Motif ID: NKX2-2,8.p2

Z-value: 1.598


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_21442663-0.312.5e-01Click!
NKX2-8chr14_-_36121536-0.029.5e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 4.731 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_102320148 3.550 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr3_-_122862391 3.455 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 3.414 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_101115677 2.448 NM_002674
PMCH
pro-melanin-concentrating hormone
chr17_-_26665144 2.394 EVI2B
ecotropic viral integration site 2B
chr9_+_122923864 2.375 CEP110
centrosomal protein 110kDa
chr3_-_15814678 2.099 NM_001195098
ANKRD28
ankyrin repeat domain 28
chrX_+_11687655 2.092 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr13_+_110653407 1.873 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_9913199 1.820 CLEC2B
C-type lectin domain family 2, member B
chr13_-_40454360 1.817 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_224993498 1.733 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr1_+_242281175 1.633 NM_205768
ZNF238
zinc finger protein 238
chr9_+_115303527 1.614 NM_130795
RGS3
regulator of G-protein signaling 3
chr17_-_26665194 1.513 EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 1.489 EVI2B
ecotropic viral integration site 2B
chr17_-_26665220 1.489 NM_006495
EVI2B
ecotropic viral integration site 2B
chr21_-_14840506 1.474 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_-_24590867 1.450 NM_173463
CCDC149
coiled-coil domain containing 149
chr1_-_197173159 1.436 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_242281199 1.359 ZNF238
zinc finger protein 238
chr10_+_97505398 1.357 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr18_+_54039730 1.302 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_95595419 1.289 PDLIM5
PDZ and LIM domain 5
chr18_+_54039779 1.256 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_54039818 1.241 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_40877053 1.241 NM_032587
CARD6
caspase recruitment domain family, member 6
chr7_+_18515488 1.239 HDAC9
histone deacetylase 9
chr1_+_185064654 1.208 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_+_86918870 1.207 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr7_+_18515440 1.192 HDAC9
histone deacetylase 9
chr4_+_86918882 1.167 ARHGAP24
Rho GTPase activating protein 24
chr1_+_239762179 1.139 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr5_+_162862808 1.099 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr3_-_102194938 1.079 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_+_133798770 1.051 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr11_+_65027721 1.047


chr10_-_98326435 1.007 TM9SF3
transmembrane 9 superfamily member 3
chr4_-_38534802 0.971 NM_006068
TLR6
toll-like receptor 6
chr11_+_65023218 0.948


chr9_-_116190038 0.945 AKNA
AT-hook transcription factor
chr3_-_113701073 0.939 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr1_+_61642287 0.925 NFIA
nuclear factor I/A
chr7_-_87180499 0.921 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr13_-_47885018 0.886 LPAR6
lysophosphatidic acid receptor 6
chr1_+_84382575 0.883 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_88155360 0.878 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr11_-_72111027 0.875 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr4_-_100070808 0.854 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr18_-_65766068 0.845 CD226
CD226 molecule
chr5_-_98290117 0.827 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_205161821 0.827 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_+_228064531 0.819 AGFG1
ArfGAP with FG repeats 1
chr13_-_98428244 0.806 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr14_-_19871267 0.803 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr17_-_19290745 0.793


chr12_-_69317441 0.792 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr7_+_139175420 0.792 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr2_+_170742900 0.789 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr6_+_20642665 0.781 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr5_+_54491702 0.760 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr11_+_65023556 0.756


chr3_-_153541468 0.743 NM_001123228
TMEM14E
transmembrane protein 14E
chr12_-_120725210 0.741 LOC338799
hypothetical LOC338799
chr20_-_49747397 0.737 ATP9A
ATPase, class II, type 9A
chr4_-_170314382 0.736 SH3RF1
SH3 domain containing ring finger 1
chr11_-_128217550 0.736 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr5_-_58607673 0.728 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_111818111 0.723 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr7_+_838663 0.715 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr8_-_17599438 0.712 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr8_+_26206648 0.711 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr3_+_188197029 0.706


chr5_-_43550891 0.670 NM_198566
C5orf34
chromosome 5 open reading frame 34
chrX_-_154216929 0.666 NM_001289
CLIC2
chloride intracellular channel 2
chr4_-_170770111 0.666 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr5_-_169340321 0.660 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr8_+_107807415 0.656 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr2_-_183095308 0.649 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr22_+_38903825 0.649 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr9_+_66293049 0.643 MGC21881
hypothetical locus MGC21881
chr12_-_48902692 0.622 NM_001113547
LIMA1
LIM domain and actin binding 1
chr10_+_5478521 0.617 NM_005863
NET1
neuroepithelial cell transforming 1
chr14_-_99911409 0.617 WARS
tryptophanyl-tRNA synthetase
chr9_-_113561613 0.612 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr2_+_183290912 0.606 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr10_-_64698831 0.603 NM_004241
JMJD1C
jumonji domain containing 1C
chr14_-_99911528 0.597 WARS
tryptophanyl-tRNA synthetase
chr2_+_33514896 0.581 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_+_55098280 0.580 CLTC
clathrin, heavy chain (Hc)
chr9_+_27099138 0.566 NM_000459
TEK
TEK tyrosine kinase, endothelial
chrX_-_30505804 0.563 NM_025159
CXorf21
chromosome X open reading frame 21
chr7_+_69869099 0.562 AUTS2
autism susceptibility candidate 2
chr6_+_142552320 0.560 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_+_113853790 0.559 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_-_37727472 0.558 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_-_153493133 0.555 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr2_-_40593074 0.553 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr19_-_60458915 0.550 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_+_176577228 0.548 NM_004841
RASAL2
RAS protein activator like 2
chr20_+_19863716 0.548 RIN2
Ras and Rab interactor 2
chr4_-_152368492 0.547 SH3D19
SH3 domain containing 19
chr1_-_109957195 0.544 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr5_-_150501393 0.544 NM_001193544
ANXA6
annexin A6
chr1_-_74971679 0.540 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr12_+_25096755 0.533 LRMP
lymphoid-restricted membrane protein
chr1_-_242073094 0.530 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_+_53253204 0.527 SCP2
sterol carrier protein 2
chr11_-_110755112 0.520 POU2AF1
POU class 2 associating factor 1
chr17_+_7532391 0.520 NM_001143992
NM_018081
WRAP53

WD repeat containing, antisense to TP53

chr1_+_160868822 0.514 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr12_+_25096472 0.512 NM_006152
LRMP
lymphoid-restricted membrane protein
chr2_+_173394560 0.510 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chrX_+_108665665 0.509 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr4_-_74307637 0.507 ANKRD17
ankyrin repeat domain 17
chr1_+_165564904 0.507 NM_001198783
POU2F1
POU class 2 homeobox 1
chr15_-_32398220 0.505 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr11_+_65023038 0.504 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr3_-_71262426 0.501 FOXP1
forkhead box P1
chr6_+_88021644 0.500 ZNF292
zinc finger protein 292
chr1_+_165565006 0.496 POU2F1
POU class 2 homeobox 1
chr3_-_71262405 0.495 FOXP1
forkhead box P1
chr22_+_40416492 0.495 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr10_+_94584449 0.488 NM_001013848
EXOC6
exocyst complex component 6
chr8_-_133841988 0.480 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr1_+_103840900 0.478 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr2_+_143603368 0.476 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr20_+_20296744 0.473 NM_002196
INSM1
insulinoma-associated 1
chr1_-_115060956 0.468 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr4_+_88147107 0.464 NM_005935
AFF1
AF4/FMR2 family, member 1
chr12_+_10054492 0.460 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr9_-_41944687 0.452 MGC21881
hypothetical locus MGC21881
chr13_+_57103789 0.446 NM_001040429
PCDH17
protocadherin 17
chr14_+_20319049 0.443 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr17_-_35975227 0.443 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr19_+_54530458 0.441 CD37
CD37 molecule
chr10_+_35524060 0.438 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr5_-_96544639 0.436 RIOK2
RIO kinase 2 (yeast)
chr4_-_152366970 0.436 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr13_-_45654327 0.436 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_90177082 0.435 CDK14
cyclin-dependent kinase 14
chr3_-_116272911 0.429 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_19727775 0.427 SH3KBP1
SH3-domain kinase binding protein 1
chr5_-_96544694 0.427 RIOK2
RIO kinase 2 (yeast)
chr7_-_107667728 0.424 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr9_+_78246401 0.421 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr10_+_35496449 0.419 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr1_-_158759606 0.419 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr19_+_54530485 0.415 NM_001040031
NM_001774
CD37

CD37 molecule

chr1_+_144149794 0.412 NM_006472
TXNIP
thioredoxin interacting protein
chr8_+_69027277 0.407 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr4_+_109763119 0.406 RPL34
ribosomal protein L34
chr9_-_3213007 0.403


chr1_+_53253161 0.401 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr5_+_108111421 0.400 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr16_+_28413421 0.399 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_115060904 0.395 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr20_+_56369012 0.395


chrX_-_19727828 0.393 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr14_-_99911679 0.392 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr1_-_115060857 0.391 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr14_-_93512647 0.389 ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_158008763 0.389 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_174598937 0.386 NM_014932
NLGN1
neuroligin 1
chr5_-_96544719 0.385 NM_001159749
NM_018343
RIOK2

RIO kinase 2 (yeast)

chr1_-_177378801 0.383 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr6_+_31604717 0.381 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr20_-_1298493 0.378 FKBP1A
FK506 binding protein 1A, 12kDa
chr7_+_2360954 0.377 NM_001037283
NM_003751
EIF3B

eukaryotic translation initiation factor 3, subunit B

chrX_+_134482212 0.376 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_+_76024466 0.376 NM_004582
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr2_-_20375497 0.375 PUM2
pumilio homolog 2 (Drosophila)
chr4_+_75393053 0.374 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr5_-_110876186 0.374 STARD4
StAR-related lipid transfer (START) domain containing 4
chr19_+_54530497 0.373 CD37
CD37 molecule
chr17_+_20048890 0.369 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr3_+_120495906 0.366 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr7_+_2361051 0.365 EIF3B
eukaryotic translation initiation factor 3, subunit B
chr4_-_35922288 0.364 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_42792676 0.363 NM_001134848
CCDC152
coiled-coil domain containing 152
chr6_+_26473376 0.362 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr3_+_120799411 0.362 NM_015900
PLA1A
phospholipase A1 member A
chr3_+_190990142 0.359 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr11_-_26700121 0.358 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr6_-_152744022 0.358 SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_134800533 0.356 LOC154092
hypothetical LOC154092
chrX_+_107569671 0.355 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr22_+_38627031 0.355 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_-_36387653 0.355 NM_014408
TRAPPC3
trafficking protein particle complex 3
chr7_-_92585205 0.354 SAMD9
sterile alpha motif domain containing 9
chr22_+_38627129 0.353 GRAP2
GRB2-related adaptor protein 2
chr14_+_66901237 0.351 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_-_11490487 0.350 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_+_25444837 0.349 NM_000965
RARB
retinoic acid receptor, beta
chrX_-_70248022 0.347 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr8_-_38324809 0.347 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr4_-_139382672 0.347 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr12_-_52305900 0.346 ATF7
activating transcription factor 7
chr2_+_58127155 0.343 NM_001130480
NM_001130482
NM_001130483
NM_006296
NM_001130481
VRK2




vaccinia related kinase 2





Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 6.14e-03 GO:0007165 signal transduction
1.33 1.84e-02 GO:0023052 signaling
1.30 3.57e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.65 2.88e-02 GO:0030234 enzyme regulator activity