Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.918


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.253.4e-01Click!
NKX2-3chr10_+_101282679-0.224.2e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_171280046 2.318 NM_001003845
SP5
Sp5 transcription factor
chr2_+_171280182 2.219


chr4_+_90252990 1.821 NM_145715
TIGD2
tigger transposable element derived 2
chr3_-_121884091 1.520 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr7_+_94135384 1.484 PEG10
paternally expressed 10
chr17_-_53849888 1.471 RNF43
ring finger protein 43
chr6_+_105511615 1.380 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_-_121883647 1.239 HGD
homogentisate 1,2-dioxygenase
chr12_-_23995109 1.217 SOX5
SRY (sex determining region Y)-box 5
chr10_+_7785360 1.127 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_-_23995220 1.116 SOX5
SRY (sex determining region Y)-box 5
chrX_+_115481774 1.113 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_-_16380967 1.111 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chrX_+_105823723 1.051 NM_024539
RNF128
ring finger protein 128
chr10_+_7785347 1.050 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_+_129066576 1.008 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr10_-_73953699 1.002 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chrX_-_24600661 0.994 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr10_+_7785290 0.948 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_61655915 0.941 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_+_7785331 0.933 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_18214891 0.905 NM_006512
SAA4
serum amyloid A4, constitutive
chr20_+_5935897 0.900 NM_001127458
CRLS1
cardiolipin synthase 1
chr13_+_23042722 0.891 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr9_-_14858974 0.865 FREM1
FRAS1 related extracellular matrix 1
chr4_+_69716298 0.847 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_+_24394281 0.819 PIPOX
pipecolic acid oxidase
chr4_+_74493174 0.812 ALB
albumin
chr4_-_69852090 0.812 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_+_113842284 0.799 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr16_+_7322751 0.757 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr8_-_72436519 0.756 EYA1
eyes absent homolog 1 (Drosophila)
chr9_-_116305273 0.752 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr19_+_50100843 0.740 NM_000041
APOE
apolipoprotein E
chr17_-_46479127 0.728 SPAG9
sperm associated antigen 9
chr5_+_53787187 0.725 NM_006308
HSPB3
heat shock 27kDa protein 3
chr4_+_74520796 0.724 NM_001134
AFP
alpha-fetoprotein
chr7_+_116238309 0.721 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr14_+_31868229 0.701 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_-_16652202 0.683 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_74493301 0.680 ALB
albumin
chr19_-_53081383 0.679 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr3_+_89239494 0.673 EPHA3
EPH receptor A3
chr8_-_72437020 0.672 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr2_-_165133239 0.655 GRB14
growth factor receptor-bound protein 14
chr8_-_72436832 0.652 EYA1
eyes absent homolog 1 (Drosophila)
chrX_-_129347101 0.645 NM_178471
GPR119
G protein-coupled receptor 119
chr10_-_52315390 0.643 A1CF
APOBEC1 complementation factor
chr16_+_20682812 0.643 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr6_+_50789215 0.642 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr19_-_53081326 0.639 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_+_74493266 0.636 ALB
albumin
chr5_+_59819761 0.632 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr17_-_36346240 0.622 KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_101488380 0.621 NM_001195045
YAP1
Yes-associated protein 1
chr10_+_24795446 0.619 KIAA1217
KIAA1217
chr10_+_101532544 0.616 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_+_115481848 0.613 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_7785235 0.605 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_36418869 0.597 NM_031958
KRTAP3-1
keratin associated protein 3-1
chrX_-_48212683 0.595 SLC38A5
solute carrier family 38, member 5
chr4_+_74493218 0.588 ALB
albumin
chr10_+_24795465 0.588 KIAA1217
KIAA1217
chr4_-_176970895 0.586 GPM6A
glycoprotein M6A
chr5_-_131907071 0.584 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr10_-_52315436 0.564 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr12_-_16650697 0.564 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16650687 0.559 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_74493331 0.541 ALB
albumin
chr13_-_35327798 0.536 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr3_+_46894239 0.533 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr10_+_101532450 0.532 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr17_-_1195096 0.530 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_-_26038817 0.523 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr10_+_102722275 0.520 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chrX_+_68752635 0.514 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr4_-_23500706 0.508 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_-_59819642 0.504 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_37134050 0.496 FOXA1
forkhead box A1
chr1_+_50342168 0.487 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_+_77213295 0.478 NM_144595
SLAIN1
SLAIN motif family, member 1
chr6_-_46401174 0.473 RCAN2
regulator of calcineurin 2
chr6_+_28237529 0.468 NM_001145129
ZNF389
zinc finger protein 389
chr4_+_74499651 0.468 ALB
albumin
chr3_+_160269836 0.467 IQCJ
IQ motif containing J
chr4_-_186970366 0.458 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_+_31731647 0.450 NM_019101
APOM
apolipoprotein M
chr12_+_49605010 0.450 METTL7A
methyltransferase like 7A
chr17_-_36456949 0.441 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr11_+_86710076 0.439 TMEM135
transmembrane protein 135
chr20_+_30160952 0.439 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr8_+_9990471 0.437 NM_001135671
MSRA
methionine sulfoxide reductase A
chr2_-_200033445 0.436 SATB2
SATB homeobox 2
chr22_-_16127520 0.435 CECR3
cat eye syndrome chromosome region, candidate 3
chr2_-_215953818 0.432 FN1
fibronectin 1
chr17_-_36347197 0.430 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chrX_+_90976314 0.422 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr16_+_70654625 0.422 NM_020995
HPR
haptoglobin-related protein
chr13_-_93929719 0.421 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr14_-_37134191 0.420 NM_004496
FOXA1
forkhead box A1
chrX_-_135783496 0.416


chr1_+_556968 0.412


chr12_+_54700955 0.410 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr6_+_31731667 0.410 APOM
apolipoprotein M
chr1_-_214963279 0.407 NM_001438
ESRRG
estrogen-related receptor gamma
chr2_+_189547377 0.405 COL3A1
collagen, type III, alpha 1
chr11_-_16454493 0.402 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_+_225973845 0.399 NM_020864
KIAA1486
KIAA1486
chr12_+_50342814 0.398 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chrX_+_9391314 0.396 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_+_161981046 0.396 TBR1
T-box, brain, 1
chr7_-_36991189 0.393 NM_001039459
ELMO1
engulfment and cell motility 1
chr6_+_155579788 0.393 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_-_106033202 0.388 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chrX_+_21960841 0.386 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr3_+_160269734 0.385 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chrX_+_123062143 0.382 STAG2
stromal antigen 2
chr8_-_82536312 0.381 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr2_+_189547358 0.381 COL3A1
collagen, type III, alpha 1
chr18_+_71051713 0.377 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr2_+_161981138 0.376 TBR1
T-box, brain, 1
chr7_-_96471544 0.369 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr14_+_69307914 0.369 SRSF5
serine/arginine-rich splicing factor 5
chr6_-_24491498 0.366 NM_001195610
DCDC2
doublecortin domain containing 2
chr12_-_9123126 0.365 A2M
alpha-2-macroglobulin
chr13_+_97856148 0.363


chr12_+_40117751 0.360 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr4_-_83566045 0.355


chr6_-_32265489 0.355 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr14_-_37133927 0.352 FOXA1
forkhead box A1
chr6_+_41128917 0.345 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr2_-_190635566 0.345 NM_005259
MSTN
myostatin
chr11_-_57275828 0.340 NM_001145101
BTBD18
BTB (POZ) domain containing 18
chr1_+_117098579 0.339 NM_001767
CD2
CD2 molecule
chrX_+_70682204 0.338 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr12_-_4358968 0.337 NM_020638
FGF23
fibroblast growth factor 23
chr5_+_140751666 0.336 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_+_161980865 0.336 NM_006593
TBR1
T-box, brain, 1
chr9_+_4829763 0.334 RCL1
RNA terminal phosphate cyclase-like 1
chr3_-_188492163 0.331 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr12_+_49604782 0.331 NM_014033
METTL7A
methyltransferase like 7A
chr12_-_120725210 0.328 LOC338799
hypothetical LOC338799
chr5_-_135259403 0.328 NM_000590
IL9
interleukin 9
chr4_+_100714995 0.328 MTTP
microsomal triglyceride transfer protein
chr15_-_53996597 0.322 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr11_+_89624017 0.322


chr15_+_38082041 0.321 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr7_+_142053693 0.320 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr19_-_5789740 0.320 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr14_+_38772870 0.320 NM_054024
MIA2
melanoma inhibitory activity 2
chr14_-_64479198 0.315 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_189547323 0.314 NM_000090
COL3A1
collagen, type III, alpha 1
chr19_-_47724365 0.313 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr10_-_97190885 0.313 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr4_+_88939725 0.312 NM_004967
IBSP
integrin-binding sialoprotein
chr3_-_15538164 0.310 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr16_-_4792857 0.309 ROGDI
rogdi homolog (Drosophila)
chr3_+_85858321 0.307 NM_153184
CADM2
cell adhesion molecule 2
chr16_+_70646008 0.306 NM_001126102
NM_005143
HP

haptoglobin

chr6_+_132915522 0.305 NM_053278
TAAR8
trace amine associated receptor 8
chr2_+_96818048 0.305 CNNM4
cyclin M4
chr6_-_53121540 0.305 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr7_-_112513379 0.302 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr1_+_100089118 0.295 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr16_-_68317855 0.295 NQO1
NAD(P)H dehydrogenase, quinone 1
chr4_-_176971175 0.295 NM_201591
GPM6A
glycoprotein M6A
chr15_+_56511466 0.294 NM_000236
LIPC
lipase, hepatic
chr8_-_17624009 0.292 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr10_+_24537725 0.290 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr1_+_50348052 0.290 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_165804157 0.289 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_140806536 0.289 MGST2
microsomal glutathione S-transferase 2
chr3_+_46370578 0.288 CCR2
chemokine (C-C motif) receptor 2
chr2_-_216654708 0.288 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr19_+_4442610 0.287 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr4_+_71418886 0.284 NM_212557
AMTN
amelotin
chr4_-_100359353 0.284 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chrX_-_130251068 0.282 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr3_+_162697289 0.281 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr8_-_82769761 0.280 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr5_-_149649593 0.275 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr11_+_91724909 0.274 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chrX_-_18600108 0.274 NM_000330
RS1
retinoschisin 1
chr12_-_16649211 0.273 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_49712483 0.272 NM_000324
RHAG
Rh-associated glycoprotein
chr9_-_103185621 0.271 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr7_-_44547382 0.271 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr14_+_99555471 0.270 EVL
Enah/Vasp-like
chr20_-_19984685 0.269 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr11_+_20577521 0.269 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr22_-_36836620 0.267 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr13_+_34948977 0.267 NBEA
neurobeachin
chr4_-_123761615 0.264 NM_021803
IL21
interleukin 21
chr12_-_23993830 0.263 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr7_+_147918589 0.262 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr17_-_31352720 0.261 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr5_-_148738980 0.261 NM_014443
IL17B
interleukin 17B
chr6_+_131190237 0.261 NM_001195597
LOC285733
hypothetical LOC285733
chr4_+_123380569 0.259 KIAA1109
KIAA1109
chr6_+_167624792 0.258 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 2.73e-17 GO:0003008 system process
2.06 3.77e-16 GO:0050877 neurological system process
1.44 1.52e-15 GO:0032501 multicellular organismal process
2.33 6.78e-14 GO:0007600 sensory perception
2.80 2.50e-13 GO:0007606 sensory perception of chemical stimulus
2.77 3.23e-11 GO:0007608 sensory perception of smell
1.26 1.25e-06 GO:0050896 response to stimulus
1.69 1.78e-02 GO:0007267 cell-cell signaling
1.85 3.18e-02 GO:0019226 transmission of nerve impulse
1.85 3.18e-02 GO:0035637 multicellular organismal signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 6.98e-09 GO:0071944 cell periphery
1.38 7.23e-09 GO:0005886 plasma membrane
1.45 5.59e-05 GO:0005576 extracellular region
1.23 9.75e-05 GO:0031224 intrinsic to membrane
1.20 2.25e-04 GO:0044425 membrane part
1.22 4.43e-04 GO:0016021 integral to membrane
3.98 5.04e-03 GO:0031983 vesicle lumen
1.53 7.33e-03 GO:0044421 extracellular region part
1.89 8.51e-03 GO:0045202 synapse
6.18 2.32e-02 GO:0032982 myosin filament
2.59 2.86e-02 GO:0043292 contractile fiber
1.13 3.19e-02 GO:0016020 membrane
2.60 3.86e-02 GO:0030016 myofibril
2.29 4.43e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.93 2.03e-12 GO:0004888 transmembrane receptor activity
2.18 3.80e-12 GO:0004930 G-protein coupled receptor activity
2.77 2.56e-11 GO:0004984 olfactory receptor activity
1.69 1.25e-09 GO:0004872 receptor activity
1.55 1.32e-07 GO:0004871 signal transducer activity
1.55 1.32e-07 GO:0060089 molecular transducer activity