Motif ID: SOX{8,9,10}.p2

Z-value: 1.687


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_367104840.401.2e-01Click!
SOX9chr17_+_676287630.263.3e-01Click!
SOX8chr16_+_9718080.068.4e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_128883125 4.860 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_+_101680594 3.051 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr7_-_27171673 2.429 NM_152739
HOXA9
homeobox A9
chr12_-_6103945 2.407 NM_000552
VWF
von Willebrand factor
chr3_+_195336625 2.369 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr7_-_27171648 2.337 HOXA9
homeobox A9
chr7_-_27171600 2.332 HOXA9
homeobox A9
chr6_-_11340869 2.268 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340886 2.213 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340887 2.197 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_-_187309442 2.016 NM_004454
ETV5
ets variant 5
chr4_-_7991992 2.008 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr5_-_16989371 1.985 NM_012334
MYO10
myosin X
chr9_+_123501186 1.970 DAB2IP
DAB2 interacting protein
chr6_+_148705421 1.957 NM_015278
SASH1
SAM and SH3 domain containing 1
chr5_-_16989290 1.929 MYO10
myosin X
chr17_-_76985538 1.844


chr1_-_95165037 1.800 CNN3
calponin 3, acidic
chr3_-_189354510 1.793 LOC339929
hypothetical LOC339929
chr21_+_17807167 1.762 NM_001338
CXADR
coxsackie virus and adenovirus receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
5.26 4.31e-02 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
2.11 6.75e-06 GO:0007264 small GTPase mediated signal transduction
2.09 6.21e-03 GO:0030036 actin cytoskeleton organization
2.01 5.49e-03 GO:0030029 actin filament-based process
1.99 1.79e-03 GO:0007411 axon guidance
1.87 1.64e-03 GO:0007409 axonogenesis
1.81 5.87e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.80 5.29e-03 GO:0048812 neuron projection morphogenesis
1.76 4.29e-03 GO:0000904 cell morphogenesis involved in differentiation
1.69 3.01e-02 GO:0032990 cell part morphogenesis
1.68 3.98e-03 GO:0032989 cellular component morphogenesis
1.68 4.20e-02 GO:0048858 cell projection morphogenesis
1.64 1.86e-02 GO:0000902 cell morphogenesis
1.54 1.14e-02 GO:0040011 locomotion
1.46 5.39e-04 GO:0007399 nervous system development
1.37 3.62e-02 GO:0009653 anatomical structure morphogenesis
1.36 3.14e-08 GO:0007275 multicellular organismal development
1.35 2.14e-08 GO:0032502 developmental process
1.35 2.77e-03 GO:0048869 cellular developmental process
1.34 5.56e-05 GO:0048731 system development

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
7.93 4.73e-02 GO:0005577 fibrinogen complex
2.92 2.03e-04 GO:0005925 focal adhesion
2.78 3.57e-04 GO:0030055 cell-substrate junction
2.78 5.67e-04 GO:0005924 cell-substrate adherens junction
2.69 2.29e-06 GO:0070161 anchoring junction
2.68 1.45e-05 GO:0005912 adherens junction
2.13 5.45e-04 GO:0016323 basolateral plasma membrane
2.03 1.52e-02 GO:0005911 cell-cell junction
1.85 1.20e-06 GO:0030054 cell junction
1.82 1.86e-02 GO:0015629 actin cytoskeleton
1.39 8.86e-04 GO:0005856 cytoskeleton
1.13 6.23e-04 GO:0005737 cytoplasm
1.09 4.06e-04 GO:0005622 intracellular
1.08 2.56e-03 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.01 3.52e-03 GO:0005096 GTPase activator activity
1.63 4.68e-02 GO:0030695 GTPase regulator activity
1.15 3.99e-04 GO:0005515 protein binding
1.08 1.93e-03 GO:0005488 binding