Motif ID: NKX6-1,2.p2

Z-value: 0.842


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-2chr10_-_1344494670.155.7e-01Click!
NKX6-1chr4_-_856384100.136.4e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_78858675 1.271 NM_006820
IFI44L
interferon-induced protein 44-like
chr9_+_81376666 1.125 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_-_151052391 1.099 NM_005168
RND3
Rho family GTPase 3
chr2_+_17861266 1.080 NM_001105569
MSGN1
mesogenin 1
chr3_-_113495763 1.029 NM_183061
SLC9A10
solute carrier family 9, member 10
chr7_+_28692122 1.025 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr8_-_122722674 0.994 NM_005328
HAS2
hyaluronan synthase 2
chr18_+_30544193 0.931 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr3_-_143230124 0.929 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr9_+_81377419 0.911 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr4_+_169654742 0.897 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr7_-_83662152 0.892 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_-_152368492 0.832 SH3D19
SH3 domain containing 19
chr1_+_185064654 0.826 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chrX_-_33139349 0.826 NM_004006
DMD
dystrophin
chr7_-_41709191 0.805 NM_002192
INHBA
inhibin, beta A
chr3_+_175641340 0.793 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr12_+_74071116 0.793 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr3_-_11585264 0.781 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr3_-_64186151 0.776 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr21_+_29439768 0.762 C21orf7
chromosome 21 open reading frame 7
chr14_+_62740878 0.757 NM_020663
RHOJ
ras homolog gene family, member J
chr13_-_32658215 0.754 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_+_75393053 0.749 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr12_-_51887266 0.744 NM_000889
ITGB7
integrin, beta 7
chr8_+_79591074 0.734 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr9_+_81377289 0.706 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_205161821 0.662 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_-_225519974 0.657 DOCK10
dedicator of cytokinesis 10
chr3_+_16191159 0.649 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr2_-_160764819 0.648 NM_000888
ITGB6
integrin, beta 6
chr1_+_78888064 0.631 NM_006417
IFI44
interferon-induced protein 44
chr1_-_89261021 0.600 NM_018284
GBP3
guanylate binding protein 3
chr6_-_56824371 0.592 DST
dystonin
chr11_+_1830763 0.587 NM_002339
LSP1
lymphocyte-specific protein 1
chr12_-_52939584 0.585 NM_001127322
CBX5
chromobox homolog 5
chr8_+_79590890 0.584 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr21_-_35343065 0.584 RUNX1
runt-related transcription factor 1
chr13_-_98757634 0.575 NM_004951
GPR183
G protein-coupled receptor 183
chr2_+_37282516 0.548 LOC100505876
hypothetical LOC100505876
chr6_+_26548678 0.542 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr12_-_51887318 0.537 ITGB7
integrin, beta 7
chr8_-_28403652 0.531 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr6_-_26151863 0.529 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr20_+_19863716 0.524 RIN2
Ras and Rab interactor 2
chr6_+_26071255 0.520 TRIM38
tripartite motif containing 38
chr6_-_32892705 0.505 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_+_24061717 0.502 NM_203282
ZNF254
zinc finger protein 254
chr1_-_110735158 0.502 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr1_+_144188375 0.485 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr2_-_202271598 0.472 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr12_-_52939636 0.471 NM_001127321
CBX5
chromobox homolog 5
chr1_+_85300580 0.469 NM_145172
WDR63
WD repeat domain 63
chr3_-_15814678 0.468 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr2_-_227952249 0.468 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_+_32713160 0.467 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_+_26070957 0.463 NM_006355
TRIM38
tripartite motif containing 38
chr6_+_114285209 0.461 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr19_+_45973139 0.453 NM_006533
MIA
melanoma inhibitory activity
chr6_-_56824672 0.448 DST
dystonin
chr2_-_160765008 0.442 ITGB6
integrin, beta 6
chr16_-_3567354 0.433 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr20_+_11846536 0.431 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr11_+_122258600 0.430 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr9_+_92629525 0.429 NM_001174167
SYK
spleen tyrosine kinase
chr1_+_208568218 0.428 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr5_-_64813459 0.421 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chrX_+_55951280 0.415


chr19_-_46504831 0.411


chr10_+_86174665 0.409 FAM190B
family with sequence similarity 190, member B
chr1_-_149004916 0.407 NM_004079
CTSS
cathepsin S
chr1_-_219982016 0.405 DUSP10
dual specificity phosphatase 10
chr3_-_150903749 0.404 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr5_+_35892747 0.400 NM_002185
IL7R
interleukin 7 receptor
chr1_-_219982049 0.387 DUSP10
dual specificity phosphatase 10
chr21_-_35343456 0.384 NM_001754
RUNX1
runt-related transcription factor 1
chr12_+_46799279 0.382 NM_000289
PFKM
phosphofructokinase, muscle
chr3_+_157877146 0.376 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_-_149004852 0.375 CTSS
cathepsin S
chr1_-_219982081 0.370 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_+_31650069 0.369 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr21_-_35343331 0.367 RUNX1
runt-related transcription factor 1
chr1_+_207668787 0.364 NM_001104548
LOC642587
NPC-A-5
chr21_-_35343448 0.361 RUNX1
runt-related transcription factor 1
chr3_-_21767819 0.351 NM_024697
ZNF385D
zinc finger protein 385D
chr12_+_25096755 0.350 LRMP
lymphoid-restricted membrane protein
chr4_-_10295412 0.348 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr9_-_21375258 0.345 NM_000605
IFNA2
interferon, alpha 2
chr7_-_76667045 0.345 NM_006682
FGL2
fibrinogen-like 2
chr20_-_7869068 0.344 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr2_-_217267742 0.342 IGFBP5
insulin-like growth factor binding protein 5
chr1_-_6343306 0.340 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr4_-_138673078 0.339 NM_019035
PCDH18
protocadherin 18
chr6_+_125346208 0.337 NM_152553
RNF217
ring finger protein 217
chr3_+_195688974 0.335 FLJ34208
hypothetical LOC401106
chr11_+_93916653 0.333 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr5_+_96237923 0.333 ERAP2
endoplasmic reticulum aminopeptidase 2
chr1_-_53972464 0.331 NM_147193
GLIS1
GLIS family zinc finger 1
chr7_+_93862137 0.331 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr14_-_74600469 0.330 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr11_+_12265022 0.328 NM_032867
MICALCL
MICAL C-terminal like
chrX_+_85404626 0.325 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chrX_-_102973762 0.324 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr11_+_59027624 0.324 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr1_+_159943385 0.323 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr1_-_27825633 0.322 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chrX_+_80343958 0.320 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_+_48443232 0.319 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr11_-_56951628 0.317 NM_017611
SLC43A3
solute carrier family 43, member 3
chr12_+_54611212 0.315 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr3_-_116272911 0.313 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_9871343 0.313 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_-_35343428 0.311 RUNX1
runt-related transcription factor 1
chr1_-_149115667 0.305 ARNT
aryl hydrocarbon receptor nuclear translocator
chr21_-_35343500 0.304 RUNX1
runt-related transcription factor 1
chrX_+_102727068 0.304 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr5_+_162862808 0.302 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr11_+_65026382 0.302


chr1_-_149004879 0.301 CTSS
cathepsin S
chr18_-_44731078 0.301 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr17_+_24598000 0.300 NM_005208
CRYBA1
crystallin, beta A1
chr1_-_114215768 0.300 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr14_+_87921818 0.298 SPATA7
spermatogenesis associated 7
chr2_+_33213111 0.292 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr12_-_53664722 0.290 NM_001136030
KIAA0748
KIAA0748
chr18_+_54013575 0.288 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_108111421 0.282 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr3_+_39346200 0.281 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr1_+_242691295 0.281 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr2_+_68815416 0.280 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr12_+_56406296 0.280 LOC100130776
hypothetical LOC100130776
chr11_+_100063061 0.278 NM_152432
ARHGAP42
Rho GTPase activating protein 42
chr12_+_25096472 0.276 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_-_138673014 0.276 PCDH18
protocadherin 18
chrX_-_114158388 0.272 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr3_-_122862447 0.270 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_152585226 0.268 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr2_+_161701711 0.266 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr5_+_49997489 0.266 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chrX_+_51503219 0.263 NM_018094
GSPT2
G1 to S phase transition 2
chr6_-_80303822 0.262 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr3_-_52269467 0.261 WDR82
WD repeat domain 82
chr5_-_111119846 0.260 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_-_149115771 0.258 ARNT
aryl hydrocarbon receptor nuclear translocator
chr4_+_54790020 0.258 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_+_80344253 0.256 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_194887630 0.255 NM_000186
NM_001014975
CFH

complement factor H

chr8_-_23768242 0.254 NM_003155
STC1
stanniocalcin 1
chr14_+_87541220 0.251 NM_003608
GPR65
G protein-coupled receptor 65
chr14_-_63076155 0.249 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr8_+_133060353 0.249 EFR3A
EFR3 homolog A (S. cerevisiae)
chr19_+_46503524 0.249 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_+_242582559 0.249 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr21_-_42219849 0.248 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr3_-_171070314 0.246 NM_024727
LRRC31
leucine rich repeat containing 31
chr12_+_91620749 0.246 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr8_+_86287161 0.245 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr1_+_242281199 0.244 ZNF238
zinc finger protein 238
chr12_-_56422120 0.244 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr17_-_36475652 0.243 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr12_+_27288344 0.242 NM_015000
STK38L
serine/threonine kinase 38 like
chrX_+_80344215 0.241 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr15_+_97990705 0.240 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr13_+_107720561 0.240 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_147562531 0.236 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr2_+_66519949 0.236 MEIS1
Meis homeobox 1
chr6_-_37773609 0.235 NM_153487
MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
chrX_+_15435351 0.233 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr13_+_26742463 0.233 NM_206827
RASL11A
RAS-like, family 11, member A
chr7_-_33047042 0.232 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr6_+_31662454 0.229 NM_205837
LST1
leukocyte specific transcript 1
chr3_-_122862391 0.228 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_12149662 0.228 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr1_-_149115686 0.227 ARNT
aryl hydrocarbon receptor nuclear translocator
chr3_+_133518900 0.226 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr20_-_51633042 0.223 NM_006526
ZNF217
zinc finger protein 217
chr6_+_96132064 0.223 NM_024641
MANEA
mannosidase, endo-alpha
chr5_+_167846023 0.222 NM_002887
RARS
arginyl-tRNA synthetase
chr2_-_162808123 0.221 NM_004460
FAP
fibroblast activation protein, alpha
chr19_+_57564981 0.221 NM_001145434
ZNF880
zinc finger protein 880
chr4_-_170314382 0.221 SH3RF1
SH3 domain containing ring finger 1
chr4_+_187227302 0.220 NM_003265
TLR3
toll-like receptor 3
chr19_+_50086362 0.219 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_-_13992351 0.219 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_133126278 0.218 NM_078488
VNN2
vanin 2
chr2_+_12775814 0.217


chr1_+_199884152 0.215 NAV1
neuron navigator 1
chr7_-_22518200 0.215 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr15_-_46890475 0.214 NM_001194998
NM_014985
CEP152

centrosomal protein 152kDa

chr3_-_152449591 0.211 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr5_-_88155360 0.210 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_+_55760774 0.210 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr1_+_108904191 0.209 FAM102B
family with sequence similarity 102, member B
chr1_-_234511917 0.208 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr3_+_179759181 0.208 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_+_53178834 0.207 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr4_-_16509126 0.207 LDB2
LIM domain binding 2
chr22_+_38627129 0.207 GRAP2
GRB2-related adaptor protein 2
chr11_-_101906640 0.206 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr4_+_54790190 0.205 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 5.41e-04 GO:0050896 response to stimulus
1.64 1.09e-03 GO:0002376 immune system process
1.32 2.32e-03 GO:0023052 signaling
1.33 2.86e-03 GO:0007165 signal transduction
1.70 4.23e-02 GO:0006955 immune response
1.43 4.53e-02 GO:0007166 cell surface receptor linked signaling pathway

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 2.85e-02 GO:0005102 receptor binding