Motif ID: NKX2-1,4.p2

Z-value: 1.022


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_360590840.439.7e-02Click!
NKX2-4chr20_-_213260460.224.2e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_78087484 3.072 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr16_+_11966464 2.783 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_-_6621078 2.304 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr21_-_14840506 2.268 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6621598 2.030 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr5_-_88155360 1.904 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_161701711 1.561 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chrX_-_154216929 1.410 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_32489426 1.353 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_+_159817752 1.275 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr3_+_190831909 1.153 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_-_143230124 1.090 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_+_59979857 1.039 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr15_-_81271859 1.031 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr2_-_100125402 1.004 NM_002285
AFF3
AF4/FMR2 family, member 3
chr1_+_159899528 0.971 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_-_242205556 0.832 NM_001164356
THAP4
THAP domain containing 4
chr12_-_101115677 0.815 NM_002674
PMCH
pro-melanin-concentrating hormone
chrX_+_48427103 0.785 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_143706196 0.782 PDE4DIP
phosphodiesterase 4D interacting protein
chr2_-_37727472 0.741 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr9_+_102380156 0.739 NM_001018116
MURC
muscle-related coiled-coil protein
chr1_-_158948176 0.725 NM_001778
CD48
CD48 molecule
chr20_+_56455866 0.707 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr19_-_50688310 0.694 NM_206901
RTN2
reticulon 2
chr12_+_111900650 0.644 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr17_-_26665220 0.640 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 0.638 EVI2B
ecotropic viral integration site 2B
chr1_+_180836050 0.596


chr12_-_51887266 0.584 NM_000889
ITGB7
integrin, beta 7
chr4_-_24590867 0.572 NM_173463
CCDC149
coiled-coil domain containing 149
chr1_-_143706265 0.570 PDE4DIP
phosphodiesterase 4D interacting protein
chr17_-_5078773 0.555 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr14_+_63752424 0.545 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_-_26665144 0.542 EVI2B
ecotropic viral integration site 2B
chr12_+_15590552 0.536 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_-_43168247 0.532 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr2_-_56266408 0.528 LOC100129434
hypothetical LOC100129434
chr6_-_32268267 0.520 GPSM3
G-protein signaling modulator 3
chr19_-_60458915 0.509 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_-_143706300 0.499 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr2_+_143603368 0.496 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr12_-_119733062 0.487 SPPL3
signal peptide peptidase 3
chr7_+_50318801 0.486 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_-_49152918 0.476 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr2_+_33554824 0.459 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr4_+_111053488 0.457 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr3_-_120761092 0.441 NM_005191
CD80
CD80 molecule
chr2_+_143603439 0.434 ARHGAP15
Rho GTPase activating protein 15
chr14_+_75058518 0.426 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr2_-_175170674 0.424 WIPF1
WAS/WASL interacting protein family, member 1
chr18_+_19286784 0.421 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr4_-_176970407 0.419 GPM6A
glycoprotein M6A
chr18_+_70317548 0.401 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr13_+_45174446 0.392 NM_152719
SPERT
spermatid associated
chr4_-_176970372 0.383 GPM6A
glycoprotein M6A
chr5_-_142795269 0.378 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_-_158815850 0.373 CD84
CD84 molecule
chr13_-_98757634 0.373 NM_004951
GPR183
G protein-coupled receptor 183
chrX_+_48427137 0.366 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_158883666 0.362 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr13_+_110637173 0.358 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr10_-_11614279 0.355 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_151498802 0.355 NM_000427
LOR
loricrin
chrX_-_72351381 0.352 NAP1L2
nucleosome assembly protein 1-like 2
chr12_-_51887318 0.348 ITGB7
integrin, beta 7
chr17_+_7846636 0.340 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr12_+_25096755 0.333 LRMP
lymphoid-restricted membrane protein
chr17_-_26665194 0.328 EVI2B
ecotropic viral integration site 2B
chr3_+_46386636 0.328 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr11_+_22646229 0.327 NM_177553
GAS2
growth arrest-specific 2
chr17_-_53761119 0.323 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr1_-_158815895 0.316 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr17_-_3407780 0.304 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_-_149847809 0.304 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr14_-_94669547 0.302 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr12_+_118515646 0.300 NM_001136534
TMEM233
transmembrane protein 233
chrX_-_100920493 0.298 GK
glycerol kinase
chr12_+_54132264 0.298 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr1_-_118123033 0.289


chrX_-_72351392 0.284 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr6_-_119137923 0.275 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr4_-_123761615 0.273 NM_021803
IL21
interleukin 21
chr17_+_65009986 0.272 MAP2K6
mitogen-activated protein kinase kinase 6
chr19_-_45132372 0.269 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr8_-_82536312 0.267 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr6_-_149847718 0.264 ZC3H12D
zinc finger CCCH-type containing 12D
chr11_+_118259684 0.259 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr7_+_63411813 0.259 ZNF736
zinc finger protein 736
chr21_+_37714470 0.258 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr6_-_155818728 0.257 NM_015718
NOX3
NADPH oxidase 3
chr3_+_46894239 0.252 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr6_-_50045296 0.251 NM_001037729
DEFB113
defensin, beta 113
chr12_+_117067214 0.250 PEBP1
phosphatidylethanolamine binding protein 1
chr6_-_11887265 0.241 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr5_-_156468614 0.238 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr6_+_101953389 0.238 GRIK2
glutamate receptor, ionotropic, kainate 2
chr2_-_88946767 0.238


chr17_-_10393664 0.233 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr14_+_75058591 0.232 BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_21310462 0.229 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr5_+_150020595 0.227 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr2_+_161980865 0.225 NM_006593
TBR1
T-box, brain, 1
chr10_-_76538859 0.224 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr10_-_75005421 0.223 NM_152586
USP54
ubiquitin specific peptidase 54
chr19_+_16691786 0.223 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr8_+_9990471 0.222 NM_001135671
MSRA
methionine sulfoxide reductase A
chr2_+_102401580 0.221 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr15_+_40481879 0.220 NM_173088
CAPN3
calpain 3, (p94)
chr12_+_12769985 0.219 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr4_+_123519570 0.218 NM_139243
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr5_-_94442941 0.218 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_37752272 0.217 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_+_196874867 0.214 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_46883341 0.214 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr2_-_26717713 0.212 NM_001029881
CIB4
calcium and integrin binding family member 4
chr1_-_9052207 0.212 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_-_137649180 0.209 NM_033642
FGF13
fibroblast growth factor 13
chr8_-_6901661 0.208 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr7_+_38984133 0.208 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr18_-_59137488 0.205 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr1_-_42574116 0.204 NM_001198850
FOXJ3
forkhead box J3
chr1_+_154120170 0.203 SYT11
synaptotagmin XI
chrX_-_72351348 0.201 NAP1L2
nucleosome assembly protein 1-like 2
chr14_-_75517844 0.196 NM_003239
TGFB3
transforming growth factor, beta 3
chr20_+_4650499 0.196 NM_012409
PRND
prion protein 2 (dublet)
chr2_+_28892366 0.195 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr2_-_104834344 0.194 LOC100506421
hypothetical LOC100506421
chr8_+_67201684 0.193 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr8_-_30826074 0.191 NM_031271
TEX15
testis expressed 15
chr7_-_107230867 0.189 NM_000111
SLC26A3
solute carrier family 26, member 3
chr4_-_46086150 0.188 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr1_+_226462363 0.185 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr7_-_115458047 0.184 TFEC
transcription factor EC
chr1_+_196874759 0.183 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_-_7724762 0.183 NM_002947
RPA3
replication protein A3, 14kDa
chr16_+_56567839 0.181 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr17_-_3408038 0.179 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr2_-_38379031 0.177 ATL2
atlastin GTPase 2
chr14_-_64359565 0.176 NM_000347
NM_001024858
SPTB

spectrin, beta, erythrocytic

chr3_+_89239494 0.176 EPHA3
EPH receptor A3
chr15_-_70385709 0.175 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr1_+_149299530 0.174 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_188397967 0.173 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr16_-_69876262 0.170 FTSJD1
FtsJ methyltransferase domain containing 1
chr17_+_20048890 0.169 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr19_+_39355151 0.166 NM_001114093
NM_015578
LSM14A

LSM14A, SCD6 homolog A (S. cerevisiae)

chr12_-_53064565 0.166 ZNF385A
zinc finger protein 385A
chr12_-_53064723 0.162 NM_015481
ZNF385A
zinc finger protein 385A
chr13_-_102144854 0.161 NM_001010977
METTL21C
methyltransferase like 21C
chr9_+_112470871 0.159 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr11_+_65740789 0.158 PACS1
phosphofurin acidic cluster sorting protein 1
chr5_-_147996769 0.157 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr1_-_9052253 0.155 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr3_-_74652952 0.153 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr4_+_102954005 0.152 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr2_+_1397186 0.151 NM_175721
NM_175722
TPO

thyroid peroxidase

chr2_-_163403485 0.148 NM_033272
NM_173162
KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_178100204 0.146


chrX_+_70682204 0.146 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr1_-_201465395 0.143 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr9_-_124329392 0.143 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr10_+_86121526 0.143 FAM190B
family with sequence similarity 190, member B
chr19_+_45797413 0.143 LTBP4
latent transforming growth factor beta binding protein 4
chr21_-_31049566 0.142 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr6_-_66473790 0.142 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr16_+_74901235 0.140 NM_138994
CNTNAP4
contactin associated protein-like 4
chr6_+_35373632 0.140 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chrX_-_110542040 0.139 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr4_-_21155376 0.138 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr11_+_4522993 0.137 NM_001004137
OR52M1
olfactory receptor, family 52, subfamily M, member 1
chr1_+_100089118 0.137 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr5_-_88004891 0.136 LOC645323
hypothetical LOC645323
chr4_+_22303645 0.134 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr6_-_41811916 0.134 NM_001167827
TFEB
transcription factor EB
chr13_-_74799898 0.133 TBC1D4
TBC1 domain family, member 4
chr6_+_155579788 0.133 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr3_+_68136056 0.132 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr2_-_74235860 0.131


chr17_-_74244539 0.130


chr2_+_1396239 0.130 NM_000547
NM_175719
TPO

thyroid peroxidase

chr1_+_150749943 0.128 NM_178438
LCE5A
late cornified envelope 5A
chr15_+_72253077 0.128 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_88021644 0.128 ZNF292
zinc finger protein 292
chr5_-_134810696 0.127 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr12_+_74160779 0.126 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr1_+_242281175 0.126 NM_205768
ZNF238
zinc finger protein 238
chr8_-_7207899 0.125 NM_001164457
ZNF705G
zinc finger protein 705G
chr10_+_90511142 0.124 NM_001102469
LIPN
lipase, family member N
chr8_+_77928372 0.124 ZFHX4
zinc finger homeobox 4
chr15_-_72287447 0.123 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chrX_+_41468351 0.123 NM_080817
GPR82
G protein-coupled receptor 82
chr17_-_59817456 0.122 PECAM1
platelet/endothelial cell adhesion molecule
chr1_+_169747788 0.122 PRRC2C
proline-rich coiled-coil 2C
chr1_-_201321711 0.122 MYOG
myogenin (myogenic factor 4)
chr9_+_6231677 0.121 NM_033439
IL33
interleukin 33
chr21_-_35343065 0.121 RUNX1
runt-related transcription factor 1
chr3_-_158704056 0.121 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr1_+_38033666 0.120 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr4_-_68793928 0.118 NM_182502
TMPRSS11B
transmembrane protease, serine 11B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 9.21e-07 GO:0032501 multicellular organismal process
1.36 2.07e-04 GO:0050896 response to stimulus
1.81 5.89e-04 GO:0003008 system process
3.63 4.22e-03 GO:0046649 lymphocyte activation
3.24 6.79e-03 GO:0045321 leukocyte activation
1.80 1.06e-02 GO:0050877 neurological system process
2.47 1.26e-02 GO:0007606 sensory perception of chemical stimulus
2.37 2.81e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 2.60e-06 GO:0071944 cell periphery
1.51 3.06e-06 GO:0005886 plasma membrane
1.30 5.19e-04 GO:0044425 membrane part
1.61 1.07e-03 GO:0044459 plasma membrane part
1.25 1.70e-03 GO:0016020 membrane
1.32 2.32e-03 GO:0031224 intrinsic to membrane
1.29 1.36e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.83 1.31e-06 GO:0004871 signal transducer activity
1.83 1.31e-06 GO:0060089 molecular transducer activity
1.88 8.43e-06 GO:0004872 receptor activity
2.18 2.23e-04 GO:0004930 G-protein coupled receptor activity
1.88 6.47e-04 GO:0004888 transmembrane receptor activity
2.50 9.54e-03 GO:0004984 olfactory receptor activity