Motif ID: REST.p3

Z-value: 0.699


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_574687920.458.4e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_61755145 1.062 NM_015894
STMN3
stathmin-like 3
chr12_+_46133 1.029 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr9_+_116131889 0.861 NM_000608
ORM2
orosomucoid 2
chr10_+_60607232 0.842 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr11_-_125278296 0.739 NM_031307
PUS3
pseudouridylate synthase 3
chr3_-_48675321 0.697 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr6_+_43711532 0.625 NM_014628
MAD2L1BP
MAD2L1 binding protein
chr6_+_43711566 0.603 MAD2L1BP
MAD2L1 binding protein
chr11_-_72170533 0.547 STARD10
StAR-related lipid transfer (START) domain containing 10
chr1_-_173979292 0.425 NM_003285
TNR
tenascin R (restrictin, janusin)
chr14_-_93829347 0.414 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr9_-_130078017 0.393 NM_004486
GOLGA2
golgin A2
chr16_+_2959362 0.381 PAQR4
progestin and adipoQ receptor family member IV
chr11_-_65871592 0.379 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr17_-_24265108 0.374 PHF12
PHD finger protein 12
chr10_+_69990050 0.372 NM_030625
TET1
tet oncogene 1
chr7_+_154943466 0.362 NM_001427
EN2
engrailed homeobox 2
chr9_+_130078242 0.348 NM_001040011
C9orf119
chromosome 9 open reading frame 119
chr16_+_2959342 0.342 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr2_-_219791638 0.340 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr10_+_99599984 0.336 NM_001010917
GOLGA7B
golgin A7 family, member B
chr4_-_175986952 0.327 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr16_+_4948318 0.323 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr3_+_195336625 0.318 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr8_-_91164100 0.308 NM_004929
CALB1
calbindin 1, 28kDa
chr9_+_130078321 0.286 C9orf119
chromosome 9 open reading frame 119
chr3_+_195336631 0.285 HES1
hairy and enhancer of split 1, (Drosophila)
chr9_-_122852356 0.275 NM_001735
C5
complement component 5
chrX_-_48943582 0.275 NM_003179
SYP
synaptophysin
chr15_-_29950188 0.271 OTUD7A
OTU domain containing 7A
chr19_-_50618599 0.268 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_44427446 0.266 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr7_-_100595552 0.262 NM_003378
VGF
VGF nerve growth factor inducible
chr17_-_77474597 0.259 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr19_-_50618659 0.245 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr7_+_145444385 0.244 NM_014141
CNTNAP2
contactin associated protein-like 2
chr6_-_32121784 0.232 NM_032470
TNXB
tenascin XB
chr15_-_29950070 0.232 OTUD7A
OTU domain containing 7A
chr3_+_9720509 0.228 NM_153635
CPNE9
copine family member IX
chr10_-_50640327 0.227 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr6_+_158877640 0.221 TMEM181
transmembrane protein 181
chr11_-_74819165 0.219 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr6_+_158877455 0.217 NM_020823
TMEM181
transmembrane protein 181
chr2_-_219791902 0.216 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr18_-_53404783 0.214 NM_000140
NM_001012515
FECH

ferrochelatase

chr20_+_30019465 0.205 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr15_-_81175542 0.204 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr9_-_138236775 0.196 NM_178138
LHX3
LIM homeobox 3
chr8_-_145723209 0.182 NM_001024678
LRRC24
leucine rich repeat containing 24
chr6_+_25760352 0.181 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr14_+_20226762 0.177 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr19_-_50618921 0.171 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_11500912 0.171 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr12_-_29828958 0.166 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr6_+_138767007 0.162 NM_014320
HEBP2
heme binding protein 2
chr22_+_18388633 0.152 C22orf25
chromosome 22 open reading frame 25
chr3_-_188870799 0.149 NM_001048
SST
somatostatin
chr22_+_18388602 0.149 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr17_+_77925441 0.147 NM_018949
UTS2R
urotensin 2 receptor
chr20_+_13713645 0.143 NM_001039375
NM_024120
C20orf7

chromosome 20 open reading frame 7

chr1_-_33108876 0.143 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr22_+_18388656 0.139 C22orf25
chromosome 22 open reading frame 25
chr19_-_50618982 0.138 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr12_+_117903682 0.137 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr2_+_46377952 0.134 NM_001430
EPAS1
endothelial PAS domain protein 1
chr12_+_112280753 0.132 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr17_+_70178850 0.126 NM_175738
RAB37
RAB37, member RAS oncogene family
chr16_+_2450081 0.124 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr7_+_8440109 0.123 NM_152745
NXPH1
neurexophilin 1
chr20_-_13713509 0.119 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr1_+_170017452 0.116 METTL13
methyltransferase like 13
chr19_-_50619015 0.114 NM_001166049
NM_001983
ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr9_-_103397023 0.113 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr5_+_175231170 0.104


chr12_-_3472245 0.103 LOC100129223
hypothetical LOC100129223
chr2_-_51112743 0.103 NRXN1
neurexin 1
chr5_+_175231210 0.101 CPLX2
complexin 2
chr12_+_112280757 0.099 PLBD2
phospholipase B domain containing 2
chr6_+_110406890 0.098 NM_005284
GPR6
G protein-coupled receptor 6
chr6_+_138767151 0.097 HEBP2
heme binding protein 2
chr11_-_122357545 0.097 NM_001098169
BSX
brain-specific homeobox
chrX_-_47364039 0.096


chr5_-_135729062 0.096 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr17_+_70178911 0.094 RAB37
RAB37, member RAS oncogene family
chr7_+_8439762 0.088 NXPH1
neurexophilin 1
chr17_+_27838041 0.088 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_+_45728270 0.087 SPTBN4
spectrin, beta, non-erythrocytic 4
chr2_+_114916368 0.085 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr5_+_175231098 0.084 NM_001008220
CPLX2
complexin 2
chr12_+_111714096 0.079 RPH3A
rabphilin 3A homolog (mouse)
chr19_+_45728207 0.076 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr19_+_9064854 0.074 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr6_+_43257903 0.073 CUL9
cullin 9
chr1_+_170017430 0.072 METTL13
methyltransferase like 13
chr16_+_24174975 0.069 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_-_102234959 0.068 OLFM3
olfactomedin 3
chr9_+_137593420 0.068 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chrX_-_47364173 0.067 NM_006950
NM_133499
SYN1

synapsin I

chr1_+_170017383 0.066 NM_001007239
NM_014955
NM_015935
METTL13


methyltransferase like 13


chr17_+_39741306 0.066 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr11_+_64565118 0.064 SAC3D1
SAC3 domain containing 1
chr11_+_22316242 0.061 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr16_+_67902751 0.058 NM_013245
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr7_+_8440541 0.055 NXPH1
neurexophilin 1
chr11_-_74818685 0.053 KLHL35
kelch-like 35 (Drosophila)
chr17_-_62793097 0.053 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr16_+_24175173 0.052 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr10_+_73225533 0.051 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr20_+_5839973 0.045 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr17_-_62793129 0.044 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr14_+_92459197 0.043 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr5_+_175231144 0.043 CPLX2
complexin 2
chr1_+_152806874 0.042 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr3_-_133236447 0.042 NM_130808
CPNE4
copine IV
chr8_+_69027143 0.040 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr6_+_43257883 0.039 NM_015089
CUL9
cullin 9
chr14_-_104142125 0.037 NM_207379
TMEM179
transmembrane protein 179
chr21_-_34749908 0.037 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chrX_+_152891184 0.036 NM_003492
TMEM187
transmembrane protein 187
chr1_-_102235377 0.030 NM_058170
OLFM3
olfactomedin 3
chr19_-_60383280 0.030 NM_003180
SYT5
synaptotagmin V
chr8_+_69027277 0.030 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr11_-_1725924 0.026 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr1_+_1836125 0.025 NM_138705
CALML6
calmodulin-like 6
chr22_+_30125581 0.025 DRG1
developmentally regulated GTP binding protein 1
chr2_-_51113040 0.025 NM_001135659
NM_004801
NRXN1

neurexin 1

chr8_+_69026895 0.025 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr15_+_65904994 0.023 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr2_+_131230252 0.023 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr11_-_1725662 0.022 LOC402778
CD225 family protein FLJ76511
chr4_+_158361185 0.022 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr12_+_111713931 0.021 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr6_+_44346457 0.020 NM_001137560
TMEM151B
transmembrane protein 151B
chr20_+_56861430 0.020 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr17_-_3248453 0.019 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr11_-_74818858 0.018 KLHL35
kelch-like 35 (Drosophila)
chr1_+_100777044 0.018 GPR88
G protein-coupled receptor 88
chr17_-_3283884 0.017 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr8_+_80685859 0.016 STMN2
stathmin-like 2
chr9_-_73251639 0.016 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr7_-_19778928 0.015 NM_152774
TMEM196
transmembrane protein 196
chr18_-_5187240 0.014 NM_001145194
LOC642597
hypothetical protein LOC642597
chr19_+_15058790 0.013 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr20_+_35445350 0.011 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_+_51804260 0.010 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr22_+_30125508 0.010 NM_004147
DRG1
developmentally regulated GTP binding protein 1
chr5_+_33972247 0.009 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr19_-_50429306 0.008 NM_138568
EXOC3L2
exocyst complex component 3-like 2
chr6_+_153113624 0.007 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr3_+_122109716 0.006 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr10_-_44200458 0.006 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr8_+_11703368 0.006 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr15_+_73074882 0.003 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr1_+_210672817 0.002 NM_013349
NENF
neuron derived neurotrophic factor
chr11_-_27698800 0.001 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.45 8.46e-03 GO:0019226 transmission of nerve impulse
4.45 8.46e-03 GO:0035637 multicellular organismal signaling
4.58 1.50e-02 GO:0007268 synaptic transmission
2.47 2.06e-02 GO:0003008 system process
3.97 2.58e-02 GO:0007186 G-protein coupled receptor protein signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
22.05 3.47e-05 GO:0030672 synaptic vesicle membrane
7.03 5.69e-05 GO:0030659 cytoplasmic vesicle membrane
6.79 7.99e-05 GO:0012506 vesicle membrane
13.62 9.84e-05 GO:0030665 clathrin coated vesicle membrane
5.84 3.52e-04 GO:0044433 cytoplasmic vesicle part
5.14 4.58e-04 GO:0045202 synapse
10.07 7.53e-04 GO:0030662 coated vesicle membrane
5.77 1.13e-03 GO:0044456 synapse part
11.54 1.64e-03 GO:0008021 synaptic vesicle
3.62 1.86e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
3.56 2.32e-03 GO:0031988 membrane-bounded vesicle
3.41 3.77e-03 GO:0031410 cytoplasmic vesicle
3.30 5.47e-03 GO:0031982 vesicle
7.24 6.43e-03 GO:0030136 clathrin-coated vesicle
6.78 9.78e-03 GO:0043025 neuronal cell body
6.58 1.17e-02 GO:0044297 cell body
5.91 2.29e-02 GO:0030135 coated vesicle

Nothing significant found in function category.