Motif ID: NRF1.p2

Z-value: 4.817


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1290571520.411.1e-01Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_6150536 6.509


chr17_-_24302597 4.068 NM_001033561
NM_020889
 PHF12

PHD finger protein 12

chr12_+_52960745 3.985 NM_002136
NM_031157
 HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr20_+_48781457 3.973 NM_032521
 PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_52960798 3.958 HNRNPA1L2
HNRNPA1
HNRNPA1P10
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
heterogeneous nuclear ribonucleoprotein A1 pseudogene 10
chr1_+_148603208 3.856 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr6_+_30722794 3.719 NM_001109938
NM_001161376
NM_145029
 C6orf136


chromosome 6 open reading frame 136


chr19_-_53558961 3.681 NM_018273
 TMEM143
transmembrane protein 143
chr4_+_6726555 3.566 LOC93622
hypothetical LOC93622
chr19_+_53559468 3.528 NM_012451
 SYNGR4
synaptogyrin 4
chr19_-_51097694 3.503 NM_001012643
 MYPOP
Myb-related transcription factor, partner of profilin
chr12_-_52960206 3.494 CBX5
chromobox homolog 5
chr7_+_99865340 3.490 MEPCE
methylphosphate capping enzyme
chr12_-_52960168 3.316 NM_012117
 CBX5
chromobox homolog 5
chr11_+_63829616 3.276 NM_004451
 ESRRA
estrogen-related receptor alpha
chr10_+_133995587 3.210 NM_001143758
NM_001143759
NM_030626
 LRRC27


leucine rich repeat containing 27


chr3_+_49701965 3.205 RNF123
ring finger protein 123
chr3_+_49701978 3.192 NM_022064
 RNF123
ring finger protein 123
chr6_-_31977747 3.190 NM_181842
 ZBTB12
zinc finger and BTB domain containing 12
chr3_+_49702018 3.159 RNF123
ring finger protein 123

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 76 entries
enrichment   p-value GO term description
3.01 4.47e-04 GO:0006405 RNA export from nucleus
2.96 3.34e-03 GO:0006406 mRNA export from nucleus
2.71 1.04e-03 GO:0051168 nuclear export
2.61 2.34e-02 GO:0006302 double-strand break repair
2.50 5.81e-04 GO:0051028 mRNA transport
2.48 2.17e-08 GO:0000375 RNA splicing, via transesterification reactions
2.43 6.21e-04 GO:0050657 nucleic acid transport
2.43 6.21e-04 GO:0050658 RNA transport
2.43 6.21e-04 GO:0051236 establishment of RNA localization
2.42 2.16e-07 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.42 2.16e-07 GO:0000398 nuclear mRNA splicing, via spliceosome
2.42 1.40e-02 GO:0022904 respiratory electron transport chain
2.35 1.54e-03 GO:0006403 RNA localization
2.21 4.16e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.18 7.75e-03 GO:0006310 DNA recombination
2.13 1.65e-07 GO:0008380 RNA splicing
2.08 2.84e-03 GO:0051169 nuclear transport
2.07 9.39e-09 GO:0006397 mRNA processing
2.06 6.08e-15 GO:0051276 chromosome organization
2.06 5.10e-03 GO:0006913 nucleocytoplasmic transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 47 entries
enrichment   p-value GO term description
2.48 2.97e-05 GO:0044455 mitochondrial membrane part
2.33 4.88e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.31 3.88e-02 GO:0071013 catalytic step 2 spliceosome
2.27 3.52e-04 GO:0005681 spliceosomal complex
2.25 4.82e-08 GO:0000785 chromatin
2.21 2.31e-02 GO:0032993 protein-DNA complex
2.06 3.95e-04 GO:0005819 spindle
2.05 1.24e-11 GO:0044427 chromosomal part
2.04 9.40e-03 GO:0000793 condensed chromosome
2.02 4.44e-02 GO:0016607 nuclear speck
1.97 2.93e-12 GO:0005694 chromosome
1.95 1.12e-10 GO:0030529 ribonucleoprotein complex
1.92 1.34e-02 GO:0044454 nuclear chromosome part
1.91 7.52e-03 GO:0005840 ribosome
1.84 1.38e-03 GO:0005759 mitochondrial matrix
1.82 1.31e-02 GO:0000228 nuclear chromosome
1.75 2.44e-19 GO:0005654 nucleoplasm
1.69 6.33e-03 GO:0005743 mitochondrial inner membrane
1.66 9.54e-27 GO:0044428 nuclear part
1.66 7.68e-22 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.50 1.44e-02 GO:0042393 histone binding
1.96 3.82e-03 GO:0003682 chromatin binding
1.82 1.22e-02 GO:0003713 transcription coactivator activity
1.80 9.52e-13 GO:0003723 RNA binding
1.61 1.70e-02 GO:0003712 transcription cofactor activity
1.60 1.87e-02 GO:0000988 protein binding transcription factor activity
1.60 1.87e-02 GO:0000989 transcription factor binding transcription factor activity
1.53 2.78e-02 GO:0016874 ligase activity
1.42 9.87e-19 GO:0003676 nucleic acid binding
1.33 1.04e-06 GO:0003677 DNA binding
1.32 4.21e-06 GO:0000166 nucleotide binding
1.28 2.28e-02 GO:0030554 adenyl nucleotide binding
1.27 1.38e-02 GO:0016740 transferase activity
1.27 4.06e-02 GO:0005524 ATP binding
1.27 4.19e-02 GO:0032559 adenyl ribonucleotide binding
1.24 4.93e-02 GO:0017076 purine nucleotide binding
1.19 4.18e-12 GO:0005515 protein binding
1.15 1.23e-03 GO:0003824 catalytic activity
1.09 2.57e-07 GO:0005488 binding