Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.918


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.253.4e-01Click!
NKX2-3chr10_+_101282679-0.224.2e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_171280046 2.318 NM_001003845
SP5
Sp5 transcription factor
chr2_+_171280182 2.219


chr4_+_90252990 1.821 NM_145715
TIGD2
tigger transposable element derived 2
chr3_-_121884091 1.520 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr7_+_94135384 1.484 PEG10
paternally expressed 10
chr17_-_53849888 1.471 RNF43
ring finger protein 43
chr6_+_105511615 1.380 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_-_121883647 1.239 HGD
homogentisate 1,2-dioxygenase
chr12_-_23995109 1.217 SOX5
SRY (sex determining region Y)-box 5
chr10_+_7785360 1.127 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_-_23995220 1.116 SOX5
SRY (sex determining region Y)-box 5
chrX_+_115481774 1.113 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_-_16380967 1.111 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chrX_+_105823723 1.051 NM_024539
RNF128
ring finger protein 128
chr10_+_7785347 1.050 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_+_129066576 1.008 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr10_-_73953699 1.002 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chrX_-_24600661 0.994 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr10_+_7785290 0.948 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_61655915 0.941 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
2.80 2.50e-13 GO:0007606 sensory perception of chemical stimulus
2.77 3.23e-11 GO:0007608 sensory perception of smell
2.33 6.78e-14 GO:0007600 sensory perception
2.06 3.77e-16 GO:0050877 neurological system process
1.96 2.73e-17 GO:0003008 system process
1.85 3.18e-02 GO:0019226 transmission of nerve impulse
1.85 3.18e-02 GO:0035637 multicellular organismal signaling
1.69 1.78e-02 GO:0007267 cell-cell signaling
1.44 1.52e-15 GO:0032501 multicellular organismal process
1.26 1.25e-06 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
6.18 2.32e-02 GO:0032982 myosin filament
3.98 5.04e-03 GO:0031983 vesicle lumen
2.60 3.86e-02 GO:0030016 myofibril
2.59 2.86e-02 GO:0043292 contractile fiber
2.29 4.43e-02 GO:0005882 intermediate filament
1.89 8.51e-03 GO:0045202 synapse
1.53 7.33e-03 GO:0044421 extracellular region part
1.45 5.59e-05 GO:0005576 extracellular region
1.38 7.23e-09 GO:0005886 plasma membrane
1.37 6.98e-09 GO:0071944 cell periphery
1.23 9.75e-05 GO:0031224 intrinsic to membrane
1.22 4.43e-04 GO:0016021 integral to membrane
1.20 2.25e-04 GO:0044425 membrane part
1.13 3.19e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.77 2.56e-11 GO:0004984 olfactory receptor activity
2.18 3.80e-12 GO:0004930 G-protein coupled receptor activity
1.93 2.03e-12 GO:0004888 transmembrane receptor activity
1.69 1.25e-09 GO:0004872 receptor activity
1.55 1.32e-07 GO:0004871 signal transducer activity
1.55 1.32e-07 GO:0060089 molecular transducer activity