Motif ID: RUNX1..3.p2

Z-value: 4.163


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.821.1e-04Click!
RUNX1chr21_-_35181278-0.731.3e-03Click!
RUNX2chr6_+_45404031-0.204.5e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_25164061 17.271 NM_001031680
 RUNX3
runt-related transcription factor 3
chr1_-_114215768 12.416 NM_001193431
NM_012411
NM_015967
 PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chrX_-_30505804 9.075 NM_025159
 CXorf21
chromosome X open reading frame 21
chr9_-_129580732 9.040 NM_170600
 SH2D3C
SH2 domain containing 3C
chr1_+_204797516 8.776 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_158008763 8.493 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr16_+_29582069 8.161 NM_003123
 SPN
sialophorin
chr1_+_207995999 7.302 NM_025228
 TRAF3IP3
TRAF3 interacting protein 3
chr9_-_122728173 7.173 TRAF1
TNF receptor-associated factor 1
chr17_-_31441390 7.095 NM_002983
 CCL3
chemokine (C-C motif) ligand 3
chr6_-_41276901 7.065 NM_024807
 TREML2
triggering receptor expressed on myeloid cells-like 2
chr1_+_204797214 7.022 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr14_+_92188329 6.975 RIN3
Ras and Rab interactor 3
chr12_-_101396459 6.845 NM_001111284
 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_1185144 6.580 LOC100130872
hypothetical LOC100130872
chr21_-_35343331 6.504 RUNX1
runt-related transcription factor 1
chr16_+_29582065 6.441 SPN
sialophorin
chr21_-_35343500 6.353 RUNX1
runt-related transcription factor 1
chr21_-_35343456 6.331 NM_001754
 RUNX1
runt-related transcription factor 1
chr21_-_35343448 6.210 RUNX1
runt-related transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
3.37 2.67e-02 GO:0030048 actin filament-based movement
2.04 7.12e-06 GO:0007608 sensory perception of smell
1.94 1.81e-05 GO:0007606 sensory perception of chemical stimulus
1.68 3.19e-02 GO:0001775 cell activation
1.58 1.77e-02 GO:0002682 regulation of immune system process
1.53 3.97e-02 GO:0006955 immune response
1.52 2.38e-02 GO:0007600 sensory perception
1.50 3.40e-04 GO:0002376 immune system process
1.44 7.96e-05 GO:0003008 system process
1.41 8.03e-03 GO:0050877 neurological system process
1.24 8.45e-03 GO:0007165 signal transduction
1.21 5.51e-06 GO:0050896 response to stimulus
1.21 3.52e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
6.27 1.30e-02 GO:0005833 hemoglobin complex
1.27 1.74e-06 GO:0005886 plasma membrane
1.26 1.54e-06 GO:0071944 cell periphery
1.13 2.17e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.50 2.88e-02 GO:0003823 antigen binding
3.29 1.68e-02 GO:0005070 SH3/SH2 adaptor activity
1.99 1.54e-05 GO:0004984 olfactory receptor activity
1.80 1.26e-02 GO:0003779 actin binding
1.63 4.35e-05 GO:0004930 G-protein coupled receptor activity
1.48 1.01e-04 GO:0004888 transmembrane receptor activity
1.47 1.90e-06 GO:0004872 receptor activity
1.44 2.56e-07 GO:0004871 signal transducer activity
1.44 2.56e-07 GO:0060089 molecular transducer activity