Motif ID: SOX2.p2

Z-value: 1.084


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1829127690.411.2e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_139654807 2.559 NM_153235
 TXLNB
taxilin beta
chr3_-_150533948 2.270 NM_001184723
NM_138786
 TM4SF18

transmembrane 4 L six family member 18

chr7_-_27186400 2.076 NM_153715
 HOXA10
homeobox A10
chr4_-_101658094 1.618 NM_001159694
NM_016242
 EMCN

endomucin

chr6_+_130381408 1.405 NM_001007102
NM_032438
 L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr1_-_171441234 1.382 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_146623405 1.349 NM_001003688
 SMAD1
SMAD family member 1
chr4_+_86918882 1.312 ARHGAP24
Rho GTPase activating protein 24
chr1_+_66570363 1.279 NM_001037339
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_-_37752272 1.278 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_-_197173159 1.270 LOC100131234
familial acute myelogenous leukemia related factor
chr12_-_6103945 1.214 NM_000552
 VWF
von Willebrand factor
chr7_-_27180398 1.212 NM_018951
 HOXA10
homeobox A10
chr2_-_188021117 1.206 NM_005795
 CALCRL
calcitonin receptor-like
chr13_-_98428244 1.205 NM_001130048
NM_001130050
 DOCK9

dedicator of cytokinesis 9

chr7_+_102340579 1.130 NM_001031692
NM_005824
 LRRC17

leucine rich repeat containing 17

chr6_+_12398514 1.107 NM_001168319
NM_001955
 EDN1

endothelin 1

chr7_+_27190688 1.089


chrX_+_15428820 1.071 NM_203281
 BMX
BMX non-receptor tyrosine kinase
chr21_-_38792173 1.069 NM_001136155
NM_182918
 ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.96 3.71e-05 GO:0030029 actin filament-based process
1.95 4.75e-04 GO:0030036 actin cytoskeleton organization
1.68 2.62e-02 GO:0007411 axon guidance
1.63 9.98e-03 GO:0007409 axonogenesis
1.60 9.11e-03 GO:0072358 cardiovascular system development
1.60 9.11e-03 GO:0072359 circulatory system development
1.59 7.74e-03 GO:0000904 cell morphogenesis involved in differentiation
1.59 2.61e-02 GO:0048812 neuron projection morphogenesis
1.58 4.22e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.56 2.24e-02 GO:0007010 cytoskeleton organization
1.55 2.04e-04 GO:2000026 regulation of multicellular organismal development
1.55 3.45e-03 GO:0000902 cell morphogenesis
1.55 2.70e-02 GO:0031175 neuron projection development
1.49 2.01e-02 GO:0030030 cell projection organization
1.48 2.87e-02 GO:0032989 cellular component morphogenesis
1.43 5.40e-03 GO:0050793 regulation of developmental process
1.42 4.81e-06 GO:0007399 nervous system development
1.40 3.03e-02 GO:0022008 neurogenesis
1.34 2.27e-03 GO:0009653 anatomical structure morphogenesis
1.32 1.38e-07 GO:0048731 system development

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
3.48 1.12e-02 GO:0001725 stress fiber
3.40 3.62e-03 GO:0042641 actomyosin
3.24 2.76e-02 GO:0032432 actin filament bundle
2.50 1.46e-04 GO:0005925 focal adhesion
2.43 1.40e-04 GO:0030055 cell-substrate junction
2.38 5.22e-04 GO:0005924 cell-substrate adherens junction
2.23 3.40e-02 GO:0030027 lamellipodium
2.21 9.29e-05 GO:0005912 adherens junction
2.04 7.97e-04 GO:0070161 anchoring junction
1.80 3.91e-02 GO:0031252 cell leading edge
1.70 4.87e-03 GO:0015629 actin cytoskeleton
1.42 4.43e-02 GO:0030054 cell junction
1.14 2.81e-02 GO:0071944 cell periphery
1.14 2.91e-02 GO:0005886 plasma membrane
1.13 5.85e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.75 2.63e-02 GO:0005070 SH3/SH2 adaptor activity
2.37 1.73e-02 GO:0031625 ubiquitin protein ligase binding
2.31 1.14e-03 GO:0017124 SH3 domain binding
1.82 6.35e-05 GO:0003779 actin binding
1.52 4.83e-03 GO:0008092 cytoskeletal protein binding
1.35 1.40e-02 GO:0030528 transcription regulator activity