Motif ID: PRRX1,2.p2

Z-value: 3.009


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX2chr9_+_131467740-0.524.1e-02Click!
PRRX1chr1_+_168899936-0.097.3e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_104696678 5.997 NM_182691
SRPK2
SRSF protein kinase 2
chrX_+_114734074 5.518 NM_001136025
NM_001172335
PLS3

plastin 3

chr3_-_152517204 5.198 NM_023915
GPR87
G protein-coupled receptor 87
chr15_+_91244563 5.186 CHD2
chromodomain helicase DNA binding protein 2
chr8_+_107807415 4.987 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr5_-_88155360 4.959 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_38710376 4.876 NM_024943
TMEM156
transmembrane protein 156
chr4_-_153820535 4.709 NM_152680
TMEM154
transmembrane protein 154
chr15_+_91244422 4.598 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr8_-_17599438 4.573 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr15_+_97990705 4.516 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr3_+_138132006 4.488 NM_001190796
NCK1
NCK adaptor protein 1
chr4_-_152368492 4.287 SH3D19
SH3 domain containing 19
chr5_-_169340321 3.986 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr10_-_32707549 3.950 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr10_+_118177371 3.931 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr12_+_14429499 3.877 ATF7IP
activating transcription factor 7 interacting protein
chr10_-_95231933 3.755 NM_013451
NM_133337
MYOF

myoferlin

chr22_-_34566367 3.753 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr12_-_15005761 3.741 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr13_-_40491405 3.691 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_40491491 3.630 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_+_69306019 3.613 SRSF5
serine/arginine-rich splicing factor 5
chr8_-_102029997 3.598 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_-_55090759 3.598 NM_007008
RTN4
reticulon 4
chr4_-_74307637 3.585 ANKRD17
ankyrin repeat domain 17
chr7_-_30032649 3.579 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr2_-_160764819 3.567 NM_000888
ITGB6
integrin, beta 6
chr5_+_162862808 3.559 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr12_-_15706340 3.546 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_153493133 3.451 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr9_+_674193 3.448


chr14_+_38653177 3.431 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr6_+_153060722 3.401 NM_025107
MYCT1
myc target 1
chr3_-_143230124 3.382 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr14_+_51025604 3.362 NM_001042481
FRMD6
FERM domain containing 6
chr13_-_40454188 3.341 ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_+_57285809 3.294 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr7_-_87180499 3.286 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_-_26202626 3.285 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_18305740 3.169 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr1_-_197173159 3.163 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_147775652 3.150 FBXO38
F-box protein 38
chr10_+_126620681 3.145 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr4_-_90197140 3.062 NM_014883
FAM13A
family with sequence similarity 13, member A
chr22_-_34566276 3.060 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_34566210 3.049 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr11_-_128567302 3.013 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr2_+_17861266 2.963 NM_001105569
MSGN1
mesogenin 1
chr4_-_152366970 2.891 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_-_89261021 2.872 NM_018284
GBP3
guanylate binding protein 3
chr18_+_59405513 2.862 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chrX_-_107569256 2.767 NM_001847
COL4A6
collagen, type IV, alpha 6
chr6_+_34314545 2.760 NM_145905
HMGA1
high mobility group AT-hook 1
chr2_-_162808123 2.736 NM_004460
FAP
fibroblast activation protein, alpha
chr21_-_34820916 2.732 NM_203418
RCAN1
regulator of calcineurin 1
chr5_+_40877053 2.728 NM_032587
CARD6
caspase recruitment domain family, member 6
chr1_-_149004852 2.690 CTSS
cathepsin S
chr5_-_94442941 2.630 MCTP1
multiple C2 domains, transmembrane 1
chr7_-_27149750 2.624 NM_019102
HOXA5
homeobox A5
chr4_+_75393053 2.623 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr7_-_13992351 2.621 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_-_1935764 2.616 NM_016358
IRX4
iroquois homeobox 4
chr4_+_74825138 2.588 NM_000584
IL8
interleukin 8
chr13_-_98428244 2.532 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr16_-_21221872 2.531 NM_001014444
NM_001888
CRYM

crystallin, mu

chr11_-_104411065 2.502 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr13_-_74799898 2.470 TBC1D4
TBC1 domain family, member 4
chr7_-_92615593 2.463 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_-_29963906 2.458 NM_021738
SVIL
supervillin
chr2_+_36777406 2.420 VIT
vitrin
chr2_-_160765008 2.405 ITGB6
integrin, beta 6
chr2_+_108604111 2.399 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_-_64698831 2.391 NM_004241
JMJD1C
jumonji domain containing 1C
chr3_+_133798770 2.376 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr5_-_98290117 2.371 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr2_-_188021117 2.361 NM_005795
CALCRL
calcitonin receptor-like
chr6_+_134800533 2.315 LOC154092
hypothetical LOC154092
chr2_-_215711313 2.275 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr4_-_87989291 2.269 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr7_-_41709191 2.253 NM_002192
INHBA
inhibin, beta A
chr12_-_48902692 2.244 NM_001113547
LIMA1
LIM domain and actin binding 1
chr4_+_86918870 2.231 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr7_+_116447527 2.222 ST7
suppression of tumorigenicity 7
chr8_-_28403652 2.218 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr3_+_157877146 2.212 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr21_+_29439768 2.189 C21orf7
chromosome 21 open reading frame 7
chr11_-_104421240 2.189 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr20_+_5935897 2.185 NM_001127458
CRLS1
cardiolipin synthase 1
chr11_+_65023556 2.183


chr11_+_5667494 2.183 NM_006074
TRIM22
tripartite motif containing 22
chr7_-_26198673 2.169 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_+_86662356 2.165 NM_006536
CLCA2
chloride channel accessory 2
chr4_+_86918882 2.164 ARHGAP24
Rho GTPase activating protein 24
chr5_+_55182963 2.147 NM_139017
IL31RA
interleukin 31 receptor A
chr4_+_88076418 2.144


chr5_+_67622242 2.111 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_126282078 2.097 NCOA7
nuclear receptor coactivator 7
chr1_-_21373816 2.094 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_128399218 2.093 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr10_+_63331018 2.083 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_101036407 2.074 NM_024057
NUP37
nucleoporin 37kDa
chr3_+_153468518 2.036 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr1_+_84540921 2.026 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chrX_-_19598912 2.017 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_33862690 1.983 NM_001143944
LEMD2
LEM domain containing 2
chr4_-_38534802 1.963 NM_006068
TLR6
toll-like receptor 6
chr3_+_123526700 1.956 NM_005213
CSTA
cystatin A (stefin A)
chr13_+_75232797 1.947 NM_015842
LMO7
LIM domain 7
chr21_-_41140908 1.933 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr2_-_98646367 1.933 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_+_69895310 1.922 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_130014957 1.908 RAB7A
RAB7A, member RAS oncogene family
chr5_+_34723420 1.888 NM_001145523
RAI14
retinoic acid induced 14
chr1_-_68470585 1.881 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_-_116608113 1.881 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr7_-_7724762 1.873 NM_002947
RPA3
replication protein A3, 14kDa
chr1_-_114215768 1.870 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_78243181 1.866 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_+_56507029 1.860 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr4_-_139382672 1.855 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr18_+_19826734 1.853 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr6_+_121798443 1.844 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr5_-_94443300 1.838 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr1_-_148936123 1.832 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr2_-_55053398 1.801


chr9_+_126460511 1.785


chr6_+_18495559 1.776 NM_182757
RNF144B
ring finger protein 144B
chr7_+_111908143 1.771 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr20_+_31613800 1.745 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr6_-_47117951 1.723 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr11_+_5667392 1.721 TRIM22
tripartite motif containing 22
chr7_+_18515488 1.719 HDAC9
histone deacetylase 9
chr7_+_115650240 1.714 NM_152829
TES
testis derived transcript (3 LIM domains)
chr11_+_128067598 1.704 NM_001167681
FLI1
Friend leukemia virus integration 1
chr21_-_14840506 1.699 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr13_+_96672705 1.694 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_18515440 1.684 HDAC9
histone deacetylase 9
chr9_-_19368815 1.677 RPS6
ribosomal protein S6
chr12_-_9913199 1.674 CLEC2B
C-type lectin domain family 2, member B
chr8_-_110689396 1.671 SYBU
syntabulin (syntaxin-interacting)
chr10_-_21847126 1.667


chr12_-_28016182 1.666 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_27108826 1.659 NM_006735
HOXA2
homeobox A2
chrX_-_64112993 1.652 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr11_+_65026382 1.651


chr11_-_3759886 1.638 NUP98
nucleoporin 98kDa
chr2_-_20390601 1.636 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr9_-_15240113 1.628 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr7_+_113853790 1.615 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr1_-_108032645 1.613 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_32730804 1.601 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr10_+_63478974 1.593 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr14_+_101346032 1.592 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr5_-_139706357 1.591 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr7_-_107667728 1.580 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr16_+_51690564 1.578 CHD9
chromodomain helicase DNA binding protein 9
chr17_-_64752550 1.577 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr13_+_96672541 1.564 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr21_+_42492867 1.563 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr17_-_64649608 1.548 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr17_-_26665220 1.546 NM_006495
EVI2B
ecotropic viral integration site 2B
chr10_-_29963847 1.544


chr3_+_29297806 1.543 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr3_+_190990142 1.530 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr14_-_19871267 1.528 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr20_-_14266200 1.526 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr9_+_27099138 1.525 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr7_+_128802719 1.522 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr7_-_83662152 1.521 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr7_+_104539548 1.513 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_+_94584449 1.512 NM_001013848
EXOC6
exocyst complex component 6
chr20_+_33223434 1.507 NM_006404
PROCR
protein C receptor, endothelial
chr1_-_149004916 1.504 NM_004079
CTSS
cathepsin S
chr11_-_58099884 1.503 NM_004811
LPXN
leupaxin
chr15_-_97607108 1.503 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr4_+_160408447 1.501 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_113495763 1.495 NM_183061
SLC9A10
solute carrier family 9, member 10
chr5_-_90714871 1.490 NM_020801
ARRDC3
arrestin domain containing 3
chr13_-_43908937 1.490 TSC22D1
TSC22 domain family, member 1
chr12_-_9913724 1.488 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr2_+_33514896 1.488 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_39430180 1.483 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_+_61910318 1.474 NM_181506
LRRC70
leucine rich repeat containing 70
chr11_-_111539881 1.459 NM_001562
IL18
interleukin 18 (interferon-gamma-inducing factor)
chr9_+_74956614 1.455 ANXA1
annexin A1
chr6_-_56615544 1.450 NM_001723
NM_015548
DST

dystonin

chr2_-_231697999 1.449 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr6_+_28425666 1.447 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr3_+_174598937 1.443 NM_014932
NLGN1
neuroligin 1
chr2_-_121964373 1.433 CLASP1
cytoplasmic linker associated protein 1
chr11_+_65027721 1.428


chr21_-_38792173 1.424 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_+_36642424 1.424 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_75954807 1.419 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr11_-_123353607 1.418 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr21_-_42219849 1.417 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr3_-_71262405 1.415 FOXP1
forkhead box P1
chr1_-_203868622 1.412 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr10_+_102113410 1.411



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 1.03e-06 GO:0010467 gene expression
1.26 2.82e-03 GO:0016070 RNA metabolic process
1.15 3.24e-03 GO:0044260 cellular macromolecule metabolic process
1.23 3.82e-03 GO:0090304 nucleic acid metabolic process
1.14 5.02e-03 GO:0043170 macromolecule metabolic process
1.43 9.24e-03 GO:0006396 RNA processing
1.39 1.46e-02 GO:2000026 regulation of multicellular organismal development
1.06 2.65e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 3.97e-08 GO:0005622 intracellular
1.07 4.32e-06 GO:0044424 intracellular part
1.10 6.16e-05 GO:0005737 cytoplasm
1.13 1.07e-04 GO:0044446 intracellular organelle part
1.13 1.93e-04 GO:0044422 organelle part
1.31 2.15e-04 GO:0005654 nucleoplasm
1.08 2.99e-04 GO:0043229 intracellular organelle
1.08 3.52e-04 GO:0043226 organelle
1.25 6.36e-04 GO:0031981 nuclear lumen
1.18 2.02e-03 GO:0043228 non-membrane-bounded organelle
1.18 2.02e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.08 3.42e-03 GO:0043231 intracellular membrane-bounded organelle
1.08 3.81e-03 GO:0043227 membrane-bounded organelle
1.20 4.26e-03 GO:0031974 membrane-enclosed lumen
1.20 4.67e-03 GO:0043233 organelle lumen
1.20 6.12e-03 GO:0070013 intracellular organelle lumen
1.19 1.20e-02 GO:0044428 nuclear part
1.10 2.95e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 5.79e-05 GO:0005515 protein binding