Motif ID: RREB1.p2

Z-value: 3.053


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_70527980.712.0e-03Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_96924582 9.248 NM_001172667
 FAM178B
family with sequence similarity 178, member B
chr1_-_30977931 5.770 LAPTM5
lysosomal protein transmembrane 5
chrX_+_151617900 4.243 NM_005363
NM_175868
 MAGEA6

melanoma antigen family A, 6

chrX_-_151688850 3.953 NM_005362
 MAGEA3
melanoma antigen family A, 3
chr11_-_74740298 3.647 NM_004041
NM_020251
 ARRB1

arrestin, beta 1

chr17_-_44058612 3.100 NM_024017
 HOXB9
homeobox B9
chr17_-_73636386 3.033 NM_001127198
 TMC6
transmembrane channel-like 6
chr17_-_73636362 2.796 TMC6
transmembrane channel-like 6
chr14_+_28305922 2.734 NM_005249
 FOXG1
forkhead box G1
chr20_+_48032918 2.673 NM_005985
 SNAI1
snail homolog 1 (Drosophila)
chr22_-_21231421 2.506 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
 PRAME




preferentially expressed antigen in melanoma




chr9_-_122679283 2.386 PHF19
PHD finger protein 19
chr9_-_122679387 2.333 NM_001009936
NM_015651
 PHF19

PHD finger protein 19

chr16_-_69030421 2.308 NM_006927
 ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr21_-_43368963 2.291 NM_000071
 CBS
cystathionine-beta-synthase
chr8_+_144706699 2.269 NM_001166237
 GSDMD
gasdermin D
chrX_-_152139267 2.243 NM_004988
 MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr20_-_55533544 2.152 NM_080618
 CTCFL
CCCTC-binding factor (zinc finger protein)-like
chrX_+_151633730 2.146 NM_005361
NM_175742
NM_175743
 MAGEA2


melanoma antigen family A, 2


chrX_-_151672985 2.112 NM_005361
NM_175742
NM_175743
 MAGEA2


melanoma antigen family A, 2



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 99 entries
enrichment   p-value GO term description
2.76 6.42e-04 GO:0048663 neuron fate commitment
2.27 1.50e-02 GO:0007519 skeletal muscle tissue development
2.21 3.56e-03 GO:0021953 central nervous system neuron differentiation
2.21 2.13e-02 GO:0060538 skeletal muscle organ development
1.93 1.80e-12 GO:0016568 chromatin modification
1.89 9.88e-05 GO:0016569 covalent chromatin modification
1.86 2.78e-04 GO:0016570 histone modification
1.85 6.77e-04 GO:0030900 forebrain development
1.81 1.40e-02 GO:0045165 cell fate commitment
1.73 4.88e-07 GO:0007420 brain development
1.71 4.54e-10 GO:0007417 central nervous system development
1.66 3.66e-02 GO:0045664 regulation of neuron differentiation
1.65 1.99e-07 GO:0006325 chromatin organization
1.65 7.14e-03 GO:0050767 regulation of neurogenesis
1.62 8.98e-04 GO:0060284 regulation of cell development
1.60 1.41e-02 GO:0045596 negative regulation of cell differentiation
1.59 1.60e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.59 1.14e-02 GO:0051960 regulation of nervous system development
1.58 5.68e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.56 1.46e-04 GO:0007268 synaptic transmission

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
3.64 4.79e-02 GO:0042627 chylomicron
3.51 2.15e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
3.07 4.08e-02 GO:0031519 PcG protein complex
1.56 8.46e-03 GO:0005667 transcription factor complex
1.43 1.05e-05 GO:0044451 nucleoplasm part
1.28 9.75e-07 GO:0031981 nuclear lumen
1.28 2.72e-04 GO:0005654 nucleoplasm
1.24 1.20e-06 GO:0043233 organelle lumen
1.24 2.71e-06 GO:0070013 intracellular organelle lumen
1.24 6.68e-06 GO:0044428 nuclear part
1.23 3.10e-06 GO:0031974 membrane-enclosed lumen
1.18 6.11e-05 GO:0043234 protein complex
1.14 1.71e-06 GO:0005634 nucleus
1.14 1.99e-03 GO:0032991 macromolecular complex
1.09 3.61e-02 GO:0044422 organelle part
1.07 1.71e-06 GO:0044424 intracellular part
1.07 2.18e-04 GO:0043226 organelle
1.07 2.51e-04 GO:0043229 intracellular organelle
1.07 7.40e-04 GO:0043227 membrane-bounded organelle
1.07 7.60e-04 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
4.04 6.83e-03 GO:0042974 retinoic acid receptor binding
1.95 2.07e-07 GO:0000975 regulatory region DNA binding
1.95 2.07e-07 GO:0001067 regulatory region nucleic acid binding
1.95 2.07e-07 GO:0044212 transcription regulatory region DNA binding
1.95 3.86e-07 GO:0010843 promoter binding
1.74 1.97e-02 GO:0022843 voltage-gated cation channel activity
1.72 7.89e-16 GO:0043565 sequence-specific DNA binding
1.72 8.54e-07 GO:0016563 transcription activator activity
1.71 2.50e-03 GO:0003682 chromatin binding
1.61 4.58e-02 GO:0005244 voltage-gated ion channel activity
1.61 4.58e-02 GO:0022832 voltage-gated channel activity
1.57 2.55e-15 GO:0030528 transcription regulator activity
1.57 1.31e-03 GO:0016564 transcription repressor activity
1.51 4.40e-02 GO:0005261 cation channel activity
1.45 4.76e-03 GO:0019904 protein domain specific binding
1.44 1.55e-08 GO:0001071 nucleic acid binding transcription factor activity
1.44 1.55e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 2.31e-02 GO:0022838 substrate-specific channel activity
1.43 3.01e-02 GO:0005216 ion channel activity
1.21 8.65e-05 GO:0003677 DNA binding