Motif ID: PBX1.p2

Z-value: 1.557


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_1627953280.731.2e-03Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27108826 4.227 NM_006735
HOXA2
homeobox A2
chr13_-_32757835 3.781 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr21_+_29439768 3.750 C21orf7
chromosome 21 open reading frame 7
chr1_+_24518501 3.261 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_24518398 2.965 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr12_-_28016182 2.726 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr3_+_157877146 2.687 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr11_+_113671744 2.574 NM_006169
NNMT
nicotinamide N-methyltransferase
chr19_+_13767207 2.447 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr2_-_189752575 2.389 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_+_195336625 2.338 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr2_+_12774264 2.222 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr5_+_3649167 2.221 NM_024337
IRX1
iroquois homeobox 1
chr3_+_195336631 2.201 HES1
hairy and enhancer of split 1, (Drosophila)
chr15_+_39032927 2.178 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr18_+_45342398 2.122 NM_006033
LIPG
lipase, endothelial
chr3_+_173951163 2.103 ECT2
epithelial cell transforming sequence 2 oncogene
chr14_+_51025604 1.951 NM_001042481
FRMD6
FERM domain containing 6
chr5_-_58607673 1.847 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_166960649 1.831 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr14_+_54104383 1.829 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr6_-_166960690 1.759 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_177950658 1.714 NM_005429
VEGFC
vascular endothelial growth factor C
chr21_-_35174742 1.686 RUNX1
runt-related transcription factor 1
chr22_-_37520049 1.667 DNAL4
dynein, axonemal, light chain 4
chr6_-_26125939 1.660 NM_005325
HIST1H1A
histone cluster 1, H1a
chr1_+_162795328 1.573 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr3_-_113495763 1.546 NM_183061
SLC9A10
solute carrier family 9, member 10
chr6_-_166960496 1.540 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr5_-_171814026 1.510 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr13_-_109236897 1.478 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_42780784 1.453 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr22_-_28972683 1.419 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr4_-_48477038 1.380 NM_015030
FRYL
FRY-like
chr17_+_70495318 1.358 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chrX_-_15263596 1.329 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chrX_-_10548458 1.302 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr6_-_26379567 1.295 NM_003534
HIST1H3G
histone cluster 1, H3g
chr4_-_48477021 1.290 FRYL
FRY-like
chrX_-_15263586 1.276 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_-_161766055 1.267 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr9_-_83494198 1.262 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chrX_-_15263555 1.250 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr7_+_106596641 1.200 NM_012257
HBP1
HMG-box transcription factor 1
chr13_+_94052022 1.183 NM_180989
GPR180
G protein-coupled receptor 180
chr4_+_87734489 1.164 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr8_-_49996353 1.153 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr5_-_171813960 1.152 SH3PXD2B
SH3 and PX domains 2B
chr13_+_96726197 1.147 MBNL2
muscleblind-like 2 (Drosophila)
chr4_-_140696740 1.106 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr10_+_99390459 1.106 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr3_-_71196696 1.103 FOXP1
forkhead box P1
chr16_+_81218074 1.102 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr14_+_75197303 1.100 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr22_-_37520092 1.078 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr20_-_45848043 1.046 NM_018837
SULF2
sulfatase 2
chr14_+_75197409 1.022 TTLL5
tubulin tyrosine ligase-like family, member 5
chrX_+_46581418 1.011 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr12_-_54409710 1.005 CD63
CD63 molecule
chr1_-_219982049 1.003 DUSP10
dual specificity phosphatase 10
chr2_+_218843358 1.000 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr1_-_147665783 0.997 HIST2H2BF
histone cluster 2, H2bf
chr14_+_75197345 0.990 TTLL5
tubulin tyrosine ligase-like family, member 5
chr11_-_56951628 0.990 NM_017611
SLC43A3
solute carrier family 43, member 3
chr9_-_37455429 0.986 ZBTB5
zinc finger and BTB domain containing 5
chr10_+_13182061 0.959 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr14_-_75196911 0.958 C14orf1
chromosome 14 open reading frame 1
chr20_-_13567529 0.947 NM_017714
TASP1
taspase, threonine aspartase, 1
chr2_+_28469850 0.944 FOSL2
FOS-like antigen 2
chr6_+_26381122 0.941 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr3_-_161766005 0.935 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr1_-_219982081 0.931 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr16_+_81218142 0.924 CDH13
cadherin 13, H-cadherin (heart)
chr14_-_91642703 0.918 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr6_-_32892705 0.915 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_77782719 0.914 SYT1
synaptotagmin I
chr4_+_86968069 0.894 ARHGAP24
Rho GTPase activating protein 24
chr14_+_99220349 0.892 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr1_-_219982016 0.890 DUSP10
dual specificity phosphatase 10
chr17_+_72380323 0.885 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr7_-_121571472 0.882 NM_005763
AASS
aminoadipate-semialdehyde synthase
chrX_+_46581368 0.877 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr12_+_27568311 0.869 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr2_+_20510312 0.868 NM_004040
RHOB
ras homolog gene family, member B
chr3_-_21767819 0.830 NM_024697
ZNF385D
zinc finger protein 385D
chr21_-_31012965 0.826 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr9_+_129604962 0.816 NM_004957
FPGS
folylpolyglutamate synthase
chr3_+_138132006 0.808 NM_001190796
NCK1
NCK adaptor protein 1
chr14_-_91642641 0.797 ATXN3
ATXN8
ataxin 3
ataxin 8
chr10_-_21847126 0.778


chr13_+_78953258 0.778 NM_001161407
NM_019080
NDFIP2

Nedd4 family interacting protein 2

chrX_+_46581290 0.776 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr10_+_102113410 0.775


chr17_+_71174993 0.769 NM_013260
SAP30BP
SAP30 binding protein
chr3_-_161765860 0.744 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr2_-_162808123 0.742 NM_004460
FAP
fibroblast activation protein, alpha
chr8_+_107807415 0.731 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr5_+_147562531 0.723 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr2_+_191454157 0.719 GLS
glutaminase
chr6_+_26333361 0.709 NM_003532
HIST1H3E
histone cluster 1, H3e
chr11_+_13646727 0.703 NM_032228
FAR1
fatty acyl CoA reductase 1
chr6_-_46728188 0.702 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr9_-_14303509 0.700 NFIB
nuclear factor I/B
chr13_-_47510033 0.694 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr5_-_94442941 0.694 MCTP1
multiple C2 domains, transmembrane 1
chr17_+_17816851 0.687 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chr13_-_97916768 0.674 STK24
serine/threonine kinase 24
chr17_+_56109940 0.669 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr3_+_161040343 0.664 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr19_-_63301386 0.656 ZSCAN18
zinc finger and SCAN domain containing 18
chr19_+_14501413 0.653 TECR
trans-2,3-enoyl-CoA reductase
chr7_+_133982070 0.635 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr11_+_13646822 0.634 FAR1
fatty acyl CoA reductase 1
chr8_+_69026895 0.628 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_69027277 0.626 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr4_+_81325447 0.623 NM_020226
PRDM8
PR domain containing 8
chr11_-_85115105 0.619 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr6_+_151603201 0.609 AKAP12
A kinase (PRKA) anchor protein 12
chr11_+_122258600 0.605 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr10_+_99390431 0.600 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr2_+_28469864 0.596 FOSL2
FOS-like antigen 2
chr14_-_90596665 0.596 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr10_-_115923874 0.594 C10orf118
chromosome 10 open reading frame 118
chr19_-_44573468 0.582 NM_019088
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr8_+_69027166 0.576 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr11_+_13646839 0.576 FAR1
fatty acyl CoA reductase 1
chr10_+_17310263 0.576 NM_003380
VIM
vimentin
chr19_+_16157198 0.575 NM_014077
FAM32A
family with sequence similarity 32, member A
chr5_+_150008030 0.574 SYNPO
synaptopodin
chr1_-_17638797 0.572 NM_018715
RCC2
regulator of chromosome condensation 2
chr8_+_69027143 0.559 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr3_+_161040439 0.558 SCHIP1
schwannomin interacting protein 1
chr2_+_73911477 0.558 STAMBP
STAM binding protein
chr3_-_191322919 0.558 NM_001134418
LEPREL1
leprecan-like 1
chr16_-_3433490 0.542 NM_152457
ZNF597
zinc finger protein 597
chr1_-_159257486 0.538 F11R
F11 receptor
chr19_+_55221023 0.527 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr1_-_205272619 0.526 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr8_-_108579270 0.521 NM_001146
ANGPT1
angiopoietin 1
chr11_+_94141151 0.520 NM_130847
AMOTL1
angiomotin like 1
chrX_-_107568211 0.519 NM_033641
COL4A6
collagen, type IV, alpha 6
chr22_-_37211467 0.516 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_-_55220495 0.515 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr12_+_28234657 0.511


chr1_+_85300580 0.511 NM_145172
WDR63
WD repeat domain 63
chr16_+_3433606 0.508 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr20_+_18396030 0.505 NM_006466
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr16_+_15503623 0.503 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr12_-_51173238 0.503 NM_005554
KRT6A
keratin 6A
chr6_+_151603264 0.502


chr11_-_102174102 0.500 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr8_-_130868315 0.498 NM_031415
GSDMC
gasdermin C
chr11_-_102174032 0.492 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chrX_-_23671317 0.492 NM_001033583
NM_001037171
ACOT9

acyl-CoA thioesterase 9

chr4_-_118226119 0.488 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr7_-_526005 0.486 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr17_+_8132539 0.481 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr3_-_161765765 0.478 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr12_+_63090008 0.478 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr4_+_77575276 0.477 NM_020859
SHROOM3
shroom family member 3
chr17_-_71174816 0.475 NM_004259
NM_001003715
NM_001003716
RECQL5


RecQ protein-like 5


chr12_-_8993460 0.475 M6PR
mannose-6-phosphate receptor (cation dependent)
chr1_+_216585298 0.475 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr19_+_44573790 0.473 NM_017592
MED29
mediator complex subunit 29
chr18_+_37789187 0.473 NM_002647
PIK3C3
phosphoinositide-3-kinase, class 3
chr7_-_7646573 0.469 RPA3
replication protein A3, 14kDa
chr19_-_63301418 0.460 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr1_+_149493861 0.459 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr3_+_185762233 0.458 NM_004443
EPHB3
EPH receptor B3
chr11_+_13646806 0.457 FAR1
fatty acyl CoA reductase 1
chr13_+_78953367 0.446 NDFIP2
Nedd4 family interacting protein 2
chr1_-_149586341 0.446 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr2_-_179380301 0.446 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr6_+_26153590 0.444 NM_003531
HIST1H3C
histone cluster 1, H3c
chr3_-_150993299 0.441 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr19_+_44573858 0.434 MED29
mediator complex subunit 29
chr12_+_52689062 0.432 NM_022658
HOXC8
homeobox C8
chr9_+_91115924 0.427 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr5_+_151131709 0.423 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr3_-_184300031 0.421 NM_020166
MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr19_-_63092099 0.419 NM_001144989
ZNF814
zinc finger protein 814
chr1_-_17638729 0.419 RCC2
regulator of chromosome condensation 2
chr1_+_149493833 0.412 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr19_+_55221088 0.410 ZNF473
zinc finger protein 473
chr19_+_44082410 0.409 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr10_+_69539255 0.408 NM_032578
MYPN
myopalladin
chr5_-_112658200 0.406 MCC
mutated in colorectal cancers
chr10_-_105835525 0.404 COL17A1
collagen, type XVII, alpha 1
chr18_+_37789209 0.403 PIK3C3
phosphoinositide-3-kinase, class 3
chr6_+_151603346 0.396 AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_44573343 0.395 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr12_-_51132129 0.390 NM_005555
KRT6B
keratin 6B
chr19_-_55220439 0.388 VRK3
vaccinia related kinase 3
chr11_+_44073674 0.387 NM_001178083
NM_207122
EXT2

exostosin 2

chr12_+_14409875 0.387 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr7_+_150356435 0.386 NM_007188
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr12_-_21545751 0.383 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chrX_-_52843112 0.380 NM_001009616
SPANXN5
SPANX family, member N5
chr3_-_150578023 0.379 TM4SF1
transmembrane 4 L six family member 1
chr9_+_81376666 0.368 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.89 8.92e-05 GO:0065004 protein-DNA complex assembly
4.63 2.03e-04 GO:0071824 protein-DNA complex subunit organization
4.97 4.41e-04 GO:0006334 nucleosome assembly
4.71 8.89e-04 GO:0031497 chromatin assembly
2.71 1.15e-03 GO:0034622 cellular macromolecular complex assembly
4.49 1.71e-03 GO:0034728 nucleosome organization
3.82 3.31e-03 GO:0006333 chromatin assembly or disassembly
3.85 5.98e-03 GO:0006323 DNA packaging
1.95 3.54e-02 GO:0071844 cellular component assembly at cellular level
3.31 4.20e-02 GO:0071103 DNA conformation change
2.18 4.92e-02 GO:0034621 cellular macromolecular complex subunit organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.46 1.88e-05 GO:0000786 nucleosome
5.08 2.13e-05 GO:0032993 protein-DNA complex
1.15 4.77e-03 GO:0043229 intracellular organelle
1.15 5.79e-03 GO:0043226 organelle
2.64 1.92e-02 GO:0000785 chromatin
1.11 2.54e-02 GO:0005622 intracellular
1.11 3.04e-02 GO:0044424 intracellular part
2.09 3.09e-02 GO:0044427 chromosomal part

Nothing significant found in function category.