Motif ID: SMAD1..7,9.p2

Z-value: 1.684


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD3chr15_+_651452480.829.4e-05Click!
SMAD4chr18_+_468104810.683.5e-03Click!
SMAD1chr4_+_1466221540.601.5e-02Click!
SMAD2chr18_-_437114520.523.8e-02Click!
SMAD7chr18_-_447310780.448.5e-02Click!
SMAD5chr5_+_1354964210.448.6e-02Click!
SMAD6chr15_+_647824680.332.1e-01Click!
SMAD9chr13_-_363923700.253.5e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_22970850 3.465 NM_001099781
NM_001099782
NM_004121
 GGT5


gamma-glutamyltransferase 5


chr15_-_81744469 2.562 NM_001717
 BNC1
basonuclin 1
chr13_-_32822759 2.202 STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_-_151046638 2.174 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_15145001 2.144 NM_001017999
 KAZN
kazrin, periplakin interacting protein
chr19_+_60691733 2.119 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr5_-_151046680 2.063 NM_003118
 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr16_+_56219802 2.047 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
 GPR56




G protein-coupled receptor 56




chr10_+_22765996 1.869 LOC100289455
hypothetical LOC100289455
chr11_-_65860450 1.775 NM_004292
 RIN1
Ras and Rab interactor 1
chr12_-_45759691 1.743 NM_001143668
NM_181847
 AMIGO2

adhesion molecule with Ig-like domain 2

chrX_+_53095230 1.499 NM_018969
 GPR173
G protein-coupled receptor 173
chr9_+_133154896 1.439 NM_032728
 PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr3_+_175641340 1.399 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr1_-_6368324 1.389 NM_181864
 ACOT7
acyl-CoA thioesterase 7
chr14_+_51850754 1.382 NM_000956
 PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr19_+_60691671 1.377 NM_001144950
NM_001195267
 SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr9_+_36026900 1.250 NM_021111
 RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr1_-_16217871 1.235 NM_014424
 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr19_-_50977586 1.233 DMPK
dystrophia myotonica-protein kinase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
6.42 2.16e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
5.34 4.69e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
4.89 1.20e-02 GO:0030513 positive regulation of BMP signaling pathway
1.75 1.10e-04 GO:0007409 axonogenesis
1.72 3.56e-05 GO:0031175 neuron projection development
1.71 3.26e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.70 3.88e-04 GO:0048812 neuron projection morphogenesis
1.70 1.41e-02 GO:0007411 axon guidance
1.69 8.88e-05 GO:0032990 cell part morphogenesis
1.69 1.08e-04 GO:0048858 cell projection morphogenesis
1.65 4.07e-02 GO:0051240 positive regulation of multicellular organismal process
1.63 3.60e-05 GO:0030030 cell projection organization
1.62 1.74e-03 GO:0000904 cell morphogenesis involved in differentiation
1.61 3.66e-04 GO:0048666 neuron development
1.56 1.74e-03 GO:0000902 cell morphogenesis
1.55 1.85e-03 GO:0032989 cellular component morphogenesis
1.52 1.65e-03 GO:0030182 neuron differentiation
1.51 3.98e-08 GO:0051239 regulation of multicellular organismal process
1.51 1.18e-03 GO:2000026 regulation of multicellular organismal development
1.48 2.20e-04 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
2.15 4.60e-02 GO:0001726 ruffle
2.12 1.81e-02 GO:0005924 cell-substrate adherens junction
2.08 4.73e-02 GO:0005925 focal adhesion
2.07 1.09e-03 GO:0005912 adherens junction
2.04 3.91e-02 GO:0030055 cell-substrate junction
2.00 1.29e-03 GO:0070161 anchoring junction
1.25 4.98e-02 GO:0005856 cytoskeleton
1.21 2.54e-02 GO:0044459 plasma membrane part
1.18 2.89e-04 GO:0071944 cell periphery
1.18 3.67e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.60 3.54e-02 GO:0003779 actin binding
1.52 4.26e-03 GO:0008092 cytoskeletal protein binding
1.34 2.25e-02 GO:0001071 nucleic acid binding transcription factor activity
1.34 2.25e-02 GO:0003700 sequence-specific DNA binding transcription factor activity