Motif ID: PAX5.p2

Z-value: 4.214


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX5chr9_-_37024358-0.185.0e-01Click!


Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_61742111 8.835 NM_020828
 ZFP28
zinc finger protein 28 homolog (mouse)
chr8_+_22513043 7.926 NM_001013842
NM_001198827
NM_173686
 C8orf58


chromosome 8 open reading frame 58


chr3_+_133923758 6.308 NCRNA00119
non-protein coding RNA 119
chr4_-_7991992 6.103 NM_001134647
NM_198595
 AFAP1

actin filament associated protein 1

chr3_-_133923992 5.980 NPHP3-ACAD11
NPHP3-ACAD11 read-through transcript
chr3_-_133923906 5.712 NM_153240
 NPHP3
nephronophthisis 3 (adolescent)
chr9_+_96807107 5.500 C9orf3
chromosome 9 open reading frame 3
chr1_-_93919789 5.444 NM_003567
 BCAR3
breast cancer anti-estrogen resistance 3
chr2_+_235525355 5.073 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr12_-_93568336 4.738 NM_020698
 TMCC3
transmembrane and coiled-coil domain family 3
chr12_+_13044604 4.642 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr21_-_43671355 4.639 NM_173354
 SIK1
salt-inducible kinase 1
chr21_-_45118037 4.624 NM_004339
 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr13_-_105985313 4.555 NM_004093
 EFNB2
ephrin-B2
chr21_+_45118353 4.544


chr20_-_23566325 4.526 NM_000099
 CST3
cystatin C
chr21_+_45318861 4.457 NM_001112
NM_001160230
NM_015833
NM_015834
 ADARB1



adenosine deaminase, RNA-specific, B1



chr13_-_43351825 4.100 NM_144974
 CCDC122
coiled-coil domain containing 122
chrX_+_43399101 4.055 MAOA
monoamine oxidase A
chr13_-_20533629 3.935 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 149 entries
enrichment   p-value GO term description
2.01 1.29e-02 GO:0006914 autophagy
1.97 2.38e-02 GO:0046519 sphingoid metabolic process
1.77 1.94e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.74 2.10e-04 GO:0006470 protein dephosphorylation
1.70 3.86e-02 GO:0006643 membrane lipid metabolic process
1.65 2.13e-03 GO:0016311 dephosphorylation
1.63 6.78e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.61 4.56e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.60 3.37e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.50 5.54e-07 GO:0009968 negative regulation of signal transduction
1.48 1.16e-02 GO:0051129 negative regulation of cellular component organization
1.46 1.25e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.45 1.13e-03 GO:0060284 regulation of cell development
1.44 2.98e-09 GO:0007167 enzyme linked receptor protein signaling pathway
1.44 1.14e-05 GO:0010648 negative regulation of cell communication
1.44 2.47e-02 GO:0030036 actin cytoskeleton organization
1.43 3.07e-05 GO:0023057 negative regulation of signaling
1.41 1.84e-05 GO:0048585 negative regulation of response to stimulus
1.41 3.03e-02 GO:0051270 regulation of cellular component movement
1.36 1.24e-14 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
2.11 2.85e-02 GO:0042641 actomyosin
1.85 3.77e-02 GO:0005793 ER-Golgi intermediate compartment
1.82 3.55e-08 GO:0005912 adherens junction
1.79 2.04e-04 GO:0005925 focal adhesion
1.76 1.84e-04 GO:0030055 cell-substrate junction
1.76 2.43e-04 GO:0005924 cell-substrate adherens junction
1.72 7.42e-07 GO:0070161 anchoring junction
1.62 2.46e-05 GO:0031252 cell leading edge
1.37 1.58e-02 GO:0015629 actin cytoskeleton
1.37 1.81e-02 GO:0005874 microtubule
1.34 1.01e-02 GO:0048471 perinuclear region of cytoplasm
1.32 2.74e-04 GO:0044431 Golgi apparatus part
1.32 2.21e-03 GO:0000139 Golgi membrane
1.31 5.24e-05 GO:0015630 microtubule cytoskeleton
1.30 3.95e-07 GO:0005794 Golgi apparatus
1.26 4.17e-13 GO:0005829 cytosol
1.24 1.19e-07 GO:0012505 endomembrane system
1.24 4.18e-02 GO:0030054 cell junction
1.23 6.69e-03 GO:0031982 vesicle
1.22 2.27e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
2.60 3.46e-02 GO:0005024 transforming growth factor beta receptor activity
2.49 4.38e-02 GO:0004675 transmembrane receptor protein serine/threonine kinase activity
1.97 3.46e-02 GO:0046332 SMAD binding
1.72 2.94e-02 GO:0019199 transmembrane receptor protein kinase activity
1.68 1.34e-02 GO:0004725 protein tyrosine phosphatase activity
1.67 3.56e-02 GO:0017016 Ras GTPase binding
1.66 1.68e-02 GO:0031267 small GTPase binding
1.65 5.86e-03 GO:0051020 GTPase binding
1.64 1.32e-02 GO:0017124 SH3 domain binding
1.63 2.14e-04 GO:0004721 phosphoprotein phosphatase activity
1.49 4.09e-04 GO:0016791 phosphatase activity
1.46 8.82e-04 GO:0016881 acid-amino acid ligase activity
1.43 6.46e-06 GO:0004674 protein serine/threonine kinase activity
1.40 3.04e-05 GO:0019904 protein domain specific binding
1.40 5.57e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.38 3.26e-03 GO:0042578 phosphoric ester hydrolase activity
1.37 1.12e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.37 1.48e-04 GO:0030695 GTPase regulator activity
1.37 2.52e-02 GO:0005083 small GTPase regulator activity
1.35 5.58e-07 GO:0019899 enzyme binding