Motif ID: RXR{A,B,G}.p2

Z-value: 2.912


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRGchr1_-_163680941-0.214.4e-01Click!
RXRBchr6_-_332763470.204.6e-01Click!
RXRAchr9_+_1363581340.087.6e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_44429748 6.269 NM_001160423
NM_006546
 IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr19_+_18391211 2.939 NM_001009998
NM_032627
 SSBP4

single stranded DNA binding protein 4

chr21_-_45532176 2.934 NM_015227
NM_133635
 POFUT2

protein O-fucosyltransferase 2

chr19_-_14089560 2.559 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr5_+_149845503 2.549 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr6_-_2916786 2.548 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_+_18391423 2.473


chr6_-_132314004 2.443 NM_001901
 CTGF
connective tissue growth factor
chr6_-_2916280 2.321 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_-_14089362 2.277 NM_002730
 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr11_+_65162114 2.089 NM_006747
 SIPA1
signal-induced proliferation-associated 1
chr17_+_6867090 2.016 NM_181844
 BCL6B
B-cell CLL/lymphoma 6, member B
chr18_+_75261231 1.955 NM_172387
NM_172389
 NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr3_+_129690735 1.949


chr12_+_50686990 1.917 NM_181711
 GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr15_-_53822468 1.893 NM_173814
 PRTG
protogenin
chr5_-_172687798 1.886 STC2
stanniocalcin 2
chr1_-_47468029 1.875 NM_003189
 TAL1
T-cell acute lymphocytic leukemia 1
chr3_-_16529996 1.823 RFTN1
raftlin, lipid raft linker 1
chr14_-_37795001 1.818 CLEC14A
C-type lectin domain family 14, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
3.65 4.00e-02 GO:0043535 regulation of blood vessel endothelial cell migration
2.91 4.77e-02 GO:0001649 osteoblast differentiation
2.33 3.40e-02 GO:0051216 cartilage development
2.15 1.66e-02 GO:0001503 ossification
1.87 4.67e-02 GO:0044087 regulation of cellular component biogenesis
1.77 8.95e-03 GO:0051130 positive regulation of cellular component organization
1.63 7.43e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.63 1.35e-04 GO:0010629 negative regulation of gene expression
1.63 5.98e-04 GO:0051253 negative regulation of RNA metabolic process
1.63 7.25e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.61 9.42e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.61 2.81e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60 1.05e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.60 1.08e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.59 5.68e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.58 2.10e-04 GO:0009890 negative regulation of biosynthetic process
1.58 4.73e-02 GO:0032583 regulation of gene-specific transcription
1.54 3.71e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.49 1.21e-02 GO:0010628 positive regulation of gene expression
1.48 4.19e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.64 5.92e-03 GO:0048471 perinuclear region of cytoplasm
1.62 4.78e-02 GO:0015629 actin cytoskeleton
1.54 3.18e-02 GO:0043005 neuron projection
1.38 4.18e-02 GO:0031975 envelope
1.12 2.05e-02 GO:0005634 nucleus
1.12 2.97e-02 GO:0044422 organelle part
1.10 3.58e-05 GO:0043226 organelle
1.10 5.76e-05 GO:0043229 intracellular organelle
1.10 1.07e-03 GO:0043231 intracellular membrane-bounded organelle
1.10 1.11e-03 GO:0043227 membrane-bounded organelle
1.09 1.03e-02 GO:0005737 cytoplasm
1.08 2.71e-05 GO:0044424 intracellular part
1.08 5.50e-05 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.46 2.11e-02 GO:0005200 structural constituent of cytoskeleton
1.71 3.16e-03 GO:0016563 transcription activator activity
1.51 2.38e-06 GO:0030528 transcription regulator activity
1.49 1.98e-03 GO:0043565 sequence-specific DNA binding
1.48 9.42e-03 GO:0005198 structural molecule activity
1.44 2.32e-04 GO:0001071 nucleic acid binding transcription factor activity
1.44 2.32e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.30 1.70e-05 GO:0003677 DNA binding
1.14 2.01e-05 GO:0005515 protein binding