Motif ID: NKX2-1,4.p2

Z-value: 1.022


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_360590840.439.7e-02Click!
NKX2-4chr20_-_213260460.224.2e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_78087484 3.072 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr16_+_11966464 2.783 NM_001192
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_-_6621078 2.304 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr21_-_14840506 2.268 NM_022136
 SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6621598 2.030 NM_003807
NM_172014
 TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr5_-_88155360 1.904 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr2_+_161701711 1.561 NM_004180
NM_133484
 TANK

TRAF family member-associated NFKB activator

chrX_-_154216929 1.410 NM_001289
 CLIC2
chloride intracellular channel 2
chr1_+_32489426 1.353 NM_005356
 LCK
lymphocyte-specific protein tyrosine kinase
chr1_+_159817752 1.275 NM_201563
 FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr3_+_190831909 1.153 NM_001114978
NM_001114979
NM_003722
 TP63


tumor protein p63


chr3_-_143230124 1.090 NM_001178141
NM_001178142
NM_006286
 TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_+_59979857 1.039 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr15_-_81271859 1.031 NM_001007122
 FSD2
fibronectin type III and SPRY domain containing 2
chr2_-_100125402 1.004 NM_002285
 AFF3
AF4/FMR2 family, member 3
chr1_+_159899528 0.971 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_-_242205556 0.832 NM_001164356
 THAP4
THAP domain containing 4
chr12_-_101115677 0.815 NM_002674
 PMCH
pro-melanin-concentrating hormone
chrX_+_48427103 0.785 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_143706196 0.782 PDE4DIP
phosphodiesterase 4D interacting protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.63 4.22e-03 GO:0046649 lymphocyte activation
3.24 6.79e-03 GO:0045321 leukocyte activation
2.47 1.26e-02 GO:0007606 sensory perception of chemical stimulus
2.37 2.81e-02 GO:0001775 cell activation
1.81 5.89e-04 GO:0003008 system process
1.80 1.06e-02 GO:0050877 neurological system process
1.48 9.21e-07 GO:0032501 multicellular organismal process
1.36 2.07e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.61 1.07e-03 GO:0044459 plasma membrane part
1.51 3.06e-06 GO:0005886 plasma membrane
1.50 2.60e-06 GO:0071944 cell periphery
1.32 2.32e-03 GO:0031224 intrinsic to membrane
1.30 5.19e-04 GO:0044425 membrane part
1.29 1.36e-02 GO:0016021 integral to membrane
1.25 1.70e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.50 9.54e-03 GO:0004984 olfactory receptor activity
2.18 2.23e-04 GO:0004930 G-protein coupled receptor activity
1.88 8.43e-06 GO:0004872 receptor activity
1.88 6.47e-04 GO:0004888 transmembrane receptor activity
1.83 1.31e-06 GO:0004871 signal transducer activity
1.83 1.31e-06 GO:0060089 molecular transducer activity