Motif ID: MTF1.p2

Z-value: 2.928


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_380978110.165.5e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_160964574 8.308 SCHIP1
schwannomin interacting protein 1
chr14_+_105012106 5.922 NM_001312
 CRIP2
cysteine-rich protein 2
chr2_-_204108151 4.477 NM_203365
NM_213589
 RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr10_+_124211353 4.470 HTRA1
HtrA serine peptidase 1
chr9_+_90339835 4.085 NM_001161625
NM_145283
 NXNL2

nucleoredoxin-like 2

chr4_+_108965167 4.070 NM_001136258
 SGMS2
sphingomyelin synthase 2
chr16_+_55217180 3.921 MT1E
metallothionein 1E
chr13_-_105985313 3.783 NM_004093
 EFNB2
ephrin-B2
chr11_+_35596310 3.758 NM_014344
 FJX1
four jointed box 1 (Drosophila)
chr16_+_55217085 3.667 NM_175617
 MT1E
metallothionein 1E
chr16_+_55199978 3.666 NM_005953
 MT2A
metallothionein 2A
chr10_-_35143900 3.614 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
 PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr2_-_40532651 3.306 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_-_135575925 3.270 NM_016201
 AMOTL2
angiomotin like 2
chr3_+_61522219 3.063 NM_002841
 PTPRG
protein tyrosine phosphatase, receptor type, G
chr13_-_25523164 2.920 NM_001007538
 SHISA2
shisa homolog 2 (Xenopus laevis)
chr3_+_61522310 2.917 PTPRG
protein tyrosine phosphatase, receptor type, G
chr15_-_68933481 2.912 NM_018357
NM_197958
 LARP6

La ribonucleoprotein domain family, member 6

chr15_-_23659329 2.882 NM_024490
 ATP10A
ATPase, class V, type 10A
chr6_-_143307976 2.880 NM_006734
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 138 entries
enrichment   p-value GO term description
3.41 4.28e-02 GO:0002040 sprouting angiogenesis
2.96 4.84e-02 GO:0016441 posttranscriptional gene silencing
2.96 4.84e-02 GO:0035194 posttranscriptional gene silencing by RNA
2.45 3.71e-03 GO:0001933 negative regulation of protein phosphorylation
2.41 1.68e-04 GO:0042326 negative regulation of phosphorylation
2.34 3.04e-04 GO:0010563 negative regulation of phosphorus metabolic process
2.34 3.04e-04 GO:0045936 negative regulation of phosphate metabolic process
2.18 4.09e-03 GO:0007173 epidermal growth factor receptor signaling pathway
2.03 8.16e-05 GO:0022604 regulation of cell morphogenesis
2.03 1.77e-03 GO:0010720 positive regulation of cell development
2.01 1.68e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.89 7.13e-03 GO:0014706 striated muscle tissue development
1.86 1.95e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.84 1.09e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.84 1.09e-02 GO:0042692 muscle cell differentiation
1.83 1.01e-02 GO:0060537 muscle tissue development
1.82 3.14e-02 GO:0010975 regulation of neuron projection development
1.75 2.12e-07 GO:0007411 axon guidance
1.74 3.78e-10 GO:0048812 neuron projection morphogenesis
1.74 1.65e-09 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
1.84 1.24e-02 GO:0005924 cell-substrate adherens junction
1.84 1.91e-02 GO:0005925 focal adhesion
1.83 2.61e-04 GO:0005912 adherens junction
1.81 1.50e-02 GO:0030055 cell-substrate junction
1.74 1.20e-03 GO:0070161 anchoring junction
1.70 1.31e-03 GO:0031252 cell leading edge
1.57 6.41e-03 GO:0016323 basolateral plasma membrane
1.49 9.51e-03 GO:0015629 actin cytoskeleton
1.23 1.70e-03 GO:0005856 cytoskeleton
1.20 4.37e-04 GO:0005829 cytosol
1.19 4.06e-02 GO:0012505 endomembrane system
1.14 1.25e-15 GO:0005737 cytoplasm
1.14 5.42e-07 GO:0005634 nucleus
1.13 1.51e-06 GO:0044444 cytoplasmic part
1.11 2.48e-22 GO:0005622 intracellular
1.11 6.77e-22 GO:0044424 intracellular part
1.11 2.18e-12 GO:0043226 organelle
1.11 6.12e-12 GO:0043229 intracellular organelle
1.11 2.43e-09 GO:0043227 membrane-bounded organelle
1.10 3.15e-09 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
2.53 1.23e-03 GO:0046332 SMAD binding
1.90 2.31e-02 GO:0019887 protein kinase regulator activity
1.86 1.22e-02 GO:0019207 kinase regulator activity
1.54 2.70e-02 GO:0019787 small conjugating protein ligase activity
1.47 2.31e-02 GO:0016563 transcription activator activity
1.47 2.75e-02 GO:0016564 transcription repressor activity
1.46 9.94e-04 GO:0019904 protein domain specific binding
1.42 5.71e-04 GO:0008092 cytoskeletal protein binding
1.31 1.48e-02 GO:0019899 enzyme binding
1.25 4.44e-02 GO:0001071 nucleic acid binding transcription factor activity
1.25 4.44e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 2.08e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.18 2.02e-02 GO:0032553 ribonucleotide binding
1.18 2.02e-02 GO:0032555 purine ribonucleotide binding
1.18 2.23e-02 GO:0017076 purine nucleotide binding
1.16 4.66e-02 GO:0000166 nucleotide binding
1.15 9.41e-14 GO:0005515 protein binding
1.08 3.83e-12 GO:0005488 binding