Motif ID: RUNX1..3.p2

Z-value: 4.163


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.821.1e-04Click!
RUNX1chr21_-_35181278-0.731.3e-03Click!
RUNX2chr6_+_45404031-0.204.5e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_25164061 17.271 NM_001031680
RUNX3
runt-related transcription factor 3
chr1_-_114215768 12.416 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chrX_-_30505804 9.075 NM_025159
CXorf21
chromosome X open reading frame 21
chr9_-_129580732 9.040 NM_170600
SH2D3C
SH2 domain containing 3C
chr1_+_204797516 8.776 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_158008763 8.493 NM_004288
CYTIP
cytohesin 1 interacting protein
chr16_+_29582069 8.161 NM_003123
SPN
sialophorin
chr1_+_207995999 7.302 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr9_-_122728173 7.173 TRAF1
TNF receptor-associated factor 1
chr17_-_31441390 7.095 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr6_-_41276901 7.065 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr1_+_204797214 7.022 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr14_+_92188329 6.975 RIN3
Ras and Rab interactor 3
chr12_-_101396459 6.845 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_1185144 6.580 LOC100130872
hypothetical LOC100130872
chr21_-_35343331 6.504 RUNX1
runt-related transcription factor 1
chr16_+_29582065 6.441 SPN
sialophorin
chr21_-_35343500 6.353 RUNX1
runt-related transcription factor 1
chr21_-_35343456 6.331 NM_001754
RUNX1
runt-related transcription factor 1
chr21_-_35343448 6.210 RUNX1
runt-related transcription factor 1
chr19_-_40925151 6.075 NM_024660
TMEM149
transmembrane protein 149
chr11_-_66961709 5.924 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr21_-_35343428 5.878 RUNX1
runt-related transcription factor 1
chr14_+_99601517 5.781 EVL
Enah/Vasp-like
chr14_+_99601498 5.722 NM_016337
EVL
Enah/Vasp-like
chr16_+_28413421 5.646 NM_018690
APOBR
apolipoprotein B receptor
chr2_-_175170674 5.558 WIPF1
WAS/WASL interacting protein family, member 1
chr4_-_38482805 5.397 NM_003263
TLR1
toll-like receptor 1
chr1_-_205161821 5.348 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr8_-_21827057 5.293 NM_003974
DOK2
docking protein 2, 56kDa
chr1_+_202000906 5.265 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr3_+_99733432 5.261 NM_005290
GPR15
G protein-coupled receptor 15
chr10_+_70517823 5.236 NM_002727
SRGN
serglycin
chr10_+_70517863 5.160 SRGN
serglycin
chrX_-_70755023 5.068 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr6_-_11490487 5.021 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_31651319 4.694 NM_000594
TNF
tumor necrosis factor
chr22_+_38627129 4.680 GRAP2
GRB2-related adaptor protein 2
chr22_+_38627031 4.674 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_-_205012348 4.504 NM_000572
IL10
interleukin 10
chr12_+_25096472 4.472 NM_006152
LRMP
lymphoid-restricted membrane protein
chr16_+_30102426 4.362 CORO1A
coronin, actin binding protein, 1A
chr13_-_45654296 4.339 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr15_-_75259714 4.267 PEAK1
NKF3 kinase family member
chr7_+_45033757 4.239 NM_001029835
CCM2
cerebral cavernous malformation 2
chr16_+_29581783 4.215 NM_001030288
SPN
sialophorin
chr19_-_55560686 4.198 NM_004851
NAPSA
napsin A aspartic peptidase
chr5_-_88155360 4.168 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr14_+_75058518 4.156 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_31648071 4.156 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr3_+_142587973 4.153


chr1_+_196874867 4.132 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_78087484 4.053 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_159306037 4.047 ARHGAP30
Rho GTPase activating protein 30
chr6_+_31647854 4.043 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr13_-_45654292 3.981 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_17495109 3.973 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr19_-_47328399 3.935 NM_002698
POU2F2
POU class 2 homeobox 2
chr1_+_204797079 3.915 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr14_+_92188546 3.914 RIN3
Ras and Rab interactor 3
chr14_+_75058591 3.891 BATF
basic leucine zipper transcription factor, ATF-like
chrX_-_77801480 3.862 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr17_-_71352090 3.831 UNC13D
unc-13 homolog D (C. elegans)
chr1_+_204797120 3.783 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr1_+_190811479 3.740 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_+_32489426 3.728 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr12_+_45896511 3.671 FAM113B
family with sequence similarity 113, member B
chr11_+_46339691 3.660 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr19_+_16115454 3.633 HSH2D
hematopoietic SH2 domain containing
chr3_+_114733907 3.615 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr17_+_71292535 3.600


chr1_-_157313179 3.585 NM_004833
AIM2
absent in melanoma 2
chr17_-_31548167 3.559 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr1_+_196874839 3.532 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_+_140871107 3.526


chr17_-_71352017 3.519 UNC13D
unc-13 homolog D (C. elegans)
chr4_-_10295412 3.450 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_-_159306273 3.442 ARHGAP30
Rho GTPase activating protein 30
chr1_-_159306210 3.383 ARHGAP30
Rho GTPase activating protein 30
chr12_-_38300109 3.360 NM_005164
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr5_+_140870881 3.351


chr4_-_113656762 3.348 NM_024019
NEUROG2
neurogenin 2
chr1_+_196874759 3.319 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_+_25096755 3.223 LRMP
lymphoid-restricted membrane protein
chr17_+_71292437 3.160 UNK
unkempt homolog (Drosophila)
chr2_+_202379442 3.146 NM_139158
CDK15
cyclin-dependent kinase 15
chr14_-_93493519 3.094 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr1_-_159306369 3.054 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr18_+_59726183 3.007 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_63864263 3.006 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr1_-_159306327 2.998 ARHGAP30
Rho GTPase activating protein 30
chr14_-_104602784 2.977 NM_013345
GPR132
G protein-coupled receptor 132
chr7_+_149761674 2.933 LOC285972
hypothetical LOC285972
chr5_+_75734759 2.914 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr19_-_18058632 2.881 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr16_+_27346079 2.873 NM_021798
IL21R
interleukin 21 receptor
chr8_-_102872354 2.851 NCALD
neurocalcin delta
chr2_+_102401580 2.818 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr16_+_48857962 2.814 ADCY7
adenylate cyclase 7
chrX_+_48427137 2.808 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chrX_-_39921525 2.793 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr17_-_26665220 2.783 NM_006495
EVI2B
ecotropic viral integration site 2B
chr22_+_35586950 2.780 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr17_+_44643067 2.779 ABI3
ABI family, member 3
chrX_+_48427103 2.779 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr14_-_104602809 2.740 GPR132
G protein-coupled receptor 132
chr17_-_44642934 2.715 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr8_-_102872372 2.715 NCALD
neurocalcin delta
chr19_-_46504831 2.714


chr12_+_9713472 2.695 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr3_+_47004457 2.650 NBEAL2
neurobeachin-like 2
chr6_-_33028790 2.593 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr2_+_169367345 2.585 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr18_+_13601664 2.571 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr17_-_26665144 2.570 EVI2B
ecotropic viral integration site 2B
chr19_+_2240996 2.568


chr17_-_26665194 2.553 EVI2B
ecotropic viral integration site 2B
chrX_-_19727775 2.547 SH3KBP1
SH3-domain kinase binding protein 1
chr19_-_60458915 2.513 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr5_+_176717553 2.489


chr3_+_120799411 2.471 NM_015900
PLA1A
phospholipase A1 member A
chrX_-_111809929 2.469 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr17_+_69974116 2.456 NM_007261
CD300A
CD300a molecule
chr6_-_149847809 2.446 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr15_+_36776090 2.446 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr17_+_43165608 2.435 NM_013351
TBX21
T-box 21
chrX_-_19727828 2.424 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr10_+_91082218 2.414 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr8_-_102872614 2.383 NM_032041
NCALD
neurocalcin delta
chr12_-_111304138 2.369 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr5_-_137099602 2.329 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr17_-_26672757 2.303 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr6_+_52159143 2.294 NM_002190
IL17A
interleukin 17A
chr6_-_32892705 2.277 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr5_+_176717449 2.274 NM_006480
RGS14
regulator of G-protein signaling 14
chr9_-_122728993 2.244 NM_005658
TRAF1
TNF receptor-associated factor 1
chr10_-_11614279 2.239 NM_001080491
USP6NL
USP6 N-terminal like
chr18_+_70317802 2.221 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_-_26665213 2.217 EVI2B
ecotropic viral integration site 2B
chr21_-_35343065 2.164 RUNX1
runt-related transcription factor 1
chr9_+_122923864 2.154 CEP110
centrosomal protein 110kDa
chr17_-_71352182 2.153 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_+_149395728 2.122 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr6_-_31853027 2.119 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr19_+_55627971 2.101 NM_004533
MYBPC2
myosin binding protein C, fast type
chr4_-_38534802 2.089 NM_006068
TLR6
toll-like receptor 6
chr15_-_32662352 2.082 GOLGA8B
golgin A8 family, member B
chr16_+_51690564 2.079 CHD9
chromodomain helicase DNA binding protein 9
chr6_-_119137923 2.074 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr22_+_37708350 2.069 NM_004900
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr16_+_31273969 2.069 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_141048358 2.063 NM_001080392
KIAA1147
KIAA1147
chr1_+_26744929 2.038 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_92724181 2.036 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr8_+_144173674 2.018 LY6E
lymphocyte antigen 6 complex, locus E
chr22_+_23333610 2.009 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr2_+_68445936 2.004 PLEK
pleckstrin
chr16_+_7322751 1.992 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr19_-_48976852 1.982 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr5_+_176807931 1.972 NM_001174102
PRR7
proline rich 7 (synaptic)
chrX_-_135690699 1.968 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_+_39874921 1.965 NM_004310
RHOH
ras homolog gene family, member H
chr17_+_77910411 1.940 NM_207459
TEX19
testis expressed 19
chr16_+_23754997 1.934 PRKCB
protein kinase C, beta
chr17_-_59363352 1.933 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr11_-_58099884 1.932 NM_004811
LPXN
leupaxin
chr1_+_26744893 1.931 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_-_137099361 1.888 KLHL3
kelch-like 3 (Drosophila)
chr2_-_213723298 1.882 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr22_-_16080265 1.847 CECR1
cat eye syndrome chromosome region, candidate 1
chr19_+_60109319 1.841 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr12_+_115481568 1.836 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chrX_-_78509662 1.834 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr16_+_28797309 1.831 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr6_-_149847718 1.799 ZC3H12D
zinc finger CCCH-type containing 12D
chr19_+_45194782 1.791 NM_178544
ZNF546
zinc finger protein 546
chr21_+_41655786 1.790 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_40631603 1.776 NM_001198979
SMAP2
small ArfGAP2
chrX_+_154880439 1.775 NM_002186
IL9R
interleukin 9 receptor
chr1_-_155788775 1.755 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr19_-_45947667 1.755 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr5_+_156628929 1.752 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_-_1478293 1.743 SLC43A2
solute carrier family 43, member 2
chr18_+_19826734 1.729 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chrX_-_135690770 1.725 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr10_-_121346517 1.725 NM_001033925
NM_003252
TIAL1

TIA1 cytotoxic granule-associated RNA binding protein-like 1

chr13_-_45654327 1.691 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_+_25155220 1.688 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr2_+_74610751 1.683 HTRA2
HtrA serine peptidase 2
chr19_-_16111695 1.678


chr15_-_100280784 1.676 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_-_76667045 1.665 NM_006682
FGL2
fibrinogen-like 2
chr12_-_56432292 1.661 CDK4
cyclin-dependent kinase 4
chr4_+_38740246 1.660 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr2_+_68445821 1.652 NM_002664
PLEK
pleckstrin
chr2_+_182030510 1.652 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr17_-_1478859 1.641 NM_152346
SLC43A2
solute carrier family 43, member 2
chrX_-_78509367 1.635 ITM2A
integral membrane protein 2A
chr3_+_186563529 1.611 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_+_154386358 1.611 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 5.51e-06 GO:0050896 response to stimulus
2.04 7.12e-06 GO:0007608 sensory perception of smell
1.94 1.81e-05 GO:0007606 sensory perception of chemical stimulus
1.44 7.96e-05 GO:0003008 system process
1.50 3.40e-04 GO:0002376 immune system process
1.41 8.03e-03 GO:0050877 neurological system process
1.24 8.45e-03 GO:0007165 signal transduction
1.58 1.77e-02 GO:0002682 regulation of immune system process
1.52 2.38e-02 GO:0007600 sensory perception
3.37 2.67e-02 GO:0030048 actin filament-based movement
1.68 3.19e-02 GO:0001775 cell activation
1.21 3.52e-02 GO:0023052 signaling
1.53 3.97e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 1.54e-06 GO:0071944 cell periphery
1.27 1.74e-06 GO:0005886 plasma membrane
6.27 1.30e-02 GO:0005833 hemoglobin complex
1.13 2.17e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 2.56e-07 GO:0004871 signal transducer activity
1.44 2.56e-07 GO:0060089 molecular transducer activity
1.47 1.90e-06 GO:0004872 receptor activity
1.99 1.54e-05 GO:0004984 olfactory receptor activity
1.63 4.35e-05 GO:0004930 G-protein coupled receptor activity
1.48 1.01e-04 GO:0004888 transmembrane receptor activity
1.80 1.26e-02 GO:0003779 actin binding
3.29 1.68e-02 GO:0005070 SH3/SH2 adaptor activity
3.50 2.88e-02 GO:0003823 antigen binding