Motif ID: NHLH1,2.p2

Z-value: 3.458


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH1chr1_+_158603480-0.524.1e-02Click!
NHLH2chr1_+_116181927-0.165.6e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_109112428 6.156 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr7_+_17304707 6.007 NM_001621
 AHR
aryl hydrocarbon receptor
chr13_-_25523164 4.927 NM_001007538
 SHISA2
shisa homolog 2 (Xenopus laevis)
chr11_-_6298284 4.761 NM_145040
 PRKCDBP
protein kinase C, delta binding protein
chr4_-_40911212 4.669 NM_001166050
NM_004307
NM_173075
 APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr9_+_17124974 3.976 NM_001114395
NM_017738
 CNTLN

centlein, centrosomal protein

chr22_+_20068039 3.805 NM_001128635
 RIMBP3B
RIMS binding protein 3B
chr14_-_88090641 3.785 NM_007039
 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_33420213 3.616 NM_018207
 TRIM62
tripartite motif containing 62
chr12_-_74710741 3.497 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_-_229844198 3.383 NM_001100818
NM_017933
 PID1

phosphotyrosine interaction domain containing 1

chr12_+_27824429 3.350 NM_020782
 KLHDC5
kelch domain containing 5
chr21_+_45318861 3.226 NM_001112
NM_001160230
NM_015833
NM_015834
 ADARB1



adenosine deaminase, RNA-specific, B1



chr3_-_73756668 3.162 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr3_-_87122936 3.086 NM_016206
 VGLL3
vestigial like 3 (Drosophila)
chr9_-_83493415 3.079 NM_005077
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_-_37752731 3.036 NM_006449
 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr22_-_20235372 3.020 NM_001128635
 RIMBP3B
RIMS binding protein 3B
chr3_-_87122958 3.005 VGLL3
vestigial like 3 (Drosophila)
chr5_-_58370693 2.928 NM_001197221
NM_001197222
 PDE4D

phosphodiesterase 4D, cAMP-specific


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 77 entries
enrichment   p-value GO term description
2.62 4.39e-02 GO:0048641 regulation of skeletal muscle tissue development
1.86 1.81e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.74 1.30e-02 GO:0001525 angiogenesis
1.71 1.55e-05 GO:0001944 vasculature development
1.68 2.29e-04 GO:0001568 blood vessel development
1.67 4.71e-03 GO:0048514 blood vessel morphogenesis
1.61 5.23e-06 GO:0007409 axonogenesis
1.61 1.67e-04 GO:0007411 axon guidance
1.60 4.00e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.58 9.49e-06 GO:0048812 neuron projection morphogenesis
1.57 1.90e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.56 5.08e-06 GO:0000904 cell morphogenesis involved in differentiation
1.55 8.23e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.53 1.91e-05 GO:0048858 cell projection morphogenesis
1.53 2.65e-05 GO:0031175 neuron projection development
1.52 3.72e-05 GO:0032990 cell part morphogenesis
1.51 1.49e-06 GO:0032989 cellular component morphogenesis
1.51 4.52e-06 GO:0000902 cell morphogenesis
1.51 1.39e-02 GO:0044057 regulation of system process
1.50 1.77e-05 GO:0048666 neuron development

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.94 6.15e-03 GO:0001726 ruffle
1.93 2.62e-03 GO:0005925 focal adhesion
1.92 1.71e-03 GO:0005924 cell-substrate adherens junction
1.89 3.65e-05 GO:0005912 adherens junction
1.85 5.57e-03 GO:0030055 cell-substrate junction
1.78 1.01e-04 GO:0031252 cell leading edge
1.76 4.72e-04 GO:0070161 anchoring junction
1.33 1.27e-02 GO:0030054 cell junction
1.19 5.75e-04 GO:0044459 plasma membrane part
1.09 9.37e-06 GO:0005737 cytoplasm
1.06 1.02e-05 GO:0005622 intracellular
1.06 1.96e-05 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.82 1.82e-02 GO:0017124 SH3 domain binding
1.48 2.78e-04 GO:0019904 protein domain specific binding
1.11 1.80e-07 GO:0005515 protein binding
1.06 7.09e-06 GO:0005488 binding