Motif ID: NFKB1_REL_RELA.p2

Z-value: 4.919


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RELchr2_+_609622790.665.7e-03Click!
NFKB1chr4_+_1036417620.657.0e-03Click!
RELAchr11_-_651870030.449.1e-02Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_104145421 11.717 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_162883062 9.804 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr11_+_101693403 9.753 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr19_+_4180494 9.073 NM_005755
EBI3
Epstein-Barr virus induced 3
chr10_+_104144218 8.980 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr17_+_35277942 8.574 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr2_+_219453487 8.010 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr20_-_4743768 7.974 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr16_+_49333513 7.934 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr16_+_49333461 7.871 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr19_-_6542012 7.864 CD70
CD70 molecule
chr2_-_231498184 7.143 NM_005683
GPR55
G protein-coupled receptor 55
chr17_+_22823151 6.792 NM_014238
KSR1
kinase suppressor of ras 1
chr3_-_58175437 6.594 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr16_+_49288550 6.433 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr6_+_30958672 6.131 DDR1
discoidin domain receptor tyrosine kinase 1
chr6_+_116798791 5.927 NM_013352
DSE
dermatan sulfate epimerase
chr1_-_207892420 5.797 NM_000228
LAMB3
laminin, beta 3
chr9_+_126094067 5.614 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr15_+_83724743 5.612 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr9_+_126094388 5.547 NM_001166169
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr3_-_113334657 5.479 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr8_-_70909754 5.190 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr19_-_7672978 5.032 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr11_-_64327197 4.905 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr14_+_102313566 4.841 NM_003300
NM_145725
NM_145726
TRAF3


TNF receptor-associated factor 3


chr19_+_47073029 4.737 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr19_+_3087026 4.702 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr14_+_102313585 4.673 TRAF3
TNF receptor-associated factor 3
chr15_+_79376295 4.604 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr5_+_10617431 4.578 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr22_-_35875890 4.532 NM_000878
IL2RB
interleukin 2 receptor, beta
chr14_-_95250155 4.428 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr19_-_4782711 4.385 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chrX_-_30505804 4.373 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_-_207891264 4.361 NM_001017402
LAMB3
laminin, beta 3
chr5_-_149772469 4.231 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr5_-_149772528 4.230


chr6_+_32713160 4.106 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_+_123279439 3.999 NM_006889
CD86
CD86 molecule
chr9_-_135334003 3.976 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr19_-_48976852 3.966 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_6542082 3.930 CD70
CD70 molecule
chr12_-_55790355 3.920 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr7_-_44985084 3.856 MYO1G
myosin IG
chr17_+_19999784 3.806 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr10_+_12431477 3.795 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr18_+_22060383 3.758 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr14_+_75058518 3.645 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr19_-_4289750 3.585 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr6_-_31432934 3.569 HLA-B
major histocompatibility complex, class I, B
chr17_-_16816113 3.567 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr14_+_75058591 3.547 BATF
basic leucine zipper transcription factor, ATF-like
chr17_-_59172852 3.543 STRADA
STE20-related kinase adaptor alpha
chr11_-_3818759 3.495 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr22_-_42539399 3.437 NM_022785
NM_198856
EFCAB6

EF-hand calcium binding domain 6

chr19_+_5082230 3.403 KDM4B
lysine (K)-specific demethylase 4B
chr20_+_44180296 3.389 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr19_+_45389356 3.355 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr2_+_208102860 3.348 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr8_-_11361594 3.331 NM_053279
FAM167A
family with sequence similarity 167, member A
chr10_-_134940315 3.281 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr10_-_105427898 3.241 SH3PXD2A
SH3 and PX domains 2A
chr16_-_21221872 3.192 NM_001014444
NM_001888
CRYM

crystallin, mu

chr19_-_48977247 3.187 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr8_-_11096257 3.184 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr11_+_66580884 3.180 RHOD
ras homolog gene family, member D
chr1_+_6767968 3.178 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr5_+_56505412 3.155 NM_022913
GPBP1
GC-rich promoter binding protein 1
chr11_+_120828058 3.150 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_+_31647854 3.142 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr5_-_149772563 3.133 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_-_93199586 3.129 NM_001006605
FAM69A
family with sequence similarity 69, member A
chr7_+_18515488 3.118 HDAC9
histone deacetylase 9
chr7_-_24763556 3.104 DFNA5
deafness, autosomal dominant 5
chr1_-_208046011 3.103 NM_006147
IRF6
interferon regulatory factor 6
chr7_-_44985202 3.100 NM_033054
MYO1G
myosin IG
chr19_+_50196526 3.097 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr4_-_147079018 3.087 NM_178835
ZNF827
zinc finger protein 827
chr16_+_84490267 3.050 NM_002163
IRF8
interferon regulatory factor 8
chr7_+_18515440 3.046 HDAC9
histone deacetylase 9
chr7_+_149042960 3.046 NM_032534
KRBA1
KRAB-A domain containing 1
chr22_-_35970133 3.041 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_-_3818713 3.028 RHOG
ras homolog gene family, member G (rho G)
chr22_-_35970230 3.013 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr20_-_24986501 3.000 ACSS1
acyl-CoA synthetase short-chain family member 1
chr11_-_60880799 2.980 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr6_+_31648071 2.979 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr2_+_237143118 2.935 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr11_+_66580861 2.915 NM_014578
RHOD
ras homolog gene family, member D
chr14_-_64040072 2.900 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr20_-_57015547 2.856 CTSZ
cathepsin Z
chr12_+_6925997 2.843 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_85235210 2.836 NM_153259
MCOLN2
mucolipin 2
chr3_+_103029523 2.741 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_+_142777172 2.738 NM_000585
NM_172174
IL15

interleukin 15

chrX_+_78087484 2.706 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr7_-_44985175 2.703 MYO1G
myosin IG
chr1_-_181826633 2.690 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr1_+_26744929 2.678 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_+_70444191 2.669 PCNX
pecanex homolog (Drosophila)
chr5_+_56505608 2.666 GPBP1
GC-rich promoter binding protein 1
chr14_-_34943574 2.663 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr17_-_59172897 2.656 NM_001003786
NM_001003787
NM_001003788
NM_001165969
NM_001165970
NM_153335
STRADA





STE20-related kinase adaptor alpha





chr6_+_14225932 2.656 CD83
CD83 molecule
chr5_+_110587546 2.648 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr5_-_150441150 2.625 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr4_-_147079410 2.620


chr6_-_31432954 2.613 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr2_+_208102937 2.608 CREB1
cAMP responsive element binding protein 1
chr7_-_129379947 2.605 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr7_+_100584397 2.600 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr1_-_149586298 2.581 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr6_-_32919751 2.579 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr17_+_7402315 2.567 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr19_+_40632456 2.561 NM_005306
FFAR2
free fatty acid receptor 2
chr2_+_208103001 2.537 CREB1
cAMP responsive element binding protein 1
chr3_-_52065130 2.529 NM_001947
DUSP7
dual specificity phosphatase 7
chr1_+_26744893 2.528 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_62804036 2.510 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr10_+_12431714 2.501 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr6_+_106640903 2.492 PRDM1
PR domain containing 1, with ZNF domain
chr19_-_53516962 2.492 CCDC114
coiled-coil domain containing 114
chr18_-_26996742 2.480 NM_004948
NM_024421
DSC1

desmocollin 1

chr15_-_38185578 2.466 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr4_+_128922930 2.448 HSPA4L
heat shock 70kDa protein 4-like
chr14_-_50367513 2.447 NM_016350
NM_020921
NM_182944
NM_182946
NIN



ninein (GSK3B interacting protein)



chr1_+_40193424 2.447 MFSD2A
major facilitator superfamily domain containing 2A
chrX_+_12795111 2.420 NM_016562
TLR7
toll-like receptor 7
chr6_+_32919873 2.420


chr1_-_24386324 2.414 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr2_+_208103068 2.407 CREB1
cAMP responsive element binding protein 1
chr5_-_150440743 2.391 TNIP1
TNFAIP3 interacting protein 1
chr6_-_31432877 2.389 HLA-B
major histocompatibility complex, class I, B
chr5_-_150440792 2.387 TNIP1
TNFAIP3 interacting protein 1
chr1_+_152644668 2.385 IL6R
interleukin 6 receptor
chr19_-_6542136 2.349 NM_001252
CD70
CD70 molecule
chr3_-_48607596 2.348 NM_000094
COL7A1
collagen, type VII, alpha 1
chr19_-_56214765 2.328 NM_145888
KLK10
kallikrein-related peptidase 10
chr6_-_116799548 2.324 LOC100287467
hypothetical LOC100287467
chr1_-_149586341 2.324 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr12_+_6926014 2.320 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr11_+_120828275 2.314 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_+_106640881 2.290 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_218790364 2.289 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr5_-_131854325 2.281 NM_002198
IRF1
interferon regulatory factor 1
chr19_+_49943773 2.256 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr6_+_30018265 2.254 HLA-A
major histocompatibility complex, class I, A
chr19_+_55614006 2.252 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr22_-_32646325 2.243 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr12_-_28016182 2.226 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_24763841 2.188 DFNA5
deafness, autosomal dominant 5
chr22_+_38720881 2.179 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_-_27834210 2.174 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_-_55091942 2.172 NM_152899
IL4I1
interleukin 4 induced 1
chr8_-_95343716 2.155 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_+_103641762 2.152 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr20_+_44180355 2.144 CD40
CD40 molecule, TNF receptor superfamily member 5
chr10_+_13182061 2.132 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr20_+_54637714 2.129 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr19_-_50925966 2.109 NM_001080469
FBXO46
F-box protein 46
chr17_-_58877276 2.102 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr11_-_76800525 2.095 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_21489235 2.092 NM_001113349
ECE1
endothelin converting enzyme 1
chr19_-_17819814 2.085 NM_000215
JAK3
Janus kinase 3
chr6_+_237033 2.081 NM_020185
DUSP22
dual specificity phosphatase 22
chrX_+_46935152 2.073 UBA1
ubiquitin-like modifier activating enzyme 1
chr19_+_1018536 2.069 HMHA1
histocompatibility (minor) HA-1
chr19_-_17819773 2.049 JAK3
Janus kinase 3
chr1_+_154389945 2.044 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr20_-_57015698 2.043 NM_001336
CTSZ
cathepsin Z
chr1_+_201541269 2.038 NM_006763
BTG2
BTG family, member 2
chr16_-_73292188 2.033 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr1_-_180840016 2.012 NM_002928
RGS16
regulator of G-protein signaling 16
chr2_+_60962206 1.996 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr12_+_55018925 1.983 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr3_+_52254782 1.981 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr17_-_35506493 1.963 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr19_+_45915122 1.961 ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chr1_-_158182006 1.961 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr2_+_233633279 1.940 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr1_-_181826292 1.938 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr11_+_58666749 1.934 NM_001142519
NM_001142520
NM_001142521
FAM111A


family with sequence similarity 111, member A


chr1_-_207892296 1.921 NM_001127641
LAMB3
laminin, beta 3
chr13_-_45654327 1.913 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_60962228 1.911 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr3_+_53170254 1.909 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr4_-_47966570 1.907 NM_003215
TEC
tec protein tyrosine kinase
chr8_+_54955962 1.902 NM_003702
RGS20
regulator of G-protein signaling 20
chr2_+_233633348 1.899 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr9_+_4480193 1.897 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr8_-_66916830 1.892 PDE7A
phosphodiesterase 7A
chr6_-_33016561 1.892 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_60962279 1.884 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr1_+_35104120 1.884


chr6_+_29963328 1.881 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr17_+_62803824 1.879 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_-_143307976 1.870 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr5_-_171547844 1.847 STK10
serine/threonine kinase 10
chr19_+_11936868 1.847 NM_001012753
ZNF763
zinc finger protein 763

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.89 1.98e-09 GO:0006955 immune response
1.91 5.57e-09 GO:0002682 regulation of immune system process
1.63 3.41e-08 GO:0002376 immune system process
2.63 6.23e-08 GO:0051249 regulation of lymphocyte activation
1.39 7.64e-08 GO:0048518 positive regulation of biological process
1.42 9.43e-08 GO:0048522 positive regulation of cellular process
1.34 1.83e-07 GO:0007165 signal transduction
2.44 1.03e-06 GO:0002694 regulation of leukocyte activation
2.03 1.13e-06 GO:0002684 positive regulation of immune system process
1.29 2.71e-06 GO:0023052 signaling
2.34 4.73e-06 GO:0050865 regulation of cell activation
2.65 5.79e-06 GO:0051251 positive regulation of lymphocyte activation
1.26 1.35e-05 GO:0051716 cellular response to stimulus
2.52 1.86e-05 GO:0002696 positive regulation of leukocyte activation
1.50 2.59e-05 GO:0035556 intracellular signal transduction
1.55 2.76e-05 GO:0010604 positive regulation of macromolecule metabolic process
2.55 2.81e-05 GO:0050863 regulation of T cell activation
2.48 3.23e-05 GO:0050867 positive regulation of cell activation
1.51 6.00e-05 GO:0009893 positive regulation of metabolic process
2.07 6.97e-05 GO:0031347 regulation of defense response
1.92 1.20e-04 GO:0007243 intracellular protein kinase cascade
1.92 1.20e-04 GO:0023014 signal transduction via phosphorylation event
1.83 5.50e-04 GO:0050776 regulation of immune response
1.16 6.34e-04 GO:0050794 regulation of cellular process
2.56 6.60e-04 GO:0050870 positive regulation of T cell activation
1.53 6.95e-04 GO:0006793 phosphorus metabolic process
1.53 6.95e-04 GO:0006796 phosphate metabolic process
2.47 7.61e-04 GO:0002697 regulation of immune effector process
2.40 8.32e-04 GO:0031349 positive regulation of defense response
2.07 1.03e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
2.33 1.29e-03 GO:0045088 regulation of innate immune response
1.37 1.37e-03 GO:0006464 protein modification process
3.22 1.40e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.22 1.40e-03 GO:0034134 toll-like receptor 2 signaling pathway
3.10 1.69e-03 GO:0002699 positive regulation of immune effector process
1.61 1.76e-03 GO:0006468 protein phosphorylation
2.72 2.09e-03 GO:0070663 regulation of leukocyte proliferation
1.87 2.25e-03 GO:0045087 innate immune response
1.14 2.26e-03 GO:0050789 regulation of biological process
1.46 2.46e-03 GO:0031325 positive regulation of cellular metabolic process
2.73 3.10e-03 GO:0050670 regulation of lymphocyte proliferation
1.56 3.30e-03 GO:0048584 positive regulation of response to stimulus
1.55 3.46e-03 GO:0016310 phosphorylation
2.00 3.56e-03 GO:0001817 regulation of cytokine production
2.70 3.84e-03 GO:0032944 regulation of mononuclear cell proliferation
1.09 4.09e-03 GO:0009987 cellular process
3.04 4.13e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.34 4.71e-03 GO:0043412 macromolecule modification
2.85 5.13e-03 GO:0002224 toll-like receptor signaling pathway
2.50 5.67e-03 GO:0045089 positive regulation of innate immune response
2.74 6.80e-03 GO:0002758 innate immune response-activating signal transduction
1.81 6.83e-03 GO:0007264 small GTPase mediated signal transduction
1.54 7.85e-03 GO:0006952 defense response
2.35 8.32e-03 GO:0034762 regulation of transmembrane transport
2.92 8.74e-03 GO:0008063 Toll signaling pathway
2.92 8.74e-03 GO:0034142 toll-like receptor 4 signaling pathway
2.41 9.32e-03 GO:0001819 positive regulation of cytokine production
1.13 9.92e-03 GO:0065007 biological regulation
4.23 1.02e-02 GO:0060443 mammary gland morphogenesis
2.68 1.04e-02 GO:0002218 activation of innate immune response
2.72 1.25e-02 GO:0002221 pattern recognition receptor signaling pathway
1.28 1.33e-02 GO:0044267 cellular protein metabolic process
1.33 1.35e-02 GO:0048583 regulation of response to stimulus
1.67 1.44e-02 GO:0080134 regulation of response to stress
1.90 1.77e-02 GO:0050778 positive regulation of immune response
3.19 1.80e-02 GO:0002819 regulation of adaptive immune response
1.25 1.89e-02 GO:0019538 protein metabolic process
1.15 2.13e-02 GO:0050896 response to stimulus
2.13 2.28e-02 GO:0002764 immune response-regulating signaling pathway
2.13 3.33e-02 GO:0002757 immune response-activating signal transduction
2.71 3.41e-02 GO:0042306 regulation of protein import into nucleus
2.95 3.52e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
1.62 4.93e-02 GO:0010647 positive regulation of cell communication
1.93 4.97e-02 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 3.75e-03 GO:0005634 nucleus
1.11 3.75e-03 GO:0043227 membrane-bounded organelle
1.29 4.17e-03 GO:0005829 cytosol
1.11 4.63e-03 GO:0005737 cytoplasm
1.10 6.09e-03 GO:0043231 intracellular membrane-bounded organelle
2.61 6.24e-03 GO:0001726 ruffle
2.58 7.60e-03 GO:0016585 chromatin remodeling complex
3.55 1.46e-02 GO:0032587 ruffle membrane
1.07 2.25e-02 GO:0044424 intracellular part
2.12 3.52e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 2.57e-06 GO:0005515 protein binding