Motif ID: MTF1.p2

Z-value: 2.928


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_380978110.165.5e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_160964574 8.308 SCHIP1
schwannomin interacting protein 1
chr14_+_105012106 5.922 NM_001312
CRIP2
cysteine-rich protein 2
chr2_-_204108151 4.477 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr10_+_124211353 4.470 HTRA1
HtrA serine peptidase 1
chr9_+_90339835 4.085 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr4_+_108965167 4.070 NM_001136258
SGMS2
sphingomyelin synthase 2
chr16_+_55217180 3.921 MT1E
metallothionein 1E
chr13_-_105985313 3.783 NM_004093
EFNB2
ephrin-B2
chr11_+_35596310 3.758 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr16_+_55217085 3.667 NM_175617
MT1E
metallothionein 1E
chr16_+_55199978 3.666 NM_005953
MT2A
metallothionein 2A
chr10_-_35143900 3.614 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr2_-_40532651 3.306 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_-_135575925 3.270 NM_016201
AMOTL2
angiomotin like 2
chr3_+_61522219 3.063 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr13_-_25523164 2.920 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr3_+_61522310 2.917 PTPRG
protein tyrosine phosphatase, receptor type, G
chr15_-_68933481 2.912 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr15_-_23659329 2.882 NM_024490
ATP10A
ATPase, class V, type 10A
chr6_-_143307976 2.880 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr2_+_54537842 2.829 SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_28469864 2.816 FOSL2
FOS-like antigen 2
chr2_-_238861830 2.774 NM_022817
PER2
period homolog 2 (Drosophila)
chr2_+_28469199 2.730 FOSL2
FOS-like antigen 2
chr16_+_85169615 2.721 NM_005250
FOXL1
forkhead box L1
chr10_+_124210980 2.699 NM_002775
HTRA1
HtrA serine peptidase 1
chr6_+_142664490 2.690 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr14_-_24588916 2.588 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr5_+_14196287 2.560 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr3_+_191714533 2.554 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr13_-_109757442 2.543 NM_001845
COL4A1
collagen, type IV, alpha 1
chr12_-_105056577 2.521 NUAK1
NUAK family, SNF1-like kinase, 1
chr2_+_28469172 2.519 FOSL2
FOS-like antigen 2
chr20_-_10602139 2.507 JAG1
jagged 1
chr8_-_134653194 2.507 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr1_-_223907283 2.469 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr2_-_207739815 2.426 KLF7
Kruppel-like factor 7 (ubiquitous)
chr13_-_20533629 2.413 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr7_+_32963486 2.411 NM_007270
FKBP9
FK506 binding protein 9, 63 kDa
chr1_-_68071635 2.391 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr21_+_41461924 2.374 BACE2
beta-site APP-cleaving enzyme 2
chr4_-_22126437 2.364 NM_145290
GPR125
G protein-coupled receptor 125
chr2_+_20510312 2.336 NM_004040
RHOB
ras homolog gene family, member B
chr5_+_34692239 2.329 RAI14
retinoic acid induced 14
chr19_-_36531958 2.309 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr2_+_28469275 2.301 NM_005253
FOSL2
FOS-like antigen 2
chr12_-_41269679 2.296 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr7_-_27136876 2.289 NM_002141
HOXA4
homeobox A4
chr2_+_235525355 2.274 NM_014521
SH3BP4
SH3-domain binding protein 4
chr2_+_85834111 2.272 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr16_+_87765661 2.260 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr10_-_725522 2.255 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr16_+_12902955 2.223 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr18_-_44731078 2.156 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr10_+_128583984 2.117 NM_001380
DOCK1
dedicator of cytokinesis 1
chr6_+_17501589 2.101 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr13_-_20533703 2.094 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr5_+_34692124 2.082 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr15_+_97010219 2.064 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr1_+_10193267 2.058 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr14_+_73073570 2.058 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr17_-_40263124 2.029 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr2_-_101134146 2.017 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr6_+_89912464 2.001 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr2_+_242146791 1.997 NM_032515
BOK
BCL2-related ovarian killer
chr2_-_160972606 1.990 RBMS1
RNA binding motif, single stranded interacting protein 1
chr8_-_121893468 1.964 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr16_+_27232745 1.941 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr4_-_125853166 1.932 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr5_+_72148173 1.929 NM_002270
TNPO1
transportin 1
chr16_+_27232770 1.908 IL4R
interleukin 4 receptor
chr9_-_93225780 1.907 NFIL3
nuclear factor, interleukin 3 regulated
chr10_+_11100111 1.891 CELF2
CUGBP, Elav-like family member 2
chr14_+_85069217 1.888


chr17_+_32924049 1.883 NM_007026
DUSP14
dual specificity phosphatase 14
chr9_+_136358134 1.882 NM_002957
RXRA
retinoid X receptor, alpha
chr2_+_28469850 1.869 FOSL2
FOS-like antigen 2
chr9_-_83493415 1.863 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr9_+_136358145 1.862 RXRA
retinoid X receptor, alpha
chr2_+_202607554 1.844 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr11_+_17697685 1.839 NM_002478
MYOD1
myogenic differentiation 1
chr8_-_121892877 1.834 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr1_+_208472817 1.817 NM_019605
SERTAD4
SERTA domain containing 4
chr9_-_83494198 1.816 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr9_-_109291575 1.793 KLF4
Kruppel-like factor 4 (gut)
chr8_+_32525269 1.784 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr10_+_99463468 1.772 MARVELD1
MARVEL domain containing 1
chr5_+_34692352 1.761 NM_001145520
RAI14
retinoic acid induced 14
chr6_-_165996031 1.761 LOC100132188
LP7097
chr14_-_88090641 1.754 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr7_-_42243142 1.743 NM_000168
GLI3
GLI family zinc finger 3
chr9_-_94936319 1.743 NM_004148
NINJ1
ninjurin 1
chr15_-_76890626 1.733 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr10_-_63698463 1.730 NM_145307
RTKN2
rhotekin 2
chr1_+_85819004 1.694 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr13_+_109757593 1.689 NM_001846
COL4A2
collagen, type IV, alpha 2
chr3_-_180651874 1.679 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr1_+_181259317 1.678


chr7_-_139123906 1.675 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr14_+_95575319 1.664 C14orf132
chromosome 14 open reading frame 132
chr11_+_35922106 1.657 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr10_+_11100075 1.657 CELF2
CUGBP, Elav-like family member 2
chr17_+_70495318 1.656 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr10_+_6284845 1.648 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr17_-_73867748 1.633 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr8_+_121892719 1.631


chr1_+_52380633 1.626 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr20_-_3944035 1.625 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr21_+_41461597 1.624 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr2_-_168812132 1.614 NM_013233
STK39
serine threonine kinase 39
chr6_+_142665057 1.602 GPR126
G protein-coupled receptor 126
chr8_-_121893449 1.602 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr9_-_133605037 1.596 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr2_+_241586927 1.593 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr4_+_151218862 1.586 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr13_-_43259032 1.583 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr10_+_23768203 1.577 NM_001145373
OTUD1
OTU domain containing 1
chr12_+_26003218 1.568 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr7_+_27102508 1.565


chr11_+_101485946 1.564 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr4_+_148872902 1.562 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr3_+_61522922 1.559 PTPRG
protein tyrosine phosphatase, receptor type, G
chr2_+_173000590 1.555 ITGA6
integrin, alpha 6
chr17_-_61618276 1.547 NM_145036
CCDC46
coiled-coil domain containing 46
chr12_+_95112131 1.545 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr16_-_63713382 1.537 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chrX_+_149282097 1.529 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr16_-_63713466 1.521 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr8_+_22513043 1.510 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr16_-_63713485 1.504 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr8_-_48813236 1.499 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr14_+_66777578 1.497 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr3_-_48607596 1.493 NM_000094
COL7A1
collagen, type VII, alpha 1
chr3_-_180652024 1.493 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr12_+_6179736 1.492 NM_001769
CD9
CD9 molecule
chrX_-_57953578 1.489 NM_007156
ZXDA
zinc finger, X-linked, duplicated A
chr7_+_116099648 1.484 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr17_+_58058783 1.474 MRC2
mannose receptor, C type 2
chr9_-_34448477 1.443 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr8_-_121893196 1.442


chr11_+_69165159 1.442 CCND1
cyclin D1
chrX_+_117745551 1.440 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr15_+_29406335 1.434 NM_015995
KLF13
Kruppel-like factor 13
chr21_+_36429079 1.433 NM_001236
CBR3
carbonyl reductase 3
chr10_-_33663984 1.432 NRP1
neuropilin 1
chr19_+_61742111 1.427 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr9_+_96807107 1.423 C9orf3
chromosome 9 open reading frame 3
chr6_-_3697244 1.421 NM_183373
C6orf145
chromosome 6 open reading frame 145
chr6_-_139351084 1.411 NM_001128617
NM_031922
REPS1

RALBP1 associated Eps domain containing 1

chr2_-_105381855 1.396 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr6_+_17389752 1.393 NM_001143942
RBM24
RNA binding motif protein 24
chr9_+_35479989 1.391 NM_014806
RUSC2
RUN and SH3 domain containing 2
chr8_-_82186832 1.388 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr3_+_137167296 1.387 PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr1_+_6767968 1.375 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr1_+_216586199 1.373 TGFB2
transforming growth factor, beta 2
chr13_-_76358433 1.364 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr9_+_96806235 1.363 C9orf3
chromosome 9 open reading frame 3
chr3_-_185025989 1.363 NM_024871
MAP6D1
MAP6 domain containing 1
chr12_+_56406296 1.357 LOC100130776
hypothetical LOC100130776
chr6_+_3697328 1.357


chr2_+_36436316 1.354 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_+_144040751 1.351 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_-_206484258 1.350 NM_025179
PLXNA2
plexin A2
chr17_-_39211706 1.333 NM_004090
DUSP3
dual specificity phosphatase 3
chr6_-_139351032 1.313 REPS1
RALBP1 associated Eps domain containing 1
chr18_-_12647736 1.309 SPIRE1
spire homolog 1 (Drosophila)
chr3_+_184454286 1.305 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr15_-_29070909 1.303 NM_017762
MTMR10
myotubularin related protein 10
chr3_-_48445719 1.293 NM_002673
PLXNB1
plexin B1
chr2_-_210744158 1.281 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr7_-_81910956 1.281 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr20_-_10602429 1.281 NM_000214
JAG1
jagged 1
chr8_+_67787206 1.280 SGK3
serum/glucocorticoid regulated kinase family, member 3
chr1_-_167721723 1.277 NM_006996
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr12_+_13045702 1.274 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr2_+_238060602 1.273 NM_001042467
NM_024101
MLPH

melanophilin

chr11_+_32068990 1.264 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr7_+_288195 1.262 FAM20C
family with sequence similarity 20, member C
chr2_+_56264627 1.261 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr8_-_120033240 1.258 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr11_+_32069183 1.257 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr8_-_143805371 1.255 LOC100288181
hypothetical LOC100288181
chr3_+_32408346 1.253 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr22_-_23318829 1.253 NM_207644
C22orf36
chromosome 22 open reading frame 36
chr11_+_76455574 1.252 NM_004055
CAPN5
calpain 5
chr3_+_137167153 1.251 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr12_-_29827952 1.247 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr9_-_112840064 1.246 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chrX_-_34585287 1.246 NM_031442
TMEM47
transmembrane protein 47
chr6_-_170442090 1.241


chr7_+_30291029 1.239 ZNRF2
zinc and ring finger 2
chr17_+_7195931 1.236 NM_001002914
KCTD11
potassium channel tetramerisation domain containing 11
chr7_-_525336 1.234 PDGFA
platelet-derived growth factor alpha polypeptide
chr13_-_76358370 1.225 KCTD12
potassium channel tetramerisation domain containing 12
chr6_-_16869579 1.225 NM_000332
NM_001128164
ATXN1

ataxin 1

chr6_-_150226854 1.220 LRP11
low density lipoprotein receptor-related protein 11
chr11_-_118286822 1.219 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr3_+_32408155 1.218 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7

chr1_+_116320698 1.216 SLC22A15
solute carrier family 22, member 15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.63 5.75e-17 GO:0022008 neurogenesis
1.48 1.18e-16 GO:0007399 nervous system development
1.64 4.13e-16 GO:0048699 generation of neurons
1.10 1.15e-14 GO:0009987 cellular process
1.27 3.79e-14 GO:0007275 multicellular organismal development
1.25 8.55e-14 GO:0032502 developmental process
1.36 2.51e-13 GO:0030154 cell differentiation
1.40 3.01e-12 GO:0023051 regulation of signaling
1.34 4.24e-12 GO:0048869 cellular developmental process
1.27 4.33e-12 GO:0048856 anatomical structure development
1.28 5.86e-12 GO:0048731 system development
1.61 1.62e-11 GO:0030182 neuron differentiation
1.42 2.04e-11 GO:0009966 regulation of signal transduction
1.14 2.14e-11 GO:0050789 regulation of biological process
1.72 4.43e-11 GO:0031175 neuron projection development
1.40 5.32e-11 GO:0009653 anatomical structure morphogenesis
1.30 6.74e-11 GO:0048519 negative regulation of biological process
1.32 7.39e-11 GO:0048523 negative regulation of cellular process
1.15 8.93e-11 GO:0050794 regulation of cellular process
1.13 1.64e-10 GO:0065007 biological regulation
1.70 3.08e-10 GO:0000904 cell morphogenesis involved in differentiation
1.74 3.78e-10 GO:0048812 neuron projection morphogenesis
1.63 1.29e-09 GO:0048666 neuron development
1.74 1.65e-09 GO:0007409 axonogenesis
1.72 1.80e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.58 3.84e-09 GO:0030030 cell projection organization
1.38 2.35e-08 GO:0051239 regulation of multicellular organismal process
1.46 3.06e-08 GO:0048468 cell development
1.55 3.73e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.48 4.04e-08 GO:0051128 regulation of cellular component organization
1.56 4.55e-08 GO:0032989 cellular component morphogenesis
1.45 4.94e-08 GO:0050793 regulation of developmental process
1.50 6.24e-08 GO:2000026 regulation of multicellular organismal development
1.57 7.14e-08 GO:0000902 cell morphogenesis
1.21 1.02e-07 GO:0016043 cellular component organization
1.61 1.22e-07 GO:0048858 cell projection morphogenesis
1.30 1.28e-07 GO:0048583 regulation of response to stimulus
1.61 1.33e-07 GO:0032990 cell part morphogenesis
1.24 1.78e-07 GO:0071842 cellular component organization at cellular level
1.41 1.80e-07 GO:0010646 regulation of cell communication
1.75 2.12e-07 GO:0007411 axon guidance
1.19 2.96e-07 GO:0023052 signaling
1.23 9.12e-07 GO:0048518 positive regulation of biological process
1.50 9.75e-07 GO:0045595 regulation of cell differentiation
1.20 1.07e-06 GO:0071840 cellular component organization or biogenesis
1.24 1.28e-06 GO:0048522 positive regulation of cellular process
1.20 1.56e-06 GO:0060255 regulation of macromolecule metabolic process
1.28 1.60e-06 GO:0006464 protein modification process
1.23 1.79e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.48 2.31e-06 GO:0009790 embryo development
1.13 2.46e-06 GO:0044237 cellular metabolic process
1.57 5.71e-06 GO:0072358 cardiovascular system development
1.57 5.71e-06 GO:0072359 circulatory system development
1.70 5.95e-06 GO:0060284 regulation of cell development
1.19 6.01e-06 GO:0007165 signal transduction
1.27 6.66e-06 GO:0043412 macromolecule modification
1.61 7.00e-06 GO:0009968 negative regulation of signal transduction
1.19 7.19e-06 GO:0080090 regulation of primary metabolic process
1.59 7.77e-06 GO:0023057 negative regulation of signaling
1.71 7.96e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.16 1.05e-05 GO:0044260 cellular macromolecule metabolic process
1.56 1.51e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.57 1.81e-05 GO:0010648 negative regulation of cell communication
1.18 1.81e-05 GO:0031323 regulation of cellular metabolic process
1.53 1.94e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.45 2.40e-05 GO:0019220 regulation of phosphate metabolic process
1.45 2.40e-05 GO:0051174 regulation of phosphorus metabolic process
1.16 2.51e-05 GO:0051716 cellular response to stimulus
1.45 2.70e-05 GO:0042325 regulation of phosphorylation
1.70 3.89e-05 GO:0001944 vasculature development
1.46 4.32e-05 GO:0001932 regulation of protein phosphorylation
1.16 4.33e-05 GO:0019222 regulation of metabolic process
2.03 8.16e-05 GO:0022604 regulation of cell morphogenesis
1.53 1.30e-04 GO:0051094 positive regulation of developmental process
2.41 1.68e-04 GO:0042326 negative regulation of phosphorylation
2.01 1.68e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.67 2.38e-04 GO:0061061 muscle structure development
1.49 2.46e-04 GO:0048585 negative regulation of response to stimulus
2.34 3.04e-04 GO:0010563 negative regulation of phosphorus metabolic process
2.34 3.04e-04 GO:0045936 negative regulation of phosphate metabolic process
1.70 3.74e-04 GO:0050767 regulation of neurogenesis
1.65 4.97e-04 GO:0051960 regulation of nervous system development
1.10 5.83e-04 GO:0008152 metabolic process
1.13 7.99e-04 GO:0043170 macromolecule metabolic process
1.58 8.99e-04 GO:0045597 positive regulation of cell differentiation
1.11 9.72e-04 GO:0044238 primary metabolic process
1.55 9.98e-04 GO:0043009 chordate embryonic development
1.54 1.07e-03 GO:0009792 embryo development ending in birth or egg hatching
1.35 1.27e-03 GO:0040011 locomotion
2.03 1.77e-03 GO:0010720 positive regulation of cell development
1.55 1.99e-03 GO:0007389 pattern specification process
1.62 2.31e-03 GO:0001568 blood vessel development
1.35 2.60e-03 GO:0031399 regulation of protein modification process
1.30 2.85e-03 GO:0051246 regulation of protein metabolic process
1.31 3.03e-03 GO:0032879 regulation of localization
1.58 3.15e-03 GO:0051130 positive regulation of cellular component organization
2.45 3.71e-03 GO:0001933 negative regulation of protein phosphorylation
2.18 4.09e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.33 5.01e-03 GO:0008219 cell death
1.89 7.13e-03 GO:0014706 striated muscle tissue development
1.30 7.31e-03 GO:0032268 regulation of cellular protein metabolic process
1.32 7.54e-03 GO:0016265 death
1.30 8.80e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.39 9.60e-03 GO:0010629 negative regulation of gene expression
1.83 1.01e-02 GO:0060537 muscle tissue development
1.67 1.07e-02 GO:0045664 regulation of neuron differentiation
1.84 1.09e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.84 1.09e-02 GO:0042692 muscle cell differentiation
1.25 1.26e-02 GO:0033036 macromolecule localization
1.29 1.40e-02 GO:0006793 phosphorus metabolic process
1.29 1.40e-02 GO:0006796 phosphate metabolic process
1.46 1.52e-02 GO:0040008 regulation of growth
1.56 1.54e-02 GO:0035295 tube development
1.29 1.54e-02 GO:0009892 negative regulation of metabolic process
1.59 1.55e-02 GO:0030036 actin cytoskeleton organization
1.35 1.60e-02 GO:0009890 negative regulation of biosynthetic process
1.27 1.67e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.30 1.69e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.31 1.82e-02 GO:0009888 tissue development
1.86 1.95e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.35 2.14e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.39 2.63e-02 GO:0023056 positive regulation of signaling
1.40 2.74e-02 GO:0006935 chemotaxis
1.40 2.74e-02 GO:0042330 taxis
1.64 2.76e-02 GO:0044087 regulation of cellular component biogenesis
1.14 2.89e-02 GO:0051179 localization
1.82 3.14e-02 GO:0010975 regulation of neuron projection development
1.30 3.57e-02 GO:0045184 establishment of protein localization
1.27 3.58e-02 GO:0008104 protein localization
1.33 3.60e-02 GO:0006468 protein phosphorylation
1.35 4.26e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
3.41 4.28e-02 GO:0002040 sprouting angiogenesis
1.29 4.30e-02 GO:0031324 negative regulation of cellular metabolic process
1.38 4.66e-02 GO:0010647 positive regulation of cell communication
1.16 4.82e-02 GO:0044267 cellular protein metabolic process
2.96 4.84e-02 GO:0016441 posttranscriptional gene silencing
2.96 4.84e-02 GO:0035194 posttranscriptional gene silencing by RNA
1.35 4.95e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 2.48e-22 GO:0005622 intracellular
1.11 6.77e-22 GO:0044424 intracellular part
1.14 1.25e-15 GO:0005737 cytoplasm
1.11 2.18e-12 GO:0043226 organelle
1.11 6.12e-12 GO:0043229 intracellular organelle
1.11 2.43e-09 GO:0043227 membrane-bounded organelle
1.10 3.15e-09 GO:0043231 intracellular membrane-bounded organelle
1.14 5.42e-07 GO:0005634 nucleus
1.04 8.93e-07 GO:0044464 cell part
1.04 9.57e-07 GO:0005623 cell
1.13 1.51e-06 GO:0044444 cytoplasmic part
1.83 2.61e-04 GO:0005912 adherens junction
1.20 4.37e-04 GO:0005829 cytosol
1.74 1.20e-03 GO:0070161 anchoring junction
1.70 1.31e-03 GO:0031252 cell leading edge
1.23 1.70e-03 GO:0005856 cytoskeleton
1.57 6.41e-03 GO:0016323 basolateral plasma membrane
1.49 9.51e-03 GO:0015629 actin cytoskeleton
1.84 1.24e-02 GO:0005924 cell-substrate adherens junction
1.81 1.50e-02 GO:0030055 cell-substrate junction
1.84 1.91e-02 GO:0005925 focal adhesion
1.19 4.06e-02 GO:0012505 endomembrane system

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 9.41e-14 GO:0005515 protein binding
1.08 3.83e-12 GO:0005488 binding
1.42 5.71e-04 GO:0008092 cytoskeletal protein binding
1.46 9.94e-04 GO:0019904 protein domain specific binding
2.53 1.23e-03 GO:0046332 SMAD binding
1.86 1.22e-02 GO:0019207 kinase regulator activity
1.31 1.48e-02 GO:0019899 enzyme binding
1.18 2.02e-02 GO:0032553 ribonucleotide binding
1.18 2.02e-02 GO:0032555 purine ribonucleotide binding
1.19 2.08e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.18 2.23e-02 GO:0017076 purine nucleotide binding
1.90 2.31e-02 GO:0019887 protein kinase regulator activity
1.47 2.31e-02 GO:0016563 transcription activator activity
1.54 2.70e-02 GO:0019787 small conjugating protein ligase activity
1.47 2.75e-02 GO:0016564 transcription repressor activity
1.25 4.44e-02 GO:0001071 nucleic acid binding transcription factor activity
1.25 4.44e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.16 4.66e-02 GO:0000166 nucleotide binding