublecortin domain containing 2
chr11_+_101488380 0.788 NM_001195045
YAP1
Yes-associated protein 1
chrX_-_24600661 0.787 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr9_-_115880494 0.779 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_237987509 0.756 COL6A3
collagen, type VI, alpha 3
chr10_-_51678318 0.744 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr5_-_42847716 0.715 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr10_+_685887 0.709 C10orf108
chromosome 10 open reading frame 108
chr9_+_130942029 0.706 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr14_+_20595820 0.703 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr1_-_229071957 0.697 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr21_+_44729875 0.695


chr4_-_155753332 0.667 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr1_+_200246312 0.648 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_+_151456683 0.593 NM_001195571
PRR9
proline rich 9
chr4_+_89115923 0.590 SPP1
secreted phosphoprotein 1
chr17_+_38306339 0.552 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr12_-_110410730 0.551 ATXN2
ataxin 2
chr3_+_25445071 0.549 RARB
retinoic acid receptor, beta
chrX_-_19598912 0.533 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr5_-_59819642 0.503 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_+_39117064 0.493 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr3_-_11660395 0.480 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr8_-_38127489 0.480 NM_000349
STAR
steroidogenic acute regulatory protein
chr20_+_31613800 0.480 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr7_+_94377145 0.477 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr2_-_68952006 0.470 NM_014482
BMP10
bone morphogenetic protein 10
chr5_+_139856688 0.451 ANKHD1
ankyrin repeat and KH domain containing 1
chr10_+_114123828 0.430 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_-_74056083 0.418 NM_145254
TMEM170A
transmembrane protein 170A
chr7_+_80145461 0.413 CD36
CD36 molecule (thrombospondin receptor)
chr5_+_176726918 0.412 RGS14
regulator of G-protein signaling 14
chr6_-_31938572 0.411 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr2_-_162638174 0.400 DPP4
dipeptidyl-peptidase 4
chr6_-_150109324 0.400 NM_198887
NUP43
nucleoporin 43kDa
chr18_+_3584056 0.397 FLJ35776
hypothetical LOC649446
chr4_+_155703581 0.397 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_-_67943157 0.396 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr14_-_23653965 0.389 NRL
neural retina leucine zipper
chr8_-_110689396 0.386 SYBU
syntabulin (syntaxin-interacting)
chr3_+_8518539 0.374 LMCD1
LIM and cysteine-rich domains 1
chr5_+_73145098 0.359 RGNEF
190 kDa guanine nucleotide exchange factor
chr20_+_71230 0.352 NM_030931
DEFB126
defensin, beta 126
chr1_+_150029798 0.351


chr6_+_71192862 0.350 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr6_+_16237264 0.350 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr11_-_114593838 0.349 CADM1
cell adhesion molecule 1
chr17_+_4795128 0.347 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr3_+_68136056 0.340 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr1_+_54132447 0.330 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr2_+_233633348 0.320 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr4_+_71330797 0.318 NM_001145006
MUC7
mucin 7, secreted
chr3_-_71262426 0.303 FOXP1
forkhead box P1
chr3_+_25444753 0.297 NM_016152
RARB
retinoic acid receptor, beta
chr11_-_72141064 0.294 NM_001040118
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_67628749 0.282 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr8_-_27171814 0.281 NM_030795
STMN4
stathmin-like 4
chr17_+_67628763 0.275 SOX9
SRY (sex determining region Y)-box 9
chr11_-_104344473 0.275 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr4_+_74566325 0.274 NM_001133
AFM
afamin
chr1_+_118273869 0.272 WDR3
WD repeat domain 3
chr5_-_178977441 0.271 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_-_31215089 0.267 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr1_-_188713324 0.262 NM_199051
FAM5C
family with sequence similarity 5, member C
chr20_-_34707971 0.259 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr19_-_17236522 0.258 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr8_-_30826074 0.254 NM_031271
TEX15
testis expressed 15
chr2_-_183095308 0.254 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr1_+_40977092 0.251 NFYC
nuclear transcription factor Y, gamma
chr5_-_22248630 0.250 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_+_46591048 0.245 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_205344200 0.242 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr3_+_25444837 0.233 NM_000965
RARB
retinoic acid receptor, beta
chr2_-_21081694 0.233 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_+_80626402 0.232 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_49634048 0.232 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr2_-_51112743 0.230 NRXN1
neurexin 1
chr2_+_114916368 0.229 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr2_-_96238234 0.227 STARD7
StAR-related lipid transfer (START) domain containing 7
chr21_-_31995972 0.227 SCAF4
SR-related CTD-associated factor 4
chr17_+_46176105 0.227 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr6_-_30633349 0.226 NM_005275
GNL1
guanine nucleotide binding protein-like 1
chr20_+_18070867 0.223 NM_020536
CSRP2BP
CSRP2 binding protein
chr6_-_123999640 0.222 NM_006073
TRDN
triadin
chr16_+_80626459 0.220 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_215957927 0.219 FN1
fibronectin 1
chr1_-_118273701 0.219 GDAP2
ganglioside induced differentiation associated protein 2
chr10_-_98315090 0.215 TM9SF3
transmembrane 9 superfamily member 3
chr4_-_157006827 0.210 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr16_+_80626456 0.207 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_3531410 0.206 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr3_-_101316038 0.202 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr22_+_34109095 0.202 HMOX1
heme oxygenase (decycling) 1
chr6_+_16237300 0.197 MYLIP
myosin regulatory light chain interacting protein
chr16_+_31105579 0.195


chr3_-_123584747 0.194 NM_001017928
CCDC58
coiled-coil domain containing 58
chr3_+_189425886 0.194 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_-_68793928 0.191 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr3_-_71262405 0.191 FOXP1
forkhead box P1
chr9_-_85773899 0.190 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr19_-_40696393 0.190 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr9_+_115970599 0.188 COL27A1
collagen, type XXVII, alpha 1
chr20_-_29360048 0.184 NM_001037731
DEFB116
defensin, beta 116
chr3_-_71625318 0.184 FOXP1
forkhead box P1
chr20_-_48686832 0.182 NM_080829
FAM65C
family with sequence similarity 65, member C
chr2_+_102744921 0.177 NM_144632
TMEM182
transmembrane protein 182
chr1_+_31823097 0.176 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_118273887 0.175 NM_006784
WDR3
WD repeat domain 3
chr4_-_44348414 0.174 NM_182592
YIPF7
Yip1 domain family, member 7
chrX_+_119621771 0.173 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr16_-_21197072 0.167 CRYM
crystallin, mu
chr1_-_19089971 0.165 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr5_+_109053034 0.164 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr5_+_140790365 0.163 PCDHGA12
protocadherin gamma subfamily A, 12
chr2_+_162908828 0.163 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr6_+_127940011 0.161 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr2_-_21087435 0.160 APOB
apolipoprotein B (including Ag(x) antigen)
chr15_-_38185865 0.158 NM_033503
BMF
Bcl2 modifying factor
chr1_+_31654998 0.158 NM_001199038
SERINC2
serine incorporator 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.46 4.46e-04 GO:0005626 insoluble fraction
2.38 1.72e-03 GO:0005624 membrane fraction
2.10 3.88e-03 GO:0000267 cell fraction
3.38 1.79e-02 GO:0042598 vesicular fraction
25.25 3.66e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
19.64 9.89e-03 GO:0042301 phosphate binding
13.86 4.45e-02 GO:0043168 anion binding