Motif ID: PAX2.p2

Z-value: 1.927


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_102495327-0.401.3e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_113330574 2.671 NM_000192
NM_080717
TBX5

T-box 5

chr17_-_44022595 1.867 HOXB3
homeobox B3
chr5_+_60663842 1.561 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr17_+_14145051 1.511 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr6_-_33493640 1.462 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr8_-_13178399 1.393 DLC1
deleted in liver cancer 1
chr6_-_84994032 1.381 NM_014895
KIAA1009
KIAA1009
chr15_+_41597097 1.271 NM_002373
MAP1A
microtubule-associated protein 1A
chr6_-_33493792 1.195 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr6_-_33493898 1.180 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr8_-_13178327 1.175


chr15_-_71712711 1.152 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr1_-_184916044 1.151 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr13_-_32757835 1.144 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_+_25467948 1.134 NM_032141
CCDC55
coiled-coil domain containing 55
chr6_-_33494042 1.110 NM_001014433
NM_001014837
NM_001014838
NM_001014840
NM_015921
CUTA




cutA divalent cation tolerance homolog (E. coli)




chr8_-_119192985 1.108 NM_000127
EXT1
exostosin 1
chr12_+_15926554 1.101 NM_007178
STRAP
serine/threonine kinase receptor associated protein
chr8_-_95343716 1.089 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr5_-_16795336 1.075 MYO10
myosin X
chr8_-_95343696 1.060 GEM
GTP binding protein overexpressed in skeletal muscle
chr2_-_216008689 1.020 FN1
fibronectin 1
chr12_+_15926681 1.006 STRAP
serine/threonine kinase receptor associated protein
chr10_+_102782151 0.974 SFXN3
sideroflexin 3
chr9_-_109291866 0.969 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_-_216009015 0.969 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr10_+_102782156 0.967 SFXN3
sideroflexin 3
chr22_+_36928972 0.958 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr9_-_89779180 0.956 CDK20
cyclin-dependent kinase 20
chr12_+_50731457 0.928 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr11_+_101485946 0.923 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr3_+_114948550 0.910 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr2_+_46779827 0.904 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr3_-_123995216 0.900 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr20_-_17487480 0.899 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr3_+_11153778 0.898 NM_001098213
HRH1
histamine receptor H1
chr18_+_30875297 0.880 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr5_+_148766632 0.877 LOC728264
hypothetical LOC728264
chr2_+_223625105 0.873 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr16_+_56219802 0.866 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr2_-_20115269 0.848 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr2_-_216944911 0.838 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr1_+_152459918 0.835 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr1_+_159550789 0.831 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr15_-_71712605 0.829 NPTN
neuroplastin
chr8_+_103889733 0.827 FLJ45248
FLJ45248 protein
chr5_+_52812165 0.826 FST
follistatin
chr16_-_27468717 0.821 GTF3C1
general transcription factor IIIC, polypeptide 1, alpha 220kDa
chr11_-_85457469 0.816 PICALM
phosphatidylinositol binding clathrin assembly protein
chr9_+_6747919 0.815 KDM4C
lysine (K)-specific demethylase 4C
chr5_+_14493905 0.814 TRIO
triple functional domain (PTPRF interacting)
chr12_+_15926743 0.812 STRAP
serine/threonine kinase receptor associated protein
chr5_+_52812236 0.799 NM_006350
NM_013409
FST

follistatin

chr5_+_52131686 0.798 PELO
pelota homolog (Drosophila)
chr4_-_177950658 0.795 NM_005429
VEGFC
vascular endothelial growth factor C
chr8_+_120289735 0.787 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr10_-_99436889 0.785 NM_021732
AVPI1
arginine vasopressin-induced 1
chr11_-_8695974 0.785 ST5
suppression of tumorigenicity 5
chr2_+_42249896 0.779 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr20_-_47965393 0.772 SPATA2
spermatogenesis associated 2
chr4_-_119493322 0.762 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr1_+_200584421 0.750 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr9_-_89779413 0.749 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr12_+_109046522 0.748 NM_001143779
NM_014055
NM_031473
IFT81


intraflagellar transport 81 homolog (Chlamydomonas)


chr17_+_56831951 0.747 NM_005994
TBX2
T-box 2
chr7_+_116099648 0.728 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr5_-_141372721 0.722 NM_005471
GNPDA1
glucosamine-6-phosphate deaminase 1
chrX_+_30581523 0.717 GK
glycerol kinase
chr3_+_114948600 0.715 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr5_+_148186348 0.714 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr1_-_112083387 0.711 NM_019099
C1orf183
chromosome 1 open reading frame 183
chr19_+_12709281 0.709 NM_004317
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr3_+_114948591 0.701 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr16_+_55199978 0.698 NM_005953
MT2A
metallothionein 2A
chr1_+_148521852 0.690 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr15_+_41871768 0.688 NM_001018108
SERF2
small EDRK-rich factor 2
chr18_-_44729700 0.685 NM_001190822
SMAD7
SMAD family member 7
chr2_+_26840626 0.685 NM_017877
CENPA
C2orf18
centromere protein A
chromosome 2 open reading frame 18
chr10_-_105427898 0.681 SH3PXD2A
SH3 and PX domains 2A
chr6_+_123152044 0.681 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chrX_+_101862297 0.670 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr1_+_32485404 0.668 NM_032648
FAM167B
family with sequence similarity 167, member B
chr10_-_62373828 0.668 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr2_-_217267742 0.665 IGFBP5
insulin-like growth factor binding protein 5
chr6_-_18230829 0.659 NM_198586
NHLRC1
NHL repeat containing 1
chr17_-_38081967 0.653 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr8_-_13416554 0.652 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr5_+_122452739 0.651 NM_001136239
PRDM6
PR domain containing 6
chr8_+_38363150 0.651 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr7_-_121571472 0.651 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr15_+_41871809 0.647 SERF2-C15ORF63
SERF2
SERF2-C15orf63 read-through transcript
small EDRK-rich factor 2
chr11_+_101291134 0.643 KIAA1377
KIAA1377
chr1_-_59020875 0.642 JUN
jun proto-oncogene
chr18_-_53621277 0.642 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr9_+_116389918 0.637 ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr8_-_38505331 0.630 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr6_+_52393763 0.629 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr1_+_152460381 0.625 UBAP2L
ubiquitin associated protein 2-like
chr12_-_113328271 0.622 NM_181486
TBX5
T-box 5
chr4_+_77446906 0.618 STBD1
starch binding domain 1
chr5_-_150118747 0.615 NM_001135643
NM_016221
DCTN4

dynactin 4 (p62)

chr7_+_28415495 0.611 LOC401317
hypothetical LOC401317
chr2_-_227372574 0.609 IRS1
insulin receptor substrate 1
chr1_+_152644668 0.607 IL6R
interleukin 6 receptor
chr3_-_188946168 0.606 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr19_-_52709975 0.606 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chrX_+_30581377 0.605 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr3_-_36961539 0.595 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr11_+_101290930 0.590 NM_020802
KIAA1377
KIAA1377
chr20_-_47965474 0.590 NM_006038
SPATA2
spermatogenesis associated 2
chr3_-_188945921 0.590 BCL6
B-cell CLL/lymphoma 6
chr4_+_120029426 0.581 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr12_-_79855580 0.580 LIN7A
lin-7 homolog A (C. elegans)
chr9_+_119506446 0.579 TLR4
toll-like receptor 4
chr5_-_150118274 0.577 NM_001135644
DCTN4
dynactin 4 (p62)
chr1_-_37792414 0.567 NM_024700
SNIP1
Smad nuclear interacting protein 1
chr3_-_188492163 0.566 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr15_-_41572660 0.563 TP53BP1
tumor protein p53 binding protein 1
chr22_+_34025872 0.562 TOM1
target of myb1 (chicken)
chr20_-_47965443 0.560 SPATA2
spermatogenesis associated 2
chr5_-_64813459 0.559 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr16_+_27468942 0.558 NM_015202
KIAA0556
KIAA0556
chr17_-_39556483 0.556 HDAC5
histone deacetylase 5
chr5_+_150807331 0.551 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr14_-_80757327 0.549 NM_201595
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr9_-_98421894 0.549 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr17_+_72795567 0.548 NM_001113492
SEPT9
septin 9
chr20_+_2744947 0.547 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr5_+_150807397 0.545 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr17_-_63965156 0.543 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr17_-_39556535 0.542 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr4_+_81337663 0.542 NM_001099403
PRDM8
PR domain containing 8
chr11_-_8788765 0.542 NM_213618
ST5
suppression of tumorigenicity 5
chr3_+_67131416 0.538 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr16_+_28893525 0.537 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr11_+_117982422 0.534 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr5_-_90645974 0.525 LOC100505994
hypothetical LOC100505994
chr9_+_116389814 0.525 NM_004888
ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr8_-_27528215 0.524 NM_001831
CLU
clusterin
chr2_+_87536174 0.522 NCRNA00152
non-protein coding RNA 152
chr11_+_61479182 0.514 BEST1
bestrophin 1
chr1_-_20685314 0.513 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr14_+_19993181 0.512 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr6_+_148705421 0.512 NM_015278
SASH1
SAM and SH3 domain containing 1
chr8_-_27528105 0.511 CLU
clusterin
chr9_-_13269562 0.511 MPDZ
multiple PDZ domain protein
chr4_+_81406765 0.511 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr12_+_28234657 0.511


chr20_-_2592777 0.510 NM_006899
NM_174855
NM_174856
IDH3B


isocitrate dehydrogenase 3 (NAD+) beta


chr15_-_99609197 0.509 CHSY1
chondroitin sulfate synthase 1
chr15_-_41572558 0.508 NM_001141979
NM_001141980
TP53BP1

tumor protein p53 binding protein 1

chr7_-_158304062 0.504 ESYT2
extended synaptotagmin-like protein 2
chr12_+_27568311 0.502 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr11_-_85457753 0.499 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr1_+_36462583 0.496 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr12_+_14818572 0.495 H2AFJ
H2A histone family, member J
chr11_-_85457736 0.495 PICALM
phosphatidylinositol binding clathrin assembly protein
chr12_-_62902279 0.494 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr1_-_152459697 0.494 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr20_+_1254033 0.493 LOC100507495
hypothetical LOC100507495
chr11_-_62213577 0.493 LRRN4CL
LRRN4 C-terminal like
chr16_+_2023279 0.493 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr16_+_65868913 0.492 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr13_-_49597776 0.489 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr11_-_82582328 0.489 DKFZp547G183
hypothetical LOC55525
chr16_-_69277355 0.485 NM_138383
MTSS1L
metastasis suppressor 1-like
chr1_+_205137410 0.484 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr5_+_96064248 0.483 NM_173060
CAST
calpastatin
chr5_+_150807380 0.481 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr16_-_65742323 0.472 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr22_+_40107878 0.472 NM_003216
TEF
thyrotrophic embryonic factor
chr22_+_39583001 0.471 NM_022098
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr6_+_112515366 0.470 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr4_-_39199527 0.468 UGDH
UDP-glucose 6-dehydrogenase
chr10_+_128583984 0.467 NM_001380
DOCK1
dedicator of cytokinesis 1
chr8_+_109525050 0.467 TTC35
tetratricopeptide repeat domain 35
chr12_-_121276513 0.466 DIABLO
diablo homolog (Drosophila)
chr6_+_116939500 0.465 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_+_80292313 0.464 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr6_+_32229771 0.463 PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr13_+_47776026 0.462 RB1
retinoblastoma 1
chr17_+_30594192 0.458 NM_144975
SLFN5
schlafen family member 5
chr8_+_109525010 0.458 NM_014673
TTC35
tetratricopeptide repeat domain 35
chr1_-_220952276 0.458 NM_022831
AIDA
axin interactor, dorsalization associated
chr8_-_145090892 0.457 NM_201381
PLEC
plectin
chr6_-_112515329 0.456 NM_016262
TUBE1
tubulin, epsilon 1
chr13_-_20533703 0.456 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr15_-_68781662 0.454 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_+_185536376 0.454 NM_001171093
FAM131A
family with sequence similarity 131, member A
chr1_+_36462625 0.453 THRAP3
thyroid hormone receptor associated protein 3
chr19_-_18175731 0.453 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr19_+_60688349 0.453 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr10_+_102662675 0.453 FAM178A
family with sequence similarity 178, member A
chr11_+_64948860 0.452 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr1_-_68470585 0.451 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_+_30622905 0.450 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr5_+_80292213 0.449 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr12_-_106011437 0.449 CRY1
cryptochrome 1 (photolyase-like)
chr13_-_20533629 0.449 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_-_45914618 0.448 NM_024876
ADCK4
aarF domain containing kinase 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.59 1.13e-06 GO:0046907 intracellular transport
1.09 2.25e-06 GO:0009987 cellular process
1.45 2.51e-05 GO:0051649 establishment of localization in cell
1.40 3.47e-05 GO:0033036 macromolecule localization
1.39 1.94e-04 GO:0051641 cellular localization
1.18 2.55e-04 GO:0044260 cellular macromolecule metabolic process
1.17 2.73e-04 GO:0043170 macromolecule metabolic process
1.31 4.13e-04 GO:0010467 gene expression
1.20 1.52e-03 GO:0071840 cellular component organization or biogenesis
1.20 2.24e-03 GO:0016043 cellular component organization
1.13 3.16e-03 GO:0044237 cellular metabolic process
1.22 3.19e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 3.55e-03 GO:0016070 RNA metabolic process
1.75 4.34e-03 GO:0006366 transcription from RNA polymerase II promoter
1.71 4.91e-03 GO:0071495 cellular response to endogenous stimulus
1.25 7.29e-03 GO:0090304 nucleic acid metabolic process
1.55 7.37e-03 GO:0034613 cellular protein localization
1.42 8.20e-03 GO:0015031 protein transport
1.37 9.09e-03 GO:0008104 protein localization
1.71 9.70e-03 GO:0032870 cellular response to hormone stimulus
1.54 1.00e-02 GO:0070727 cellular macromolecule localization
1.40 1.54e-02 GO:0045184 establishment of protein localization
1.46 2.89e-02 GO:0071310 cellular response to organic substance
1.22 3.36e-02 GO:0048522 positive regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.27e-12 GO:0044424 intracellular part
1.10 1.01e-11 GO:0005622 intracellular
1.12 5.36e-09 GO:0043229 intracellular organelle
1.13 6.37e-09 GO:0043231 intracellular membrane-bounded organelle
1.12 7.91e-09 GO:0043226 organelle
1.13 9.39e-09 GO:0043227 membrane-bounded organelle
1.13 4.78e-08 GO:0005737 cytoplasm
1.16 1.47e-05 GO:0005634 nucleus
1.15 6.43e-05 GO:0044422 organelle part
1.15 7.61e-05 GO:0044446 intracellular organelle part
1.14 1.46e-04 GO:0044444 cytoplasmic part
1.17 4.20e-03 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 5.20e-15 GO:0005515 protein binding
1.08 3.82e-07 GO:0005488 binding
1.54 3.19e-02 GO:0000988 protein binding transcription factor activity
1.54 3.19e-02 GO:0000989 transcription factor binding transcription factor activity