Motif ID: NFKB1_REL_RELA.p2

Z-value: 4.919


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RELchr2_+_609622790.665.7e-03Click!
NFKB1chr4_+_1036417620.657.0e-03Click!
RELAchr11_-_651870030.449.1e-02Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_104145421 11.717 NM_002502
 NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_162883062 9.804 NM_022168
 IFIH1
interferon induced with helicase C domain 1
chr11_+_101693403 9.753 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr19_+_4180494 9.073 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr10_+_104144218 8.980 NM_001077493
NM_001077494
 NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr17_+_35277942 8.574 NM_198844
NM_199321
 ZPBP2

zona pellucida binding protein 2

chr2_+_219453487 8.010 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr20_-_4743768 7.974 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr16_+_49333513 7.934 NM_001042412
 CYLD
cylindromatosis (turban tumor syndrome)
chr16_+_49333461 7.871 NM_001042355
NM_015247
 CYLD

cylindromatosis (turban tumor syndrome)

chr19_-_6542012 7.864 CD70
CD70 molecule
chr2_-_231498184 7.143 NM_005683
 GPR55
G protein-coupled receptor 55
chr17_+_22823151 6.792 NM_014238
 KSR1
kinase suppressor of ras 1
chr3_-_58175437 6.594 NM_004944
 DNASE1L3
deoxyribonuclease I-like 3
chr16_+_49288550 6.433 NM_022162
 NOD2
nucleotide-binding oligomerization domain containing 2
chr6_+_30958672 6.131 DDR1
discoidin domain receptor tyrosine kinase 1
chr6_+_116798791 5.927 NM_013352
 DSE
dermatan sulfate epimerase
chr1_-_207892420 5.797 NM_000228
 LAMB3
laminin, beta 3
chr9_+_126094067 5.614 NM_001166170
NM_001166171
 NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr15_+_83724743 5.612 NM_006738
NM_007200
 AKAP13

A kinase (PRKA) anchor protein 13


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 74 entries
enrichment   p-value GO term description
4.23 1.02e-02 GO:0060443 mammary gland morphogenesis
3.22 1.40e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.22 1.40e-03 GO:0034134 toll-like receptor 2 signaling pathway
3.19 1.80e-02 GO:0002819 regulation of adaptive immune response
3.10 1.69e-03 GO:0002699 positive regulation of immune effector process
3.04 4.13e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.95 3.52e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.92 8.74e-03 GO:0008063 Toll signaling pathway
2.92 8.74e-03 GO:0034142 toll-like receptor 4 signaling pathway
2.85 5.13e-03 GO:0002224 toll-like receptor signaling pathway
2.74 6.80e-03 GO:0002758 innate immune response-activating signal transduction
2.73 3.10e-03 GO:0050670 regulation of lymphocyte proliferation
2.72 2.09e-03 GO:0070663 regulation of leukocyte proliferation
2.72 1.25e-02 GO:0002221 pattern recognition receptor signaling pathway
2.71 3.41e-02 GO:0042306 regulation of protein import into nucleus
2.70 3.84e-03 GO:0032944 regulation of mononuclear cell proliferation
2.68 1.04e-02 GO:0002218 activation of innate immune response
2.65 5.79e-06 GO:0051251 positive regulation of lymphocyte activation
2.63 6.23e-08 GO:0051249 regulation of lymphocyte activation
2.56 6.60e-04 GO:0050870 positive regulation of T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.55 1.46e-02 GO:0032587 ruffle membrane
2.61 6.24e-03 GO:0001726 ruffle
2.58 7.60e-03 GO:0016585 chromatin remodeling complex
2.12 3.52e-02 GO:0009897 external side of plasma membrane
1.29 4.17e-03 GO:0005829 cytosol
1.16 3.75e-03 GO:0005634 nucleus
1.11 3.75e-03 GO:0043227 membrane-bounded organelle
1.11 4.63e-03 GO:0005737 cytoplasm
1.10 6.09e-03 GO:0043231 intracellular membrane-bounded organelle
1.07 2.25e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.17 2.57e-06 GO:0005515 protein binding