Motif ID: NHLH1,2.p2

Z-value: 3.458


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH1chr1_+_158603480-0.524.1e-02Click!
NHLH2chr1_+_116181927-0.165.6e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_109112428 6.156 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr7_+_17304707 6.007 NM_001621
AHR
aryl hydrocarbon receptor
chr13_-_25523164 4.927 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr11_-_6298284 4.761 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr4_-_40911212 4.669 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr9_+_17124974 3.976 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr22_+_20068039 3.805 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr14_-_88090641 3.785 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_33420213 3.616 NM_018207
TRIM62
tripartite motif containing 62
chr12_-_74710741 3.497 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_-_229844198 3.383 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr12_+_27824429 3.350 NM_020782
KLHDC5
kelch domain containing 5
chr21_+_45318861 3.226 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr3_-_73756668 3.162 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr3_-_87122936 3.086 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr9_-_83493415 3.079 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_-_37752731 3.036 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr22_-_20235372 3.020 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr3_-_87122958 3.005 VGLL3
vestigial like 3 (Drosophila)
chr5_-_58370693 2.928 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr16_-_71650034 2.917 NM_001164766
ZFHX3
zinc finger homeobox 3
chrX_+_152699616 2.916 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr1_-_59020875 2.910 JUN
jun proto-oncogene
chr19_+_10597167 2.908 NM_020428
SLC44A2
solute carrier family 44, member 2
chr5_-_72779585 2.900 FOXD1
forkhead box D1
chr10_+_112247614 2.870 NM_004419
DUSP5
dual specificity phosphatase 5
chr19_-_1083109 2.862 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr9_-_21549696 2.795 LOC554202
hypothetical LOC554202
chr2_-_227371698 2.776 NM_005544
IRS1
insulin receptor substrate 1
chr6_-_82518576 2.720 FAM46A
family with sequence similarity 46, member A
chr9_-_35679799 2.712 TPM2
tropomyosin 2 (beta)
chrX_-_106846253 2.671 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr9_-_35679902 2.663 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr4_-_86106567 2.660 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr17_+_36515166 2.656 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr14_+_99220349 2.602 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr1_+_68070573 2.566


chr6_-_119079712 2.557 NM_001042475
NM_206921
C6orf204

chromosome 6 open reading frame 204

chr1_-_158091296 2.537 C1orf204
chromosome 1 open reading frame 204
chr19_-_50977485 2.530 DMPK
dystrophia myotonica-protein kinase
chr10_+_17311307 2.517 VIM
vimentin
chr13_-_43259032 2.516 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr6_+_3696224 2.516


chr2_+_29191711 2.514 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr14_+_22375753 2.500 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_-_45927263 2.498 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr6_-_82519093 2.483 NM_017633
FAM46A
family with sequence similarity 46, member A
chr12_-_26166485 2.464 BHLHE41
basic helix-loop-helix family, member e41
chr3_+_49034050 2.459 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr1_+_31658549 2.454 NM_178865
SERINC2
serine incorporator 2
chr10_+_17311283 2.449 VIM
vimentin
chr13_-_73606362 2.437 KLF12
Kruppel-like factor 12
chr6_-_105691675 2.434 BVES
blood vessel epicardial substance
chr15_+_90738108 2.430 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr10_+_17311242 2.414 VIM
vimentin
chr8_-_82186832 2.406 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr20_+_25176698 2.403 NM_002862
PYGB
phosphorylase, glycogen; brain
chr10_+_17311282 2.394 VIM
vimentin
chr13_-_76358370 2.386 KCTD12
potassium channel tetramerisation domain containing 12
chr10_+_99463446 2.384 NM_031484
MARVELD1
MARVEL domain containing 1
chr13_-_95094920 2.356 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr10_+_17311347 2.329 VIM
vimentin
chr9_+_133154896 2.317 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr17_-_36528113 2.313 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr7_+_55054416 2.311 EGFR
epidermal growth factor receptor
chr10_+_99463468 2.309 MARVELD1
MARVEL domain containing 1
chr1_-_85703321 2.301 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_140696740 2.269 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr12_+_64504835 2.264 HMGA2
high mobility group AT-hook 2
chr13_+_113546841 2.250 NM_000820
GAS6
growth arrest-specific 6
chr6_-_105691235 2.248 NM_007073
BVES
blood vessel epicardial substance
chr11_+_12355600 2.179 NM_018222
PARVA
parvin, alpha
chr6_+_129245978 2.177 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr1_-_199704773 2.124 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr15_+_83724743 2.119 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr9_-_21999270 2.107 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr17_-_15106579 2.104 PMP22
peripheral myelin protein 22
chr12_-_29827952 2.091 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr5_-_73972055 2.091 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr11_+_86189138 2.084 NM_007173
PRSS23
protease, serine, 23
chr9_-_130980359 2.083 NM_203434
IER5L
immediate early response 5-like
chr7_-_130891861 2.081 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_+_20336849 2.073 ITGB8
integrin, beta 8
chr18_-_21185968 2.059 ZNF521
zinc finger protein 521
chr1_+_216586199 2.055 TGFB2
transforming growth factor, beta 2
chr21_-_45118037 2.055 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr3_+_57236818 2.054 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr3_+_160964574 2.053 SCHIP1
schwannomin interacting protein 1
chr17_-_15106597 2.051 NM_153321
PMP22
peripheral myelin protein 22
chr1_-_95165089 2.040 NM_001839
CNN3
calponin 3, acidic
chr12_+_27824211 2.033 KLHDC5
kelch domain containing 5
chr21_+_45118353 2.026


chr18_-_16945613 2.016 ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr16_+_27320983 2.005 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr9_-_25668230 1.989 TUSC1
tumor suppressor candidate 1
chr3_+_150191884 1.976 NM_001184720
NM_001184721
NM_004130
GYG1


glycogenin 1


chr5_+_129268352 1.968 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr15_-_90999606 1.962 NM_207446
FAM174B
family with sequence similarity 174, member B
chr13_+_113546897 1.943 GAS6
growth arrest-specific 6
chr18_-_16945763 1.941 NM_005406
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr5_+_102229612 1.932 PAM
peptidylglycine alpha-amidating monooxygenase
chr21_-_45117989 1.923 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr13_+_113546943 1.918 GAS6
growth arrest-specific 6
chr21_-_45118026 1.914 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr8_+_104452877 1.892 CTHRC1
collagen triple helix repeat containing 1
chr5_+_271355 1.866 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr3_+_30623376 1.859 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr2_+_5750229 1.856 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr6_+_17389752 1.856 NM_001143942
RBM24
RNA binding motif protein 24
chr14_+_58174489 1.833 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr13_-_73605914 1.829 NM_007249
KLF12
Kruppel-like factor 12
chr1_-_84237316 1.827 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr11_+_110916629 1.816 LAYN
layilin
chr3_-_185912240 1.808 NM_022149
MAGEF1
melanoma antigen family F, 1
chr2_-_19421852 1.789 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr5_+_102229425 1.777 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr11_+_133444175 1.754 JAM3
junctional adhesion molecule 3
chr8_+_104452961 1.750 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr12_+_51730101 1.743 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr3_-_147361465 1.731 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr4_-_57671307 1.725 IGFBP7
insulin-like growth factor binding protein 7
chr19_-_50977586 1.716 DMPK
dystrophia myotonica-protein kinase
chr10_+_27833167 1.709 NM_021252
RAB18
RAB18, member RAS oncogene family
chr21_-_45117960 1.693 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr3_-_151171576 1.691 PFN2
profilin 2
chr3_+_49034494 1.685 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr1_+_15145001 1.681 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr9_+_101623957 1.681 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr11_+_44543716 1.679 NM_001024844
NM_002231
CD82

CD82 molecule

chr3_+_151171755 1.674 LOC646903
hypothetical LOC646903
chr16_+_82490230 1.667 NM_012213
MLYCD
malonyl-CoA decarboxylase
chr1_+_238321794 1.665 NM_020066
FMN2
formin 2
chr17_+_36493927 1.660 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr14_-_60185659 1.653 NM_005982
SIX1
SIX homeobox 1
chr2_-_219404755 1.647 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr10_+_104667991 1.645 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr5_+_271428 1.645 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr20_-_23566325 1.644 NM_000099
CST3
cystatin C
chr6_-_33864863 1.636 LEMD2
LEM domain containing 2
chr9_+_109085372 1.636 RAD23B
RAD23 homolog B (S. cerevisiae)
chr6_-_33864876 1.632 LEMD2
LEM domain containing 2
chr9_+_109085337 1.630 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr19_-_50977592 1.629 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr5_+_271447 1.625 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr16_+_53522611 1.623 NM_005853
IRX5
iroquois homeobox 5
chr1_-_22136263 1.621 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr2_+_56264627 1.620 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr5_+_72148173 1.605 NM_002270
TNPO1
transportin 1
chr18_+_19848749 1.605 TTC39C
tetratricopeptide repeat domain 39C
chr7_-_526005 1.601 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr10_+_72642274 1.589 NM_170744
UNC5B
unc-5 homolog B (C. elegans)
chr1_-_143750988 1.580 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr9_-_71476917 1.579 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr9_+_71848555 1.578 MAMDC2
MAM domain containing 2
chrX_+_73557809 1.574 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr2_+_202949289 1.569 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr3_-_121550767 1.565 NM_001099678
LRRC58
leucine rich repeat containing 58
chr2_+_191818124 1.565 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr17_-_53387493 1.558 CUEDC1
CUE domain containing 1
chr7_+_129919330 1.557 MEST
mesoderm specific transcript homolog (mouse)
chr3_-_126088530 1.552 ITGB5
integrin, beta 5
chr12_+_62523648 1.546


chr9_+_98252200 1.543 NM_014282
HABP4
hyaluronan binding protein 4
chr6_-_128883125 1.542 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr17_+_1906262 1.525 NM_001098202
HIC1
hypermethylated in cancer 1
chr15_+_72006015 1.524 LOXL1
lysyl oxidase-like 1
chr1_-_72520735 1.513 NM_173808
NEGR1
neuronal growth regulator 1
chr19_-_2207415 1.511 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr1_-_154737162 1.511 MEF2D
myocyte enhancer factor 2D
chr11_+_7997366 1.491 TUB
tubby homolog (mouse)
chr2_+_241586927 1.485 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr13_-_22905822 1.484 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr10_-_125841840 1.475 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr10_+_124211353 1.473 HTRA1
HtrA serine peptidase 1
chr5_-_54317102 1.471 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr3_+_57236816 1.466 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr16_-_3295375 1.465


chr19_-_63301402 1.456 ZSCAN18
zinc finger and SCAN domain containing 18
chr2_+_202607554 1.455 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr12_-_50871953 1.446 NM_001081492
NM_182507
KRT80

keratin 80

chr4_-_57671273 1.446 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr4_-_81213207 1.442


chr18_+_19848347 1.441 NM_001135993
TTC39C
tetratricopeptide repeat domain 39C
chr11_+_124539814 1.438 PKNOX2
PBX/knotted 1 homeobox 2
chr1_-_39877928 1.429 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr2_+_56265260 1.423


chr4_-_122837579 1.418 ANXA5
annexin A5
chr3_+_57236769 1.414 NM_012096
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr10_-_62373828 1.409 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr8_+_98856984 1.409 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr4_+_86615275 1.407 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr5_+_14196287 1.406 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr20_+_773283 1.404 NM_031424
FAM110A
family with sequence similarity 110, member A
chr7_+_98084531 1.400 NM_002523
NPTX2
neuronal pentraxin II
chr11_+_124539768 1.398 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr1_-_154737189 1.394 MEF2D
myocyte enhancer factor 2D
chr7_+_27102508 1.391


chr2_+_85834111 1.385 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr19_-_63301386 1.365 ZSCAN18
zinc finger and SCAN domain containing 18
chr6_-_33864883 1.363 NM_181336
LEMD2
LEM domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 3.14e-11 GO:0050794 regulation of cellular process
1.22 1.66e-10 GO:0032502 developmental process
1.24 2.44e-10 GO:0007165 signal transduction
1.13 5.43e-10 GO:0050789 regulation of biological process
1.23 6.20e-10 GO:0007275 multicellular organismal development
1.37 1.07e-09 GO:0009653 anatomical structure morphogenesis
1.12 1.52e-09 GO:0065007 biological regulation
1.30 2.46e-09 GO:0048869 cellular developmental process
1.23 4.84e-09 GO:0048856 anatomical structure development
1.21 5.47e-09 GO:0023052 signaling
1.30 5.75e-09 GO:0030154 cell differentiation
1.45 6.88e-08 GO:0048468 cell development
1.32 1.23e-07 GO:0023051 regulation of signaling
1.18 1.79e-07 GO:0051716 cellular response to stimulus
1.36 2.77e-07 GO:0051239 regulation of multicellular organismal process
1.43 2.79e-07 GO:0022008 neurogenesis
1.25 3.90e-07 GO:0048519 negative regulation of biological process
1.23 5.08e-07 GO:0048731 system development
1.33 6.14e-07 GO:0007399 nervous system development
1.39 9.57e-07 GO:0010646 regulation of cell communication
1.43 1.11e-06 GO:0048699 generation of neurons
1.26 1.21e-06 GO:0048523 negative regulation of cellular process
1.51 1.49e-06 GO:0032989 cellular component morphogenesis
1.46 2.61e-06 GO:2000026 regulation of multicellular organismal development
1.51 4.52e-06 GO:0000902 cell morphogenesis
1.56 5.08e-06 GO:0000904 cell morphogenesis involved in differentiation
1.61 5.23e-06 GO:0007409 axonogenesis
1.46 6.58e-06 GO:0030182 neuron differentiation
1.48 6.71e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.27 8.90e-06 GO:0007166 cell surface receptor linked signaling pathway
1.58 9.49e-06 GO:0048812 neuron projection morphogenesis
1.71 1.55e-05 GO:0001944 vasculature development
1.50 1.77e-05 GO:0048666 neuron development
1.57 1.90e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.53 1.91e-05 GO:0048858 cell projection morphogenesis
1.53 2.65e-05 GO:0031175 neuron projection development
1.38 2.82e-05 GO:0050793 regulation of developmental process
1.52 3.72e-05 GO:0032990 cell part morphogenesis
1.30 4.20e-05 GO:0009966 regulation of signal transduction
1.46 4.94e-05 GO:0030030 cell projection organization
1.35 1.21e-04 GO:0009605 response to external stimulus
1.61 1.67e-04 GO:0007411 axon guidance
1.06 1.75e-04 GO:0009987 cellular process
1.47 1.97e-04 GO:0006928 cellular component movement
1.68 2.29e-04 GO:0001568 blood vessel development
1.28 4.54e-04 GO:0035556 intracellular signal transduction
1.49 6.55e-04 GO:0072358 cardiovascular system development
1.49 6.55e-04 GO:0072359 circulatory system development
1.16 7.00e-04 GO:0031323 regulation of cellular metabolic process
1.46 9.46e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.34 1.59e-03 GO:0040011 locomotion
1.15 1.73e-03 GO:0080090 regulation of primary metabolic process
1.19 3.96e-03 GO:0048522 positive regulation of cellular process
1.67 4.71e-03 GO:0048514 blood vessel morphogenesis
1.15 4.73e-03 GO:0060255 regulation of macromolecule metabolic process
1.31 4.90e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.48 4.90e-03 GO:0016477 cell migration
1.17 6.11e-03 GO:0048518 positive regulation of biological process
1.55 8.23e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.44 1.06e-02 GO:0048870 cell motility
1.44 1.06e-02 GO:0051674 localization of cell
1.38 1.27e-02 GO:0042060 wound healing
1.74 1.30e-02 GO:0001525 angiogenesis
1.51 1.39e-02 GO:0044057 regulation of system process
1.86 1.81e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.35 2.04e-02 GO:0045595 regulation of cell differentiation
1.13 2.23e-02 GO:0019222 regulation of metabolic process
1.34 3.19e-02 GO:0009890 negative regulation of biosynthetic process
1.18 3.22e-02 GO:0065008 regulation of biological quality
1.30 3.29e-02 GO:0009888 tissue development
1.35 3.52e-02 GO:0001932 regulation of protein phosphorylation
1.31 3.59e-02 GO:0051128 regulation of cellular component organization
1.60 4.00e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.35 4.23e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.29 4.36e-02 GO:0016265 death
1.29 4.36e-02 GO:0008219 cell death
2.62 4.39e-02 GO:0048641 regulation of skeletal muscle tissue development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 9.37e-06 GO:0005737 cytoplasm
1.06 1.02e-05 GO:0005622 intracellular
1.06 1.96e-05 GO:0044424 intracellular part
1.89 3.65e-05 GO:0005912 adherens junction
1.78 1.01e-04 GO:0031252 cell leading edge
1.76 4.72e-04 GO:0070161 anchoring junction
1.19 5.75e-04 GO:0044459 plasma membrane part
1.92 1.71e-03 GO:0005924 cell-substrate adherens junction
1.93 2.62e-03 GO:0005925 focal adhesion
1.85 5.57e-03 GO:0030055 cell-substrate junction
1.94 6.15e-03 GO:0001726 ruffle
1.33 1.27e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.80e-07 GO:0005515 protein binding
1.06 7.09e-06 GO:0005488 binding
1.48 2.78e-04 GO:0019904 protein domain specific binding
1.82 1.82e-02 GO:0017124 SH3 domain binding