Motif ID: NFE2L2.p2

Z-value: 2.436


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1778375400.533.5e-02Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_977163 7.056 NM_022042
NM_134425
NM_213613
 SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr16_+_2023279 5.359 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_-_76538859 4.895 NM_001007271
NM_001007272
NM_001007273
 DUSP13


dual specificity phosphatase 13


chr19_-_54350457 4.417 NM_002152
 HRC
histidine rich calcium binding protein
chr20_-_581844 4.211 NM_080725
 SRXN1
sulfiredoxin 1
chr22_+_43451600 4.144 PRR5
proline rich 5 (renal)
chr22_+_19699441 4.037 NM_001159554
NM_005446
 P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr11_+_118463906 3.836 NM_001024382
 HMBS
hydroxymethylbilane synthase
chr1_+_153232685 3.727 NM_018655
 LENEP
lens epithelial protein
chr8_-_11242408 3.685 LOC100129129
hypothetical LOC100129129
chr22_+_43451351 3.618 NM_001017530
NM_001198721
NM_015366
 PRR5


proline rich 5 (renal)


chrX_-_100527799 3.597 NM_000061
 BTK
Bruton agammaglobulinemia tyrosine kinase
chr1_-_156923111 3.577 NM_003126
 SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_37926943 3.551 EPDR1
ependymin related protein 1 (zebrafish)
chrX_-_154216929 3.547 NM_001289
 CLIC2
chloride intracellular channel 2
chr6_+_150112537 3.474 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_-_30704762 3.451 GSR
glutathione reductase
chr16_-_1369613 3.408 NM_001193389
NM_023076
 UNKL

unkempt homolog (Drosophila)-like

chrX_+_9391314 3.352 NM_001139466
NM_001139467
NM_001139468
 TBL1X


transducin (beta)-like 1X-linked


chr16_+_88515917 3.334 NM_001197181
 TUBB3
tubulin, beta 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
5.69 1.72e-04 GO:0006521 regulation of cellular amino acid metabolic process
4.94 1.14e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.94 1.14e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
4.94 1.14e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.94 1.14e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.94 1.14e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.94 1.14e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
4.94 1.14e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.94 1.14e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.74 2.84e-02 GO:0032313 regulation of Rab GTPase activity
4.74 2.84e-02 GO:0032483 regulation of Rab protein signal transduction
4.71 2.12e-03 GO:0033238 regulation of cellular amine metabolic process
4.71 2.12e-03 GO:0071158 positive regulation of cell cycle arrest
4.55 1.42e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.46 3.49e-04 GO:0051351 positive regulation of ligase activity
4.43 4.60e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.19 4.22e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.18 2.09e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.14 5.00e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
4.04 6.97e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
5.13 4.46e-05 GO:0000502 proteasome complex
1.39 1.59e-02 GO:0044459 plasma membrane part
1.28 4.31e-03 GO:0005886 plasma membrane
1.28 5.83e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
4.64 7.93e-03 GO:0005097 Rab GTPase activator activity
2.06 2.54e-02 GO:0004175 endopeptidase activity