Motif ID: NR1H4.p2

Z-value: 1.456


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H4chr12_+_993918700.611.3e-02Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_27113018 2.679 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr11_-_116168316 2.667 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr12_-_7172641 2.555 NM_031491
RBP5
retinol binding protein 5, cellular
chr6_+_31731647 2.534 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 2.518 APOM
apolipoprotein M
chr10_-_95350949 2.435 NM_006744
RBP4
retinol binding protein 4, plasma
chr3_+_52803823 2.208 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr15_+_63124760 2.017 NM_178859
OSTBETA
organic solute transporter beta
chr22_+_43451351 1.966 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_+_45046740 1.954 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr22_+_43451600 1.907 PRR5
proline rich 5 (renal)
chr17_-_71352017 1.731 UNC13D
unc-13 homolog D (C. elegans)
chr22_+_23329113 1.720 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr4_-_69852090 1.706 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr17_-_71352090 1.702 UNC13D
unc-13 homolog D (C. elegans)
chr1_-_47468029 1.616 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_+_93830106 1.596 LOC100129046
hypothetical LOC100129046
chr17_-_71352182 1.544 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr16_-_1369613 1.513 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr1_+_93830169 1.483 LOC100129046
hypothetical LOC100129046
chr20_+_61839931 1.434 LIME1
Lck interacting transmembrane adaptor 1
chr19_-_17377383 1.316 NM_004335
BST2
bone marrow stromal cell antigen 2
chr3_-_127719283 1.297 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr3_-_50315983 1.281 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr1_+_32489426 1.269 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr17_-_7023283 1.241 ASGR1
asialoglycoprotein receptor 1
chr2_+_219354692 1.203 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr3_-_49701085 1.164 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr12_+_68028407 1.134 LYZ
lysozyme
chr19_+_55398680 1.064 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chrX_+_65152004 1.058


chr8_-_37576515 1.056 LOC157860
hypothetical protein LOC157860
chr19_+_59064471 1.036 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr17_-_7023378 1.019 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chrX_-_106033202 1.016 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr1_+_12046020 1.012 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr9_+_130231027 1.009 CERCAM
cerebral endothelial cell adhesion molecule
chr2_-_73723001 0.997 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr19_-_10474266 0.996 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr21_+_41663853 0.991 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr19_-_56585603 0.981 NM_001193623
LOC147646
hypothetical protein LOC147646
chr17_+_37942034 0.952


chr15_-_38185578 0.949 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr17_-_78599695 0.939 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr2_+_73294852 0.930 NM_006062
SMYD5
SMYD family member 5
chr17_-_53764867 0.923


chr6_-_32268267 0.910 GPSM3
G-protein signaling modulator 3
chr8_+_145692916 0.894 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr10_+_685887 0.883 C10orf108
chromosome 10 open reading frame 108
chrX_+_7147471 0.880 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr7_+_26298136 0.868 SNX10
sorting nexin 10
chr5_-_149772469 0.861 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr19_+_15644885 0.857 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_25619863 0.850 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr19_+_59064795 0.848 MYADM
myeloid-associated differentiation marker
chr17_+_1612092 0.828 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_22825148 0.827 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr1_-_150070849 0.820 NM_005060
RORC
RAR-related orphan receptor C
chr6_+_24465109 0.817 NM_181337
KAAG1
kidney associated antigen 1
chr12_-_56200547 0.814 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr12_+_54677271 0.800 NM_000456
NM_001032386
NM_001032387
SUOX


sulfite oxidase


chr10_-_101831579 0.797 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chrX_-_132947290 0.797 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr14_+_23095028 0.795 NM_001126339
NM_024328
THTPA

thiamine triphosphatase

chr6_+_167456230 0.793 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr6_+_108722752 0.787 NM_145315
LACE1
lactation elevated 1
chr17_+_1612031 0.778 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1612056 0.770 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr13_+_49658016 0.764


chr22_-_22304486 0.750 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr20_-_22512893 0.737 FOXA2
forkhead box A2
chr2_+_108271526 0.727 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr17_-_3651236 0.725 NM_002208
ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr1_+_1324762 0.722 LOC148413
hypothetical LOC148413
chr19_-_47638890 0.721 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr20_-_3097070 0.718 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr14_-_23095240 0.696


chr22_-_29231597 0.691 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr17_+_1611983 0.689 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_-_100359353 0.687 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr4_-_176970407 0.684 GPM6A
glycoprotein M6A
chrX_+_117745551 0.681 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr4_-_186934059 0.680 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr16_+_1979959 0.680 NM_004209
SYNGR3
synaptogyrin 3
chr17_-_57295451 0.679 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr4_+_74500748 0.679 ALB
albumin
chr9_+_139566129 0.676 NM_032477
MRPL41
mitochondrial ribosomal protein L41
chrX_-_118711350 0.675 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr17_-_77647505 0.672 FASN
fatty acid synthase
chr17_-_9880598 0.661 GAS7
growth arrest-specific 7
chr5_+_61910318 0.647 NM_181506
LRRC70
leucine rich repeat containing 70
chr6_-_43703057 0.636 GTPBP2
GTP binding protein 2
chr1_+_29113589 0.633 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr8_+_21938299 0.633 NM_182795
NPM2
nucleophosmin/nucleoplasmin 2
chr7_-_10946277 0.631 NM_002489
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr1_-_158306570 0.629 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr11_+_61276576 0.628 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr1_-_159459814 0.628 APOA2
apolipoprotein A-II
chrX_-_118711144 0.626 SEPT6
septin 6
chr17_-_9880729 0.618 NM_201432
GAS7
growth arrest-specific 7
chr8_-_13018123 0.614 NM_001164271
DLC1
deleted in liver cancer 1
chr19_-_10311262 0.613 NM_002162
ICAM3
intercellular adhesion molecule 3
chr9_-_115880366 0.611 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_+_67635593 0.608 YIPF6
Yip1 domain family, member 6
chr1_+_64983312 0.604 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr1_+_200584421 0.604 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr14_-_22825072 0.598 HOMEZ
homeobox and leucine zipper encoding
chr1_-_1324511 0.591 NM_001039577
NM_030937
CCNL2

cyclin L2

chr19_-_47724365 0.590 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr2_-_74228506 0.588 NM_001035505
NM_212552
BOLA3

bolA homolog 3 (E. coli)

chr19_+_11211282 0.587 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr3_+_123779122 0.587 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_-_29635680 0.582 NM_006398
UBD
ubiquitin D
chr1_+_25471470 0.576 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr16_+_28782682 0.576 NM_001145812
NM_015503
SH2B1

SH2B adaptor protein 1

chr1_+_148496792 0.571 NM_012113
CA14
carbonic anhydrase XIV
chr12_-_120781002 0.561 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr6_-_43703024 0.552 GTPBP2
GTP binding protein 2
chr17_+_75319476 0.548 NM_178543
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr4_-_176970372 0.545 GPM6A
glycoprotein M6A
chr1_-_2129031 0.544 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr16_+_56259657 0.537 NM_170776
GPR97
G protein-coupled receptor 97
chr2_-_178645718 0.535 NM_016953
PDE11A
phosphodiesterase 11A
chr11_-_57054756 0.533 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr11_+_22646229 0.529 NM_177553
GAS2
growth arrest-specific 2
chr16_+_70654625 0.528 NM_020995
HPR
haptoglobin-related protein
chr17_+_69950782 0.526 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_+_65162114 0.525 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr6_+_43846735 0.524 VEGFA
vascular endothelial growth factor A
chr20_+_57027703 0.523 NM_030773
TUBB1
tubulin, beta 1
chr7_+_45899080 0.521 IGFBP1
insulin-like growth factor binding protein 1
chr6_+_36272506 0.515 NM_015695
BRPF3
bromodomain and PHD finger containing, 3
chr5_-_95184221 0.515 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr11_+_71317415 0.514 NM_018320
RNF121
ring finger protein 121
chr17_-_7107229 0.509 NM_001185022
CLDN7
claudin 7
chr6_+_41622267 0.509 FOXP4
forkhead box P4
chr2_+_58127419 0.506 VRK2
vaccinia related kinase 2
chr1_-_180622083 0.506 GLUL
glutamate-ammonia ligase
chr16_-_23559978 0.505 NM_024675
PALB2
partner and localizer of BRCA2
chr16_+_23560187 0.503 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr22_+_18085891 0.497 SEPT5
septin 5
chr17_-_24062998 0.494 NM_152465
PROCA1
protein interacting with cyclin A1
chr20_-_32163743 0.494 NM_003908
EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr3_+_134947940 0.493 TF
transferrin
chr1_+_559618 0.492


chr17_+_73676219 0.492 NM_004710
SYNGR2
synaptogyrin 2
chr1_+_26433200 0.491 NM_022778
CCDC21
coiled-coil domain containing 21
chr1_-_159543847 0.486 MPZ
myelin protein zero
chr1_-_11029737 0.484 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr22_+_18085990 0.479 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chrX_-_118711088 0.478 SEPT6
septin 6
chr15_-_38185865 0.474 NM_033503
BMF
Bcl2 modifying factor
chr11_+_74539679 0.473 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr1_+_46541913 0.470 NM_006004
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr22_+_23309717 0.468 NM_013430
GGT1
gamma-glutamyltransferase 1
chr6_+_2190964 0.465


chr1_+_32530289 0.461 HDAC1
histone deacetylase 1
chr1_+_32530294 0.460 NM_004964
HDAC1
histone deacetylase 1
chrX_-_153397566 0.458 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr16_+_52081836 0.457 RBL2
retinoblastoma-like 2 (p130)
chr16_+_65552600 0.455 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr20_-_2437777 0.453 NM_024325
ZNF343
zinc finger protein 343
chr1_-_166171838 0.452 NM_015415
BRP44
brain protein 44
chr19_-_47438563 0.451 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chrX_+_151617900 0.448 NM_005363
NM_175868
MAGEA6

melanoma antigen family A, 6

chr1_+_32530298 0.445 HDAC1
histone deacetylase 1
chr14_+_99601498 0.444 NM_016337
EVL
Enah/Vasp-like
chr19_+_1199548 0.440 NM_177401
MIDN
midnolin
chr17_-_15463742 0.439 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr19_+_4180494 0.438 NM_005755
EBI3
Epstein-Barr virus induced 3
chr12_+_100615530 0.435 NM_020244
CHPT1
choline phosphotransferase 1
chr9_-_116305273 0.435 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr11_-_5232480 0.434 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr6_+_107456020 0.432 NM_001142468
NM_001142470
NM_016487
C6orf203


chromosome 6 open reading frame 203


chr17_-_42250961 0.427 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr14_-_24173205 0.427 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr3_+_134947788 0.427 TF
transferrin
chr10_-_21854616 0.426 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr18_-_65775139 0.426 NM_006566
CD226
CD226 molecule
chr9_-_115880281 0.425 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_149221122 0.424 NM_003568
ANXA9
annexin A9
chr17_+_40581704 0.423 HEXIM1
hexamethylene bis-acetamide inducible 1
chr9_-_34366831 0.420 NM_020702
KIAA1161
KIAA1161
chr3_+_185356003 0.419 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr3_+_134947894 0.418 TF
transferrin
chr1_-_166171702 0.417 BRP44
brain protein 44
chr1_-_218329684 0.416 BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr16_-_23515104 0.415 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr3_-_180460372 0.412 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr4_+_25524903 0.412 NM_001145432
C4orf52
chromosome 4 open reading frame 52
chr19_-_54350457 0.410 NM_002152
HRC
histidine rich calcium binding protein
chrX_-_118711183 0.405 SEPT6
septin 6
chr9_-_14858974 0.403 FREM1
FRAS1 related extracellular matrix 1
chr19_+_18357966 0.402 NM_004864
GDF15
growth differentiation factor 15
chr1_-_211031727 0.400 NM_001042549
NM_015471
NSL1

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr3_-_198784590 0.400 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr9_-_129699389 0.399 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr7_+_93977267 0.397 CASD1
CAS1 domain containing 1
chr17_+_18588050 0.396 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr19_-_47438518 0.395 GSK3A
glycogen synthase kinase 3 alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.02 1.04e-02 GO:0010035 response to inorganic substance
2.28 1.64e-02 GO:0010038 response to metal ion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.43e-03 GO:0005739 mitochondrion
2.92 1.90e-02 GO:0070469 respiratory chain

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.88 8.77e-03 GO:0051087 chaperone binding